Evidence for phosphorylation requirement for human bilirubin UDP-glucuronosyltransferase (UGT1A1) activity

Biochemical and Biophysical Research Communications

Volumn 303, Issue 1, 2003, Pages 98-104

  Basu, Nikhil K ^a   Kole, Labanyamoy ^a   Owens, Ida S ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

Bilirubin; Calphostin C; Curcumin; Phosphorylation; PKC; UDP glucuronosyltransferase

Indexed keywords

ANTHRAFLAVIC ACID; BILIRUBIN URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE; CALPHOSTIN C; EUGENOL; ISOENZYME; PHOSPHATE; PHOSPHORUS; PROTEIN KINASE C INHIBITOR; TRANSFERASE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT; BETA GLUCURONIDASE; BILIRUBIN; BILIRUBIN URIDINE DIPHOSPHOGLUCURONOSYL TRANSFERASE 1A1; BILIRUBIN URIDINE-DIPHOSPHOGLUCURONOSYL TRANSFERASE 1A1; CURCUMIN; ENZYME INHIBITOR; GLUCURONOSYLTRANSFERASE; NAPHTHALENE DERIVATIVE; PROTEIN KINASE C; RECOMBINANT PROTEIN;

ACIDITY; ALKALINITY; ANALYTICAL PARAMETERS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MUTANT; PH; PREDICTION; PRIORITY JOURNAL; WILD TYPE; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CATALYSIS; CELL CULTURE; CELL STRAIN COS1; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; TIME; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; BILIRUBIN; BINDING SITES; BLOTTING, WESTERN; CATALYSIS; COS CELLS; CURCUMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GLUCURONIDASE; GLUCURONOSYLTRANSFERASE; HUMANS; HYDROGEN-ION CONCENTRATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NAPHTHALENES; PHOSPHORYLATION; PROTEIN KINASE C; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0037470720     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)00241-9     Document Type: Article

References (19)

1. Roy Chowdhury J., Wolkoff A.W., Roy Chowdhury N., Arias I.M. Hereditary jaundice and disorders of bilirubin metabolism. Scriver C.R., Beaudet A.L., Sly W.S., Valle D. The Metabolic Basis of Inherited Disease. 1995;2161-2208 McGraw-Hill, New York.
2. Ritter J.K., Yeatman M.T., Ferreira P., Owens I.S. Identification of a genetic alteration in the code for bilirubin UDP-glucuronosyltransferase in the UGT1 gene complex of a Crigler-Najjar Type I patient. J. Clin. Invest. 90:1992;150-155.
3. Bosma P.J., Roy Chowdhury J., Bakker C., Gantla S., De Boer A.et al. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome. New Engl. J. Med. 333:1995;1171-1175.
4. McDonnell W.M., Hitomi E., Askari F.K. Identification of bilirubin UDP-GTs in the human alimentary tract in accordance with the gut as a putative metabolic organ. Biochem. Pharmacol. 51:1996;483-488.
5. Strassburg C.P., Nguyen N., Manns M.P., Tukey R.H. UDP-glucuronosyltransferase activity in human liver and colon. Gastroenterology. 116:1999;149-160.
6. Kühnau J. The flavonoids. A class of semi-essential food components. World Rev. Nutr. Diet. 24:1976;117-191.
7. Brown J.P. A review of the genetic effects of naturally occurring flavonoids, anthraquinones, and related compounds. Mutation Res. 75:1980;243-277.
8. Gräslund A., Jernström B. DNA-carcinogen interaction: covalent DNA-adducts of benzo(a)pyrene 7,8-dihydrodiol 9,10-epoxides studied by biochemical and biophysical techniques. Q. Rev. Biophys. 22:1989;1-37.
9. Larsen E.C., Digennaro J.A., Saito N., Mehta S., Loegering D.J., Mazurkiewicz J.E., Lennartz M.R. Differential requirements for classic and novel PKC isoforms in respiratory burst and phagocytosis in RAW 264.7 cells. J. Immunol. 165:2000;2809-2817.
10. Chen H-W., Huang H-C. Effect of curcumin on cell cycle progression and apoptosis in vascular smooth muscle cells. Br. J. Pharmacol. 124:1998;1029-1040.
11. Ritter J.K., Yeatman M.T., Kaiser C., Gridelli B., Owens I.S. A phenylalanine codon deletion at the UGT1 gene complex locus of a Crigler-Najjar Type I patient generates a pH sensitive bilirubin UDP-glucuronosyltransferase. J. Biol. Chem. 268:1993;23573-23579.
12. Ciotti M., Owens I.S. Evidence for overlapping active sites for 17α-ethynlestradiol and bilirubin in the human major bilirubin UDP-glucuronosyltransferase. Biochemistry. 35:1996;10119-10124.
13. Ciotti M., Basu N., Brangi M., Owens I.S. Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38) by the human UDP-glucuronosyltransferases encoded by the UGT1 locus. Biochem. Biophys. Res. Commun. 260:1999;199-202.
14. Akhand A.A., Pu M., Senga T., Kato M., Suzuki H., Miyata T., Hamaguchi M., Nakashima I. Nitric oxide controls Src kinase activity through a sulfhydryl group modification-mediated Tyr-527-independent and Tyr-416-linked mechanism. J. Biol. Chem. 274:1999;25821-25826.
15. Ritter J.K., Sheen Y.Y., Owens I.S. Cloning and expression of human liver UDP-glucuronosyltransferase in COS-1 cells. J. Biol. Chem. 265:1990;7900-7906.
16. Jee S-H., Shen S-C., Tseng C-R., Chiu H-C., Kuo M-L. Curcumin induces a p53-dependent apoptosis in human basal cell carcinoma cells. J. Invest. Dermatol. 111:1998;656-661.
17. Rao C.V., Rivenson A., Simi B., Reddy B.S. Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound. Cancer Res. 55:1995;259-266.
18. Okada K., Wangpoengtrakul C., Tanaka T., Toyokuni S., Uchida K., Osawa T. Curcumin and especially tetrahydrocurcumin ameliorate oxidative stress-induced renal injury in mice. J. Nutr. 131:2001;2090-2095.
19. Mackenzie P.I., Owens I.S. Cleavage of nascent UDP-glucuronosyltransferase from rat liver by dog pancreatic microsomes. Biochem. Biophys. Res. Commun. 122:1984;1441-1449.