Shear stress activates Tie2 receptor tyrosine kinase in human endothelial cells

Biochemical and Biophysical Research Communications

Volumn 304, Issue 2, 2003, Pages 399-404

  Jong Lee, Hyuek ^a   Young Koh, Gou ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; TYROSINE KINASE WITH IMMUNOGLOBULIN AND EPIDERMAL GROWTH FACTOR HOMOLOGY DOMAIN 2; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL SURVIVAL; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SERUM; SHEAR STRESS; SIGNAL TRANSDUCTION; TIME; VELOCITY;

EID: 0037414450     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)00592-8     Document Type: Article

References (26)

1. Dumont D.J., Gradwohl G.J., Fong G.H., Auerbach R., Breitman M.L. The endothelial-specific receptor tyrosine kinase, tek, is a member of a new subfamily of receptors. Oncogene. 8:1993;1293-1301.
2. Mustonen T., Alitalo K. Endothelial receptor tyrosine kinases involved in angiogenesis. J. Cell Biol. 129:1995;895-898.
3. Iwama A., Hamaguchi I., Hashiyama M., Murayama Y., Yasunaga K., Suda T. Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells. Biochem. Biophys. Res. Commun. 195:1993;301-309.
4. Sato T.N., Tozawa Y., Deutsch U., Wolburg-Buchholz K., Fujiwara Y., Gendron-Maguire M., Gridley T., Wolburg H., Risau W., Qin Y. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature. 376:1995;70-74.
5. Davis S., Aldrich T.H., Jones P.F., Acheson A., Compton D.L., Jain V., Ryan T.E., Bruno J., Radziejewski C., Maisonpierre P.C., Yancopoulos G.D. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell. 87:1996;1161-1169.
6. Maisonpierre P.C., Suri C., Jones P.F., Bartunkova S., Wiegand S.J., Radziejewski C., Compton D., McClain J., Aldrich T.H., Papadopoulos N., Daly T.J., Davis S., Sato T.N., Yancopoulos G.D. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science. 277:1996;55-60.
7. Valenzuela D.M., Griffiths J.A., Rojas J., Aldrich T.H., Jones P.F., Zhou H., McClain J., Copeland N.G., Gilbert D.J., Jenkins N.A., Huang T., Papadopoulos N., Maisonpierre P.C., Davis S., Yancopoulos G.D. Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. Proc. Natl. Acad. Sci. USA. 96:1999;1904-1909.
8. Kim I., Kim J.H., Ryu Y.S., Jung S.H., Nah J.J., Koh G.Y. Characterization and expression of a novel alternatively spliced human angiopoietin-2. J. Biol. Chem. 275:2000;18550-18556.
9. ′ -kinase/Akt signal transduction pathway Oncogene. 19:2000;4549-4552.
10. Fisher A.B., Chien S., Barakat A.I., Nerem R.M. Endothelial cellular response to altered shear stress. Am. J. Physiol. Lung Cell Mol. Physiol. 281:2001;L529-L533.
11. Okajima M., Takamura M., Vequaud P., Parent R., Lavallee M. β-Adrenergic receptor blockade impairs NO-dependent dilation of large coronary arteries during exercise. Am. J. Physiol. Heart Circ. Physiol. 284:2003;H501-H510.
12. Laughlin M.H., McAllister R.M. Exercise training-induced coronary vascular adaptation. J. Appl. Physiol. 73:1992;2209-2225.
13. Chen K.D., Li Y.S., Kim M., Li S., Yuan S., Chien S., Shyy J.Y. Mechanotransduction in response to shear stress. Roles of receptor tyrosine kinases, integrins, and Shc. J. Biol. Chem. 25:1999;18393-18400.
14. Shay-Salit A., Shushy M., Wolfovitz E., Yahav H., Breviario F., Dejana E., Resnick N. VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells. Proc. Natl. Acad. Sci. USA. 99:2002;9462-9467.
15. ′ -kinase/Akt signal transduction pathway Circ. Res. 86:2000;24-29.
16. Noris M., Morigi M., Donadelli R., Aiello S., Foppolo M., Todeschini M., Orisio S., Remuzzi G., Remuzzi A. Nitric oxide synthesis by cultured endothelial cells is modulated by flow conditions. Circ. Res. 76:1995;536-543.
17. Kwak H.J., Lee S.J., Lee Y.H., Ryu C.H., Koh K.N., Choi H.Y., Koh G.Y. Angiopoietin-1 inhibits radiation-, and mannitol-induced apoptosis in endothelial cells. Circulation. 101:2000;2317-2324.
18. Wong A.L., Haroon Z.A., Werner S., Dewhirst M.W., Greenberg C.S., Peters K.G. Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues. Circ. Res. 81:1997;567-574.
19. Koh G.Y., Kim I., Kwak H.J., Yun M.J., Leem J.C. Biomedical significance of endothelial cell specific growth factor, angiopoietin. Exp. Mol. Med. 34:2001;1-11.
20. Jones N., Iljin K., Dumont D.J., Alitalo K. Tie receptors: new modulators of angiogenic and lymphangiogenic responses. Nat. Rev. Mol. Cell Biol. 2:2001;257-267.
21. Veikkola T., Alitalo K. VEGFs, receptors and angiogenesis. Semin. Cancer Biol. 9:1999;211-220.
22. Saltiel A.R., Kahn C.R. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 414:2001;799-806.
23. Dimmeler S., Assmus B., Hermann C., Haendeler J., Zeiher A.M. Fluid shear stress stimulates phosphorylation of Akt in human endothelial cells: involvement in suppression of apoptosis. Circ. Res. 83:1998;334-341.
24. Cines D.B., Pollak E.S., Buck C.A., Loscalzo J., Zimmerman G.A., McEver R.P., Pober J.S., Wick T.M., Konkle B.A., Schwartz B.S., Barnathan E.S., McCrae K.R., Hug B.A., Schmidt A.M., Stern D.M. Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood. 91:1998;3527-3561.
25. Stefanec T. Endothelial apoptosis: could it have a role in the pathogenesis and treatment of disease? Chest. 117:2000;841-854.
26. Davis S., Papadopoulos N., Aldrich T.H., Maisonpierre P.C., Huang T., Kovac L., Xu A., Leidich R., Radziejewska E., Rafique A., Goldberg J., Jain V., Bailey K., Karow M., Fandl J., Samuelsson S.J., Ioffe E., Rudge J.S., Daly T.J., Radziejewski C., Yancopoulos G.D. Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering. Nat. Struct. Biol. 10:2003;38-44.