A short, stereocontrolled, and practical synthesis of α-methylomuralide, a potent inhibitor of proteasome function

Journal of Organic Chemistry

Volumn 68, Issue 7, 2003, Pages 2760-2764

  Saravanan, P ^a   Corey, E J ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

STEREOCONTROL;

STEREOCHEMISTRY;

SYNTHESIS (CHEMICAL);

2,3 DIHYDROXY 4 METHYLPENTANOIC ACID METHYL ESTER; ALPHA METHYLOMURALIDE; LACTACYSTIN; PROTEOME; UNCLASSIFIED DRUG; VALERIC ACID DERIVATIVE;

ARTICLE; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; ENZYME INHIBITION; IN VIVO STUDY; SCALE UP; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

CATALYSIS; COMBINATORIAL CHEMISTRY TECHNIQUES; CYSTEINE ENDOPEPTIDASES; INDICATORS AND REAGENTS; LACTAMS; LACTONES; MOLECULAR STRUCTURE; MULTIENZYME COMPLEXES; PROTEASE INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX; STEREOISOMERISM;

EID: 0037419155     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo0268916     Document Type: Article

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