Minor groove orientation for the (1S,2R,3S,4R)-N2[1-(1,2,3,4-tetrahydro-2,3, 4-trihydroxybenz[a]anthracenyl)]-2′-deoxyguanosyl adduct in the N-ras codon 12 sequence

Biochemistry

Volumn 42, Issue 8, 2003, Pages 2328-2338

  Kim, Hye Young H ^a   Wilkinson, Amanda S ^a   Harris, Constance M ^a   Harris, Thomas M ^a   Stone, Michael P ^a  

^a VANDERBILT INGRAM CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MOLECULAR TOPOLOGY;

CONFORMATIONS; CRYSTAL ORIENTATION; INTERCALATION COMPOUNDS; MOLECULAR DYNAMICS; STEREOCHEMISTRY;

ORGANIC COMPOUNDS;

1,2 EPOXY 1,2,3,4 TETRAHYDROBENZ[A]ANTHRACENYL 3,4 DIOL; BENZ[A]ANTHRACENE DERIVATIVE; BENZO[C]PHENANTHRENE; BENZYL DERIVATIVE; CARBON; DEOXYGUANOSINE DERIVATIVE; DEOXYRIBOSE; DOUBLE STRANDED DNA; N2 [1 (1,2,3,4 TETRAHYDRO 2,3,4 TRIHYDROXYBENZ[A]ANTHRACENYL)] 2' DEOXYGUANOSYL DERIVATIVE; PHENANTHRENE DERIVATIVE; PROTON; UNCLASSIFIED DRUG;

ARTICLE; CALCULATION; CHEMICAL BOND; CHEMICAL STRUCTURE; CODON; CONFORMATIONAL TRANSITION; GENE SEQUENCE; MOLECULAR DYNAMICS; ONCOGENE N RAS; PRIORITY JOURNAL; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

BENZ(A)ANTHRACENES; CODON; DEOXYGUANOSINE; DNA ADDUCTS; GENES, RAS; HUMANS; INTERCALATING AGENTS; MUTAGENS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; NUCLEIC ACID CONFORMATION; OLIGODEOXYRIBONUCLEOTIDES; POLYDEOXYRIBONUCLEOTIDES; PROTONS; STEREOISOMERISM; THERMODYNAMICS;

EID: 0037418565     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi020462k     Document Type: Article

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