Chronic hormone replacement therapy alters thermoregulatory and vasomotor function in postmenopausal women

Journal of Applied Physiology

Volumn 83, Issue 2, 1997, Pages 477-484

  Brooks, E M ^a   Morgan, A L ^a   Pierzga, J M ^a   Wladkowski, S L ^a   O'Gorman, J T ^a   Derr, J A ^a   Kenney, W L ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Core temperature; Estrogen; Progesterone; Reproductive hormones; Skin blood flow; Temperature regulation; Vasodilation

Indexed keywords

CONJUGATED ESTROGEN; ESTRADIOL; ESTROGEN; GESTAGEN; HORMONE; MEDROXYPROGESTERONE ACETATE; PROGESTERONE;

ADULT; ARTICLE; BICYCLE ERGOMETRY; CONDUCTANCE; CONTROLLED STUDY; CORE TEMPERATURE; FEMALE; HORMONE BLOOD LEVEL; HORMONE SUBSTITUTION; HUMAN; HUMAN EXPERIMENT; IONTOPHORESIS; LASER DOPPLER FLOWMETRY; LONG TERM CARE; ORAL DRUG ADMINISTRATION; POSTMENOPAUSE; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RECTUM TEMPERATURE; SKIN; SKIN BLOOD FLOW; THERMOREGULATION; VASOMOTOR REFLEX; VEIN OCCLUSION PLETHYSMOGRAPHY;

EID: 0030796184     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1997.83.2.477     Document Type: Article

References (39)

1. Baker, M. A., D. D. Dawson, C. E. Peters, and A. M. Walker. Effects of estrogen on thermoregulatory evaporation in rats exposed to heat. Am. J. Physiol. 267 (Regulatory Integrative Comp. Physiol. 36): R673-R677, 1994.
2. Braverman, I. M., and E. Fonferko. Correlation of laser Doppler wave patterns with underlying microvascular anatomy. J. Invest. Dermatol. 95: 283-286, 1990.
3. Cannon, J. G., and C. A. Dinarello. Increased plasma interleukin-1 activity in women after ovulation. Science 227: 1247-1249, 1985.
4. Carpenter, A. J., and S. A. Nunneley. Endogenous hormones subtly alter women's response to heat stress. J. Appl. Physiol. 65: 2313-2317, 1988.
5. Detry, J. R., G. L. Brengelmann, L. B. Rowell, and C. Wyss. Skin and muscle components of forearm blood flow in directly heated resting man. J. Appl. Physiol. 32: 506-511, 1972.
6. DiPietro, L., C. J. Casperson, A. M. Ostfeld, and E. R. Nadel. A survey for assessing physical activity among older adults. Med. Sci. Sports Exerc. 25: 628-642, 1993.
7. DuBois, D., and E. F. DuBois. Clinical calorimetry: a formula to estimate the appropriate surface area if height and weight be known. Arch. Intern. Med. 17: 863-871, 1916.
8. Farhat, M. Y., S. Abi-Younes, and P. W. Ramwell. Non-genomic effects of estrogen and the vessel wall. Biochem. Pharmacol. 51: 571-576, 1996.
9. Flynn, A. Stimulation of interleukin-1 production from placental monocytes. Lymphokine Res. 3: 1-5, 1984.
10. Fortney, S. M., W. S. Beckett, A. J. Carpenter, J. Davis, H. Drew, N. D. LaFrance, J. A. Rock, C. G. Tankersley, and N. B. Vroman. Changes in plasma volume during bed rest: effects of menstrual cycle and estrogen administration. J. Appl. Physiol. 65: 525-533, 1988.
11. Fortney, S. M., E. R. Nadel, C. B. Wenger, and J. R. Bove. Effect of blood volume on sweating rate and body fluids in exercising humans. J. Appl. Physiol. 51: 1594-1600, 1981.
12. Gilligan, D. M., D. M. Badar, J. A. Panza, A. A. Quyyumi, and R. O. Cannon III. Acute vascular effects of estrogen in postmenopausal women. Circulation 90: 786-791, 1994.
13. Hardy, J. D. Physiology of temperature regulation. Physiol. Rev. 41: 421-606, 1961.
14. Hessemer, V., and K. Bruck. Influence of menstrual cycle on shivering, skin blood flow, and sweating responses measured at night. J. Appl. Physiol.: 1902-1920, 1985.
15. Hogansen, A. K., L. Nordsletten, A. O. Aasen, and J. A. Falch. There is no difference in spontaneous and 17β-estradiol-induced interleukin-1β release by peripheral blood mononuclear cells from nonosteoporotic women with different rates of early postmenopausal bone loss. Clin. Endocrinol. Metab. 80: 2480-2484, 1995.
16. Israel, S. L., and O. Schneller. The thermogenic property of progesterone. Fertil. Steril. 1: 53-65, 1950.
17. Johnson, J. M., G. L. Brengelman, J. R. S. Hales, P. M. Vanhoutte, and C. B. Wenger. Regulation of the cutaneous circulation. Federation Proc. 45: 2841-2850, 1986.
18. Johnson, J. M., D. S. O'Leary, W. F. Taylor, and W. Kosiba. Effect of local warming on forearm reactive hyperemia. Clin. Physiol. 6: 337-346, 1986.
19. Johnson, J. M., and L. B. Rowell. Forearm skin and muscle vascular responses to prolonged leg exercise in man. J. Appl. Physiol. 39: 920-924, 1975.
20. Kellogg, D. L., J. M. Johnson, and W. A. Kosiba. Selective abolition of adrenergic vasoconstrictor responses in skin by local iontophoresis of bretylium. Am. J. Physiol. 257 (Heart Circ. Physiol. 26): H1599-H1606, 1989.
21. Kenney, W. L., A. L. Morgan, W. B. Farquhar, E. M. Brooks, J. M. Pierzga, and J. A. Derr. Decreased active vasodilator sensitivity in aged skin. Am. J. Physiol. 272 (Heart Circ. Physiol. 41): H1609-H1614, 1997.
22. Lindstrom, M. J., and D. M. Bates. Nonlinear mixed effects models for repeated measures data. Biometrics 46: 673-687, 1990.
23. Lynch, E. A., C. A. Dinarello, and J. G. Cannon. Gender differences in IL-1a, IL-1β, and IL-1 receptor antagonist secretion from mononuclear cells and urinary excretion. J. Immunol. 153: 300-306, 1994.
24. McEwen, B. S. Neural gonadal steroid actions. Science 211: 1303-1311, 1981.
25. Moseley, P. L., H. E. Sandy, C. V. Gisolfi, and K. C. Kregel. Effects of estradiol on thermotolerance during exercise and heat stress in female rats (Abstract). Physiologist 54: 23.2, 1996.
26. Nakayama, T., and M. Suzuki. Action of progesterone on preoptic thermosensitive neurons. Nature 258: 80, 1975.
27. Pacifici, R., J. L. Vannice, L. Rifas, and R. B. Kimble. Monocytic secretion of interleukin-1 receptor antagonist in normal and osteoporotic women: effects of menopause and estrogen/ progesterone therapy. J. Clin. Endocrinol. Metab. 77: 1135-1141, 1993.
28. Polan, M. L., A. Daniele, and A. Kuo. Gonadal steroids modulate human monocyte interleukin-1 (IL-1) activity. Fertil. Steril. 49: 964, 1988.
29. Ramanathan, N. L. A new weighting system for mean surface temperature of the human body. J. Appl. Physiol. 19: 531-533, 1964.
30. Reis, S. E., S. T. Gloth, R. S. Blumenthal, J. R. Resar, H. A. Zacur, and G. Gerstenblith, and J. A. Brinker. Ethinyl estradiol acutely attenuates abnormal coronary vasomotor responses to acetylcholine in postmenopausal women. Circulation 89: 52-60, 1994.
31. Rothchild, I., and A. C. Barnes. The effects of dosage, and of estrogen, androgen or salicylate administration on the degree of body temperature elevation induced by progesterone. Endocrinology 50: 485-496, 1952.
32. Savage, M. V., and G. L. Brengelmann. Control of skin blood flow in the neutral zone of human body temperature regulation. J. Appl. Physiol. 80: 1249-1257, 1996.
33. Silva, N. L., and J. A. Boulant. Effects of testosterone, estradiol, and temperature on neurons in preoptic tissue slices. Am. J. Physiol. 250 (Regulatory Integrative Comp. Physiol. 19): R625-R632, 1986.
34. Stephenson, L. A., and M. A. Kolka. Menstrual cycle phase and time of day alter reference signal controlling arm blood flow and sweating. Am. J. Physiol. 249 (Regulatory Integrative Comp. Physiol. 18): R186-R191, 1985.
35. Stolwijk, J. A. J., and J. D. Hardy. Paritional calorimetric studies of responses of man to thermal transients. J. Appl. Physiol. 21: 967-977, 1966.
36. Tankersley, C. G., W. C. Nicholas, D. R. Deaver, D. Mikita, and W. L. Kenney. Estrogen replacement in middle-aged women: thermoregulatory responses to exercise in the heat. J. Appl. Physiol. 73: 1238-1245, 1992.
37. Taylor, F. W., J. M. Johnson, D. O'Leary, and M. K. Park. Effect of high local temperature on reflex cutaneous vasodilation. J. Appl. Physiol. 57: 191-196, 1984.
38. Whitney, R. J. The measurement of volume changes in human limbs. J. Physiol. (Lond.) 123: 1-27, 1953.
39. Winer, B. J. Statistical Principles in Experimental Design (2nd ed.). New York: McGraw-Hill, 1971, p. 907.