Vitamin D receptor genotypes are not associated with rheumatoid arthritis or biochemical parameters of bone turnover in German RA patients

Clinical and Experimental Rheumatology

Volumn 21, Issue 3, 2003, Pages 333-339

  Goertz, Birgit ^a   Fassbender, Walter J ^b   Williams, Janet C ^a   Marzeion, Axel M ^a   Bretzel, Reinhard G ^a   Stracke, Hilmar ^a   Berliner, Michael N ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

Bone metabolism; Genetics; Rheumatoid arthritis; Vitamin D receptor

Indexed keywords

25 HYDROXYVITAMIN D; ALKALINE PHOSPHATASE BONE ISOENZYME; BIOCHEMICAL MARKER; C REACTIVE PROTEIN; DEOXYPYRIDINOLINE; OSTEOCALCIN; PARATHYROID HORMONE; PROCOLLAGEN C PROTEINASE; RHEUMATOID FACTOR; VITAMIN D; VITAMIN D RECEPTOR;

ADULT; AGED; ALLELE; ARTICLE; AUTOIMMUNE DISEASE; BIOCHEMISTRY; BONE DENSITY; BONE METABOLISM; BONE TURNOVER; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME BLOOD LEVEL; ERYTHROCYTE SEDIMENTATION RATE; FAMILY HISTORY; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENOTYPE; GERMANY; HUMAN; IMMUNOMODULATION; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; OSSIFICATION; OSTEOLYSIS; PARATHYROID HORMONE BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RHEUMATOID ARTHRITIS; STATISTICAL ANALYSIS; URINARY EXCRETION;

ADULT; AGED; ALLELES; ARTHRITIS, RHEUMATOID; BASE SEQUENCE; BONE DENSITY; BONE REMODELING; C-REACTIVE PROTEIN; CASE-CONTROL STUDIES; FEMALE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GERMANY; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; RECEPTORS, CALCITRIOL; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX; STATISTICS, NONPARAMETRIC;

EID: 0037534426     PISSN: 0392856X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. STRAUB RH, CUTOLO M: Involvement of the hypothalamic-pituitary-adrenal/gonadal axis and the peripheral nervous system in rheumatoid arthritis: viewpoint based on a systemic pathogenetic role. Arthritis Rheum 2001; 44: 493-507.
2. GRIFFITHS B, SITUNAYAKE RD, CLARK B, TENNANT A, SALMON M, EMERY P: Racial origin and its effect on disease expression and HLA-DRB1 types in patients with rheumatoid arthritis: A matched cross-sectional study. Rheumatology 2000; 39: 857-64.
3. SHIBUE T, TSUCHIYA N, KOMATA T et al.: Tumor necrosis factor a 5′-flanking region, tumor necrosis factor receptor II, and HLA-DRB1 polymorphisms in Japanese patients with rheumatoid arthritis. Arthritis Rheum 2000; 43: 753-7.
4. GREGERSEN PK, SILVER J, WINCHESTER RJ: The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987; 30: 1205-13.
5. SAAL JG, KRIMMEL M, STEIDLE M et al.: Synovial Epstein-Barr virus infection increases the risk of rheumatoid arthritis in individuals with the shared HLA-DR4 epitope. Arthritis Rheum 1999; 42: 1485-96.
6. TAKAGI H, ISHIGURO N, IWATA H, KANAMONO T: Genetic association between rheumatoid arthritis and estrogen receptor microsatellite polymorphism. J Rheumatol 2000; 27: 1638-42.
7. BLASCHKE S, SCHWARZ G, MONEKE D, BINDER L, MULLER G, REUSS-BORST M: Epstein-Barr virus infection in peripheral blood mononuclaer cells, synovial fluid cells, and synovial membranes of patients with rheumatoid arthritis. J Rheumatol 2000; 27: 866-73.
8. NIEDOBITEK G, LISNER R, SWOBODA B et al.: Lack of evidence for an involvement of Ep-stein-Barr virus infection of synovial membranes in the pathogenesis of rheumatoid arth-ritis. Arthritis Rheum 2000; 43: 151-4.
9. 3 in rheumatoid arthritis patients. Clin Exp Rheumatol 1999; 17: 453-6.
10. + cells. Autoimmunity 1992; 14: 3743.
11. CIPPITELLI M, SANTONI A: Vitamin D3: A transcriptional modulator of the interferongamma gene. Eur J Immunol 1998; 28: 3017-30.
12. TSOUKAS CD, PROVVEDINI DM, MANOLAGAS SC: 1,25-dihydroxyvitamin D3: A novel inummoregulatory hormone. Science 1984; 224: 1438-40.
13. REICHEL H, KOEFFLER HP, TOBLER A, NORMAN AW: 1 Alpha,25-dihydroxyvitamin D3 inhibits gamma-interferon synthesis by normal human peripheral blood lymphocytes. Proc Natl Acad Sci USA 1987; 84: 3385-9.
14. D'AMBROSIO D, CIPPITELLI M, COCCIOLO MG et al.: Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappa B downregulation in transcriptional repression of the p40 gene. J Clin Invest 1998; 101: 252-62.
15. FUKAZAWA T, YABE I, KIKUCHI S, SASAKI H, HAMADA T, MIYASAKA K, TASHIRO K: Association of vitamin D receptor gene polymorphism with multiple sclerosis in Japanese. J Neurol Sci 1999; 166: 47-52.
16. MCDERMOTT MF, RAMACHANDRAN A, OGUNKOLADE BW et al.: Allelic variation in the vitamin D receptor influences susceptibility to IDDM in Indian Asians. Diabetologia 1997; 40: 971-5.
17. PANI MA, KNAPP M, DONNER H et al.: Vitamin D receptor allele combinations influence genetic susceptibility to type 1 diabetes in Germans. Diabetes 2000; 49: 504-7.
18. MORRISON NA, YEOMAN R, KELLY PJ, EISMAN JA: Contribution of trans-acting factor alleles to normal physiological variability: Vitamin D receptor gene polymorphisms and circulating osteocalcin. Proc Natl Acad Sci 1992; 89: 6665-9.
19. TOKITA A, MATSUMOTO H, MORRISON NA et al.: Vitamin D receptor alleles, bone mineral density and turnover in premenopausal Japanese women. J Bone Miner Res 1996; 11: 1003-9.
20. KRALL EA, PARRY P, LICHTER JB, DAWSON-HUGHES B: Vitamin D receptor alleles and rates of bone loss: Influences of years since menopause and calcium intake. J Bone Miner Res 1995; 10: 978-84.
21. RIGGS BL, NGUYEN TV, MELTON LJ 3rd et al.: The contribution of vitamin D receptor gene alleles to the determination of bone mineral density in normal and osteoporotic women. J Bone Miner Res 1995; 10: 991-6.
22. ARNETT FC, EDWORTHY SM, BLOCH DA et al.: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315-24.
23. HOCHBERG MC, CHANG RW, DWOSH I, LINDSEY S, PINCUS T, WOLFE F: The American College of Rheumatology 1991 revised criteria for the classification of global functional status in rheumatoid arthritis. Arthritis Rheum 1992; 35: 498-502.
24. WITHOLD W, SCHULTE U, REINAUER H: Method for determination of bone alkaline phosphatase activity: Analytical performance and clinical usefulness in patients with metabolic and malignant bone diseases. Clin Chem 1996; 42: 210-7.
25. GARNERO P, GRIMAUX M, SEGUIN P, DELMAS PD: Characterisation of immunoreactive forms of human osteocalcin generated in vivo and in vitro. J Bone Miner Res 1994; 9: 255-64.
26. MELKKO J, NIEMI S, RISTELI L, RIESTELI J: Radioimmunoassay of the carboxyterminal propeptide of human type I procollagen. Clin Chem 1990; 36: 1328-32.
27. HADDAD JG, CHYU KJ: Competitive protein-binding radioimmunoassay for 25-hydroxycholecalciferol. J Clin Endocrinol Metab 1971; 33: 992-95
28. KAO P C, JIANG N-S, KLEE GG, PURNELL DC: Development and validation of a new radioimmunoassay for parathyrin (PTH). Clin Chem 1982; 28: 69-74
29. SEIBEL M J, COSMAN V, SHEN V, RATCLIFFE A, LINDSAY R: Urinary hydroxy-pyridinium crosslinks of collagen as markers of bone resorption and estrogen efficacy in postmenopausal osteoporosis. J Bone Miner Res 1993; 8: 881-9
30. FASSBENDER WJ, GOERTZ B, WEISMÜLLER K et al.: VDR gene polymorphisms are over-represented in German patients with type 1 diabetes compared to healthy controls without effect on biochemical parameters of bone metabolism. Horm Metab Res 2002; 34: 3307.
31. MORRISON NA, QI JC, TOKITA A et al.: Prediction of bone density from vitamin D receptor alleles. Nature 1994; 367: 284-7
32. CARLING T, RIDEFELT P, HELLMANN P, RASTADT J, AKERSTRÖM G: Vitamin D receptor polymorphism correlate to parathyroid cell function in primary hyperparathyroidism. J Clin Endocrinol Metab 1997; 82: 1772-5.
33. GROSS C, KRISHNAN AV, MALLOY PJ, ECCLESHALL TR, ZHAO XY, FELDMAN D: The vitamin D receptor gene start codon polymorphism: A functional analysis of FokI variants. J Bone Miner Res 1998; 13: 1691-99.
34. TETLOW LC, SMITH SJ, MAWER EB, WOOLEY DE: Vitamin D receptors in the rheumatoid lesion: expression by chondrocytes, macrophages, and synoviocytes. Ann Rheum Dis 1999; 58: 118-121
35. MATHIEU C, LAUREYS J, SOBIS H, VANDEPUTTE M, WAER M, BOUILLON R: 1,25-dihydroxyvitamin D3 prevents insulitis in NOD mice. Diabetes 1992; 41: 1491-5
36. NASHOLD FE, MILLER DJ, HAYES CE: 1,25-dihydroxyvitamin D3 treatment decreases macrophage accumulation in the CNS of mice with experimental autoimmune encephalomyelitis. J Neuroimmunol 2000; 103: 171-9.
37. DURRIN LK, HAILE RW, INGLES SA, COETZEE GA: Vitamin D receptor 3′-untranslated region polymorphisms: Lack of effect on mRNA stability. Biochim Biophys Acta 1999; 1453: 311-20
38. OHTERA K, ISHII S, MATSUYAMA T: Influence of the vitamin D receptor alleles on human osteoblast-like cells. J Bone Joint Surg Br 2001; 83: 134-8
39. RAUCH F, RADERMACHER A, DANZ A et al.: Vitamin D receptor genotypes and changes of bone density in physically active German women with high calcium intake. Exp Clin Endocrinol Diabetes 1997; 105: 103-8
40. UITTERLINDEN AG, POLS HAP, BURGER H et al.: A large-scale population-based study of the association of vitamin D receptor gene polymorphisms with bone mineral density. J Bone Miner Res 1996; 11: 1241-8
41. GARNERO P, BOREL O, SORNAY-RENDU E, ARLOT ME, DELMAS PD: Vitamin D receptor gene polymorphisms are not related to bone turnover, rate of bone loss, and bone mass in postmenopausal women: The OFLEY Study. J Bone Miner Res 1996; 11: 827-34.
42. FOUNTAS L, MOUTSATSOU P, KASTANIAS I et al.: The contribution of vitamin D receptor gene polymorphisms in osteoporosis and familial osteoporosis. Osteoporosis Int 1999; 10: 392-8.
43. SPECTOR TD, KEEN RW, ARDEN NK et al.: Influence of vitamin D receptor genotype on bone mineral density in postmenopausal women: A twin study in Britain. BMJ 1995; 310: 1357-60.
44. HURSTMYER FG, PEACOCK M, HUI S, JOHNSTON CC, CHRISTIAN J: Bone mineral density in relation to polymorphism at the vitamin D receptor gene locus. J Clin Invest 1994; 94: 2130-4.
45. LEE C-K, HONG J-S, CHO Y-S, BIN Y, KIM G-S, MOON H-B: Lack of relationship between vitamin D receptor polymorphism and bone erosion in rheumatoid arthritis. J Korean Med Sci 2001; 16: 188-92.
46. GARCIA-LOZANO JR, GONZALEZ-ESCRIBANO MF, VALENZUELA A, GARCIA A, NÚÑEZ-ROLDÁN A: Association of vitamin D receptor genotypes with early onset rheumatoid arthritis. Eur J Immunogenet 2001; 28: 89-93.
47. GOUGH A, SAMBROOK P, DEVLIN J et al.: Effect of vitamin D receptor gene alleles on bone loss in early rheumatoid arthritis. J Rheumatol 1998; 25: 864-8.
48. FLEET JC, HARRIS SS, WOOD RJ, DAWSON-HUGHES B: The BsmI vitamin D receptor restriction fragment length polymorphism (BB) predicts low bone density in premenopausal black and white women. J Bone Miner Res 1995; 10: 985-90.
49. HO M-L, CHANG J-K, CHUANG L-Y, HSU H-K, WANG G-J: Effects of nonsteroidal anti-inflammatory drugs and prostaglandins on osteoblastic functions. Biochem Pharmacol 1999; 58: 983-90.
50. UEHARA R, SUZUKI Y, ICHIKAWA Y: Methotrexate (MTX) inhibits osteoblastic differentiation in vitro: Possible mechanism of MTX osteopathy. J Rheumatol 2001; 28: 251-6.
51. NISHIMURA L, IKUYAMA S: Glucocorticoid-induced osteoporosis: Pathogenesis and management. J Bone Miner Metab 2000; 18: 350-2.
52. SHIMIZU S, SHIOZAWA S, SHIOZAWA K, IMURA S, FUJITA T: Quantitative histologic studies on the pathogenesis of periarticular osteoporosis in rheumatoid arthritis. Arthritis Rheum 1985; 28: 25-31.
53. OELZNER P, FRANKE S, MÜLLER A, HEIN G, STEIN G: Relationship between soluble markers of immune activation and bone turnover in post-menopausal women with rheumatoid arthritis. Rheumatology 1999; 38: 841-7.