Synthesis and characterization of the first potent inhibitor of yapsin 1: Implications for the study of yapsin-like enzymes

Journal of Biological Chemistry

Volumn 278, Issue 8, 2003, Pages 5523-5530

  Cawley, Niamh X ^a,c   Chino, Masao ^b   Maldonado, Alex ^a   Rodriguez, Yazmin M ^a   Loh, Y Peng ^a   Ellman, Jonathan A ^b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Bldg 49/5A38 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; PURIFICATION; SYNTHESIS (CHEMICAL); YEAST;

SEQUENCE ANALYSIS;

ENZYMES;

ASPARTIC PROTEINASE; ASPARTIC PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; YAPSIN 1; YAPSIN 1 INHIBITOR; ASPARTIC PROTEINASE A; ENKEPHALIN; PROENKEPHALIN; PROTEIN PRECURSOR; PROTEIN SUBUNIT; PROTEINASE INHIBITOR; SACCHAROMYCES CEREVISIAE PROTEIN; YPS1 PROTEIN, S CEREVISIAE;

AMINO ACID SEQUENCE; ARTICLE; CANDIDA ALBICANS; COMPETITIVE INHIBITION; DRUG SYNTHESIS; ENZYME PURIFICATION; PRIORITY JOURNAL; AFFINITY CHROMATOGRAPHY; CHEMICAL STRUCTURE; DRUG ANTAGONISM; ISOLATION AND PURIFICATION; KINETICS; METABOLISM; REGRESSION ANALYSIS; STRUCTURE ACTIVITY RELATION; SYNTHESIS; WESTERN BLOTTING;

CANDIDA; CANDIDA ALBICANS; CHEN; MAMMALIA;

ASPARTIC ENDOPEPTIDASES; BLOTTING, WESTERN; CHROMATOGRAPHY, AFFINITY; ENKEPHALINS; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEASE INHIBITORS; PROTEIN PRECURSORS; PROTEIN SUBUNITS; REGRESSION ANALYSIS; SACCHAROMYCES CEREVISIAE PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037458676     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M207230200     Document Type: Article

References (34)

1. Egel-Mitani, M., Flygenring, H. P., and Hansen, M. T. (1990) Yeast 6, 127-137
2. Julius, D., Brake, A., Blair, L., Kunisawa, R., and Thorner, J. (1984) Cell 37, 1075-1089
3. Dunn, B. M., Jimenez, M., Parten, B. F., Valler, M. J., Rolph, C. E., and Kay, J. (1986) Biochem. J. 237, 899-906
4. Cawley, N. X., and Loh, Y. P. (2003) in Handbook of Proteolytic Enzymes (Barrett, A. J., and Woessner, F., eds) 2nd Ed., Academic Press, London, in press
5. Komano, H., and Fuller, R. S. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 10752-10756
6. Olsen, V., Cawley, N. X., Brandt, J., Egel-Mitani, M., and Loh, Y. P. (1999) Biochem. J. 339, 407-411
7. Monod, M., Hube, B., Hess, D., and Sanglard, D. (1998) Microbiology 144, 2731-2737
8. Loh, Y. P., and Cawley, N. X. (2003) in Handbook of Proteolytic Enzymes (Barrett, A. J., and Woessner, F., eds) 2nd Ed., Academic Press, London, in press
9. Loh, Y. P., Parish, D. C., and Tuteja, R. (1985) J. Biol. Chem. 260, 7194-7205
10. Azaryan, A. V., Wong, M., Friedman, T. C., Cawley, N. X., Estivariz, F. E., Chen, H. C., and Loh, Y. P. (1993) J. Biol. Chem. 268, 11968-11975
11. Cawley, N. X., Olsen, V., Zhang, C. F., Chen, H. C., Tan, M., and Loh, Y. P. (1998) J. Biol. Chem. 273, 584-591
12. Cawley, N. X. (1995) Characterization of Yeast Aspartic Protease 3: A Novel Basic-Residue Specific Prohormone Processing Enzyme. Ph.D. Thesis, Biochemistry Department, Uniformed Services University of the Health Sciences, Bethesda, MD
13. Angliker, H., Neumann, U., Molloy, S. S., and Thomas, G. (1995) Anal. Biochem. 224, 409-412
14. Hatsuzawa, K., Nagahama, M., Takahashi, S., Takada, K., Murakami, K., and Nakayama, K. (1992) J. Biol. Chem. 267, 16094-16099
15. Cawley, N. X., Chen, H.-C., Beinfeld, M. C., and Loh, Y. P. (1996) J. Biol. Chem. 271, 4168-4176
16. Bakker, A. V., Jung, S., Spencer, R. W., Vinick, F. J., and Faraci, W. S. (1990) Biochem. J. 271, 559-562
17. Cawley, N. X., Wong, M., Pu, L.-P., Tam, W., and Loh, Y. P. (1995) Biochemistry 34, 7430-7437
18. Lindberg, I., and Zhou, Y. (1995) Methods Neurosci. 23, 94-108
19. Fernandez-Garcia, C., and McKervey, M. A. (1995) Tetrahedron Asymmetry 6, 2905-2906
20. Thompson, L. A., and Ellman, Jonathan A. (1994) Tetrahedron Lett. 35, 9333-9336
21. Kick, E. K., and Ellman, J. A. (1995) J. Med. Chem. 38, 1427-1430
22. Ledgerwood, E. C., George, P. M., Peach, R. J., and Brennan, S. O. (1995) Biochem. J. 308, 321-325
23. Ledgerwood, E. C., Brennan, S. O., Cawley, N. X., Loh, Y. P., and George, P. M. (1996) FEBS Lett. 383, 67-71
24. Olsen, V., Guruprasad, K., Cawley, N. X., Chen, H. C., Blundell, T. L., and Loh, Y. P. (1998) Biochemistry 37, 2768-2777
25. Copley, K. S., Alm, S. M., Schooley, D. A., and Courchesne, W. E. (1998) Biochem. J. 330, 1333-1340
26. Bourbonnais, Y., Larouche, C., and Tremblay, G. M. (2000) Protein Expression Purif. 20, 485-491
27. Kerry-Williams, S. M., Gilbert, S. C., Evans, L. R., and Ballance, D. J. (1998) Yeast 14, 161-169
28. Kang, H. A., Kim, S. J., Choi, E. S., Rhee, S. K., and Chung, B. H. (1998) Appl. Microbiol. Biotechnol. 50, 187-192
29. Song, G. Y., and Chung, B. H. (2000) Process. Biochem. 35, 503-508
30. Zhang, W., Espinoza, D., Hines, V., Innis, M., Mehta, P., and Miller, D. L. (1997) Biochim. Biophys. Acta 1359, 110-122
31. Ash, J., Dominguez, M., Bergerson, J. J., Thomas, D. Y., and Bourbonnais, Y. (1995) J. Biol. Chem. 270, 20847-20854
32. Naglik, J. R., Newport, G., White, T. C., Fernandes-Naglik, L. L., Greenspan, J. S., Greenspan, D., Sweet, S. P., Challacombe, S. J., and Agabian, N. (1999) Infect. Immun. 67, 2482-2490
33. Newport, G., and Agabian, N. (1997) J. Biol. Chem. 272, 28954-28961
34. Borg-von Zepelin, M., Beggah, S., Boggian, K., Sanglard, D., and Monod, M. (1998) Mol. Microbiol. 28, 543-554