Factor associated with neutral sphingomyelinase activation and its role in cardiac cell death

Circulation Research

Volumn 92, Issue 6, 2003, Pages 589-591

  O'Brien, Nicole W ^a   Gellings, Nicole M ^a   Guo, Mei ^a   Barlow, Steven B ^a   Glembotski, Christopher C ^a   Sabbadini, Roger A ^a  

^a SAN DIEGO STATE UNIVERSITY   (United States)

Author keywords

Apoptosis; FAN; Hypoxia; Sphingomyelinase

Indexed keywords

ADAPTOR PROTEIN; CERAMIDE; COMPLEMENTARY DNA; FACTOR ASSOCIATED WITH NEUTRAL SPHINGOMYELINASE ACTIVATION; SPHINGOLIPID; UNCLASSIFIED DRUG;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL HYPOXIA; DNA ISOLATION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; IMMUNOELECTRON MICROSCOPY; IMMUNOFLUORESCENCE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REOXYGENATION; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; CELL HYPOXIA; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MOLECULAR SEQUENCE DATA; MYOCYTES, CARDIAC; PROTEINS; RATS; SEQUENCE ALIGNMENT;

EID: 0037418961     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000066290.29715.67     Document Type: Article

References (15)

1. Levade T, Auge N, Jan Veldman R, Cuvillieer O, Negre-Salvayre A, Salvayre R. Sphingolipid mediators in cardiovascular cell biology and pathology. Circ Res. 2001;89:957-968.
2. Hernandez O, Discher D, Bishorpric N, Webster K. Rapid activation of neutral sphingomyelinase by hypoxia-reoxygenation of cardiac myocytes. Circ Res. 2000;86:198-204.
3. Bielawska AE, Shapiro JP, Jiang L, Melkonyan HS, Piot C, Wolfe CL, Tomei LD, Hannun YA, Umansky SR. Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion. Am J Pathol. 1997;151:1257-1263.
4. Cavalli AL, Ligutti JA, Gellings NM, Castro EN, Page MT, Klepper RE, Palade PT, McNutt WT, Sabbadini RA. The role of TNFα and sphingolipid signaling in cardiac hypoxia: evidence that cardiomyocytes release TNFα and sphingosine. Basic Appl Myol. 2002;12:167-176.
5. Adam-Klages S, Adam D, Wiegmann K, Struve S, Kolanus W, Schneider-Mergener J, Krönke M. FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase. Cell. 1996;86:937-947.
6. Ségui B, Andrieu-Abadie N, Adam-Klages S, Meihac O, Kreder D, Garcia V, Bruno AP, Jaffrézou J, Salvayre R, Krönke M, Levade T. CD40 Signals apoptosis through FAN-regulated activation of the sphinogmyelin-ceramide pathway. J Biol Chem. 1999;274:37251-37258.
7. Ségui B, Cuilier O, Adam-Klages S, Garcia V, Malagarie-Cazenave S, Lévêque S, Caspar-Bauguil C, Coudert J, Salvayre R, Krönke M, Levade T. Involvement of FAN in TNF-induced apoptosis. J Clin Invest. 2001;108:143-151.
8. Song KS, Scherer PE, Tang Z, Okamoto T, Li S, Chafel M, Chu C, Kohtz DS, Lisanti MP. Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells: caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins. J Biol Chem. 1996;271:15160-15165.
9. Tcherkasowa AE, Adam-Klages S, Kruse ML, Wiegmann K, Mathieu S, Kolanus W, Kronke M, Adam D. Interaction with factor associated with neutral sphingomyelinase activation, a WD motif-containing protein, identifies receptor for activated C-kinase 1 as a novel component of the signaling pathways of the p55 TNF receptor. J Immunol. 2002;169:5161-5170.
10. 1 cannabinoid receptor of astrocytes is coupled to sphingomyelin hydrolysis through the adaptor protein fan. Mol Pharmacol. 2001;59:955-959.
11. Marber MS. Ischemic preconditioning in isolated cells. Circ Res. 2000; 86:926-931.
12. Morrison LE, Hoover HE, Thuerauf DJ, Glembotski CC. Mimicking phosphorylation of aB-Crystallin on serine-59 is necessary and sufficient to provide maximal protection of cardiac myocytes from apoptosis. Circ Res. 2003;92:203-211.
13. Torre-Amione G, Bozkurt B, Deswal A, Mann DL. An overview of tumor necrosis factor α and the failing human heart. Curr Opin Cardiol. 1999;14: 206-210.
14. Krown KA, Page MT, Nguyen C, Zechner D, Gutierrez V, Comstock KL, Glembotski CC, Quintana PJE, Sabbadini RA. TNFα-induced apoptosis in cardiac myocytes: involvement of the sphingolipid signaling cascade in cardiac cell death. J Clin Invest. 1996;98:2854-2865.
15. Nakano M, Knowlton AA, Dibbs Z, Mann DL. Tumor necrosis factor-α confers resistance to hypoxic injury in the adult mammalian cardiac myocyte. Circulation. 1998;97:1392-1400.