Quantitation of an orally available thrombin inhibitor in rat, monkey and human plasma and in human urine by high-performance liquid chromatography and fluorescent post-column derivatization of arginine

Journal of Chromatography A

Volumn 762, Issue 1-2, 1997, Pages 299-310

  Mendoza, C B ^a   Dixon, S A ^a   Lods, M M ^a   Ma, M G ^a   Nguyen, K T ^a   Nutt, R F ^a   Tran, H S ^a   Nolan, T G ^a  

^a Dendreon   (United States)

Author keywords

Derivatization, LC; Pharmaceutical analysis; Thrombin inhibitors

Indexed keywords

CVS 1123; THROMBIN INHIBITOR; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; DERIVATIZATION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG URINE LEVEL; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; MONKEY; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLID PHASE EXTRACTION; TECHNIQUE;

EID: 0031581864     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9673(96)00865-5     Document Type: Conference Paper

References (16)

1. [1] R.J. Ardecky, S.H. Carpenter, Y.Ge, P. Leon, R.F. Nutt, W.C. Ripka, D.C. Rowley, J.E. Semple, B.S. Shamblin, S.Y. Tamura, M. Weinhouse and M. Lim-Wilby, J. Org. Chem., (1996) submitted.
2. [2] W.E. Rote, E.M. Demsey, G.L. Oldeschulte, R.J. Ardecky, S.Y. Tamura, R.F. Nutt, P. Bergum, H. Tran, S. Anderson and G.P. Vlasuk, Circulation, 90 (1994) I-344.
3. [3] G.R. Cousins, G.S. Friedrichs, Y. Sudo, W.E. Rote, G.P. Vlasuk, T. Nolan, C. Mendoza, B.R. Lucchesi, Circulation, 92 (1995) I-303.
4. [4] B.M. Richard, T.G. Nolan, H.S. Tran, M.M. Miller, R.F. Nutt and G.P. Vlasuk, Circulation, 90 (1994) I-180.
5. [5] R.M. Schultz, P. Varma-Nelson, R. Ortiz, K.A. Kozlowski, A.T. Orawski, P. Pagast and A. Frankfater, J. Biol. Chem., 264 (1989) 1497-1507.
6. [6] S. Bajusz, E. Szell, D. Bagdy, E. Barabas, G. Horvath, M. Dioszegi, A. Fittler, G. Szabo, A. Juhasz, E. Tomori and G. Szilagyi, J. Med. Chem., 33 (1990) 1729-1735.
7. [7] J.J. Kirkland, M.A. van Strafen and H.A. Claessens, J. Chromatogr. A, 691 (1995) 3-19.
8. [8] R.B. Conn, Jr. and R.B. Davis, Nature, 183 (1959) 1053-1055.
9. [9] R.B. Conn, Jr., Clin. Chem. 6 (1960) 537-548.
10. [10] A.S. Jones and T.W. Thompson, J. Chromatogr., 10 (1963) 248.
11. [11] Y. Hiraga and T. Kinoshita, J. Chromatogr., 226 (1981) 43-51.
12. [12] G.R. Rhodes and V.K. Boppana, J. Chromatogr., 444 (1988) 123-131.
13. [13] V.K. Boppana and G.R. Rhodes, J. Chromatogr., 507 (1990) 79-94.
14. [14] V.P. Shah, K.K. Midha, S. Dighe, I.J. McGilveray, J.P. Skelly, A. Yacobi, T. Layloff, C.T. Viswanathan, C.E. Cook, R.D. McDowall, K.A. Pittman and S. Spector, Pharm. Res., 9 (1992) 588-592.
15. [15] R.M. Schultz, P. Varma-Nelson, R. Ortiz, K.A. Kozlowski, A.T. Orawski, P. Pagast and A. Frankfater, J. Biol. Chem., 264 (1989) 1497-1507.
16. [16] S.Y. Tamura, J.E. Semple, R.J. Ardecky, P. Leon, S.H. Carpenter, Y. Ge, B.M. Shamblin, M.I. Weinhouse, W.C. Ripka, R.F. Nutt, Tet. Lett., 37 (1996) 4109-4112.