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Volumn 14, Issue 3, 1999, Pages 206-210

An overview of tumor necrosis factor α and the failing human heart

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; AMRINONE; CYTOKINE; DEXAMETHASONE; DOBUTAMINE; NEUROHORMONE; PENTOXIFYLLINE; THALIDOMIDE; TUMOR NECROSIS FACTOR ALPHA;

EID: 0032945406     PISSN: 02684705     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001573-199905000-00003     Document Type: Review
Times cited : (87)

References (44)
  • 2
    • 0032515950 scopus 로고    scopus 로고
    • Pathophysiologically relevant concentrations of tumor necrosis factor-α promote progressive left ventricular dysfunction and remodeling in rats
    • 2 Bozkurt B, Kribbs S, Clubb FJ Jr, Michael LH, Didenko VV, Hornsby PJ, et al.: Pathophysiologically relevant concentrations of tumor necrosis factor-α promote progressive left ventricular dysfunction and remodeling in rats. Circulation 1998, 97:1382-1391. This experimental study shows that pathophysiologically relevant concentrations of TNF-α were sufficient to produce LV dysfunction and LV remodeling in rats. In this study, the increase in LV remodeling seemed to be caused by TNF-α-induced changes in the fibrillar collagen content in the rats.
    • (1998) Circulation , vol.97 , pp. 1382-1391
    • Bozkurt, B.1    Kribbs, S.2    Clubb F.J., Jr.3    Michael, L.H.4    Didenko, V.V.5    Hornsby, P.J.6
  • 3
    • 0031159090 scopus 로고    scopus 로고
    • Cardiac-specific overexpression of tumor necrosis factor-alpha causes lethal myocarditis in transgenic mice
    • 3 Kubota T, McTiernan CF, Frye CS, Demetris AJ, Feldman AM: Cardiac-specific overexpression of tumor necrosis factor-alpha causes lethal myocarditis in transgenic mice. J Cardiac Failure 1997, 3:117-124. This important experimental study shows that when TNF-α was selectively overexpressed in the hearts of transgenic mice, the mice developed LV dysfunction and LV remodeling and an increase in mortality compared with littermate controls.
    • (1997) J Cardiac Failure , vol.3 , pp. 117-124
    • Kubota, T.1    McTiernan, C.F.2    Frye, C.S.3    Demetris, A.J.4    Feldman, A.M.5
  • 4
    • 0032515897 scopus 로고    scopus 로고
    • Cardiac failure in transgenic mice with myocardial expression of tumor necrosis factor-α (TNF)
    • 4 Bryant D, Becker L, Richardson J, Shelton J, Franco F, Pechock RM, et al.: Cardiac failure in transgenic mice with myocardial expression of tumor necrosis factor-α (TNF). Circulation 1998, 97:1375-1381. This study confirms that transgenic mice overexpressing TNF-α in the myocardium developed a dilated cardiomyopathy and increased mortality.
    • (1998) Circulation , vol.97 , pp. 1375-1381
    • Bryant, D.1    Becker, L.2    Richardson, J.3    Shelton, J.4    Franco, F.5    Pechock, R.M.6
  • 5
    • 0029871896 scopus 로고    scopus 로고
    • Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: A report from the Studies of Left Ventricular Dysfunction (SOLVD)
    • 5 Torre-Amione G, Kapadia S, Benedict CR, Oral H, Young JB, Mann DL: Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: a report from the Studies of Left Ventricular Dysfunction (SOLVD). J Am Coll Cardiol 1996, 27:1201-1206.
    • (1996) J Am Coll Cardiol , vol.27 , pp. 1201-1206
    • Torre-Amione, G.1    Kapadia, S.2    Benedict, C.R.3    Oral, H.4    Young, J.B.5    Mann, D.L.6
  • 6
    • 0030273548 scopus 로고    scopus 로고
    • Circulating levels of cytokines and their endogenous modulators in patients with mild to severe congestive heart failure due to coronary artery disease or hypertension
    • 6 Testa M, Yeh M, Lee P, Fanelli R, Loperfido F, Berman JW, LeJemtel TH: Circulating levels of cytokines and their endogenous modulators in patients with mild to severe congestive heart failure due to coronary artery disease or hypertension. J Am Coll Cardiol 1996, 28:964-971.
    • (1996) J Am Coll Cardiol , vol.28 , pp. 964-971
    • Testa, M.1    Yeh, M.2    Lee, P.3    Fanelli, R.4    Loperfido, F.5    Berman, J.W.6    LeJemtel, T.H.7
  • 7
    • 0030116255 scopus 로고    scopus 로고
    • Attivazione e ruolo del fattore di necrosi tumorale alfa nello scompenso cardiaco congestizio
    • 7 Bachetti T, Comini L, Agnoletti L, Gaia G, Milanesi B, Curello S, et al.: Attivazione e ruolo del fattore di necrosi tumorale alfa nello scompenso cardiaco congestizio. Cardiologia 1996, 41:343-347.
    • (1996) Cardiologia , vol.41 , pp. 343-347
    • Bachetti, T.1    Comini, L.2    Agnoletti, L.3    Gaia, G.4    Milanesi, B.5    Curello, S.6
  • 8
    • 0025286817 scopus 로고
    • Elevated circulating levels of tumor necrosis factor in severe chronic heart failure
    • 8 Levine B, Kalman J, Mayer L, Fillit HM, Packer M: Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med 1990, 223:236-241.
    • (1990) N Engl J Med , vol.223 , pp. 236-241
    • Levine, B.1    Kalman, J.2    Mayer, L.3    Fillit, H.M.4    Packer, M.5
  • 10
    • 0030603619 scopus 로고    scopus 로고
    • Tumour necrosis factor and inducible nitric oxide synthase in dilated cardiomyopathy
    • 10 Habib FM, Springall DR, Davies GJ, Oakley CM, Yacoub MH, Polak JM: Tumour necrosis factor and inducible nitric oxide synthase in dilated cardiomyopathy. Lancet 1996, 347:1151-1155.
    • (1996) Lancet , vol.347 , pp. 1151-1155
    • Habib, F.M.1    Springall, D.R.2    Davies, G.J.3    Oakley, C.M.4    Yacoub, M.H.5    Polak, J.M.6
  • 12
    • 0030159210 scopus 로고    scopus 로고
    • Tumour necrosis factor is expressed in cardiac tissues of patients with heart failure
    • 12 Doyama K, Fujiwara H, Fukumoto M, Tanaka M, Fujiwara Y, Oda T, et al.: Tumour necrosis factor is expressed in cardiac tissues of patients with heart failure. Int J Cardiol 1996, 54:217-225.
    • (1996) Int J Cardiol , vol.54 , pp. 217-225
    • Doyama, K.1    Fujiwara, H.2    Fukumoto, M.3    Tanaka, M.4    Fujiwara, Y.5    Oda, T.6
  • 13
    • 0031977811 scopus 로고    scopus 로고
    • Interleukin-6 spillover in the peripheral circulation increases with the severity of heart failure, and the high plasma level of interleukin-6 is an important prognostic predictor in patients with congestive heart failure
    • 13 Tsutamoto T, Hisanaga T, Wada A, Maeda K, Ohnishi M, Fukai D, et al.: Interleukin-6 spillover in the peripheral circulation increases with the severity of heart failure, and the high plasma level of interleukin-6 is an important prognostic predictor in patients with congestive heart failure. J Am Coll Cardiol 1998, 31:391-398.
    • (1998) J Am Coll Cardiol , vol.31 , pp. 391-398
    • Tsutamoto, T.1    Hisanaga, T.2    Wada, A.3    Maeda, K.4    Ohnishi, M.5    Fukai, D.6
  • 14
    • 0030977889 scopus 로고    scopus 로고
    • Elevated soluble CD14 receptors and altered cytokines in chronic heart failure
    • 14 Anker SD, Egerer KR, Volk HD, Kox WJ, Poole-Wilson PA, Coats AJS: Elevated soluble CD14 receptors and altered cytokines in chronic heart failure. Am J Cardiol 1997, 79:1426-1429. This interesting study showed that patients with advanced heart failure had increased circulating levels of CD14 (a marker of immune activation and possible exposure to circulating endotoxin) in their peripheral circulation. These results led the authors to suggest that the explanation for the increase in TNF-α levels in patients with chronic heart failure mesenteric venous congestion might be increased bowel permeability, bacterial translocation, and thereby endotoxin release.
    • (1997) Am J Cardiol , vol.79 , pp. 1426-1429
    • Anker, S.D.1    Egerer, K.R.2    Volk, H.D.3    Kox, W.J.4    Poole-Wilson, P.A.5    Coats, A.J.S.6
  • 15
    • 0029880580 scopus 로고    scopus 로고
    • -308 Tumor necrosis factor (TNF) polymorphism is not associated with survival in severe sepsis and is unrelated to lipopolysaccharide inducibility of the human TNF promoter
    • 15 Stuber F, Udalova IA, Book M, Drutskaya LN, Kuprash DV, Turetskaya RL, et al.: -308 tumor necrosis factor (TNF) polymorphism is not associated with survival in severe sepsis and is unrelated to lipopolysaccharide inducibility of the human TNF promoter. J Inflamm 1996, 46:42-50.
    • (1996) J Inflamm , vol.46 , pp. 42-50
    • Stuber, F.1    Udalova, I.A.2    Book, M.3    Drutskaya, L.N.4    Kuprash, D.V.5    Turetskaya, R.L.6
  • 16
    • 0032581020 scopus 로고    scopus 로고
    • Effects of tumor necrosis factor gene polymorphisms on patients with congestive heart failure
    • 16 Kubota T, McNamara DM, Wang JJ, Trost M, McTiernan CF, Mann DL, Feldman AM: Effects of tumor necrosis factor gene polymorphisms on patients with congestive heart failure. Circulation 1998, 97:2499-2501. This study was the first to examine TNF polymorphisme in patients with advanced heart failure. In this study, no significant differences were found in the frequency of the TNF polymorphisms that have been associated with increased TNF production in patients with advanced heart failure and control subjects.
    • (1998) Circulation , vol.97 , pp. 2499-2501
    • Kubota, T.1    McNamara, D.M.2    Wang, J.J.3    Trost, M.4    McTiernan, C.F.5    Mann, D.L.6    Feldman, A.M.7
  • 17
    • 0027231850 scopus 로고
    • Inhibition of endogenous TNF formation by pentoxifylline
    • 17 Zabel P, Schade FU, Schlaak M: Inhibition of Endogenous TNF Formation by Pentoxifylline. Immunobiology 1993, 187:447-463.
    • (1993) Immunobiology , vol.187 , pp. 447-463
    • Zabel, P.1    Schade, F.U.2    Schlaak, M.3
  • 19
    • 0031906155 scopus 로고    scopus 로고
    • Adenosine inhibitis lipopolysaccharide-induced cardiac expression of tumor necrosis factor-α
    • 19 Wagner DR, Combes A, McTiernan CF, Sanders VJ, Lemster B, Feldman AM: Adenosine inhibitis lipopolysaccharide-induced cardiac expression of tumor necrosis factor-α. Circ Res 1998, 82:47-56.
    • (1998) Circ Res , vol.82 , pp. 47-56
    • Wagner, D.R.1    Combes, A.2    McTiernan, C.F.3    Sanders, V.J.4    Lemster, B.5    Feldman, A.M.6
  • 20
    • 0026080801 scopus 로고
    • Thalidomide selectively inhibits tumor necrosis factor a production by stimulated human monocytes
    • 20 Sampaio EP, Sarno EN, Galilly R, Cohn ZA, Kaplan G: Thalidomide selectively inhibits tumor necrosis factor a production by stimulated human monocytes. J Exp Med 1991, 173:699-703.
    • (1991) J Exp Med , vol.173 , pp. 699-703
    • Sampaio, E.P.1    Sarno, E.N.2    Galilly, R.3    Cohn, Z.A.4    Kaplan, G.5
  • 21
    • 0027230553 scopus 로고
    • Thalidomide exerts its inhibitory action on tumor necrosis factor-alpha by enhancing messenger RNA degradation
    • 21 Moreira AL, Sampaio EP, Zmuidzinas A, Frindt P, Smith KA, Kaplan G: Thalidomide exerts its inhibitory action on tumor necrosis factor-alpha by enhancing messenger RNA degradation. J Exp Med 1993, 177:1675-1680.
    • (1993) J Exp Med , vol.177 , pp. 1675-1680
    • Moreira, A.L.1    Sampaio, E.P.2    Zmuidzinas, A.3    Frindt, P.4    Smith, K.A.5    Kaplan, G.6
  • 22
    • 0024345562 scopus 로고
    • In vivo dynamics of murine tumor necrosis factor-α gene expression: Kinetics of dexamethasone-induced suppression
    • 22 Remick DG, Strieter RM, Lynch UP, Nguyen D, Eskandari M, Kunkel SL: In vivo dynamics of murine tumor necrosis factor-α gene expression: kinetics of dexamethasone-induced suppression. Lab Invest 1989, 60:766-771.
    • (1989) Lab Invest , vol.60 , pp. 766-771
    • Remick, D.G.1    Strieter, R.M.2    Lynch, U.P.3    Nguyen, D.4    Eskandari, M.5    Kunkel, S.L.6
  • 23
    • 0001708370 scopus 로고
    • Reversal of low flow state attenuates immune activation in severe decompensated congestive heart failure
    • 23 Sindhwani R, Yuen J. Hirsch H, Tegguy A, Galvao M, Levato P, LeJemtel TH: Reversal of low flow state attenuates immune activation in severe decompensated congestive heart failure [abstract]. Circulation 1993, 88:1-255.
    • (1993) Circulation , vol.88 , pp. 1-255
    • Sindhwani, R.1    Yuen, J.2    Hirsch, H.3    Tegguy, A.4    Galvao, M.5    Levato, P.6    LeJemtel, T.H.7
  • 24
    • 0020055439 scopus 로고
    • Drug-induced conditioning in congestive heart failure
    • 24 Leier CV, Huss P, Lewis RP, Unverferth DV: Drug-induced conditioning in congestive heart failure. Circulation 1982, 65:1382-1387.
    • (1982) Circulation , vol.65 , pp. 1382-1387
    • Leier, C.V.1    Huss, P.2    Lewis, R.P.3    Unverferth, D.V.4
  • 25
    • 0029958555 scopus 로고    scopus 로고
    • The clinical relevance of circulating tumor necrosis factor-α in acute decompensated chronic heart failure without cachexia
    • 25 Milani RV, Mehra MR, Endres S, Eigler A, Cooper S, Lavie CJ Jr, Ventura HO: The clinical relevance of circulating tumor necrosis factor-α in acute decompensated chronic heart failure without cachexia. Chest 1996, 110:992-997.
    • (1996) Chest , vol.110 , pp. 992-997
    • Milani, R.V.1    Mehra, M.R.2    Endres, S.3    Eigler, A.4    Cooper, S.5    Lavie C.J., Jr.6    Ventura, H.O.7
  • 26
    • 0031913938 scopus 로고    scopus 로고
    • Adenosine inhibits lipopolysaccharide-induced secretion of tumor necrosis factor-α in the failing human heart
    • 2G Wagner DR, McTiernan CF, Sanders VJ, Feldman AM: Adenosine inhibits lipopolysaccharide-induced secretion of tumor necrosis factor-α in the failing human heart. Circulation 1998, 97:521-524. This study showed that pretreating myocardial slices of failing human myocardium (ex vivo) with adenosine was sufficient to prevent the endotoxin stimulated release of TNF-α from the failing myocardium. These studies raise the interesting possibility that adenosine might be used in the setting of heart failure to suppress TNF-α production in patients with human heart failure.
    • (1998) Circulation , vol.97 , pp. 521-524
    • Wagner, D.R.1    McTiernan, C.F.2    Sanders, V.J.3    Feldman, A.M.4
  • 27
    • 0030816872 scopus 로고    scopus 로고
    • Adenosine decreases post-ischemic cardiac TNF-α production: Anti-inflammatory implications for preconditioning and transplantation
    • 27 Meldrum DR, Cain BS, Cleveland JC Jr, Meng X, Ayala A, Banerjee A, Harken AH: Adenosine decreases post-ischemic cardiac TNF-α production: anti-inflammatory implications for preconditioning and transplantation. Immunology 1997, 92:472-477.
    • (1997) Immunology , vol.92 , pp. 472-477
    • Meldrum, D.R.1    Cain, B.S.2    Cleveland J.C., Jr.3    Meng, X.4    Ayala, A.5    Banerjee, A.6    Harken, A.H.7
  • 28
    • 0032507428 scopus 로고    scopus 로고
    • Randomized investigation of effects of pentoxifylline on left ventricular performance in idiopathic dilated
    • 28 Sliwa K, Skudicky D, Candy G, Wisenbaugh T, Sareli P: Randomized investigation of effects of pentoxifylline on left ventricular performance in idiopathic dilated. Lancet 1998, 351:1091-1093. This important study showed that treating heart failure patients with pentoxifylline for 6 months led to an improvement in ejection fraction and survival and a decrease in peripheral TNF-α levels compared with patients treated with conventional therapy alone. Although this study did not prove that lowering TNF-α levels had a salutary effect on clinical outcome, it is the first to link decrease cytokine levels with an improved clinical outcome.
    • (1998) Lancet , vol.351 , pp. 1091-1093
    • Sliwa, K.1    Skudicky, D.2    Candy, G.3    Wisenbaugh, T.4    Sareli, P.5
  • 29
    • 0000251958 scopus 로고    scopus 로고
    • A phase I trial of tumor necrosis factor receptor (p75) fusion protein (TNFR:Fc) in patients with advanced heart failure
    • 29 Deswal A, Seta Y, Blosch CM, Mann DL: A phase I trial of tumor necrosis factor receptor (p75) fusion protein (TNFR:Fc) in patients with advanced heart failure [abstract]. Circulation 1997, 96:1-1802.
    • (1997) Circulation , vol.96 , pp. 1-1802
    • Deswal, A.1    Seta, Y.2    Blosch, C.M.3    Mann, D.L.4
  • 31
    • 0024437786 scopus 로고
    • Tumor necrosis factor in bronchopulmonary secretions of patients with adult respiratory distress syndrome
    • 31 Millar AB, Singer M, Meager A, Foley NM, Johnson NM, Rook GA: Tumor necrosis factor in bronchopulmonary secretions of patients with adult respiratory distress syndrome. Lancet 1989, 2:712-713.
    • (1989) Lancet , vol.2 , pp. 712-713
    • Millar, A.B.1    Singer, M.2    Meager, A.3    Foley, N.M.4    Johnson, N.M.5    Rook, G.A.6
  • 34
    • 0026779727 scopus 로고
    • Left ventricular systolic and diastolic dysfunction after infusion of tumor necrosis factor-α in conscious dogs
    • 34 Pagani FD, Baker LS, Hsi C, Knox M, Fink MP, Visner MS: Left ventricular systolic and diastolic dysfunction after infusion of tumor necrosis factor-α in conscious dogs. J Clin Invest 1992, 90:389-398.
    • (1992) J Clin Invest , vol.90 , pp. 389-398
    • Pagani, F.D.1    Baker, L.S.2    Hsi, C.3    Knox, M.4    Fink, M.P.5    Visner, M.S.6
  • 35
    • 0024520830 scopus 로고
    • Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock
    • 35 Natanson C, Eichenholz PW, Danner RL, Eichacker W, Hoffman D, Kuo SM, et al.: Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock. J Exp Med 1989, 169:823-832.
    • (1989) J Exp Med , vol.169 , pp. 823-832
    • Natanson, C.1    Eichenholz, P.W.2    Danner, R.L.3    Eichacker, W.4    Hoffman, D.5    Kuo, S.M.6
  • 36
    • 0023202754 scopus 로고
    • Multiple effects of tumor necrosis factor on lipoprotein lipase in vivo
    • 36 Semb H, Peterson J, Tavernier J, Olivecrona T: Multiple effects of tumor necrosis factor on lipoprotein lipase in vivo. J Biol Chem 1987, 262:8390-8394.
    • (1987) J Biol Chem , vol.262 , pp. 8390-8394
    • Semb, H.1    Peterson, J.2    Tavernier, J.3    Olivecrona, T.4
  • 38
    • 0027324558 scopus 로고
    • Through thick and thin: Wasting, obesity, and TNF-α
    • 38 Spiegelman BM, Hotamisligil GS: Through thick and thin: wasting, obesity, and TNF-α. Cell 1993, 73:625-627.
    • (1993) Cell , vol.73 , pp. 625-627
    • Spiegelman, B.M.1    Hotamisligil, G.S.2
  • 39
    • 0023801419 scopus 로고
    • Recombinant human tumor necrosis factor induces reductions in food intake and body weight in mice
    • 39 Socher SH, Friedman A, Martinez D: Recombinant human tumor necrosis factor induces reductions in food intake and body weight in mice. J Exp Med 1988, 167:1957-1962.
    • (1988) J Exp Med , vol.167 , pp. 1957-1962
    • Socher, S.H.1    Friedman, A.2    Martinez, D.3
  • 40
    • 0025148071 scopus 로고
    • Mechanism of action of cytokine inhibition of B-adrenergic agonist stimulation of cyclic AMP in rat cardiac myocytes: Impairment of signal transduction
    • 40 Chung MK, Gulick TS, Rotondo RE, Schreiner GF, Lange LG: Mechanism of action of cytokine inhibition of B-adrenergic agonist stimulation of cyclic AMP in rat cardiac myocytes: impairment of signal transduction. Circ Res 1990, 67:753-763.
    • (1990) Circ Res , vol.67 , pp. 753-763
    • Chung, M.K.1    Gulick, T.S.2    Rotondo, R.E.3    Schreiner, G.F.4    Lange, L.G.5
  • 41
    • 0024542475 scopus 로고
    • Inhibition of target cell mitochondrial electron transfer by tumor necrosis factor
    • 41 Lancaster JR Jr, Laster SM, Gooding LR: Inhibition of target cell mitochondrial electron transfer by tumor necrosis factor. FEBS Lett 1989, 248:169-174.
    • (1989) FEBS Lett , vol.248 , pp. 169-174
    • Lancaster J.R., Jr.1    Laster, S.M.2    Gooding, L.R.3
  • 43
    • 0028982834 scopus 로고
    • Interleukin-1b modulates the growth and phenotype of neonatal rat cardiac myocytes
    • 43 Thaik CM, Calderone A, Takahashi N, Colucci WS: Interleukin-1b modulates the growth and phenotype of neonatal rat cardiac myocytes. J Clin Invest 1995, 96:1093-1099.
    • (1995) J Clin Invest , vol.96 , pp. 1093-1099
    • Thaik, C.M.1    Calderone, A.2    Takahashi, N.3    Colucci, W.S.4


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