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Volumn 117, Issue 24, 2002, Pages 11396-11403

A permeation theory for single-file ion channels: Corresponding occupancy states produce Michaelis-Menten behavior

Author keywords

[No Author keywords available]

Indexed keywords

ASYMMETRIC SOLUTION; MICHAELIS-MENTEN KINETICS; PERMEATION THEORY; SINGLE FILE ION CHANNELS;

EID: 0037461514     PISSN: 00219606     EISSN: None     Source Type: Journal    
DOI: 10.1063/1.1522709     Document Type: Article
Times cited : (43)

References (47)
  • 32
    • 84880756669 scopus 로고    scopus 로고
    • note
    • The proposed mechanism of single-file transport in a finite channel between two bulk reservoirs is thus distinct from the traditional mechanism of single-file diffusion in (infinitely) long channels that requires the presence of one or more vacancies.
  • 33
    • 84880750863 scopus 로고    scopus 로고
    • note
    • The (high concentration) KcsA channel example discussed here has n=3 ions. The derivation is the same for any n > 1.
  • 36
    • 84880760749 scopus 로고    scopus 로고
    • note
    • The model assumptions concerning the differeing voltage dependencies of the association and dissociation steps can be justified by analogy with the Metropolis sampling technique, wherein negative energy transitions occur with unit probability, and positive energy transitions are weighted by a Boltzmann factor.
  • 37
    • 84880711631 scopus 로고    scopus 로고
    • note
    • More generally, c* is a reduced activity.
  • 46
    • 84880734234 scopus 로고    scopus 로고
    • note
    • While the proposed translocation mechanism does not require the formation of long-lived voids within the channel, it does not preclude the formation of (short-lived) voids as part of the translocation process.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.