메뉴 건너뛰기




Volumn 6, Issue 5, 2003, Pages 464-469

Status of therapies in development for the treatment of age-related macular degeneration

Author keywords

Age related macular degeneration; Anti angiogenics; Anti inflammatories; Choroidal neovascularization; Photo dynamic therapy

Indexed keywords

AMFENAC; ANECORTAVE; ANGIOGENESIS INHIBITOR; ANTIINFLAMMATORY AGENT; APTAMER; ATX S 10; BENZOPORPHYRIN DERIVATIVE; COMBRETASTATIN A4 PRODRUG; CORTICOSTEROID; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; ETIOPURPURIN; FLUOCINOLONE ACETONIDE; LUTETIUM TEXAPHYRIN; NEPAFENAC; PEGAPTANIB; PHOTOSENSITIZING AGENT; PIGMENT EPITHELIUM DERIVED FACTOR; PLACEBO; PLANT EXTRACT; PORPHYRIN DERIVATIVE; RECOMBINANT ANTIBODY; RECOMBINANT HUMAN VASCULOTROPIN MONOCLONAL ANTIBODY V2; ROSTAPORFIN; SQUALAMINE; STEROID; TIN; TRIAMCINOLONE ACETONIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN ANTIBODY;

EID: 0037531605     PISSN: 13697056     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (14)

References (55)
  • 2
    • 0032159819 scopus 로고    scopus 로고
    • Wet-type macular degeneration
    • Thompson J, Daniels C: Wet-type macular degeneration. Radiol Technol (1998) 70:85-88.
    • (1998) Radiol Technol , vol.70 , pp. 85-88
    • Thompson, J.1    Daniels, C.2
  • 3
    • 0035063982 scopus 로고    scopus 로고
    • Treatment of subfoveal choroidal neovascularization in age related macular degeneration: Focus on clinical application of verteporfin photodynamic therapy
    • Soubrane G, Bressler NM: Treatment of subfoveal choroidal neovascularization in age related macular degeneration: Focus on clinical application of verteporfin photodynamic therapy. Br J Ophthalmol (2001) 85:483-495.
    • (2001) Br J Ophthalmol , vol.85 , pp. 483-495
    • Soubrane, G.1    Bressler, N.M.2
  • 5
    • 0036719070 scopus 로고    scopus 로고
    • The age-related eye disease study (AREDS)
    • Hammond BR Jr, Johnson MA: The age-related eye disease study (AREDS). Nutr Rev (2002) 60:283-288.
    • (2002) Nutr Rev , vol.60 , pp. 283-288
    • Hammond B.R., Jr.1    Johnson, M.A.2
  • 6
    • 0035023496 scopus 로고    scopus 로고
    • Verteporfin: A milestone in ophthalmology and photodynamic therapy
    • Brown SB, Mellish KJ: Verteporfin: A milestone in ophthalmology and photodynamic therapy. Exp Opin Pharmacother (2001) 2:351-361.
    • (2001) Exp Opin Pharmacother , vol.2 , pp. 351-361
    • Brown, S.B.1    Mellish, K.J.2
  • 8
    • 0035132136 scopus 로고    scopus 로고
    • Photodynamic therapy: Shedding light on the biochemical pathways regulating porphyrin-mediated cell death
    • Granville DJ, McManus BM, Hunt DW: Photodynamic therapy: Shedding light on the biochemical pathways regulating porphyrin-mediated cell death. Histol Histopathol (2001) 16:309-317.
    • (2001) Histol Histopathol , vol.16 , pp. 309-317
    • Granville, D.J.1    McManus, B.M.2    Hunt, D.W.3
  • 9
    • 0033694993 scopus 로고    scopus 로고
    • Mechanisms of action of photodynamic therapy with verteporfin for the treatment of age-related macular degeneration
    • Schmidt-Erfurth U, Hasan T: Mechanisms of action of photodynamic therapy with verteporfin for the treatment of age-related macular degeneration. Surv Ophthalmol (2000) 45:195-214.
    • (2000) Surv Ophthalmol , vol.45 , pp. 195-214
    • Schmidt-Erfurth, U.1    Hasan, T.2
  • 10
    • 0032833645 scopus 로고    scopus 로고
    • Release of cytochrome c, Bax migration, Bid cleavage, and activation of caspases 2, 3, 6, 7, 8, and 9 during endothelial cell apoptosis
    • Granville DJ, Shaw JR, Leong S, Carthy CM, Margaron P, Hunt DW, McManus BM: Release of cytochrome c, Bax migration, Bid cleavage, and activation of caspases 2, 3, 6, 7, 8, and 9 during endothelial cell apoptosis. Am J Pathol (1999) 155:1021-1025.
    • (1999) Am J Pathol , vol.155 , pp. 1021-1025
    • Granville, D.J.1    Shaw, J.R.2    Leong, S.3    Carthy, C.M.4    Margaron, P.5    Hunt, D.W.6    McManus, B.M.7
  • 11
    • 0036480513 scopus 로고    scopus 로고
    • Guidelines for using verteporfin (Visudyne) in photodynamic therapy to treat choroidal neovascularization due to age-related macular degeneration and other causes
    • Verteporfin Roundtable 2000 and 2001 Participants, Treatment of Age-Related Macular Degeneration with Photodynamic Therapy (TAP) Study Group Principal Investigators, Verteporfin in Photodynamic Therapy (VIP) Study Group Principal Investigators: Guidelines for using verteporfin (Visudyne) in photodynamic therapy to treat choroidal neovascularization due to age-related macular degeneration and other causes. Retina (2002) 22:6-18.
    • (2002) Retina , vol.22 , pp. 6-18
  • 12
    • 0342632445 scopus 로고    scopus 로고
    • Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: One-year results of 2 randomized clinical trials - TAP report 1
    • Treatment of Age-Related Macular Degeneration with Photodynamic Therapy (TAP) Study Group: Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: One-year results of 2 randomized clinical trials - TAP report 1. Arch Ophthalmol (1999) 117:1329-1345.
    • (1999) Arch Ophthalmol , vol.117 , pp. 1329-1345
  • 13
    • 0036875646 scopus 로고    scopus 로고
    • Verteporfin therapy of subfoveal choroidal neovascularization in patients with age-related macular degeneration: Additional information regarding baseline lesion composition's impact on vision outcomes - TAP report No. 3
    • Bressler NM, Arnold J, Benchaboune M, Blumenkranz MS, Fish GE, Gragoudas ES, Lewis H, Schmidt-Erfurth U, Slakter JS, Bressler SB, Manos K et al: Verteporfin therapy of subfoveal choroidal neovascularization in patients with age-related macular degeneration: Additional information regarding baseline lesion composition's impact on vision outcomes - TAP report No. 3. Arch Ophthalmol (2002) 120:1443-1454.
    • (2002) Arch Ophthalmol , vol.120 , pp. 1443-1454
    • Bressler, N.M.1    Arnold, J.2    Benchaboune, M.3    Blumenkranz, M.S.4    Fish, G.E.5    Gragoudas, E.S.6    Lewis, H.7    Schmidt-Erfurth, U.8    Slakter, J.S.9    Bressler, S.B.10    Manos, K.11
  • 14
    • 0036950994 scopus 로고    scopus 로고
    • Photodynamic therapy for choroidal neovascular disease: Photosensitizers and clinical trials
    • Lim JI: Photodynamic therapy for choroidal neovascular disease: Photosensitizers and clinical trials. Ophthalmol Clin North Am (2002) 15:473-478.
    • (2002) Ophthalmol Clin North Am , vol.15 , pp. 473-478
    • Lim, J.I.1
  • 15
    • 0035980354 scopus 로고    scopus 로고
    • Photosensitizer delivery for photodynamic therapy for choroidal neovascularization
    • Renno RZ, Miller JW: Photosensitizer delivery for photodynamic therapy for choroidal neovascularization. Adv Drug Deliv Rev (2001) 52:63-78.
    • (2001) Adv Drug Deliv Rev , vol.52 , pp. 63-78
    • Renno, R.Z.1    Miller, J.W.2
  • 16
    • 0032908193 scopus 로고    scopus 로고
    • Selective occlusion of choroidal neovascularization by photodynamic therapy with a water-soluble photosensitizer, ATX-S10
    • Obana A, Gohto Y, Kaneda K, Nakajima S, Takemura T, Miki T: Selective occlusion of choroidal neovascularization by photodynamic therapy with a water-soluble photosensitizer, ATX-S10. Lasers Surg Med (1999) 24:209-222.
    • (1999) Lasers Surg Med , vol.24 , pp. 209-222
    • Obana, A.1    Gohto, Y.2    Kaneda, K.3    Nakajima, S.4    Takemura, T.5    Miki, T.6
  • 17
    • 0034798353 scopus 로고    scopus 로고
    • PDT to monkey CNV with ATX-S10(Na): Inappropriateness of early laser irradiation for selective occlusion
    • Obana A, Gohto Y, Kaneda K, Nakajima S, Miki T: PDT to monkey CNV with ATX-S10(Na): Inappropriateness of early laser irradiation for selective occlusion. Invest Ophthalmol Vis Sci (2001) 42:2639-2645.
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 2639-2645
    • Obana, A.1    Gohto, Y.2    Kaneda, K.3    Nakajima, S.4    Miki, T.5
  • 18
    • 0036672017 scopus 로고    scopus 로고
    • Photodynamic therapy for choroidal neovascularization: A review
    • Woodburn KW, Engelman CJ, Blumenkranz MS: Photodynamic therapy for choroidal neovascularization: A review. Retina (2002) 22:391-405.
    • (2002) Retina , vol.22 , pp. 391-405
    • Woodburn, K.W.1    Engelman, C.J.2    Blumenkranz, M.S.3
  • 19
    • 0035211504 scopus 로고    scopus 로고
    • Angiogenesis-dependent diseases
    • Folkman J: Angiogenesis-dependent diseases. Semin Oncol (2001) 28:536-542.
    • (2001) Semin Oncol , vol.28 , pp. 536-542
    • Folkman, J.1
  • 21
    • 0035173448 scopus 로고    scopus 로고
    • Novel mechanism for age-related macular degeneration: An equilibrium shift between the angiogenesis factors VEGF and PEDF
    • note
    • Ohno-Matsui K, Morita I, Tombran-Tink J, Mrazek D, Onodera M, Uetama T, Hayano M, Murota SI, Mochizuki M: Novel mechanism for age-related macular degeneration: An equilibrium shift between the angiogenesis factors VEGF and PEDF. J Cell Physiol (2001) 189:323-333. This review examines the balance between PEDF and VEGF, and examines the theory that PEDF may counteract the angiogenic properties of VEGF.
    • (2001) J Cell Physiol , vol.189 , pp. 323-333
    • Ohno-Matsui, K.1    Morita, I.2    Tombran-Tink, J.3    Mrazek, D.4    Onodera, M.5    Uetama, T.6    Hayano, M.7    Murota, S.I.8    Mochizuki, M.9
  • 24
    • 0033882695 scopus 로고    scopus 로고
    • Overexpression of vascular endothelial growth factor (VEGF) in the retinal pigment epithelium leads to the development of choroidal neovascularization
    • Spilsbury K, Garrett KL, Shen WY, Constable IJ, Rakoczy PE: Overexpression of vascular endothelial growth factor (VEGF) in the retinal pigment epithelium leads to the development of choroidal neovascularization. Am J Pathol (2000) 157:135-144.
    • (2000) Am J Pathol , vol.157 , pp. 135-144
    • Spilsbury, K.1    Garrett, K.L.2    Shen, W.Y.3    Constable, I.J.4    Rakoczy, P.E.5
  • 26
    • 0036959644 scopus 로고    scopus 로고
    • Preclinical and phase 1A clinical evaluation of an anti-VEGF PEGylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration
    • The Eyetech Study Group: Preclinical and phase 1A clinical evaluation of an anti-VEGF PEGylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration. Retina (2002) 22:143-152.
    • (2002) Retina , vol.22 , pp. 143-152
  • 27
    • 1542381472 scopus 로고    scopus 로고
    • Anti-VEGF therapy for subfoveal choroidal neovascularization secondary to age-related macular degeneration: Phase IB results
    • Abs 2908
    • Singerman LJ: Anti-VEGF therapy for subfoveal choroidal neovascularization secondary to age-related macular degeneration: Phase IB results. Invest Ophthalmol Vis Sci (2002) 43:Abs 2908.
    • (2002) Invest Ophthalmol Vis Sci , vol.43
    • Singerman, L.J.1
  • 31
    • 0036329579 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor is deficient in the vitreous of patients with choroidal neovascularization due to age-related macular degeneration
    • Holekamp NM, Bouck N, Volpert O: Pigment epithelium-derived factor is deficient in the vitreous of patients with choroidal neovascularization due to age-related macular degeneration. Am J Ophthalmol (2002) 134:220-227.
    • (2002) Am J Ophthalmol , vol.134 , pp. 220-227
    • Holekamp, N.M.1    Bouck, N.2    Volpert, O.3
  • 33
    • 0036297886 scopus 로고    scopus 로고
    • Regression of ocular neovascularization in response to increased expression of pigment epithelium-derived factor
    • Mori K, Gehlbach P, Ando A, McVey D, Wei L, Campochiaro PA: Regression of ocular neovascularization in response to increased expression of pigment epithelium-derived factor. Invest Ophthalmol Vis Sci (2002) 43:2428-2434.
    • (2002) Invest Ophthalmol Vis Sci , vol.43 , pp. 2428-2434
    • Mori, K.1    Gehlbach, P.2    Ando, A.3    McVey, D.4    Wei, L.5    Campochiaro, P.A.6
  • 35
    • 0035514256 scopus 로고    scopus 로고
    • Clinical protocol. An open-label, phase I, single administration, dose-escalation study of ADGVPEDF.11D (ADPEDF) in neovascular age-related macular degeneration (AMD)
    • Rasmussen H, Chu KW, Campochiaro P, Gehlbach PL, Haller JA, Handa JT, Nguyen QD, Sung JU: Clinical protocol. An open-label, phase I, single administration, dose-escalation study of ADGVPEDF.11D (ADPEDF) in neovascular age-related macular degeneration (AMD). Hum Gene Ther (2001) 12:2029-2032.
    • (2001) Hum Gene Ther , vol.12 , pp. 2029-2032
    • Rasmussen, H.1    Chu, K.W.2    Campochiaro, P.3    Gehlbach, P.L.4    Haller, J.A.5    Handa, J.T.6    Nguyen, Q.D.7    Sung, J.U.8
  • 36
    • 0035262598 scopus 로고    scopus 로고
    • Targeting tumour vasculature: The development of combretastatin A4
    • Griggs J, Metcalfe JC, Hesketh R: Targeting tumour vasculature: The development of combretastatin A4. Lancet Oncol (2001) 2:82-87.
    • (2001) Lancet Oncol , vol.2 , pp. 82-87
    • Griggs, J.1    Metcalfe, J.C.2    Hesketh, R.3
  • 37
    • 0038455044 scopus 로고    scopus 로고
    • Vascular targeting activity of combretastatin A-4 phosphate (CA4P) in an ocular model of angiogenesis
    • Abs 1752
    • Armstrong D, Higa A, Iwabuchi S, Wood M: Vascular targeting activity of combretastatin A-4 phosphate (CA4P) in an ocular model of angiogenesis. Invest Ophthalmol Vis Sci (2002) 43:Abs 1752.
    • (2002) Invest Ophthalmol Vis Sci , vol.43
    • Armstrong, D.1    Higa, A.2    Iwabuchi, S.3    Wood, M.4
  • 38
    • 0033944912 scopus 로고    scopus 로고
    • Intravitreal triamcinolone acetonide in exudative age-related macular degeneration
    • Danis RP, Ciulla TA, Pratt LM, Anliker W: Intravitreal triamcinolone acetonide in exudative age-related macular degeneration. Retina (2000) 20:244-250.
    • (2000) Retina , vol.20 , pp. 244-250
    • Danis, R.P.1    Ciulla, T.A.2    Pratt, L.M.3    Anliker, W.4
  • 39
    • 0028953762 scopus 로고
    • Posterior sub-tenon injections of repository corticosteroids in uveitis patients with cystoid macular edema
    • Yoshikawa K, Kotake S, Ichiishi A, Sasamoto Y, Kosaka S, Matsuda H: Posterior sub-tenon injections of repository corticosteroids in uveitis patients with cystoid macular edema. Jpn J Ophthalmol (1995) 39: 71-76.
    • (1995) Jpn J Ophthalmol , vol.39 , pp. 71-76
    • Yoshikawa, K.1    Kotake, S.2    Ichiishi, A.3    Sasamoto, Y.4    Kosaka, S.5    Matsuda, H.6
  • 40
    • 0033825585 scopus 로고    scopus 로고
    • Intravitreal injection of crystalline cortisone as adjunctive treatment of proliferative vitreoretinopathy
    • Jonas JB, Hayler JK, Panda-Jonas S: Intravitreal injection of crystalline cortisone as adjunctive treatment of proliferative vitreoretinopathy. Br J Ophthalmol (2000) 84:1064-1067.
    • (2000) Br J Ophthalmol , vol.84 , pp. 1064-1067
    • Jonas, J.B.1    Hayler, J.K.2    Panda-Jonas, S.3
  • 42
    • 0042029477 scopus 로고    scopus 로고
    • Combined photodynamic therapy with verteporfin and intravitreal triamcinolone acetonide for choroidal neovascularization
    • Abs 5032
    • Spaide RF, Sorenson J: Combined photodynamic therapy with verteporfin and intravitreal triamcinolone acetonide for choroidal neovascularization. Ann Meet Assoc Res Vision Ophthalmol, Fort Lauderdale, FL, USA (2003):Abs 5032.
    • (2003) Ann Meet Assoc Res Vision Ophthalmol, Fort Lauderdale, FL, USA
    • Spaide, R.F.1    Sorenson, J.2
  • 43
    • 0034041303 scopus 로고    scopus 로고
    • Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: II. In vitro bioactivation and permeation of external ocular barriers
    • Ke TL, Graff G, Spellman JM, Yanni JM: Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: II. In vitro bioactivation and permeation of external ocular barriers. Inflammation (2000) 24:371-384.
    • (2000) Inflammation , vol.24 , pp. 371-384
    • Ke, T.L.1    Graff, G.2    Spellman, J.M.3    Yanni, J.M.4
  • 44
    • 0034045508 scopus 로고    scopus 로고
    • Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: I. Assessment of anti-inflammatory efficacy
    • Gamache DA, Graff G, Brady MT, Spellman JM, Yanni JM: Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: I. Assessment of anti-inflammatory efficacy. Inflammation (2000) 24:357-370.
    • (2000) Inflammation , vol.24 , pp. 357-370
    • Gamache, D.A.1    Graff, G.2    Brady, M.T.3    Spellman, J.M.4    Yanni, J.M.5
  • 46
    • 0038455042 scopus 로고    scopus 로고
    • Sub-Tenon's administration of the angiostatic agent anecortave acetate in AMD patients with subfoveal choroidal neovascularization (CNV) - The clinical outcome
    • Abs 2909
    • Slakter JS, Singerman LJ, Yannuzzi LA, Russell SR, Hudson HL, Jerdan J, Zilliox P, Robertson S: Sub-Tenon's administration of the angiostatic agent anecortave acetate in AMD patients with subfoveal choroidal neovascularization (CNV) - The clinical outcome. Invest Ophthalmol Vis Sci (2002) 43:Abs 2909.
    • (2002) Invest Ophthalmol Vis Sci , vol.43
    • Slakter, J.S.1    Singerman, L.J.2    Yannuzzi, L.A.3    Russell, S.R.4    Hudson, H.L.5    Jerdan, J.6    Zilliox, P.7    Robertson, S.8
  • 47
    • 0035161760 scopus 로고    scopus 로고
    • The effect of an angiostatic steroid on neovascularization in a rat model of retinopathy of prematurity
    • Penn JS, Rajaratnam VS, Collier RJ, Clark AF: The effect of an angiostatic steroid on neovascularization in a rat model of retinopathy of prematurity. Invest Ophthalmol Vis Sci (2001) 42:283-290.
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 283-290
    • Penn, J.S.1    Rajaratnam, V.S.2    Collier, R.J.3    Clark, A.F.4
  • 48
    • 0038455043 scopus 로고    scopus 로고
    • Alcon launches new anecortave acetate clinical trial for macular degeneration based on positive results from ongoing studies
    • September 03
    • Alcon Inc: Alcon launches new anecortave acetate clinical trial for macular degeneration based on positive results from ongoing studies. Press Release (2002) September 03.
    • (2002) Press Release
  • 54
    • 0036956091 scopus 로고    scopus 로고
    • Use of radiation in the treatment of age-related macular degeneration
    • Flaxel CJ: Use of radiation in the treatment of age-related macular degeneration. Ophthalmol Clin North Am (2002) 15:437-444.
    • (2002) Ophthalmol Clin North Am , vol.15 , pp. 437-444
    • Flaxel, C.J.1
  • 55
    • 0034957199 scopus 로고    scopus 로고
    • Thalidomide and prednisolone inhibit growth factor-induced human retinal pigment epithelium cell proliferation in vitro
    • Kaven C, Spraul CW, Zavazava N, Lang GK, Lang GE: Thalidomide and prednisolone inhibit growth factor-induced human retinal pigment epithelium cell proliferation in vitro. Ophthalmologica (2001) 215:284-289.
    • (2001) Ophthalmologica , vol.215 , pp. 284-289
    • Kaven, C.1    Spraul, C.W.2    Zavazava, N.3    Lang, G.K.4    Lang, G.E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.