Specific heat shock proteins protect microtubules during simulated ischemia in cardiac myocytes

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 275, Issue 6 44-6, 1998, Pages

  Bluhm, Wolfgang F ^a   Martin, Jody L ^a   Mestril, Ruben ^a   Dillmann, Wolfgang H ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Confocal microscopy; Cytoskeleton; Image analysis; Immunofluorescence; Tubulin

Indexed keywords

HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 70;

ANIMAL CELL; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CYTOSKELETON; GENE OVEREXPRESSION; HEART MUSCLE ISCHEMIA; MICROTUBULE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TRANSGENE;

EID: 33750857016     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1998.275.6.h2243     Document Type: Article

References (29)

1. Armstrong, S. C., and C. E. Ganote. Flow cytometric analysis of isolated adult cardiomyocytes: vinculin and tubulin fluorescence during metabolic inhibition and ischemia. J. Mol. Cell. Cardiol. 24: 149-162, 1992.
2. B-Crystallin in cardiac tissue. Association with actin and desmin filaments. Circ. Res. 71: 288-294, 1992.
3. Brown, C. R., S. J. Doxsey, L. Q. Hong-Brown, R. L. Martini, and W. J. Welch. Molecular chaperones and the centrosome. A role for TCP-1 in microtubule nucleation. J. Biol. Chem. 271: 824-832, 1996.
4. Brown, C. R., L. Q. Hong-Brown, S. J. Doxsey, and W. J. Welch. Molecular chaperones and the centrosome. A role for HSP 73 in centrosomal repair following heat shock treatment. J. Biol. Chem. 271: 833-840, 1996.
5. Ganote, C., and S. Armstrong. Ischaemia and the myocyte cytoskeleton: review and speculation. Cardiovasc. Res. 27: 1387-1403, 1993.
6. Ganote, C. E., and R. S. vander Heide. Cytoskeletal lesions in anoxic myocardial injury. A conventional and high-voltage electron-microscopic and immunofluorescence study. Am. J. Pathol. 129: 327-344, 1987.
7. Gomez-Foix, A. M., W. S. Coats, S. Baque, T. Alam, R. D. Gerard, and C. B. Newgard. Adenovirus-mediated gene transfer of the muscle glycogen phosphorylase gene into hepatocytes confers altered regulation of glycogen metabolism. J. Biol. Chem. 267: 25129-25134, 1992.
8. Graham, F. L., and L. Prevec. Manipulation of adenovirus vectors. In: Methods in Molecular Biology, edited by E. J. Murray. Clifton, NJ: Humana, 1991, vol. 7, p. 109-128.
9. Gupta, R. S. Microtubules, mitochondria, and molecular chaperones: a new hypothesis for in vivo assembly of microtubules. Biochem. Cell Biol. 68: 1352-1363, 1990.
10. Hein, S., T. Scheffold, and J. Schaper. Ischemia induces early changes to cytoskeletal and contractile proteins in diseased human myocardium. J. Thorac. Cardiovasc. Surg. 110: 89-98, 1995.
11. Hutter, J. J., R. Mestril, E. K. W. Tam, R. E. Sievers, W. H. Dillmann, and C. L. Wolfe. Overexpression of heat shock protein 72 in transgenic mice decreases infarct size in vivo. Circulation 94: 1408-1411, 1996.
12. Iwai, K., M. Hori, A. Kitabatake, H. Kurihara, K. Uchida, M. Inoue, and T. Kamada. Disruption of microtubules as an early sign of irreversible ischemic injury. Immunohistochemical study of in situ canine hearts. Circ. Res. 67: 694-706, 1990.
13. Iwaki, K., S. H. Chi, W. H. Dillmann, and R. Mestril. Induction of HSP70 in cultured rat neonatal cardiomyocytes by hypoxia and metabolic stress. Circulation 87: 2023-2032, 1993.
14. Jennings, R. B., C. E. Murry, C. Steenbergen, Jr., and R. A. Reimer. Development of cell injury in sustained acute ischemia. Circulation 82, Suppl. II: II.2-II.12, 1990.
15. B crystallin in C6 glioma cells is induced by agents that promote the disassembly of microtubules. J. Biol. Chem. 271: 26989-26994, 1996.
16. Lavoie, J. N., G. Gingras-Breton, R. M. Tanguay, and L. Landry. Induction of Chinese hamster HSP27 gene expression in mouse cells confers resistance to heat shock. HSP27 stabilization of the microfilament organization. J. Biol. Chem. 268: 3420-3429, 1993.
17. Marber, M., R. Mestril, S. H. Chi, M. R. Sayen, D. M. Yellon, and W. H. Dillmann. Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury. J. Clin. Invest. 95: 1446-1456, 1995.
18. Martin, J. L., R. Mestril, R. Hilal-Dandan, L. L. Brunton, and W. H. Dillmann. Small heat shock proteins and protection against ischemic injury in cardiac myocytes. Circulation 96: 4343-4348, 1997.
19. Mestril, R., S. H. Chi, M. R. Sayen, K. O'Reilly, and W. H. Dillmann. Expression of inducible stress protein 70 in rat heart myogenic cells confers protection against simulated ischemia-induced injury. J. Clin. Invest. 93: 759-767, 1994.
20. Mestril, R., F. J. Giordano, A. G. Conde, and W. H. Dillmann. Adenovirus-mediated gene transfer of a heat shock protein 70 (hsp 70i) protects against simulated ischemia. J. Mol. Cell. Cardiol. 26: 2351-2358, 1996.
21. Nicholl, I. D., and R. A. Quinlan. Chaperone activity of α-crystallins modulates intermediate filament assembly. EMBO J. 13: 945-953, 1994.
22. O'Malley, K., A. Mauron, J. D. Barchas, and L. Kedes. Constitutively expressed rat mRNA encoding a 70-kilodalton heat-shock-like protein. Mol. Cell. Biol. 5: 3476-3483, 1985.
23. Plumier, J. C. L., B. Ross, R. W. Currie, C. E. Angelidis, H. Kazlaris, G. Kollias, and G. N. Pagoulatous. Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery. J. Clin. Invest. 95: 1854-1860, 1995.
24. Radford, N. B., M. Fina, I. J. Benjamin, R. W. Moreadith, K. H. Graves, P. Zhao, S. Gawa, A. Wiethoff, A. D. Sherry, C. R. Malloy, and R. S. Williams. Cardioprotective effects of 70-kDa heat shock protein in transgenic mice. Proc. Natl. Acad. Sci. USA 93: 2339-2342, 1996.
25. Rappaport, L., and J. L. Samuel. Microtubules in cardiac myocytes. Int. Rev. Cytol. 113: 101-143, 1988.
26. Sánchez, C., R. Padilla, R. Paciucci, J. C. Zabala, and J. Avila. Binding of heat-shock protein 70 (hsp70) to tubulin. Arch. Biochem. Biophys. 310: 428-432, 1994.
27. Sato, H., M. Hori, M. Kitakaze, K. Iwai, S. Takashima, H. Kurihara, M. Inoue, and T. Kamada. Reperfusion after brief ischemia disrupts the microtubule network in canine hearts. Circ. Res. 72: 361-375, 1993.
28. Steenbergen, C., M. L. Hill, and R. B. Jennings. Cytoskeletal damage during myocardial ischemia: changes in vinculin immunofluorescence staining during total in vitro ischemia in canine heart. Circ. Res. 60: 478-486, 1987.
29. Sternlicht, H., G. W. Farr, M. L. Sternlicht, J. K. Driscoll, K. Willison, and M. B. Yaffe. The t-complex polypeptide 1 complex is a chaperonin for tubulin and actin in vivo. Proc. Natl. Acad. Sci. USA 90: 9422-9426, 1993.