Oral retinoids in the treatment of seborrhoea and acne

Dermatology

Volumn 196, Issue 1, 1998, Pages 140-147

  Orfanos, C E ^a   Zouboulis, Ch C ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Acne; Isotretinoin; Retinoids; Seborrhoea

Indexed keywords

4 OXOISOTRETINOIN; DRUG METABOLITE; GLUCURONIDE; ISOTRETINOIN; RETINOIC ACID; RETINOID;

ACNE; ANTIINFLAMMATORY ACTIVITY; ARTHRALGIA; BRAIN PSEUDOTUMOR; CELL DIFFERENTIATION; CELL PROLIFERATION; CONFERENCE PAPER; CONTRACEPTION; DRUG BLOOD LEVEL; DRUG CONTRAINDICATION; DRUG ELIMINATION; DRUG FECES LEVEL; DRUG HALF LIFE; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG TISSUE LEVEL; DRUG URINE LEVEL; DRY EYE; DRY SKIN; EPIDERMIS; HUMAN; HYPEROSTOSIS; HYPERTRIGLYCERIDEMIA; LIPOGENESIS; LIVER DYSFUNCTION; MYALGIA; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RETINOL INTOXICATION; SEBACEOUS GLAND; SEBORRHEA; SEBUM SECRETION; SOFT TISSUE CALCIFICATION; TERATOGENICITY;

ACNE VULGARIS; ADMINISTRATION, ORAL; DERMATITIS, SEBORRHEIC; FEMALE; HUMANS; ISOTRETINOIN; KERATOLYTIC AGENTS; RETINOIDS;

EID: 0031929424     PISSN: 10188665     EISSN: None     Source Type: Journal    
DOI: 10.1159/000017848     Document Type: Conference Paper

References (54)

1. Peck GL, Olsen TG, Yoder FW, Strauss JS, Downing DT, Pandya M, Butkus D, Arnaud-Battandier J: Prolonged remissions of cystic and conglobate acne with 13-cis retinoic acid. N Engl J Med 1979;300:329-333.
2. Orfanos CE, Zouboulis ChC, Almond-Roesler B, Geilen CC: Current use and future potential role of retinoids in dermatology. Drugs 1997; 53:358-388.
3. Chalker DK, Lesher JL Jr, Smith JG Jr, Klauda HC, Pochi PE, Jacoby WS, Yonkosky DM, Voorhees JJ, Ellis CN, Matsuda-John S, Shalita AR, Smith EB, Raimer SS, Knox JM II, Kantor II: Efficacy of topical isotretinoin 0.05% gel in acne vulgaris: Results of a multicenter, double-blind investigation. J Am Acad Dermatol 1987;17:251-254.
4. Tang G, Russel RM: 13-cis-Retinoic acid is an endogenous compound in human serum. J Lipid Res 1990;31:175-182.
5. Matsuoka LY, Wortsman J, Tang G, Russell RM, Parker L, Gelfand R, Mehta RG: Are endogenous retinoids involved in the pathogenesis of acne? Arch Dermatol 1991;127: 1072-1073.
6. Sulik KK, Alles AJ: Teratogenicity of retinoids; in Saurat J-H (ed): Retinoids - 10 Years On. Basel, Karger, 1991, pp 282-295.
7. Dai WS, LaBraico JM, Stern RS: Epidemiology of isotretinoin exposure during pregnancy. J Am Acad Dermatol 1992;26:599-606.
8. Mitchell AA, Van Bennekom CM, Louik C: A pregnancy-prevention program in women of childbearing age receiving isotretinoin. N Engl J Med 1995;333:101-106.
9. Benifla JL, Ville Y, Imbert MC, Frydman R, Thomas A, Pons JC: Fetal tissue dosages of retinoids: Experimental study concerning a case of isotretinoin (Roaccutan) administration and pregnancy. Fetal DiagnTher 1995;10: 189-191.
10. Vane FM, Bugge CJL, Rodriguez LC, Rosenberger M, Doran TI: Human biliary metabolites of isotretinoin: Identification, quantification, synthesis, and biological activity. Xenobiotica 1990;20:193-207.
11. Rollmann Q, Vahlquist A: Oral isotretinoin (13-cis-retinoic acid) therapy in severe acne: Drug and vitamin A concentrations in serum and skin. J Invest Dermatol 1986;86:384-389.
12. Strauss JS, Stranteri AM, Farrell LN, Downing DT: The effect of marked inhibition of sebum production with 13-cis-retinoic acid on skin surface lipid composition. J Invest Dermatol 1980;74:66-67.
13. Jones H, Blanc D, Cunliffe W: 13-cis-Retinoic acid and acne. Lancet 1980;ii:1048-1049.
14. Landthaler M, Kummermehr J, Wagner A, Plewig G: Inhibitory effects of 13-cis-retinoic acid on human sebaceous glands. Arch Dermatol Res 1980;269:297-309.
15. Melnik B, Kinner T, Plewig G: Influence of oral isotretinoin treatment on the composition of comedonal lipids: Implications for comedogenesis in acne vulgaris. Arch Dermatol Res 1988;280:97-102.
16. Hommel L, Geiger J-M, Harms M, Saurat J-H: Sebum excretion rate in subjects treated with oral all-trans-retinoic acid. Dermatology 1996; 193:127-130.
17. Geiger J-M, Hommel L, Harms M, Saurat J-H: Oral 13-cis retinoic acid is superior to 9-cis retinoic acid in sebosuppression in human beings. J Am Acad Dermatol 1996;34:513-515.
18. Doran T, Shapiro SS: Retinoid effects on sebocyte proliferation; in Packer L (ed): Methods in Enzymology. San Diego, Academic Press, 1990, pp 334-338.
19. Zouboulis ChC, Korge B, Akamatsu H, Xia L, Schiller S, Gollnick H, Orfanos CE: Effects of 13-cis-retinoic acid, all-trans-retinoic acid and acitretin on the proliferation, lipid synthesis and keratin expression of cultured human sebocytes in vitro. J Invest Dermatol 1991;96: 792-797.
20. Zouboulis ChC, Xia L, Korge B, Gollnick H, Orfanos CE: Cultivation of human sebocytes in vitro: Cell characterization and influence of synthetic retinoids; in Saurat J-H (ed): Retinoids: 10 Years On. Basel, Karger, 1991, pp 254-273.
21. Zouboulis ChC, Krieter A, Gollnick H, Mischke D, Orfanos CE: Progressive differentiation of human sebocytes in vitro is characterized by increasing cell size and altering antigen expression and is regulated by culture duration and retinoids. Exp Dermatol 1994;2:151-160.
22. Ridden J, Ferguson D, Kealey T: Organ maintenance of human sebaceous glands: In vitro effects of 13-cis retinoic acid and testosterone. J Cell Sci 1990;95:125-136.
23. Geiger J-M: Retinoids and sebaceous gland activity. Dermatology 1995;191:305-310.
24. Crettaz M, Baron A, Siegenthaler G, Hunziker W: Ligand specificities of recombinant retinoic acid receptors RARα and RARβ. Biochem J 1990;272:391-397.
25. Siegenthaler G, Saurat J-H: Binding of isotretinoin to cellular retinoic acid-binding protein: A reappraisal; in Marks R, Plewig G (eds): Acne and Related Disorders. London, Dunitz, 1989, pp 169-177.
26. Zouboulis ChC, Xia L, Akamatsu H, Seltmann H, Fritsch M, Hornemann S, Rühl R, Chen W, Orfanos CE: The human sebocyte culture model provides new insights into development and management of seborrhoea and acne. Dermatology 1998;196:21-31.
27. Guy R, Green MR, Kealey T: Modeling acne in vitro. J Invest Dermatol 1996;106:176-182.
28. King K, Jones DH, Daltrey DC, Cunliffe WJ: A double-blind study of the effects of 13-cis-retinoic acid on acne, sebum excretion rate and microbial population. Br J Dermatol 1982;107: 583-590.
29. 4-induced migration of polymorphonuclear leukocytes into human skin. Arch Dermatol Res 1991;283:158-161.
30. Bécherel P-A, Mossalayi MD, Le Goff L, Frances C, Chosidow O, Debré P, Arock M: Mechanism of anti-inflammatory action of retinoids on keratinocytes. Lancet 1994;344: 1570-1571.
31. Jones DH, Cunliffe WJ, Löffler A: A comparative study on 13-cis-retinoic acid and erythromycin therapy in severe acne; in Cunliffe WJ, Miller AJ (eds): Retinoid Therapy. Lancaster, MTP Press, 1984, pp 293-301.
32. Goldstein JA, Socha-Szott A, Thomsen RJ, Pochi PE, Shalita AR, Strauss JS: Comparative effect of isotretinoin and etretinate on acne and sebaceous gland secretion. J Am Acad Dermatol 1982;6:760-765.
33. Harms M, Philippe I, Radeff B, Masouyé I, Geiger J-M, Saurat J-H: Arotinoid Ro 13-6298 and etretin: Two new retinoids inferior to isotretinoin in sebum suppression and acne treatment. Acta Derm Venereol (Stockh) 1986;66: 149-154.
34. Strauss JS, Davey WP, Denton SJ, Stranieri AM: Effect of an orally administered arotinoid, Ro 15-0778, on sebum production in man. Arch Dermatol Res 1988;280:152-154.
35. Vane FM, Chari SS, Shapiro S, Nordsrom KM, Leyden JJ: Comparison of the plasma and sebum concentrations of the arotinoid Ro 15-0778 and isotretinoin in acne patients; in Marks R, Plewig G (eds): Acne and Related Disorders. London, Dunitz, 1989, pp 183-189.
36. Saurat J-H, Mérot Y, Borsky M, Abba Z, Hirschel-Scholz S: Arotinoid acid (Ro 13-7410): A pilot study in dermatology. Dermatologica 1988;176:191-199.
37. Ott F, Bollag W, Geiger J-M: Oral 9-cis-retinoic acid versus 13-cis-retinoic acid in acne therapy. Dermatology 1996;193:124-126.
38. Stüttgen G: Oral vitamin A acid therapy. Acta Derm Venereol (Stockh) 1975;74(suppl): 174-179.
39. Plewig G, Steger M: Acne inversa (alias acne triad, acne tetrad or hidradenitis suppurativa); in Marks R, Plewig G (eds): Acne and Related Disorders. London, Dunitz, 1989, pp 345-357.
40. Goulden V, Layton AM, Cunliffe WJ: Longterm safety of isotretinoin as a treatment for acne vulgaris. Br J Dermatol 1994;131: 360-363.
41. Meigel W, Gollnick H, Wokalek H, Plewig G, und 44 Kollegen aus 19 Hautkliniken: Orale Behandlung der Acne conglobata mit 13-cis-Retinsäure: Ergebnisse der deutschen multizentrischen Studie nach 24wöchiger Behandlung. Hautarzt 1983;34:387-397.
42. Layton AM, Knaggs H, Taylor J, Cunliffe WJ: Isotretinoin for acne vulgaris - 10 years later: A safe and successful treatment. Br J Dermatol 1993;129:292-296.
43. Stainforth JM, Layton AM, Taylor JP, Cunliffe WJ: Isotretinoin for the treatment of acne vulgaris: Which factors may predict the need for more than one course? Br J Dermatol 1993; 129:297-301.
44. Cunliffe WJ, Layton AM: Oral isotretinoin: Patient selection and management. J Dermatol Treat 1993;4(suppl 2):S10-S15.
45. Cunliffe WJ, van de Kerkhof PCM, Caputo R, Cavicchini S, Cooper A, Fyrand OL, Gollnick H, Layton AM, Leyden JJ, Mascaró J-M, Ortonne J-P, Shalita A: Roaccutane treatment guidelines: Results of an international survey. Dermatology 1997;194:351-357.
46. Karvonen SJ: Acne fulminans. Report of clinical findings and treatment of twenty-four patients. J Am Acad Dermatol 1993;28:572-579.
47. Mills CM, Marks R: Adverse reactions to oral retinoids: An update. Drugs Safety 1993; 9:280-290.
48. Goulden V, Layton AM, Cunliffe WJ: Longterm safety of isotretinoin as a treatment for acne vulgaris. Br J Dermalol 1994;131: 360-363.
49. Colemann R, MacDonald D: Effects of isotretinoin on male reproductive system. Lancet 1994;344:198.
50. Almond-Roesler B, Blume-Peytavi U, Bisson S, Krahn M, Rohloff E, Orfanos CE: Monitoring of isotretinoin therapy by measuring the plasma levels of isotretinoin and 4-oxoisotretinoin. A useful tool for the management of severe acne. Dermatology 1998;196: 176-181.
51. Barth JH, MacDonald-Hull SP, Mark J, Jones RG, Cunliffe WJ: Isotretinoin therapy for acne vulgaris: A re-evaluation of the need for measurements of plasma lipids and liver function tests. Br J Dermatol 1993;129:704-707.
52. Margolis DJ, Attie M, Leyden JJ: Effects of isotretinoin on bone mineralization during routine therapy with isotretinoin for acne vulgaris. Arch Dermatol 1996;132:769-774.
53. Biesalski HK: Comparative assessment of the toxicology of vitamin A and retinoids in man. Toxicology 1989;57:117-161.
54. Fex GA, Aronsson A, Andersson A, Larsson K, Nilsson-Ehle P: In vivo effects of 13-cis retinoic acid treatment on the concentration of proteins and lipids in serum. Eur J Clin Chem Clin Biochem 1996;34:3-7.