Development of genetically engineered human intestinal cells for regulated insulin secretion using rAAV-mediated gene transfer

Biochemical and Biophysical Research Communications

Volumn 303, Issue 2, 2003, Pages 645-652

  Tang, Shiue Cheng ^a   Sambanis, Athanassios ^a  

^a Georgia Institute of Technology   (United States)

Author keywords

Diabetes; Enteroendocrine; Fusion protein; GLP 1; Insulin; Pancreatic substitute; rAAV

Indexed keywords

GLUCAGON LIKE PEPTIDE 1; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; PARVOVIRUS VECTOR; PROTEIN HYDROLYSATE; RECOMBINANT HUMAN INSULIN; RECOMBINANT PROTEIN;

ARTICLE; CELL BASED GENE THERAPY; CELL LINE; CELL SECRETION; CONTROLLED STUDY; ENDOCRINE FUNCTION; GENE TRANSFER; GENETIC ENGINEERING; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; INTESTINE CELL; MEDICAL ASSESSMENT; PRIORITY JOURNAL; SOMATIC CELL GENETICS;

ADENO-ASSOCIATED VIRUS;

EID: 0037418771     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)00399-1     Document Type: Article

References (33)

1. Thule P.M., Liu J., Phillips L.S. Glucose regulated production of human insulin in rat hepatocytes. Gene Ther. 7:2000;205-214.
2. Thule P.M., Liu J.M. Regulated hepatic insulin gene therapy of STZ-diabetic rats. Gene Ther. 7:2000;1744-1752.
3. Lee H.C., Kim S.J., Kim K.S., Shin H.C., Yoon J.W. Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue. Nature. 408:2000;483-488.
4. Barry S.C., Ramesh N., Lejnieks D., Simonson W.T., Kemper L., Lernmark A., Osborne W.R. Glucose-regulated insulin expression in diabetic rats. Hum. Gene Ther. 12:2001;131-139.
5. Chen R., Meseck M.L., Woo S.L. Auto-regulated hepatic insulin gene expression in type 1 diabetic rats. Mol. Ther. 3:2001;584-590.
6. Ramshur E.B., Rull T.R., Wice B.M. Novel insulin/GIP co-producing cell lines provide unexpected insights into Gut K-cell function in vivo. J. Cell. Physiol. 192:2002;339-350.
7. McLenithan J.C., Tanner K., Pray J., Roth J., Shuldiner A.R. Human insulin expression in rat intestinal STC-1 cells. Diabetes. 49:2000;A338.
8. Cheung A.T., Dayanandan B., Lewis J.T., Korbutt G.S., Rajotte R.V., Bryer-Ash M., Boylan M.O., Wolfe M.M., Kieffer T.J. Glucose-dependent insulin release from genetically engineered K cells. Science. 290:2000;1959-1962.
9. Corbett J.A. K cells: a novel target for insulin gene therapy for the prevention of diabetes. Trends Endocrinol. Metab. 12:2001;140-142.
10. Holst J.J., Orskov C. Incretin hormones - an update. Scand. J. Clin. Lab. Invest. Suppl. 234:2001;75-85.
11. R. Moss, A multicenter, double-blind, placebo controlled, phase II study of aerosolized tgAAVCF in cystic fibrosis patients with mild lung disease, in: 16th Annual North American Cystic Fibrosis Conference in New Orleans, LA, October 3-6, 2002.
12. Park J.G., Oie H.K., Sugarbaker P.H., Henslee J.G., Chen T.R., Johnson B.E., Gazdar A. Characteristics of cell lines established from human colorectal carcinoma. Cancer Res. 47:1987;6710-6718.
13. Reimer R.A., Darimont C., Gremlich S., Nicolas-Metral V., Ruegg U.T., Mace K. A human cellular model for studying the regulation of glucagon-like peptide-1 secretion. Endocrinology. 142:2001;4522-4528.
14. de Bruine A.P., Dinjens W.N., Pijls M.M., vd Linden E.P., Rousch M.J., Moerkerk P.T., de Goeij A.F., Bosman F.T. NCI-H716 cells as a model for endocrine differentiation in colorectal cancer. Virchows Arch. B Cell Pathol. Incl. Mol. Pathol. 62:1992;311-320.
15. de Bruine A.P., Dinjens W.N., van der Linden E.P., Pijls M.M., Moerkerk P.T., Bosman F.T. Extracellular matrix components induce endocrine differentiation in vitro in NCI-H716 cells. Am. J. Pathol. 142:1993;773-782.
16. Groskreutz D.J., Sliwkowski M.X., Gorman C.M. Genetically engineered proinsulin constitutively processed and secreted as mature, active insulin. J. Biol. Chem. 269:1994;6241-6245.
17. Auricchio A., Hildinger M., O'Connor E., Gao G.P., Wilson J.M. Isolation of highly infectious and pure adeno-associated virus type 2 vectors with a single-step gravity-flow column. Hum. Gene Ther. 12:2001;71-76.
18. Mukundan N.E., Flanders P.C., Constantinidis I., Papas K.K., Sambanis A. Oxygen consumption rates of free and alginate-entrapped β TC3 mouse insulinoma cells. Biochem. Biophys. Res. Commun. 210:1995;113-118.
19. Sambanis A., Stephanopoulos G., Sinskey A.J., Lodish H.F. Use of regulated secretion in protein production from animal cells: an evaluation with the AtT-20 model cell line. Biotechnol. Bioeng. 35:1990;771-780.
20. Herrmann C., Goke R., Richter G., Fehmann H.C., Arnold R., Goke B. Glucagon-like peptide-1 and glucose-dependent insulin-releasing polypeptide plasma levels in response to nutrients. Digestion. 56:1995;117-126.
21. Elliott R.M., Morgan L.M., Tredger J.A., Deacon S., Wright J., Marks V. Glucagon-like peptide-1 (7-36)amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: acute post-prandial and 24-h secretion patterns. J. Endocrinol. 138:1993;159-166.
22. Eissele R., Goke R., Willemer S., Harthus H.P., Vermeer H., Arnold R., Goke B. Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pig, and man. Eur. J. Clin. Invest. 22:1992;283-291.
23. Schirra J., Katschinski M., Weidmann C., Schafer T., Wank U., Arnold R., Goke B. Gastric emptying and release of incretin hormones after glucose ingestion in humans. J. Clin. Invest. 97:1996;92-103.
24. Croyle M.A., Stone M., Amidon G.L., Roessler B.J. In vitro and in vivo assessment of adenovirus 41 as a vector for gene delivery to the intestine. Gene Ther. 5:1998;645-654.
25. Lau C., Soriano H.E., Ledley F.D., Finegold M.J., Wolfe J.H., Birkenmeier E.H., Henning S.J. Retroviral gene transfer into the intestinal epithelium. Hum. Gene Ther. 6:1995;1145-1151.
26. During M.J., Xu R., Young D., Kaplitt M.G., Sherwin R.S., Leone P. Peroral gene therapy of lactose intolerance using an adeno-associated virus vector. Nat. Med. 4:1998;1131-1135.
27. Nian M., Gu J., Irwin D.M., Drucker D.J. Human glucagon gene promoter sequences regulating tissue-specific versus nutrient-regulated gene expression. Am. J. Physiol. Regul. Integr. Comp. Physiol. 282:2002;R173-R183.
28. Tang S.-C., Sambanis A. Preproinsulin mRNA engineering and its application to the regulation of insulin secretion from human hepatomas. FEBS Lett. 537:2003;193-197.
29. Lipes M.A., Cooper E.M., Skelly R., Rhodes C.J., Boschetti E., Weir G.C., Davalli A.M. Insulin-secreting non-islet cells are resistant to autoimmune destruction. Proc. Natl. Acad. Sci. USA. 93:1996;8595-8600.
30. Motoyoshi S., Shirotani T., Araki E., Sakai K., Kaneko K., Motoshima H., Yoshizato K., Shirakami A., Kishikawa H., Shichiri M. Cellular characterization of pituitary adenoma cell line (AtT20 cell) transfected with insulin, glucose transporter type 2 (GLUT2), and glucokinase genes: insulin secretion in response to physiological concentrations of glucose. Diabetologia. 41:1998;1492-1501.
31. Meoni C., Bertuzzi F., Pontiroli A.E., Falqui L., Monaco L., Soria M., Arcelloni C., Paroni R., Foglieni C., Polastri L., Galbiati F., Folli F., Davalli A.M. Development and characterization of pituitary GH3 cell clones stably transfected with a human proinsulin cDNA. Cell Transplant. 9:2000;829-840.
32. Davalli A.M., Galbiati F., Bertuzzi F., Polastri L., Pontiroli A.E., Perego L., Freschi M., Pozza G., Folli F., Meoni C. Insulin-secreting pituitary GH3 cells: a potential β-cell surrogate for diabetes cell therapy. Cell Transplant. 9:2000;841-851.
33. Faradji R.N., Havari E., Chen Q., Gray J., Tornheim K., Corkey B.E., Mulligan R.C., Lipes M.A. Glucose-induced toxicity in insulin-producing pituitary cells that coexpress GLUT2 and glucokinase. Implications for metabolic engineering. J. Biol. Chem. 276:2001;36695-36702.