High-activity catalysts for Suzuki coupling and amination reactions with deactivated aryl chloride substrates: Importance of the palladium source

Organometallics

Volumn 22, Issue 5, 2003, Pages 987-999

  Bedford, Robin B ^a   Cazin, Catherine S J ^a   Coles, Simon J ^b   Gelbrich, Thomas ^b   Horton, Peter N ^b   Hursthouse, Michael B ^b   Light, Mark E ^b  

^a UNIVERSITY OF EXETER   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINATION; CATALYST ACTIVITY; CHEMICAL BONDS; CRYSTAL STRUCTURE; SUBSTRATES; SYNTHESIS (CHEMICAL); X RAY ANALYSIS;

COUPLING REACTIONS;

PALLADIUM COMPOUNDS;

EID: 0037416262     PISSN: 02767333     EISSN: None     Source Type: Journal    
DOI: 10.1021/om020841+     Document Type: Article

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50. + - Me], 148.7 (20%), 134.1 (100%), 107.1 (18), 92.1 (14%), 77.1 (35%), 64.1 (10%).
51. tBu (1.39 mmol), 4a (1.0 mol % Pd), toluene (3 mL), 110 °C, 17 h. Column chromatography (silica, hexane/ethyl acetate/methanol 90:10:2) gave impure 10a (<4 mg) and N-(4-methoxyphenyl)morpholine (0.099 g, 51%).
52. +], 174.0 (8%), 132.9 (19%), 117.9 (100%), 90.9 (90%), 65.0 (57%).
53. tBu (5.75 mmol), 4a (2.0 mol % Pd), toluene (3 mL), 110 °C, 17 h.
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