Evidence for overlapping active sites for 17α-ethynlestradiol and bilirubin in the human major bilirubin UDPglucuronosyltransferase

Biochemistry

Volumn 35, Issue 31, 1996, Pages 10119-10124

  Ciotti, M ^a   Owens, Ida S ^a,b  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; ETHINYLESTRADIOL; GLUCURONOSYLTRANSFERASE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME INACTIVATION; ENZYME SUBSTRATE; GLUCURONIDATION; HORMONE PROTEIN COMPLEX; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BILIRUBIN; BINDING SITES; CELL LINE; CERCOPITHECUS AETHIOPS; DNA PRIMERS; ETHINYL ESTRADIOL; GLUCURONOSYLTRANSFERASE; HUMANS; HYDROGEN-ION CONCENTRATION; ISOENZYMES; KINETICS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TRANSFECTION;

ANIMALIA;

EID: 0029774577     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi960584a     Document Type: Article

References (22)

1. Arion, W. J., Wallin, B. K., Carlson, P. W., & Lange, A. J. (1972) J. Biol. Chem. 247, 2558-2565.
2. Ciotti, M., Yeatman, M. T., Sokol, R. J., & Owens, I. S. (1995) J. Biol. Chem. 270, 3284-3291.
3. Crigler, J. F., & Najjar, V. A. (1952) Pediatrics 10, 169-180.
4. de Morais, S. M. F., & Wells, P. G. (1989) Hepatology 10, 163-167.
5. Ebner, T., Remmel, R. P., & Burchell, B. (1993) Mol. Pharmacol. 43, 649-654.
6. Hargus, S. J., Martin, B. M., George, J. W., & Pohl, L. R. (1995) Chem. Res. Toxicol. 8, 993-996.
7. Mackenzie, P. I., Lang, M. A., & Owens, I. S. (1984) Membr. Biochem. 5, 193-207.
8. Miners, J. O., & Mackenzie, P I. (1991) Pharmacol. Ther. 51, 347-369.
9. Owens, I. S., & Ritter, J. K. (1992) Pharmacogenetics. 2, 93-108.
10. Owens, I. S., Koteen, G. M., & Legraverend, C. (1979) Biochem. Pharmacol. 28, 1615-1622.
11. Richardson, J. S., & Richardson, D. C. (1988) Science 240, 1648-1652.
12. Ritter, J. K., Sheen, Y. Y., & Owens, I. S. (1990) J. Biol. Chem. 265, 7900-7906.
13. Ritter, J. K., Crawford, J. M., & Owens, I. S. (1991) J. Biol. Chem. 266, 1043-1047.
14. Ritter, J. K., Yeatman, M. T., Ferriera, P., & Owens, I. S. (1992) J. Clin. Invest. 90, 150-155.
15. Ritter, J. K., Yeatman, M. T., Kaiser, C., Gridelli, B., & Owens, I. S. (1993) J. Biol. Chem. 268, 23573-23579.
16. Sato, H., Koiwai, O., Tanabe, K., & Kashiwamata, S. (1990) Biochem. Biophys. Res. Commun. 169, 260-264.
17. Seppen, J., Bosma, P. J., Goldhoorn, B. G., Bakker, C. T. M., Roy Chowdhury, J., Roy Chowdhury, N., Jansen, P. L., & Oude Elferink, R. P. J. (1994) J. Clin. Invest. 94, 2385-2391.
18. Sibanda, B. L., & Thornton, J. M. (1993) J. Mol. Biol. 24, 229, 428-447.
19. Spahn Langguth, H., & Bene, L. Z. (1992) Drug Metab. Rev. 24, 5-48.
20. Tephly, T. R., & Burchell, B (1990) Trends Pharmacol. Sci. 11, 276-279.
21. Thigpen, A. E., Davis, D. L , Milatovich, A., Mendonca, B. B., Imperato-McGinley, J., Griffin, J. E., Francke, U., Wilson, J. D., & Russell, D. W. (1992) J. Clin. Invest. 90, 799-809.
22. Thornton, J. M., Sibanda, B. L., Edwards, M. S., & Barlow, D. J. (1988) Bioessays 8, 63-69.