Neuroprotective effects of a new synthetic peptide, CMX-9236, in in vitro and in vivo models of cerebral ischemia

Brain Research

Volumn 963, Issue 1-2, 2003, Pages 214-223

  Shashoua, Victor E ^a   Adams, David S ^a,b   Boyer Boiteau, Anne ^a   Cornell Bell, Ann ^c   Li, Fuhai ^d   Fisher, Marc ^d  

^a NORTHEASTERN UNIVERSITY   (United States)

^b Life Science and Bioengineering Center   (United States)

^c ANSCANS   (United States)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

AP 1; Ependymin; Fos; Infarct volume; Ischemia; Jun; Neurotrophic peptide; Stroke; Synaptic plasticity

Indexed keywords

AMINO ACID DERIVATIVE; CALCIUM ION; CMX 8933; CMX 9236; DOCOSAHEXAENOIC ACID; GLUTAMIC ACID; KAINIC ACID; NEUROPROTECTIVE AGENT; NEUROTROPHIC FACTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; ASSAY; BLOOD BRAIN BARRIER; BRAIN CORTEX; BRAIN ISCHEMIA; CONTROLLED STUDY; DOSE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; STROKE;

EID: 0037435969     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)04058-1     Document Type: Article

References (47)

1. Adams D.S., Nathans R., Pero S.C., Sen A., Wakshnell E. Activation of a Rel-A/CEBP-beta-related transcription factor heteromer by PGG-glucan in murine monocytic cell line. J. Cell. Biochem. 77:2000;221-233.
2. Albanese C., D'Amico M., Reutens A.T., Fu M., Watanabe G., Lee R.J., Kitsis R.N., Henglein B., Avantaggiati M., Somasundaram K., Thimmapaya B., Pestell R.G. Activation of the cyclin D1 gene by the E1A-associated Protein 300 through AP-1 inhibits cellular apoptosis. J. Biol. Chem. 274:1999;34186-34195.
3. Angel P., Imagawa M., Chiu R., Stein B., Imbra R.J., Rahmsdorf H.J., Jonat C., Herrlich P., Karin M. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell. 49:1987;729-739.
4. Barco A., Alarcon J.M., Kandel E.R. Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture. Cell. 108:2002;689-703.
5. Bederson J.B., Pitts L.H., Germano S.M., Nishimura M.C., Davis R.L., Bartkowski H.M. Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats. Stroke. 17:1986;1304-1308.
6. Brenneman D.E., Gozes I.A. A femtomolar-acting neuroprotective peptide. J. Clin. Invest. 97:1996;2299-2307.
7. Choi D.W. Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. Trends Neurosci. 11:1988;465-469.
8. Choi D.W. Excitotoxic cell death. J. Neurobiol. 23:1992;1261-1276.
9. Cornell-Bell A.H., Finkbeiner S.M. Calcium waves in astrocytes. Cell Calcium. 21:1991;185-204.
10. Cornell-Bell A.H., Finkbeiner S.M., Cooper M.S., Smith S.J. Glutamate induces calcium waves in cultured astrocytes: long-range glial signaling. Science. 247:1990;470-473.
11. Curran T., Morgan J.I. Fos: an immediate-early transcription factor in neurons. J. Neurobiol. 26:1995;403-412.
12. Davis G.W., Schuster C.M., Goodman C.S. Genetic dissection of structural and functional components of synaptic plasticity. III. CREB is necessary for presynaptic functional plasticity. Neuron. 17:1996;669-679.
13. Deshmukh M., Johnson E.M. Jr. Programmed cell death in neurons: focus on the pathway of nerve growth factor deprivation-induced death of sympathetic neurons. Mol. Pharmacol. 51:1997;897-906.
14. Du C., Hu R., Csernansky C.A., Hsu C.Y., Choi D.W. Very delayed infarction after mild focal cerebral ischemia: a role for apoptosis? J. Cereb. Blood Flow Metab. 16:1996;195-201.
15. Ferrer I., Lopez E., Pozas E., Ballabriga J., Marti E. Multiple neurotrophic signals converge in surviving CA1 neurons of the gerbil hippocampus following transient forebrain ischemia. J. Comp. Neurol. 394:1998;416-430.
16. Finklestein S.P. The potential use of neurotrophic growth factors in the treatment of cerebral ischemia. Adv. Neurol. 71:1996;413-417.
17. Gaiddon C., Loeffler J.P., Larmet Y. Brain-derived neurotrophic factor stimulates AP-1 and cyclic AMP-responsive element dependent transcriptional activity in central nervous system neurons. J. Neurochem. 66:1996;2279-2286.
18. Gross E., Meienhofer J. The Peptides: Analysis, Synthesis. Biology. Vol. 2:1983;Academic Press, New York.
19. Hamberg L.M., Macfarlane R., Tasdemiroglu E., Boccalini P., Hunter G.J., Belliveau J.W., Moskowitz M.A., Rosen B.R. Measurement of cerebrovascular changes in cats after transient ischemia using dynamic magnetic resonance imaging. Stroke. 24:1993;444-451.
20. Hefti F. Pharmacology of neurotrophic factors. Annu. Rev. Pharmacol. Toxicol. 37:1997;239-267.
21. Hsu C.Y., An G., Liu J.S., Xue J.J., He Y.Y., Lin T.N. Expression of immediate early gene and growth factor mRNAs in a focal cerebral ischemia model in the rat. Stroke. 24:(Suppl. I):1993;I78-I81.
22. Kaiser E., Colescott R.L., Bossinger C.D., Cook P.I. Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides. Anal. Biochem. 34:1970;595-598.
23. Kerr L.D. Electrophoretic mobility shift assay. Methods Enzymol. 254:1995;619-632.
24. Koizumi J., Yoshida Y., Nakazawa T., Ooneda G. Experimental studies of ischemic brain edema, I: a new experimental model of cerebral embolism in rats in recirculation can be introduced in the ischemic area. Jpn. J. Stroke. 8:1986;1-8.
25. Kristian T., Siesjö B.K. Calcium in ischemic cell death. Stroke. 29:1998;705-718.
26. Kuroda S., Tsuchidate R., Smith M.L., Maples K.R., Siesjö B.K. Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemia in the rat. J. Cereb. Blood Flow Metab. 19:1999;778-787.
27. Lenardo M.J., Baltimore D. NF-kappa B: a pleiotropic mediator of inducible and tissue-specific gene control. Cell. 58:1989;227-229.
28. Li F., Irie K., Anwer M.S., Fisher M. Delayed triphenyltetrazolium chloride staining remains useful for evaluating infarct volume in a rat stroke model. J. Cereb. Blood Flow Metab. 17:1997;1132-1135.
29. Mayevsky A. Level of ischemia and brain functions in the Mongolian gerbil in vivo. Brain Res. 524:1990;1-9.
30. Meador W.E., Means A.R., Quiocho F.A. Target enzyme recognition by calmodulin: 2.4 A structure of calmodulin-peptide complex. Science. 257:1992;1251-1255.
31. Meadows M.E., Fisher M., Minematsu K. Delayed treatment with a non-competitive NMDA antagonist, CNS-1102, reduces infarct size in rats. Cerebrovasc. Dis. 4:1994;26-31.
32. Minematsu K., Li L., Fisher M., Sotak C.H., Davis M.A., Fiandaca M.S. Diffusion-weighted magnetic resonance imaging: rapid and quantitative detection of focal brain ischemia. Neurology. 42:1992;235-240.
33. Mitani A., Kataoka K. Critical levels of extracellular glutamate mediating gerbil hippocampal delayed neuronal death during hypothermia: brain microdialysis study. Neuroscience. 42:1991;661-670.
34. Nagasawa H., Kogure K. Correlation between cerebral blood flow and histologic changes in a new rat model of MCA occlusion. Stroke. 20:1989;1037-1043.
35. Pulsinelli W.A., Levy D.E., Duffy T.E. Regional cerebral blood flow and glucose metabolism following transient forebrain ischemia. Ann. Neurol. 11:1982;499-502.
36. Sanyal S., Sandstrom D.J., Hoeffer C.A., Ramaswami M. AP-1 functions upstream of CREB to control synaptic plasticity in Drosophila. Nature. 416:2002;870-874.
37. Schabitz W.R., Schwab S., Spanger M., Hacke W. Intraventricular brain-derived neurotrophic factor reduces infarct size after focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab. 17:1997;500-506.
38. Schwartz L.M., Milligan C.E. Cold thoughts of death: the role of ICE proteases in neuronal cell death. Trends Neurosci. 19:1996;555-562.
39. Shashoua V.E. Ependymin, a brain extracellular glycoprotein, and CNS plasticity. Ann. NY Acad. Sci. 627:1991;94-114.
40. Shashoua V.E. Procedures for penetrating the blood-brain barrier: studies of γ-aminobutyric acid (GABA). Adv. Behav. Biol. 40:1992;333-345.
41. Shashoua V.E., Hesse G.W. N-Docosahexaenoyl, 3 hydroxytyramine: a dopaminergic compound that penetrates the blood-brain barrier and suppresses appetite. Life Sci. 58:1996;1347-1357.
42. Shashoua V.E., Adams D., Boyer-Boiteau A. CMX-8933, a peptide fragment of the glycoprotein ependymin, promotes activation of AP-1 transcription factor in mouse neuroblastoma and rat cortical cell cultures. Neurosci. Lett. 312:2001;103-107.
43. Soderberg M., Edlund C., Kristensson K., Dallner G. Fatty acid composition of brain phospholipids in aging and in Alzheimer's disease. Lipids. 26:1991;421-425.
44. Sun G.Y., Yau T.M. Changes in acyl group composition of diacyl-glycerophosphorylethanolamine, alkenylacyl-glycerophosphorylethanolamine and diacyl-glycerophosphorylcholine in myelin and microsomal fractions of mouse brain during development. J. Neurochem. 26:1976;291-295.
45. Wendland M.F., White D.L., Aicher K.P., Tzika A.A., Moseley M.E. Detection with echo-planar MR imaging of transit of susceptibility contrast medium in a rat model of regional brain ischemia. J. Magn. Reson. Imaging. 1:1991;285-292.
46. Zea E. Longa, Weinstein P.R., Carlson S., Cummings R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 20:1989;84-91.
47. Zhao Q., Pahlmark K., Smith M.L., Siesjö B.K. Delayed treatment with the spin trap-phenyl- N-tert -butyl nitrone (PBN) reduced infarct size following transient middle cerebral artery occlusion in rats. Acta Physiol. Scand. 152:1994;349-350.