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For recent synthesis of amphidinolides, see: (a) Trost, B. M.; Chisholm, J. D.; Wrobleski, S. T.; Jung, M. J. Am. Chem. Soc. 2002, 124, 12420. (b) Maleczka, R. E., Jr.; Terrell, L. R.; Geng, F.; Ward, J. S., III. Org. Lett. 2002, 4, 17, 2841. (c) Lam, H. W.; Pattenden, G. Angew. Chem., Int. Ed. 2002, 41, 508. (d) Williams, D.; Meyer, K. G. J. Am. Chem. Soc. 2001, 123, 765.
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For recent synthesis of amphidinolides, see: (a) Trost, B. M.; Chisholm, J. D.; Wrobleski, S. T.; Jung, M. J. Am. Chem. Soc. 2002, 124, 12420. (b) Maleczka, R. E., Jr.; Terrell, L. R.; Geng, F.; Ward, J. S., III. Org. Lett. 2002, 4, 17, 2841. (c) Lam, H. W.; Pattenden, G. Angew. Chem., Int. Ed. 2002, 41, 508. (d) Williams, D.; Meyer, K. G. J. Am. Chem. Soc. 2001, 123, 765.
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Lam, H.W.1
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For recent synthesis of amphidinolides, see: (a) Trost, B. M.; Chisholm, J. D.; Wrobleski, S. T.; Jung, M. J. Am. Chem. Soc. 2002, 124, 12420. (b) Maleczka, R. E., Jr.; Terrell, L. R.; Geng, F.; Ward, J. S., III. Org. Lett. 2002, 4, 17, 2841. (c) Lam, H. W.; Pattenden, G. Angew. Chem., Int. Ed. 2002, 41, 508. (d) Williams, D.; Meyer, K. G. J. Am. Chem. Soc. 2001, 123, 765.
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note
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Attempted reaction of 2 and silyl derivatives of 3 under a variety of conditions resulted in complete decomposition of starting materials.
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0242528573
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note
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Full investigation will be reported in due course.
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21
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This stereochemical outcome is consistent with the recent observation by Woerpel and co-workers; please see: Larsen, C. H.; Ridgway, B. H.; Shaw, J. T.; Woerpel, K. A. J. Am. Chem. Soc. 1999, 121, 12208.
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