5-Hydroxytryptamine and platelets: Uptake and aggregation in hypoxic pulmonary hypertensive rats

European Journal of Pharmacology

Volumn 459, Issue 1, 2003, Pages 1-7

  Awabdy, Doreen ^a   Bryan Lluka, Lesley J ^a   Wanstall, Janet C ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

5 HT (5 hydroxytryptamine, serotonin); Aggregation; Hypoxic pulmonary hypertension; Platelet; SERT (serotonin transporter)

Indexed keywords

ADENOSINE DIPHOSPHATE; COLLAGEN; OXYGEN; SEROTONIN;

AMBIENT AIR; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG UPTAKE; HYPOXIA; MALE; NONHUMAN; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAT; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT;

ADENOSINE DIPHOSPHATE; ANIMALS; ANOXIA; BLOOD PLATELETS; COLLAGEN; DOSE-RESPONSE RELATIONSHIP, DRUG; HEMATOCRIT; HYPERTENSION, PULMONARY; MALE; MYOCARDIUM; ORGAN SIZE; PAROXETINE; PLATELET AGGREGATION; PLATELET COUNT; RATS; RATS, WISTAR; SEROTONIN; SEROTONIN UPTAKE INHIBITORS;

EID: 0037427951     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(02)02734-6     Document Type: Article

References (26)

1. Awabdy D., Bryan-Lluka L.J., Wanstall J.C. 5-Hydroxytryptamine and platelet function in hypoxic pulmonary hypertensive rats: studies on uptake and aggregation. Proc. Australas. Soc. Clin. Exp. Pharmacol. Toxicol. 9:2001;63.
2. Born G.V., Juengjaroen K., Michal F. Relative activities on and uptake by human blood platelets of 5-hydroxytryptamine and several analogues. Br. J. Pharmacol. 44:1972;117-139.
3. Brink C., Cerrina C., Labat C., Verley J., Benveniste J. The effect of contractile agonists on isolated pulmonary arterial and venous muscle preparations derived from patients with primary pulmonary hypertension. Am. Rev. Respir. Dis. 137:1988;A106.
4. Chaouat A., Weitzenblum E., Higenbottam T. The role of thrombosis in severe pulmonary hypertension. Eur. Respir. J. 9:1996;356-363.
5. Doggrell S.A., Wanstall J.C., Gambino A. Functional effects of 4-aminopyridine (4-AP) on pulmonary and systemic vessels from normoxic control and hypoxic pulmonary hypertensive rats. Naunyn-Schmiedeberg's Arch. Pharmacol. 360:1999;317-323.
6. Douglas J.G., Munro J.F., Kitchin A.H., Kuir A.L., Proudfoot A.T. Pulmonary hypertension and fenfluramine. Br. Med. J. 283:1981;881-883.
7. Eddahibi S., Raffestin B., Pham I., Launy J., Aegerter P., Sitbon M., Adnot S. Treatment with 5-HT potentiates development of pulmonary hypertension in chronically hypoxic rats. Am. J. Physiol. 272:1997;H1173-H1181.
8. Eddahibi S., Fabre V., Boni C., Martres M.P., Raffestin B., Hamon M., Adnot S. Induction of serotonin transporter by hypoxia in pulmonary vascular smooth muscle cells. Relationship with the mitogenic action of serotonin. Circ. Res. 84:1999;329-336.
9. Eddahibi S., Hanoun N., Lanfumey L., Lesch K.P., Raffestin B., Hamon M., Adnot S. Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene. J. Clin. Invest. 105:2000;1555-1562.
10. Eddahibi S., Humbert M., Sediame S., Chouaid C., Partovian C., Maître B., Teiger E., Rideau D., Simonneau G., Sitbon O., Adnot S. Imbalance between platelet vascular endothelial growth factor and platelet-derived growth factor in pulmonary hypertension. Effect of prostacyclin therapy. Am. J. Respir. Crit. Care Med. 162:2000;1493-1499.
11. Eddahibi S., Humbert M., Fadel E., Raffestin B., Darmon M., Capron F., Simmoneau G., Dartevelle P., Hamon M., Adnot S. Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension. J. Clin. Invest. 108:2001;1141-1150.
12. Egermayer P., Town G.I., Peacock A.J. Role of serotonin in the pathogenesis of acute and chronic pulmonary hypertension. Thorax. 54:1999;161-168.
13. Gurtner H.P. Aminorex and pulmonary hypertension. Cor Vasa. 27:1985;160-171.
14. Herve P., Drouet L., Dosquet C., Launay J., Rain B., Simonneau G., Caen J., Duroux P. Primary pulmonary hypertension in a patient with a familial platelet storage pool disease: role of serotonin. Am. J. Med. 89:1990;117-120.
15. Herve P., Launay J., Scrobohaci M., Brenot F., Simonneau G., Petitpretz P., Poubeau P., Cerrina J., Duroux P., Drouet L. Increased plasma serotonin in primary pulmonary hypertension. Am. J. Med. 99:1995;249-254.
16. Jeffery T.K., Wanstall J.C. Comparison of pulmonary vascular function and structure in early and established hypoxic pulmonary hypertension in rats. Can. J. Phys. Pharm. 79:2001;227-237.
17. Jeffery T.K., Bryan-Lluka L.J., Wanstall J.C. Specific uptake of 5-hydroxytryptamine is reduced in lungs from hypoxic pulmonary hypertensive rats. Eur. J. Pharmacol. 396:2000;137-140.
18. Kanai Y., Hori S., Tanaka T., Yasuoka M., Watanabe K., Aikawa N., Hosoda Y. Role of 5-hydroxytryptamine in the progression of monocrotaline induced pulmonary hypertension in rats. Cardiovasc. Res. 27:1993;1619-1623.
19. Lee S.L., Wang W.W., Moore B.J., Fanburg B.L. Dual effect of serotonin on growth of bovine pulmonary artery smooth muscle cells in culture. Circ. Res. 68:1991;1362-1368.
20. MacLean M.R., Sweeney G., Baird M., McCulloch K.M., Houslay M., Morecroft I. 5-Hydroxytryptamine receptors mediating vasoconstriction in pulmonary arteries from control and pulmonary hypertensive rats. Br. J. Pharmacol. 119:1996;917-930.
21. MacLean M.R., Herve P., Eddahibi S., Adnot S. 5-Hydroxytryptamine and the pulmonary circulation: receptors, transporters and relevance to pulmonary hypertension. Br. J. Pharmacol. 131:2000;161-168.
22. Poole A.W. The study of platelet function in other species. Watson S.P., Authi K.S. Platelets. A Practical Approach. 1996;341-350 Oxford Univ. Press, Oxford.
23. Prina R., Dolfini E., Mennini T., Palermo A., Libretti A. Reduced serotonin uptake by spontaneously hypertensive rat platelets. Life Sci. 29:1981;2375-2379.
24. Rothman R.B., Ayestas M.A., Dersch C.M., Baumann M.H. Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension. Circulation. 100:1999;869-875.
25. Wanstall J.C., O'Donnell S.R. Endothelin and 5-hydroxytryptamine on rat pulmonary artery in pulmonary hypertension. Eur. J. Pharmacol. 176:1990;159-168.
26. Wanstall J.C., Awabdy D., Gambino A., Bryan-Lluka L.J. 5-Hydroxytryptamine and platelet function in hypoxic pulmonary hypertensive rats. J. Vasc. Res. 39(Suppl. 1):2002;82.