Thrombopoietin promotes mixed lineage and megakaryocytic colony-forming cell growth but inhibits primitive and definitive erythropoiesis in cells isolated from early murine yolk sacs

Blood

Volumn 101, Issue 4, 2003, Pages 1329-1335

  Xie, Xiaodong ^a   Chan, Rebecca J ^a   Johnson, Scott A ^a   Starr, Mark ^a   McCarthy, Jennifer ^a   Kapur, Reuben ^a   Yoder, Mervin C ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; METHYLCELLULOSE; STEM CELL FACTOR; THROMBOPOIETIN; THROMBOPOIETIN RECEPTOR;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL ISOLATION; CELL LINEAGE; COLONY FORMING CELL; COLONY FORMING UNIT; CONTROLLED STUDY; EMBRYO; ERYTHROPOIESIS; HEMATOPOIESIS; MEGAKARYOCYTE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; YOLK SAC;

EID: 0037441759     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-05-1468     Document Type: Article

References (40)

1. Kaushansky K. Thrombopoietin: the primary regulator of platelet production. Blood. 1995;86:419-431.
2. Wendling F. Thrombopoietin: its role from early hematopoiesis to platelet production. Haematologica. 1999;84:158-166.
3. Baatout S. Thrombopoietin: a review. Haemostasis. 1997;27:1-8.
4. Kaushansky K. Thrombopoietin: understanding and manipulating platelet production. Annu Rev Med. 1997;48:1-11.
5. von dem Borne AE, Folman C, Linthorst GE, et al. Thrombopoietin and its receptor: structure, function and role in the regulation of platelet production. Baillieres Clin Haematol. 1998;11:409-426.
6. Methia N, Louache F, Vainchenker W, Wendling F. Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis. Blood. 1993;82:1395-1401.
7. Lok S, Kaushansky K, Holly RD, et al. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature. 1994;369:565-568.
8. Gurney AL, Carver-Moore K, de Sauvage FJ, Moore MW. Thrombocytopenia in c-mpl-deficient mice. Science. 1994;265:1445-1447.
9. Zeigler FC, de Sauvage F, Widmer HR, et al. In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells. Blood. 1994;84:4045-4052.
10. Kaushansky K, Lin N, Grossmann A, Humes J, Sprugel KH, Broudy VC. Thrombopoietin expands erythroid, granulocyte-macrophage, and megakaryocytic progenitor cells in normal and myelosuppressed mice. Exp Hematol. 1996;24:265-269.
11. Kimura S, Roberts AW, Metcalf D, Alexander WS. Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin. Proc Natl Acad Sci U S A. 1998;95:1195-1200.
12. Yagi M, Ritchie KA, Sitnicka E, Storey C, Roth GJ, Bartelmez S. Sustained ex vivo expansion of hematopoietic stem cells mediated by thrombopoietin. Proc Natl Acad Sci U S A. 1999;96:8126-8131.
13. Era T, Takahashi T, Sakai K, Kawamura K, Nakano T. Thrombopoietin enhances proliferation and differentiation of murine yolk sac erythroid progenitors. Blood. 1997;89:1207-1213.
14. Mitjavila MT, Filippi MD, Cohen-Solal K, Le Pesteur F, Vainchenker W, Sainteny F. The Mpl-ligand is involved in the growth-promoting activity of the murine stromal cell line MS-5 on ES cell-derived hematopoiesis. Exp Hematol. 1998;26:124-134.
15. Keller G, Lacaud G, Robertson S. Development of the hematopoietic system in the mouse. Exp Hematol. 1999;27:777-787.
16. Lemer C, Harrison DE. 5-Fluorouracil spares hemopoietic stem cells responsible for long-term repopulation. Exp Hematol. 1990;18:114-118.
17. Yoder MC, Papaioannou VE, Breitfeld PP, Williams DA. Murine yolk sac endoderm- and mesoderm-derived cell lines support in vitro growth and differentiation of hematopoietic cells. Blood. 1994;83:2436-2443.
18. Downs KM, Davies T. Staging of gastrulating mouse embryos by morphological landmarks in the dissecting microscope. Development. 1993;118:1255-1266.
19. Palis J, Robertson S, Kennedy M, Wall C, Keller G. Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse. Development. 1999;126:5073-5084.
20. Rugh R. The Mouse: Its Reproduction and Development. New York, NY: Oxford University Press; 1990.
21. Dagher RN, Hiatt K, Traycoff C, Srour EF, Yoder MC. c-Kit and CD38 are expressed by long-term reconstituting hematopoietic cells present in the murine yolk sac. Biol Blood Marrow Transplant. 1998;4:69-74.
22. Yoder MC, Hiatt K, Dutt P, Mukherjee P, Bodine DM, Orlic D. Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac. Immunity. 1997;7:335-344.
23. Yoder MC, Hiatt K, Mukherjee P. In vivo repopulating hematopoietic stem cells are present in the murine yolk sac at day 9.0 postcoitus. Proc Natl Acad Sci U S A. 1997;94:6776-6780.
24. Keller G, Kennedy M, Papayannopoulou T, Wiles MV. Hematopoietic commitment during embryonic stem cell differentiation in culture. Mol Cell Biol. 1993;13:473-486.
25. Yoder MC, Hiatt K. Engraftment of embryonic hematopoietic cells in conditioned newborn recipients. Blood. 1997;89:2176-2183.
26. Long MW, Smolen JE, Szczepanski P, Boxer LA. Role of phorbol diesters in in vitro murine megakaryocyte colony formation. J Clin Invest. 1984;74:1686-1692.
27. Gregory T, Yu C, Ma A, Orkin SH, Blobel GA, Weiss MJ. GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-xL expression. Blood. 1999;94:87-96.
28. Kapur R, Zhang L. A novel mechanism of cooperation between c-Kit and erythropoietin receptor: stem cell factor induces the expression of Stat5 and erythropoietin receptor, resulting in efficient proliferation and survival by erythropoietin. J Biol Chem. 2001;276:1099-1106.
29. Kapur R, Cooper R, Xiao X, Weiss MJ, Donovan P, Williams DA. The presence of novel amino acids in the cytoplasmic domain of stem cell factor results in hematopoietic defects in Steel(17H) mice. Blood. 1999;94:1915-1925.
30. Kaushansky K, Broudy VC, Grossmann A, et al. Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy. J Clin Invest. 1995;96:1683-1687.
31. Yoder MC. Introduction: spatial origin of murine hematopoietic stem cells. Blood. 2001;98:3-5.
32. Haar JL, Ackerman GA. A phase and electron microscopic study of vasculogenesis and erythropoiesis in the yolk sac of the mouse. Anat Rec. 1971;170:199-223.
33. Palis J, Chan RJ, Koniski A, Patel R, Starr M, Yoder MC. Spatial and temporal emergence of high proliferative potential hematopoietic precursors during murine embryogenesis. Proc Natl Acad Sci U S A. 2001;98:4528-4533.
34. Carver-Moore K, Broxmeyer HE, Luoh SM, et al. Low levels of erythroid and myeloid progenitors in thrombopoietin-and c-mpl-deficient mice. Blood. 1996;88:803-808.
35. Debili N, Coulombel L, Croisille L, et al. Characterization of a bipotent erythro-megakaryocytic progenitor in human bone marrow. Blood. 1996;88:1284-1296.
36. Porteu F, Rouyez MC, Cocault L, et al. Functional regions of the mouse thrombopoietin receptor cytoplasmic domain: evidence for a critical region which is involved in differentiation and can be complemented by erythropoietin. Mol Cell Biol. 1996;16:2473-2482.
37. Uchida M, Kirito K, Shimizu R, Miura Y, Ozawa K, Komatsu N. A functional role of mitogen-activated protein kinases, erk1 and erk2, in the differentiation of a human leukemia cell line, UT-7/GM: a possible key factor for cell fate determination toward erythroid and megakaryocytic lineages. Int J Hematol. 2001;73:78-83.
38. Goncalves F, Lacout C, Feger F, et al. Inhibition of erythroid differentiation and induction of megakaryocytic differentiation by thrombopoietin are regulated by two different mechanisms in TPO-dependent UT-7/c-mpl and TF-1/c-mpl cell lines. Leukemia. 1998;12:1355-1366.
39. Ogawa M, Nishikawa S, Yoshinaga K, et al. Expression and function of c-Kit in fetal hemopoietic progenitor cells: transition from the early c-Kitindependent to the late c-Kit-dependent wave of hemopoiesis in the murine embryo. Development. 1993;117:1089-1098.
40. Lee R, Kertesz N, Joseph SB, Jegalian A, Wu H. Erythropoietin (Epo) and EpoR expression and 2 waves of erythropoiesis. Blood. 2001;98:1408-1415.