Immunity under the skin: Potential application for topical delivery of vaccines

Vaccine

Volumn 21, Issue 7-8, 2003, Pages 776-780

  Partidos, C D ^a   Beignon, A S ^a   Mawas, F ^b   Belliard, G ^a   Briand, J P ^a   Muller, S ^a  

^a INSTITUT DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

Author keywords

CTL responses; Haemophilus influenzae type b; Skin immunisation

Indexed keywords

HAEMOPHILUS INFLUENZAE TYPE B VACCINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CONFERENCE PAPER; COST EFFECTIVENESS ANALYSIS; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG SAFETY; HAEMOPHILUS INFLUENZAE TYPE B; IMMUNE SYSTEM; IMMUNITY; IMMUNOGENICITY; INFECTION; MUCOSAL IMMUNITY; NONHUMAN; PATIENT COMPLIANCE; PRIORITY JOURNAL; RAT; VACCINATION;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTIGENS; HAEMOPHILUS VACCINES; POLYSACCHARIDES, BACTERIAL; RATS; SKIN; T-LYMPHOCYTES, CYTOTOXIC; VACCINES; VACCINES, CONJUGATE;

EID: 0037472398     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(02)00597-2     Document Type: Conference Paper

References (18)

1. Kane A., Lloyd J., Zaffran M., Simonsen L., Kane M. Transmission of hepatitis B, hepatitis C and human immunodeficiency viruses through unsafe injections in the developing world: model-based regional estimates. Bull. World Health Organ. 77:1999;801-807.
2. Streilein J.W. Skin-associated lymphoid tissues (SALT): origins and functions. J. Invest. Dermatol. 80:1983;S12-S16.
3. Uchi H., Terao H., Koga T., Furue M. Cytokines and chemokines in the epidermis. J. Dermatol. Sci. 24:2000;S29-S38.
4. Debenedictis C., Joubeh S., Zhang G., Barria M., Ghohestani R.F. Immune functions of the skin. Clin. Dermatol. 19:2001;573-585.
5. Barry B.W. Novel mechanisms and devices to enable successful transdermal drug delivery. Eur. J. Pharm. Sci. 14:2001;101-114.
6. Glenn G.M., Rao M., Matyas G.R., Alving C.R. Skin immunization made possible by cholera toxin. Nature. 391:1998;851.
7. Glenn G.M., Scharton-Kersten T., Vassell R., Mallett C.P., Hale T.L., Alving C.R. Transcutaneous immunization with cholera toxin protects mice against lethal mucosal toxin challenge. J. Immunol. 161:1998;3211-3214.
8. Beignon A.-S., Briand J.-P., Muller S., Partidos C.D. Immunization onto bare skin with heat-labile enterotoxin of Escherichia coli enhances immune responses to co-administered protein and peptide antigens and protects mice against lethal toxin challenge. Immunology. 102:2001;344-351.
9. + T cells and secrete IFN-γ after co-application onto bare skin. Infect. Immun. 70:2002;3012-3019.
10. Glenn G.M., Taylor D.N., Li X., Frankel S., Montemarano A., Alving C.R. Transcutaneous immunization: a human vaccine delivery strategy using a patch. Nat. Med. 6:2000;1403-1406.
11. El-Ghorr A.A., Williams R.M., Heap C., Norval M. Transcutaneous immunisation with herpes simplex virus stimulates immunity in mice. FEMS Immunol. Med. Microbiol. 29:2000;255-261.
12. Hammond S.A., Tsonis C., Sellins K., Rushlow K., Scharton-Kersten T., Colditz I.et al. Transcutaneous immunization of domestic animals: opportunities and challenges. Adv. Drug Deliv. Rev. 43:2000;45-55.
13. Scharton-Kersten T., Yu J., Vassell R., O'Hagan D., Alving C.R., Glenn G.M. Transcutaneous immunization with bacterial ADP-ribosylating exotoxins, subunits, and unrelated adjuvants. Infect. Immun. 68:2000;5306-5613.
14. Beignon A.-S., Briand J.-P., Muller S., Partidos C.D. Immunization onto bare skin with synthetic peptides: immunomodulation with a CpG-containing oligodeoxynucleotide and effective priming of influenza virus-specific CD4+ T cells. Immunology. 105:2002;204-212.
15. Levi R., Arnon R. Synthetic recombinant influenza vaccine induces efficient long-term immunity and cross-strain protection. Vaccine. 14:1996;85-92.
16. Bolgiano B., Mawas F., Yost S.E., Crane D.T., Lemercinier X., Corbel M.J. Effect of physico-chemical modification on the immunogenicity of Haemophilus influenzae type b oligosaccharide-CRM(197) conjugate vaccines. Vaccine. 19:2001;3189-3200.
17. Guerena-Burgueno F., Hall E.R., Taylor D.N., Cassels F.J., Scott D.A., Wolf M.K.et al. Safety and immunogenicity of a prototype enterotoxigenic Escherichia coli vaccine administered transcutaneously. Infect. Immun. 70:2002;1874-1880.
18. Wester RC, Maibach HI. Animal models for transdermal delivery. In: Kydonieus AF, Berner B, editors. Transdermal delivery of drugs, vol. I. Bocca Raton, FL: CRC Press; 1987. p. 61-70.