Leishmaniasis in HIV infection

Journal of Postgraduate Medicine

Volumn 49, Issue 1, 2003, Pages 39-49

  Paredes, Roger ^a,b   Munoz J ^a,b   Domingo, P ^a,b   Gurgui, M ^a,b   Clotet, B ^a,b  

^a HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^b HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

Author keywords

AIDS; Hepatitis; HIV; Interferon; Leishmaniasis

Indexed keywords

ALLOPURINOL; AMPHOTERICIN B; AMPHOTERICIN B DEOXYCHOLATE; ANTIMONY DERIVATIVE; GAMMA INTERFERON; ITRACONAZOLE; MEGLUMINE ANTIMONATE; MILTEFOSINE; PARASITE ANTIGEN; STIBOGLUCONATE SODIUM;

CLINICAL FEATURE; DISEASE TRANSMISSION; DRUG CHOICE; DRUG COST; DRUG EFFECT; DRUG EFFICACY; DRUG INDICATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INCIDENCE; LEISHMANIASIS; MEDLINE; PARASITE ISOLATION; PATHOGENESIS; POLYMERASE CHAIN REACTION; REVIEW; RISK ASSESSMENT; SEROLOGY;

EID: 0037531398     PISSN: 00223859     EISSN: None     Source Type: Journal    
DOI: 10.4103/0022-3859.929     Document Type: Review

References (182)

1. Palella FJ, Delaney KM, Moorman AC, Loveless MO, Fuhrer J, Satten GA, et al. Declining Morbidity and Mortality among Patients with Advanced Human Immunodeficiency Virus Infection. N Engl J Med 1998;338:853-60.
2. Mocroft A, Vella S, Benfield T L, Chiesi A, Miller V, Gargalianos P et al. Changing patterns of mortality across Europe in patients infected with HIV-1. Lancet 1998;352:1725-30.
3. UNAIDS: AIDS Epidemic Update 2002. www.unaids.org.
4. Montalban C, Calleja JL, Erice A, Laguna F Clotet B, Podzamczer D, et al. Visceral leishmaniasis in patients infected with human immunodeficiency virus. Co-operative Group for the Study of Leishmaniasis in AIDS. J Infect 1990;21:261-70.
5. Guerin PJ, Olliaro P, Sundar S, Boelaert M, Croft SL, Desjeux P et al. Visceral leishmaniasis: current status of control, diagnosis, and treatment, and a proposed research and development agenda. Lancet Infect Dis 2002;2:494-501.
6. Desjeux P, et al. Leishmania/HIV co-infection in south-western Europe, 1990-1998, retrospective analysis of 965 cases, World Health Organization 2000, WHO/Leish/2000.42.
7. Desjeux P, UNAIDS. Leishmania and HIV in Gridlock. WHO/CTD/ LEISH/98.9 Add.I, UNAIDS/98.23.1998. Geneva: WHO, 1998.
8. Alvar J, Canavate C, Gutierrez-Solar B, Jiménez M, Laguna F, López-Vélez R, et al. Leishmania and human immunodeficiency virus coinfection: the first 10 years. Clin Microbiol Rev 1997;10:298-319.
9. Alvar J. Leishmaniasis and AIDS co-infection the Spanish example. Parasitol Today 1994;10:160-3.
10. Pintado V, Martín-Rabadán P Rivera ML, Moreno S, Bouza E. Visceral Leishmaniasis in Human Immunodeficiency Virus (HIV) -Infected and Non-HIV-Infected Patients. A Comparative Study. Medicine 2001;80:54-73.
11. Pintado V, López-Vélez R. Leishmaniasis visceral asociada al virus de la inmunodeficiencia humana. Enferm Infecc Microbiol Clin 2001;19:353-7.
12. Kubar J, Marty Lelievre A, Quaranta JF, Staccini P, Caroli BC, et al. Visceral leishmaniosis in HIV-positive patients: Primary infection, reactivation and latent infection. Impact of the CD4 T-lymphocyte counts. AIDS 1998;12:2147-53.
13. Wolday D, Akuffo H, Britton S, Hathaway A, Sander B. HIV-1 inhibits Leishmania-induced cell proliferation, but not TNF-alpha and IL-6 production. Scand J Immunol 1994;39:380-6.
14. Reiner, SL, Locksley RM. The regulation of immunity to Leishmania major. Annu Rev Immunol 1995;13:151-77.
15. Bernier, Turco RSJ, Olivier M, Tremblay M. Activation of human immunodeficiency virus type 1 in monocytoid cells by the protozoan parasite Leishmania donovani. J Virol 1995;69:7282-5.
16. Kalinkovich A, Weisman Z, Bentwich Z. Chemokine and chemokine receptors: role in HIV infection. Immunol 1999;68:281-7.
17. Fahey JL. Cytokines, plasma immune asctivation markers, a clinically relevant-surrogate markers in human immunodeficiency virus infection. Clin Diag Lab Immunol 1998;597-603.
18. Srebel K, Bour S. Molecular interactions of HIV with human factors. AIDS 1999;13(Suppl A):S13-S24.
19. World Health Organization. Leishmania/HIV co-infection. Epidemiological analysis of 692 retrospective cases. Wkly Epiderniol Rec 1997;72:49-54.
20. Sundar S. Drug resistance in Indian visceral leishmaniasis. Trop Med Int Health 2001;6:849-54.
21. Sundar S, Jha TK, Thakur CP, Engel J, Sindermann H, Fischer C, et al. Oral Miltefosine for Indian Visceral Leishmaniasis. N Engl J Med 2002;347:1739-6.
22. + T Cell Homeostasis and Function in Advanced HIV Disease. Science 1997;277:112-6.
23. De Quiros J. C. L. B, Miro JM, Pena JM, et al. A Randomized Trial of the Discontinuation of Primary and Secondary Prophylaxis against Pneumocystis carinii Pneumonia after Highly Active Antiretroviral Therapy in Patients with HIV Infection. N Engl J Med 2001;344:159-67.
24. Weverling GJ, Mocroft A, Ledergerber B, et al. Discontinuation of Pneumocystis carinii pneumonia prophylaxis after start of highly active antiretroviral therapy in HIV-1 infection. Lancet 1999;353:1293-8.
25. Jouan M, Saves M, Tubiana R, Carcelain G, Cassoux N, Aubron-Olivier C, et al. Discontinuaition of maintenance therapy for cytomegalovirus retinitis in HIV-infected patients receiving highly active antiretroviral therapy. AIDS 2001;15:23-31
26. Tural C, Romeu J, Sirera G, Andreu D, Conejero M, Ruiz S, Jou A, Bonjoch A, Ruiz L, Arno A, Clotet B. Long-lasting remission of cytomegalovirus retinitis without maintenance therapy in human immunodeficiency virus-infected patients. J Infect Dis 1998;177:1080-3.
27. Carr A, Marriott D, Field A, Vasak E, Cooper DA. Treatment of HIV1-associated microsporidiosis and cryptosporidiosis with combination antiretroviral therapy. Lancet 1998;351:256-61.
28. Foudraine NA, Weverling GJ, van Gool T, Roos MT, de Wolf F, Koopmans PP, et al. Improvement of chronic diarrhea in patients with advanced HIV-1 infection during potent antiretroviral therapy. AIDS 1998;12:35-41.
29. Miro JM, Lopez JC, Podzamczer D, Pena JM, Alberdi C, Claramonte X, et al. and the GESIDA 04/98-B Study. Discontinuation of toxoplasmic encephalitis prophylaxis is safe in HIV-1 and T. gondii coinfected patients after immunological recovery with HAART. Preliminary results of the GESIDA 04/98-B study. Abstract 230. San Francisco: Proceedings of the 7th Conference on Retroviruses and Opportunistic Infections, 2000.
30. del Giudice P, Mary-Krause M, Pradier C, Grabar S, Dellamonica P, Marty P et al. Impact of highly active antiretroviral therapy on the incidence of visceral leishmaniasis in a French cohort of patients infected with human immunodeficiency virus. J Infect Dis 2002;186:1366-70.
31. de La Rosa R, Pineda JA, Delgado J, Macias J, Morillas F, Mira JA, et al. Incidence and risk factors for symptomatic visceral leishmaniasis among human immunodeficiency virus type 1-infected patients from Spain in the era of highly active antiretroviral therapy. J Clin Microbiol 2002;40:762-7.
32. Fisk DT, Meshnick S, Kazanjian PH. Pneumocystis carinii pneumonia in patients in the developing world who have acquired immunodeficiency syndrome. Clin Infect Dis 2003;36:70-8.
33. WHO. The world health report 2001. Geneva: WHO, 2001.
34. Gutiérrez J. Prevalence of anti-Leishmania antibodies in parenteral drug addicts: yield value of 2 study techniques. Med Clin 1993;100:168.
35. Medrano FJ, Jimenez-Mejias E, Calderon E, Regordan C, Leal M. An easy and quick method for the diagnosis of visceral leishmaniasis in HIV-1-infected individuals. AIDS 1993;7:1399.
36. Pineda JA, Macias J, Morillas E Fernandez-Ochoa J, Cara J, de La Rosa R, et al. Evidence of increased risk for Leishmania infantum infection among HIV-seronegative intravenous drug users from southern Spain. Eur J Clin Microbiol Infect Dis 2001;20:354-7.
37. Cruz I, Morales MA, Noguer I, Rodríguez A, Alvar J. Leishmania in discarded syringes from intravenous drug users. Lancet 2002; 359:1124-25.
38. Pineda JA, Martín-Sánchez J, Macías J, Morillas E Leishmania spp. infection in injecting drug users. Lancet 2002;360:950-1.
39. Molina R, Canavate C, Cercenado E, Laguna F, Lopez-Velez R, Alvar J. Indirect xenodiagnosis of visceral leishmaniasis in 10 HIV-infected patients using colonized Phlebotomus perniciosus. AIDS 1994;8:277-9.
40. Cohen C, Corazza F, Mol PD, et al. Leishmaniasis acquired in Belgium. Lancet 1991;338:128.
41. Kostman R, Barr M, Bengtsson E, et al. Kala-azar transferred by exchange blood transfusion in two Swedish infants. In: Proceedings of the Seventh International Congress of Tropical Medicine and Malaria 1963:384.
42. Mauny I, Blanchot I, Degeihl B, et al. Leishmaniose viscerale chez un nourrisson en Bretagne: discussion sur les modes de transmission hors des zones endemiques. Pediatrie 1993;48:237.
43. Andre R, Brumpt L, Dreyfus B, et al. Cutaneous leishmaniasis, cutaneous-glandular leishmaniasis and transfusional kala-azar. Trop Dis Bull 1958;55:379.
44. Chung H-L, Chow H-K, Lu J-P The first two cases of transfusion kala-azar. Chinese Med J 1948;66:325.
45. Walker R, ed. Technical Manual. 11th edn. Bethesda, Md: American Association of Blood Banks; 1993. pp.1.
46. Magill AJ. Epidemiology of leishmaniases. Dermatol Clin 1995;13:505-23.
47. Loke Y. Transmission of parasites across the placenta. In: Advances in Parasitology. New York, NY. Academic Press; 1982;21:155.
48. Nuwayri-Salti N, Khansa H. Direct non-insect-vector transmission of Leishmania parasites in mice. Int J Parasitol 1985;15:497.
49. Hiu-Lan Z, Nai-Zheng Z. Studies on leishmaniasis in China: historical background, epidemiology, clinical aspects, legislature and control program. Chinese Med J 1986;99:281.
50. Napier L, Gupta CD. Indian kala-azar in a new born. Indian Med Gazette 1928;62:199.
51. Mebrahtu Y, Hendricks L, Oster C, et al. Leishmania donovani parasites in the nasal secretions, tonsillopharyngeal mucosa, and urine centrifugates of visceral leishmaniasis patients in Kenya. Am J Trop Med Hyg 1989;41:289.
52. Teng C, Forkner C. The presence of infective Leishmania donovani in the urine and prostatic fluid of patients with kala-azar. Chinese Med J 1936;1(suppl):394.
53. Symmers WSC. Leishmaniasis acquired by contagion: a case of marital infection in Britain. Lancet 1960;127.
54. Rosenthal PJ, Chaisson RE, Hadley WK, Leech JH. Rectal leishmaniasis in a patient with acquired immunodeficiency syndrome. Am J Med 1988;84:307-9
55. Herwaldt B, Juranek D. Laboratory-acquired malaria, leishmaniasis, trypanosomiasis, and toxoplasmosis. Am J Trop Med Hyg 1993;48:313.
56. Evans TG, Teixeira MJ, McAuliffe IT, Vasconcelos I, Vasconcelos AW, Sousa Ade A, et al. Epidemiology of visceral leishmaniasis in Northeast Brazil. J Infect Dis 1992;166:1124-32.
57. Belazzoug S. Leishmaniasis in Mediterranean countries. Vet Pathol 1992;44:15.
58. Aggarwal P, Prakash-Wali J. Profile of kala-azar in North India. Asia Pacific J Public Health 1991;5:90.
59. Heisch R. Studies in leishmaniasis in East Africa, I: the epidemiology of an outbreak of kala-azar in Kenya. Trans R Soc Trop Med Hyg 1954;118:779.
60. Cascio A, Colomba C, Antinori S, Orobello M, Paterson D, Titone L. Pediatric visceral leishmaniasis in Western Sicily, Italy: a retrospective analysis of 111 cases. Eur J Clin Microbiol Infect Dis 2002; 21(4):277-82.
61. Alexander J. Sex differences and cross immunity in DBA/2 mice infected with Leishmania mexicana and L major. Parasitology 1988;96:297.
62. Brabin L, Brabin B. Parasitic infections in women and their consequences. Adv Parasitol 1992;31:1.
63. Lopez-Velez R, Perez-Molina JA, Guerrero A, Baquero F, Villarubia J, Escribano L, et al. Clinico-epidemiological characteristics, prognostic factors and survival analysis of patients coinfected with HIV and Leishmania in an area of Madrid, Spain. Am J Trop Med Hyg 1998;58:436-43.
64. Pineda JA, Gallardo JA, Macias J, Delgado J, Regordan C, Morillas F, et al. Prevalence of and factors associated with visceral leishmaniasis in human immunodeficiency virus type 1-infected patients in southern Spain. J Clin Microbiol 1998;36:2419-22.
65. Ribera E, Cucurull E, Ocana I, Vallespi T, Gasser I, Juste C. [Visceral leishmaniasis in patients with HIV infection.] Enferm Infecc Microbiol Clin 1995;13:73-9.
66. Rosenthal E, Marty P, Poizot-Martin I, Reynes J, Praflong F, Lafeuillade A, et al. Visceral leishmaniasis and HIV-1 co-infection in southern France. Trans R Soc Trop Med Hyg 1995; 89:159-2.
67. Berhe N, Wolday D, Hailu A, Abraham Y, Ali A, Gebre-Michael T, et al. HIV viral load and response to antileishmanial chemotherapy in co-infected patients. AIDS 1999;13:1921-5.
68. Da-Cruz AM, Machado ES, Menezes JA, Rutowitsch MS, Coutinho SG. Cellular and humoral immune responses of a patient with American cutaneous leishmaniasis and AIDS. Trans R Soc Trop Med Hyg 1992;86:511-2.
69. Echevarria J, Campos P, Chang J, Cuellar L, Gotuzzo E, Paz, et al. Mucocutaneous leishmaniasis and AIDS: case report. Trans R Soc Trop Med Hyg 1993;87:186.
70. Hernéndez, DE, Oliver M, Martínez C, Planas G. Visceral leishmaniasis with cutaneous and rectal dissemination due to Leishmania braziliensis in AIDS. Int J Dermatol 1995;34:114-5.
71. Machado, ES, Braga MP, Da-Cruz AM, Coutinho SG, Vieira ARM, et al. Disseminated american muco-cutaneous leishmaniasis caused by Leishmania braziliensis braziliensis in a patient with AIDS: a case report. Mem Inst Oswaldo Cruz Rio J 1992;6:1499-503.
72. Berhe N, A Hailu, T Gemetchu. Human immunodeficiency virus and recurrence of cutaneous leishmaniasis long after healed localized cutaneous leishmaniasis due to L aethiopica. Trans R Soc Trop Med Hyg 1995;89:400-1.
73. Centers for Disease Control. Viscerotropic leishmaniasis in persons returning from operation Desert Storm 1990-1991. Morbid Mortal Weekly Rep 1992;41:131-4.
74. Magill, AL, Grogl M, RA, Gasser, Sun W, et al. Visceral infection caused by Leishmania tropica in veterans of operation Desert storm. N Engl J Med 1993;387:1383-7.
75. Gillis, Klaus DS, Schnur LF, Piscopos P Maayan S, Okon E, et al. Diffusely disseminated cutaneous Leishmania major infection in a child with acquired immunodeficiency syndrome. Pediatr Infect Dis J 199;514:247-9.
76. Silva ES, Pacheco RS, Gontijo CM, Carvalho IR, Brazil IP. Visceral leishmaniasis caused by Leishmania (Viannia) braziliensis in a patient infected with human immunodeficiency virus. Rev Inst Med Trop Sao Paulo 2002;44:145-9.
77. Ramon-Santos C, Hernandez-Montes O, Sanchez-Tejeda G, Monroy-Ostria A. Visceral leishmaniasis caused by Leishmania (L) mexicana in a Mexican patient with human immunodeficiency virus infection. Mem Inst Oswaldo Cruz 2000;95:733-7.
78. Barral A, Pedral-Sampaio D, Grimaldi Junior G, Momen H, McMahon-Pratt D, Ribeiro de Jesus A, et al. Leishmaniasis in Bahia, Brazil:evidence that Leishmania amazonensis produces a wide spectrum of clinical disease. Am J Trop Med Hyg 1991;44:536-46.
79. Barral A, Badaro R, Barral-Netto M, Grimaldi G Jr, Momem H, Carvalho EM. Isolation of Leishmania. mexicana amazonensis from the bone marrow in a case of American visceral leishmaniasis. Am J Trop Med Hyg 1986;35:732-4.
80. Bosch RJ, Rodrigo AB, Sanchez P, de Galvez MV, Herrera E. Presence of Leishmania organisms in specific and non-specific skin lesions in HIV-infected individuals with visceral leishmaniasis. Int J Dermatol 2002;41:670-5.
81. Orsini M, Silva M, Luz ZM, Disch J, Fernandes O, Moreira D, et al. Identification of Leishmania chagasi from skin in Leishmania/HIV co-infection:a case report. Rev Soc Bras Med Trop 2002;35:259-2.
82. Ponce C, Ponce E, Morrison A, Cruz A, Kreutzer R, McMahon-Pratt D, et al. Leishmania donovani chagasi: new clinical variant of cutaneous leishmaniasis in Honduras. Lancet 1991;337:67-70.
83. Gonzalez-Beato MJ, Moyano B, Sanchez C, Gonzalez-Beato MT, Perez-Molina JA, Miralles P et al. Kaposi's sarcoma-like lesions and other nodules as cutaneous involvement in AIDS-related visceral leishmaniasis. Br J Dermatol 2000;143:1316-8.
84. Bhattacharyya S, Ghosh S, Dasgupta B, Mazumder D, Roy S, Majumdar S. Chemokine-Induced leishmanicidal Activity in Murine Macrophages via the Generation of Nitric Oxide. J Infect Dis 2002;185:1704-8.
85. Haldar JP, Ghose S, Saha C, Ghose AC. Cell-mediated immune response in Indian kala-azarand post-kala azar dermal leishmaniasis. Infect Inmun 1983;42:702-7.
86. Levy JA. HIV and the Pathogenesis of AIDS 2nd Edn Chapter 9: Effects of HIV on various tissues and organ systems. Edn American Society for Microbiology 1998.
87. Bentwich Z, Maartens G, Torten D, Lai AA, Lal RB. Concurrent infections and HIV pathogenesis. AIDS 2000;14:2071-81.
88. Cohen OJ, Fauci AS. Host factors that affect sexual transmission of HIV Int J Infect Dis 1998;2:182-5.
89. Grossman Z, Feinberg MB, Paul WE. Multiple modes of cellular activation and virus transmission in HIV infection: a role for chronically and latently infected cells sustaining viral replication. Proc Natl Acad Sci USA 1998;95:6341-9.
90. Bentwich Z, Kalinkoovich A, Weisman Z, Grossman Z. Immune activation in the context of HIV infection. Clin Exp Immunol 1998; 111: 1-2.
91. Anderson RW, Ascher M, Sheppard HW. Direct HIV cythopaticity cannot account for CD4 decline in AIDS in the presence of homeostasis: a worst-case dynamic analysis. J AIDS 1998; 17:245-2.
92. Gougon ML, Montagnier L. Programmed cell eath as a mechanism of CD4 and Cd8 T cell deletion in AIDS. Molecular control and effect of highly active antiretroviral therapy. Ann N Y Acaf Sci 1999;887: 199-212.
93. Lane HC, Gea-Banacloche JC. Lymphocite turnover in the setting of HIV infection. Immunologist 1999;7:124-31.
94. Hazenberg MD, Stuart JW, Otto SA, Borleffs JC, Boucher CA, de Boer RJ, et al. T-cell division in HIV-1 infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART). Blood 2000;95:249-55.
95. Cacopardo, Nigro BL, Preiser W, Fama A, Satariano MI, Braner J, et al. Prolonged Th2 cell activation and increased viral replication in HIV-Leishmania co-infected patients despite treatment. Trans R Soc Trop, Med Hyg 1996;90:434-5.
96. Nigro L, Cacopardo B, Preiser W, Braner J, Cinatl J, Palermo F, et al. In vitro production of type 1 and type 2 cytokines by peripheral blood mononuclear cells from subjects co-infected with HIV and Leishmania infantum. Am J Trop Med Hyg 1999;60:142-5.
97. Di Piro JT. Cytokine networkswith infection: mycobacterial infections, leishmaniasis, human iummunodeficiency virus and sepsis. Pharmacotherapy 1997;17:205-23.
98. Ribeiro-de-Jesus A, Almeida RP, Lessa H, Bacellar O, Carvalho EM. Cytokine profile and pathology in human leishmaniasis. Braz J Med Biol Res 1998;31:143-48.
99. Folks, TM, Clouse KA, Justement J, Rabson A, Duh E, et al. Tumor necrosis factor alpha induces expression of human inmunodeficiency virus in a chronically infected T-cell clone. Proc Natl Acad Sci USA 1989;86:2365-8.
100. Folks, TM, Justement J, Kinter A, Dinarello CA, Fauci AS. Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line. Science 1987;238:800-2.
101. Blackwell JM. Tumor necrosis factor alpha and mucocutaneous leishmaniasis. Parasitol Today 1999;15:73-5.
102. Montalban C, Martinez-Fernandez R, Calleja JL, Garcia-Diaz JD, Rubio R, Dronda F, et al. Visceral leishmaniasis (kala-azar) as an opportunistic infection in patients infected with the human immunodeficiency virus in Spain. Rev Infect Dis 1989;11:655-60.
103. Sanz MdM, Rubio R, Casillas A, et al. Visceral leishmaniasis in HIV-infected patients. AIDS 1991;5:1272.
104. Gonzalez-Anglada MI, Pena JM, Barbado FJ, Gonzalez JJ, Redondo C, Galera C, et al. Two cases of laryngeal leishmaniasis in patients infected with HIV Eur J Clin Microbiol Infect Dis 1994;13:509-11.
105. Laguna F, Garcia-Samaniego J, Soriano V, Valencia E, Redondo C, Alonso MJ, et al. Gastrointestinal leishmaniasis in human immunodeficiency virus-infected patients: report of five cases and review. Clin Infect Dis 1994;19:48-53.
106. Badaro R, Carvalho EM, Rocha H, Queiroz AC, Jones TC. Leishmania donovani: an opportunistic microbe associated with progressive disease in three immunocompromised patients. Lancet 1986;1:647-9.
107. Martinez P, de la Vega E, Laguna F, Soriano V, Puente S, Moreno V, et al. Diagnosis of visceral leishmaniasis in HIV-infected individuals using peripheral blood smears. AIDS 1993;7:227-30.
108. Ramos A, Portero JL, Gazapo T, Yebra M, Portero F, Martin T. [Visceral leishmaniasis in immunocompromised patients.] An Med Interna 1998;15:301-4.
109. Reus S, Sanchez R, Portilla J, Boix V, Priego M, Merino E, et al. Visceral leishmaniasis: Comparative study in patients with and without HIV infection. Enferm Infecc Microbiol Clin 1999;17:515-20.
110. Evans TG. Leishmaniasis. Infect Dis Clin North Am 1993;7:527-46.
111. Bryceson AD. Leishmaniasis. In: Cook CG, ed. Manson's tropical diseases. 1996, 20th edn. London: WB Saunders; pp. 1213.
112. Duarte MIS, da Matta VLR, Corbett CEP, Laurenti MD, Chebabo R, Goto H. Interstitial pneumonitis in human visceral leishmaniasis. Trans R Soc Trop, Med Hyg 1989;83:73-6.
113. Muigai R, Gatei D, Shaunak S, et al. Jejunal function and pathology in visceral leishmaniasis. Lancet 1983:27:476-9.
114. Navarro CM, Villanueva MJ, Torre CJ, Ostos AP, Lopez RF, Lopez VP. Isolated laryngeal leishmaniasis in an immunocompetent patient: Successful treatment with surgery. J Laryngol Otol 1994;108:249-51.
115. Alvar J, Gutiérrez-Solar B, Molina R, et al. Prevalence of Leishmania infection among AIDS patients. Lancet 1992;339:264-5.
116. Bissuel F, Leport C, Perronne C, Longuet P, Vilde JL. Fever of unknown origin in HIV-infected patients:a critical analysis of a retrospective series of 57 cases. J Intern Med 1994;236:529-35.
117. Miralles P, Moreno S, Perez-Tascon M, Cosin J, Diaz MD, Bouza E. Fever of uncertain origin in patients infected with the human immunodeficiency virus. Clin Infect Dis 1995;20:872-75.
118. Janoff EN, Smith PD. Perspectives on gastrointestinal infections in AIDS. Gastroenterol Clin North Am 1988;17:451-63.
119. Malebranche R, Arnoux E, Guerin JM, Pierre GD, Laroche AC, Pean-Guichard C, et al. Acquired immunodeficiency syndrome with severe gastrointestinal manifestations in Haiti. Lancet 1983;2:873-8.
120. Villanueva JL, Torre-Cisneros J, Jurado R, et al. Leishmania esophagitis in an AIDS patient: an unusual form of visceral leishmaniasis. Am J Gastroenterol 1994;89:273-5.
121. McBride MO, Fisher M, Skinner CJ, Golden R, Main J. An unusual gastrointestinal presentation of leishmaniasis. Scand J Infect Dis 1995;27:297-8.
122. Mondain-Miton V, Toussaint-Gari M, Hofman P, Marty P, Carles M, De Salvador F, et al. Atypical leishmaniasis in a patient infected with human immunodeficiency virus. Clin Infect Dis 1995;21:663-5.
123. Bryceson ADM. Visceral leishmaniasis (kala-azar, ponos). In: Wyngaarden JB, Smith LH Jr, ed. Textbook of Medicine. 16th edn, Philadelphia: Pa WB Saunders; 1982. pp. 1731-4.
124. Betz P, Elsing C, Purrmann J, et al. Leishmaniasis of the upper gastrointestinal tract in an HIV positive patient. Pathology 1990;11:97-100.
125. Pesce A, Saint-Paul MC, Vinti H, et al. Leishmaniose gastrique chez un malade atteint de syndrome d'immunodéficience acquise. Presse Med 1990;19:178.
126. Banerjee M, Pal A, Ghosh S, Maitra TK. Small intestinal involvement in visceral leishmaniasis. Am J Gastroenterol 1990;85:1433-4.
127. Serrao Neto A, Neves Sousa E, Valente HB, et al. Un cas original de leishmaniose viscerale. Presse Med 1986;27:1286.
128. Sendino A, Barbado J, Mostaza JM, et al. Visceral leishmaniasis with malabsorption syndrome in a patient with acquired immunodeficiency syndrome. Am J Med 1990;87:673-5.
129. Smith PD, Quinn TC, Strober W, Janoff EN, Masur H. NIH conference Gastrointestinal infections in AIDS. Ann Intern Med 1992;116:63-77.
130. Laguna F, Garcia-Samaniego J, Moreno V, Gonzalez-Lahoz JM. Prevalence of gastrointestinal leishmaniasis in Spanish HIV-positive patients with digestive symptoms. Am J Gastroenterol 1994;89:1606.
131. Perrin C, Taillan B, Hofman P Mondain V, Lefichoux Y, Michiels JF. Atypical cutaneous histological features of visceral leishmaniasis in acquired immunodeficiency syndrome. Am J Dermatopathol 1995;17:145-50.
132. World Health Organization. Report of the consultative meeting on Leishmania/HIV co-infection. WHO/LEISH 1995;95:1-14.
133. Girgla HS, Marsden RA, Singh GM, Ryan TJ. Post kala-azar dermal leishmaniasis. Br J Dermatol 1977;97:307-11.
134. El Safi SH, Peters W, Evans DA, et al. Studies on the leishmaniases in the Sudan, III: clinical and parasitological studies on visceral and mucosal leishmaniasis. Trans Roy Soc Trop Med Hyg 1991;85:465-70.
135. Romeu J, Sirera G, Ferrandiz C, Carreres A, Condom MJ, Clotet B. Visceral leishmaniasis involving lung and a cutaneous Kaposi's sarcoma lesion. AIDS 1991;5:272.
136. Yebra M, Segovia J, Manzano L, et al. Disseminated to skin kala-azar and the acquired immunodeficiency syndrome. Ann Intern Med 1988;108:490-1.
137. Lahdevirta J, Maury CP, Teppo AM, Repo H. Elevated levels of circulating cachectin/TNF in patients with AIDS. Am J Med 1988;85:289-91.
138. Barrio J, Lecona M, Cosin J, Olalquiaga FJ, Hernanz JM, Soto J. Leishmania infection occurring in herpes zoster lesions in an HIV-positive patient. Br J Dermatol 1996;134:164-6.
139. Colebunders R, Depraetere K, Verstraeten T, Lambert J, Hauben E, Van Marck E, et al. Unusual cutaneous lesions in two patients with visceral leishmaniasis and HIV infection. J Am Acad Dermatol 1999;41:847-50.
140. Dauden E, Penas PF, Rios L, Jimenez M, Fraga J, Alvar J, et al. Leishmaniasis presenting as a dermatomyositis-like eruption in AIDS. J Am Acad Dermatol 1996;35:316-9.
141. Alarcon CR, Garcia C, Garcia E, et al. Leishmaniasis cutanea post kala-azar en un paciente con immunodeficiencia adquirida. Actas Dermo Sif 1987;78:475-7.
142. Clevenbergh P, Okome MN, Benoit S, et al. Acute renal failure as initial presentation of visceral leishmaniasis in an HIV-1 infected patient. Scand J Infect Dis 2002;100:71-4.
143. Dutra MR, Martinelli R, Carvalho EM, et al. Renal involvement in visceral leishmaniasis. Am J Kidney Dis 1985;6:22-7.
144. Van Velthuysen MLF, Florquin S. Glomerulopathy associated with parasitic infections. Clin Microb Rev 2000;13:55-6.
145. Lopez-Velez R, Laguna F, Alvar J, Perez-Molina JA, Molina R, Martinez P, et al. Parasitic culture of buffy coat for diagnosis of visceral leishmaniasis in human immunodeficiency virus-infected patients. J Clin Microbiol 1995;33:937-9.
146. Rosenthal, E, Marty P, le Fichoux Y, Cassuto JP. Clinical manifestations of visceral leishmaniasis associated with HIV infection: a retrospective study of 91 French cases. Ann Trop Med Parasitol 2000; 94:37-42.
147. Berenguer J, Moreno S, Cercenado E, Bernaldo de Quiros JC, Garcia de la Fuente A, et al. Visceral leishmaniasis in patients infected with human immunodeficiency vinis (HIV). Ann Intern Med 1989;111:129-32.
148. Greder A, Malet M, Gautier P, et al. Pleurisy revealing leishmaniasis in acquired immunodeficiency syndrome. Presse Med 1989;18:1390-1.
149. Mofredj A, Guerin MJ, Leibinger F Masmoudi R. Visceral leishmaniasis with pericarditis in an HIV-infected patient. Scand J Infect Dis 2002;34:151-3.
150. Vazquez-Piñeiro T, Fernandez Alvarez JM, Gonzalo Lafuente JC, Cano J, Gimeno M, Berenguer J, et al. Visceral leishmaniasis: a lingual presentation in a patient with HIV infection. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;86:179-82.
151. World Health Organization. AIDS, leishmaniasis dangers of clash highlighted. TDR News 1991;36:1.
152. Miralles ES, Nunez M, Hilara Y, Harto A, Moreno R, Ledo A. Mucocutaneous leishmaniasis and HIV. Dermatology 1994;189:275-7.
153. Gari-Toussaint M, Lelievre A, Marty P, Le Fichoux Y. Contribution of serological tests to the diagnosis of visceral leishmaniasis in patients infected with the human immunodeficiency virus. Trans R Soc Trop Med Hyg 1994;88:301-2.
154. Mary C, Lamouroux D, Dunan S, Quilici M. Western blot analysis of antibodies to Leishmania infantum antigens: potential of the 14-KD and 16-KD antigens for diagnosis and epidemiologic purposes. Am J Trop Med Hyg 1992;47:764-71.
155. Santos-Gomes G, Gomes-Perreira S, Campino L, Araujo MD, Abranches P. Performance of immunoblotting in diagnosis of visceral Leishmaniasis in human immunodeficiency virus-Leishmania sp.-coinfected patients. J Clin Microbiol 2000;38:175-8.
156. Zijlstra EE, Ali MS, el-Hassan AM, el-Toum IA, Satti M, Ghalib HW, et al. Kala-azar: a comparative study of parasitological methods and the direct agglutination test in diagnosis. Trans R Soc trop Med Hyg 1992;86:505-7.
157. Badaro R, Benson D, Eulalio MC, Freire M, Cunha S, Netto EM, et al. rK39: a cloned antigen of Leishmania chagasi that predicts active visceral leishmaniasis. J Infect Dis 1996;173:758-61.
158. Sundar S, Reed S, Singh V, Kumar P, Murray H. Rapid accurate field diagnosis of Indian visceral leishmaniasis. Lancet 1998;351:563-5.
159. Medrano FJ, Hernandez-Quero J, Jimenez E, Pineda JA, Rivero A, Sanchez-Quijano A, et al. Visceral leishmaniasis in HIV-1-infected individuals: A common opportunistic infection in Spain? AIDS 1992;6:1499-503.
160. Smyth AJ, Searle S, Ready PD, et al. A kinetoplast DNA probe diagnostic for Leishmania major: sequence homologies between regions of Leishmania minicircles. Mol Biochem Parasitol 1989;37:213-24.
161. Howard MK, Kelly JM, Lane RP, Miles MA. A sensitive repetitive DNA probe that is specific to the Leishmania donovani complex and its use as an epidemiological and diagnostic reagent. Mol Biochem Parasitol 1991;44:63-72.
162. Lopez M, Inga R, Cangalaya M, Echevarria J, Llanos-Cuentas A, Orrego C, et al. Diagnosis of Leishmania using the polymerase chain reaction:a simplified procedure for field work. Am J Trop Med Hyg 1993;49:348-56.
163. de Brujin MH, Labrada LA, Smyth AJ, Santrich C, Barker DC. A comparative study of diagnosis by the polymerase chain reaction and by current clinical methods using biopsies from Colombian patients with suspected leishmaniasis. Trop Med Parasitol 1993;44:201-7.
164. Smyth AJ, Ghosh A, Hassan MQ, Basu D, De Bruijn MH, Adhya S, et al. Rapid and sensitive detection of Leishmania kinetoplast DNA from spleen and blood samples of kala-azar patients. Parasitology 1992;105:183-92.
165. Ravel S, Cuny G, Reynes J, Veas F. A highly sensitive and rapid procedure for direct PCR detection of Leishmania infantum within human peripheral blood mononuclear cells. Acta Trop 1995;59:187-96.
166. Piarroux R, Gambarelli F, Dumon H, Fontes M, Dunan S, Mary C, et al. Comparison of PCR with direct examination of bone marrow aspiration, myeloculture, and serology for diagnosis of visceral leishmaniasis in immunocompromised patients. J Clin Microbiol 1994;32:746-9.
167. Martin-Sanchez J, López-López MC, Acedo-Sanchez C, Castro-Fajardo JJ, Pineda JA, Morillas-Marquez F et al. Diagnosis of infection with Leishmania infantum using PCR-ELISA. Parasitology 2001;122:607-15.
168. Schalling HD, Schoone GJ, Kroon CC, Hailu A, Chappuis F, Veeken H. Development and application of "simple" diagnostic tools for visceral leishmaniasis. Med Microbiol Immunol 2001;190:69-71.
169. Cruz I, Canavate C, Rubio JM, et al. A nested polumerase chain reaction (Ln-PCR) for diagnosing and monitoring Leishmania infantum infection in patients co-infected with human immunodeficiency virus. Trans R Soc Trop Med Hyg 2002;96(Suppl1):S185-9.
170. Fisa R, Riera C, Ribera E, Gallego M, Portus M. A nested poolymerase Caín reaction for diagnosis and follow-upof human visceral leishmaniasis patients using blood samples. Trans R Soc Trop Med Hyg 2002; 96(Suppl1):S191-4.
171. Hendricks L, Wright N. Diagnosis of cutaneous leishmaniasis by in vitro cultivation of saline aspirates in Schneider's Drosophila medium. Am J Trop Med Hyg 1979;28:962.
172. Hockmeyer WT, Kager PA, Rees PH, Hendricks LD. The culture of Leishmania donovani in Schneider's insect medium: its value in the diagnosis and management of patients with visceral leishmaniasis. Trans R Soc Trop Med Hyg 1981;75:861-3.
173. Laguna, F, López-Vélez R, Pulido F, et al. Treatment of visceral leishmaniasis in HIV-infected patients: a randomized trial comparing meglumine antimoniate with amphotericin B. Spanish HIV-Leishmania Study Group. AIDS 1999;13(9):1063-9.
174. Delgado J, Macias J, Pineda JA, Corzo JE, Gonzalez-Moreno MP, de la Rosa R, et al. High frequency of serious side effects of meglumine antimoniate given without an upper limit dose for the treatment of visceral leishmaniasis in human immunodeficiency virus type-1-infected patients. Am J trop Med Hyg 1999;61:766-9.
175. Ritmeijer K, Veeken H, Melaku Y, Leal G, Amsalu R, Seaman J, et al. Ethiopian visceral leishmaniasis:generic and propietary sodium stibogluconate are equivalent: HIV co-infected patients have a poor outcome. Trans R Soc Trop Med Hyg 2001;95:668-72.
176. Paredes R, Laguna F, Clotet B. Leishmaniasis In HIV-infected persons: a review. Journal of the International Association of Physicians in AIDS Care 1997;3:22-39.
177. Jha TK, Sundar S, Thakur CP, Bachmann P, Karbwang J, Fischer C, et al. Miltefosine, an Oral Agent, for the Treatment of Indian Visceral Leishmaniasis N Engl J Med 1999;341:1795-800
178. Morales MA, Cruz I, Rubio JM, Chicharro C, Canavate C, Laguna F, et al. Relapses vs reinfections in patients coinfected with Leishmania infantum and human immunodeficiency virus type 1. J Infect Dis 2002;185:1533-7.
179. Ribera E, Ocana I, de Otero J, Cortes E, Gasser I, Pahissa A. Prophylaxis of visceral leishmaniasis in human immunodeficiency virus-infected patients. Am J Med 1996;100:496-501.
180. Matheron S, Cable A, Parquin F, Mayaud C, Roux P, Antoine M, et al. Visceral leishmaniasis and HIV infection: unusual presentation with pleuropulmonar involvement, and effect of secondary prophylaxis. AIDS 1992;6:238-40.
181. McBride M, Linney M, Calydon EJ, Weber J. Visceral. Leishmaniasis following treatment with liposomal amphotericin B. Clin Infect Dis 1994;19:362.
182. Lafeuillade A, Chaffanjon P, Delbeque E, et al. Maintenance itraconazole for visceral leishmaniasis in HIV infection. Am J Med 1992;92:449.