Suppression of NF-κB activation and proinflammatory cytokine expression by Shiga toxin-producing Escherichia coli

Journal of Immunology

Volumn 170, Issue 4, 2003, Pages 2074-2082

  Hauf, Nadja ^a   Chakraborty, Trinad ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GENTAMICIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; SHIGA TOXIN; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BACTERIAL COLONIZATION; BACTERIUM ADHERENCE; CONTROLLED STUDY; CYTOKINE RELEASE; ESCHERICHIA COLI; GENE EXPRESSION; HOST CELL; HOST RESISTANCE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFLAMMATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN SECRETION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

EID: 0037442015     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.4.2074     Document Type: Article

References (50)

1. Ireton, K., and P. Cossart. 1998. Interaction of invasive bacteria with host signaling pathways. Curr. Opin. Cell Biol. 10:276.
2. Sansonetti, P. 2001. Phagocytosis of bacterial pathogens: implications in the host response. Semin. Immunol. 13:381.
3. Jung, H. C., L. Eckmann, S. K. Yang, A. Panja, J. Fierer, E. Morzycka-Wroblewska, and M. F. Kagnoff. 1995. A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion. J. Clin. Invest. 95:55.
4. Eckmann, L., J. R. Smith, M. P. Housley, M. B. Dwinell, and M. F. Kagnoff. 2000. Analysis by high density cDNA arrays of altered gene expression in human intestinal epithelial cells in response to infection with the invasive enteric bacteria Salmonella. J. Biol. Chem. 275:14084.
5. Cornelis, G. R., A. Boland, A. P. Boyd, C. Geuijen, M. Iriarte, C. Neyt, M. P. Sory, and I. Stainier. 1998. The virulence plasmid of Yersinia, an antihost genuine. Microbiol. Mol. Biol. Rev. 62:1315.
6. Kagnoff, M., and L. Eckmann. 1997. Perspectives series. Host/pathogen interactions: epithelial cells as sensors for microbial infection. J. Clin. Invest. 100:6.
7. Siebenlist, U., G. Franzoso, and K. Brown. 1994. Structure, regulation and function of NF-κB. Annu. Rev. Cell Biol. 10:405.
8. Ghosh, S., M. J. May, and E. B. Kopp. 1998. NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16: 225.
9. Hatada, E, N., D. Krappmann, and C. Scheidereit. 2000. NF-κB and the innate immune response. Curr. Opin. Immunol. 12:52.
10. Karin, M., and Y. Ben-Neriah. 2000. Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu. Rev. Immunol. 18:621.
11. Paton, J. C., and A. W. Paton. 1998. Pathogenesis and diagnosis of Shiga toxin-producing Escherichia coli infections. Clin. Microbiol. Rev. 11:450.
12. Nataro, J. P., and J. B. Kaper. 1998. Diarrheagenic Escherichia coli. Clin. Microbiol. Rev. 11:142.
13. Elliott, S. J., L. A. Wainwright, T. K. McDaniel, K. G. Jarvis, Y. K. Deng, L. C. Lai, B. P. McNamara, M. S. Donnenberg, and J. B. Kaper. 1998. The complete sequence of the locus of enterocyte effacement (LEE) from enteropathogenic Escherichia coli E2348/69. Mol. Microbiol. 28:1.
14. Perna, N. T., G. F. Mayhew, G. Posfai, S. Elliott, M. S. Donnenberg, J. B. Kaper, and F. R. Blattner. 1998. Molecular evolution of a pathogenicity island from enterohemorrhagic Escherichia coli O157:H7. Infect. Immun. 66:3810.
15. Frankel, G., A. D. Phillips, I. Rosenshine, G. Dougan, J. B. Kaper, and S. Knutton. 1998. Enteropathogenic and enterohaemorrhagic. Escherichia coli: more subversive elements. Mol. Microbiol. 30:911.
16. Vallance, B. A., and B. B. Finlay. 2000. Exploitation of host cells by enteropathogenic Escherichia coli. Proc. Natl. Acad. Sci. USA 97:8799.
17. Ebel, F., T. Podszadel, M. Rohde, A. U. Kresse, S. Krämer, C. Deibel, C. A. Guzman, and T. Chakraborty. 1998. Initial binding of Shiga toxin-producing Escherichia coli to host cells and subsequent induction of actin rearrangements depend on filamentous EspA-containing surface appendages. Mol. Microbiol. 30:147.
18. Knutton, S., I. Rosenshine, M. J. Pallen, I. Nisan, B. C. Neves, C. Bain, C. Wolff, G. Dougan, and G, Frankel. 1998. A novel EspA-associated surface organelle of enteropathogenic E. coli involved in protein translocation into epithelial cells. EMBO J. 17:2166.
19. Wachter, C., C. Beinke, M. Mattes, and M. A. Schmidt. 1999. Insertion of EspD into epithelial target cell membranes by infecting enteropathogenic Escherichia coli. Mol. Microbiol. 31:1695.
20. Kresse, A. U., M. Rohde, and C. A. Guzman. 1999. The EspD protein of enterohemorrhagic Escherichia coli is required for the formation of bacterial surface appendages and is incorporated in the cytoplasmic membranes of target cells. Infect. Immun. 67:4834.
21. Wolff, C., I. Nisan, E. Hanski, G. Frankel, and I. Rosenshine. 1998. Protein translocation into host epithelial cells by infecting enteropathogenic Escherichia coli. Mol. Microbiol. 28:143.
22. Hartland, E. L., S. J. Daniell, R. M. Delahay, B. C. Neves, T. Wallis, R. K. Shaw, C. Hale, S. Knutton, and G. Frankel. 2000. The type III protein translocation system of enteropathogenic Escherichia coli involves EspA-EspB protein interactions. Mol. Microbiol. 35:1483.
23. Kenny, B., R. DeVinney, M. Stein, D. J. Reinscheid, E. A. Frey, and B. B. Finlay. 1997. Enteropathogenic E. coli (EPEC) transfers its receptor for intimate adherence into mammalian cells. Cell 91:511.
24. Deibel, C., S. Krämer, T. Chakraborty, and F. Ebel. 1998. EspE, a novel secreted protein of attaching and effacing bacteria, is directly translocated into infected host cells, where it appears as a tyrosin-phosphorylated 90 kDa protein. Mol. Microbiol. 28:463.
25. McNamara, B. P., A. Koutsouris, C. B. O'Connell, J. P. Nougayrede, M. S. Donnenberg, and G. Hecht. 2001. Translocated EspF protein from enteropathogenic Escherichia coli disrupts host intestinal barrier function. J. Clin. Invest. 107:621.
26. Taylor, K. A., C. B. O'Connell, P. W. Luther, and M. S. Donnenberg. 1998. The EspB protein of enteropathogenic Escherichia coli is targeted to the cytoplasm of infected HeLa cells. Infect. Immun. 66:5501.
27. Taylor, K. A., P. W. Luther, and M. S. Donnenberg. 1999. Expression of the EspB protein of enteropathogenic Escherichia coli within HeLa cells affects stress fibers and cellular morphology. Infect. Immun. 67:120.
28. Kodama, T., Y. Akeda, G. Kono, A. Takahashi, K. Imura, T. Iida, and T. Honda. 2002. The EspB protein of enterohaemorrhagic Escherichia coli interacts directly with α-catenin. Cell. Microbiol. 4:213.
29. Savkovic, S. D., A. Koutsouris, and G. Hecht. 1997. Activation of NF-κB in intestinal epithelial cells by enteropathogenic Escherichia coli. Am. J. Physiol. 273:1160.
30. - secretion from intestinal epithelia by upregulating galanin-1 receptor expression. J. Clin. Invest. 104:253.
31. Donnenberg, M. S., and J. B. Kaper. 1991. Construction of an eae deletion mutant of enteropathogenic Escherichia coli by using a positive-selection suicide vector. Infect. Immun. 59:4310.
32. O'Brien, A. D., T. A. Lively, T. W. Chang, and S. Gorbach. 1983. Purification of Shigella dysenteriae 1 (Shiga)-like toxin from Escherichia coli 0157:H7 strain associated with haemorrhagic colitis. Lancet 2:573.
33. Wieler, L. H., M. Tigges, F. Ebel, S. Schäferkordt, S. Djafari, T. Schlapp, G. Baljer, and T. Chakraborty. 1996. The enterohemolysin phenotype of bovine Shiga-like toxin-producing E. coli (SLTEC) is encoded by the EHEC-hemolysin gene. Vet. Microbiol. 52:153.
34. Podszadel, T. 2001. Molekularbiologische und funktionelle Charakterisierung von drei Pathogenitätsfaktoren des Shiga Toxin-produzierenden Escherichia coli (STEC) Stammes 413/89-1. Doctoral thesis, Faculty of Medicine, Justus-Liebig-Universität Giessen, Giessen, Germany.
35. Deibel, C. 2000. Molekulare Analyse der durch Shiga-Toxin-produzierende Escherichia coli (STEC) induzierten Umorganisation des Cytoskeletts. Doctoral thesis, Faculty of Natural Sciences, Justus-Liebig-Universität Giessen, Giessen, Germany.
36. Viret, J. F., S. J. Cryz, Jr., and D. Favre. 1996. Expression of Shigella sonnei lipopolysaccharide in Vibrio cholerae. Mol. Microbiol. 19:949.
37. Schreiber, E., P. Mathias, M. M. Müller, and W. Schaffner. 1989. Rapid detection of octamer binding proteins with "mini-extracts," prepared from a small number of cells. Nucleic Acids Res. 17:6419.
38. 1 macrophage-like cells. Infect. Immun. 62:2740.
39. 1 macrophages results in a biphasic NF-κB (RelA/p50) activation induced by lipoteichoic acid and bacterial phospholipases and mediated by IκBα and IκBβ degradation. Proc. Natl. Acad. Sci. USA 94: 9394.
40. 2+ dependence, and differential half-site recognition. J. Biol. Chem. 266:252.
41. Kristie, T. M., and B. Roizman. 1986. Alpha 4, the major regulatory protein of herpes simplex virus type 1, is stably and specifically associated with promoter-regulatory domains of alpha genes and of selected other viral genes. Proc. Natl. Acad. Sci. USA 83:3218.
42. Ruckdeschel, K., S. Harb, A. Roggenkamp, M. Hornef, R. Zumbihl, S. Kohler, J. Heesemann, and B. Rouot. 1998. Yersinia enterocolitica impairs activation of transcription factor NF-κB: involvement in the induction of programmed cell death and in the suppression of the macrophage tumor necrosis factor α production. J. Exp. Med. 187:1069.
43. Schesser, K., A.-K. Spiik, J.-M. Dukuzumuremyi, M. F. Neurath, S. Pettersson, and H. Wolf-Watz. 1998. The yopJ locus is required for Yersinia-mediated inhibition of NF-κB activation and cytokine expression: YopJ contains a eukaryotic SH2-like domain that is essential for its repressive activity. Mol. Microbiol. 28: 1067.
44. Orth, K., L. E. Palmer, Z. Q. Bao, S. Stewart, A. E. Rudolph, J. B. Bliska, and J. E. Dixon. 1999. Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector. Science 285:1920.
45. Schulte, R., G. A. Grassl, S. Preger, S. Fessele, C. A. Jacobi, M. Schaller, P. J. Nelson, and I. B. Autenrieth. 2000. Yersinia enterocolitica invasin protein triggers IL-8 production in epithelial cells via activation of Rel p65-p65 homodimers. FASEB J. 14:1471.
46. Vanden Berghe, W., L. Vermeulen, G. De Wilde, K. De Bosscher, E. Boone, and G. Haegeman. 2000. Signal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6. Biochem. Pharmacol. 60: 1185.
47. Mori, N., and D. Prager. 1996. Transactivation of the interleukin-1α promoter by human T-cell leukemia virus type I and type II Tax proteins. Blood 87:3410.
48. Baggiolini, M., P. Loetscher, and B. Moser. 1995. Interleukin-8 and the chemokine family. Int. J. Immunopharmacol. 17:103.
49. Raqib, R., A. A. Lindberg, B. Wretlind, P. K. Bardhan, U. Andersson, and J. Andersson. 1995. Persistence of local cytokine production in shigellosis in acute and convalescent stages. Infect. Immun. 63:289.
50. Hurley, B. P., C. M. Thorpe, and D. W. Acheson. 2001. Shiga toxin translocation across intestinal epithelial cells is enhanced by neutrophil transmigration. Infect. Immun. 69:6148.