Both intracellular and extracellular vitamin C inhibit atherogenic modification of LDL by human vascular endothelial cells

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 17, Issue 8, 1997, Pages 1583-1590

  Martin, Antonio ^a   Frei, Balz ^a,b  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b OREGON STATE UNIVERSITY   (United States)

Author keywords

Ascorbate; Atherosclerosis; Human endothelial cells; Metal ions; Modified LDL

Indexed keywords

ASCORBIC ACID; LOW DENSITY LIPOPROTEIN;

ANTIOXIDANT ACTIVITY; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; HUMAN; HUMAN CELL; LIPID OXIDATION; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM; VITAMIN INTAKE;

EID: 0030928673     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.17.8.1583     Document Type: Article

References (20)

1. Ross R. The pathogenesis of atherosclerosis - an update. N Engl J Med. 1986;314:488-500.
2. Goldstein JL, Ho YK, Basu SK, Brown MS. Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proc Natl Acad Sci U S A. 1979;76:333-337.
3. Henriksen T, Manoney EM, Steinberg D. Enhanced macrophage degradation of iow density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins. Proc Natl Acad Sci U S A. 1981;78:6499-6503.
4. Steinberg D, Panhasarathy S, Carcw TE, Khoo JC, Witztum JL. Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med. 1989;320:915-924.
5. Steinbrecher UP, Parthasaralhy S, Leake DS, Witztum JL, Steinberg D. Modification of low density lipoprotein by endothelial ceils involves lipid peroxidation and degradation of low density lipoprotein phospholipids. Proc Natl Acad Sci U S A. 1984;81:3883-3887.
6. Keaney JF Jr, Frei B. Antioxidant protection of low density lipoprotein and its role in the prevention of atherosclerotic vascular disease. In: Frei B, ed. Natural Antioxidants in Human Health and Disease. San Diego, Calif: Academic Press; 1994:303-351.
7. Berliner JA, Heinecke JW. The role of oxidized lipoproteins in atherogcncsts. Free Radic Biol Med. 1996;20:707-727.
8. Weis JR, Pitas RE, Wilson BD, Rodgers GM. Oxidized low-density lipoprotein increases cultured human endothelial cell tissue factor activity and reduces protein C activation. FASEB J. 1991;5:2459-2465.
9. Latron Y, Chautan M, Anfosso F, Alessi MC, Nalbone G, Lafont H, Juhan-Vague I. Stimulating effect of oxidized low density lipoproteins on plasminogen activator inhibitor-1 synthesis by endothelial cells. Arterioscler Thromb. 1991;11:1821-1829.
10. Heinecke JW, Rosen H, Chait A. Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture. J Clin Invest. 1984;74:1890-1894.
11. Steinbrecher UP. Role of Superoxide in endothclial-cell modification of low-density lipoprotains. Biochim Biophys Acta. 1988;959:20-30.
12. Sparrow CP, Olszewski J. Cellular oxidation of low density lipoprotein is caused by thiol production in media containing transition metal ions. J Lipid Res. 1993;34:1219-1228.
13. Esterbauer H, Gebicki J. Puhi H, Jürgens G. The role of lipid peroxidation and antioxidants in oxidative modification of LDL. Free Radic Biol Med. 1992;13:341-390.
14. Frei B, Stocker R, Ames BN. Antioxidant defenses and lipid peroxidaiion in human blood plasma. Proc Natl Acad Sci U S A. 1988;85:9748-9752.
15. Frei B, England L, Ames BN. Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci U S A. 1989;86:6377-6381.
16. Retsky KL, Freeman MW, Frei B. Ascorbic acid oxidation product(s) protect human low density lipoprotein against atherogenic modification: anti- rather than prooxidant activity of vitamin C in the presence of transition metal ions. J Biol Chem. 1993;268:1304-1309.
17. Retsky KL, Frei B. Vitamin C prevents metal ion-dependent initiation and propagation of lipid peroxidation in human low density lipoprotein. Biochim Biophys Acta. 1996;1257:279-287.
18. Lynch SM, Gaziano JM, Frei B. Ascorbic acid and atherosclerotic cardiovascular disease. In: Harris JR, ed. Ascorbic Acid: Biochemistry and Biomedical Cell Biology. New York, NY: Plenum Press; 1996:331-367.
19. Navab M, Imes SS, Hama SY, Hough GP, Ross, LA, Bork RW, Valente AJ, Berliner JA, Drinkwater DC, Laks H, Fogelman AM. Monocyte transmigration induced by modification of low density lipoprotein in cocultures of human aortic wall cells is due to induction of monocyte chemotactic protein 1 synthesis and is abolished by high density lipoprotein. J Clin Invest. 1991;88:2039-2046.
20. Reaven PD, Ferguson E, Navab M, Powell FL. Susceptibility of human LDL to oxidative modification: effects of variations in β-carotene concentration and oxygen tension. Arterioscler Thromb. 1994;14:1162-1169.