Enhancer substances: Selegiline and R-(-)-1-(benzofuran-2-yl)-2-propylaminopentane [(-)-BPAP] enhance the neurotrophic factor synthesis on cultured mouse astrocytes

Life Sciences

Volumn 72, Issue 24, 2003, Pages 2785-2792

  Shimazu, Seiichiro ^a   Tanigawa, Akie ^a   Sato, Noriyuki ^a   Yoneda, Fumio ^a   Hayashi, Kyozo ^b   Knoll, Joseph ^c  

^a Fujimoto Pharmaceutical Corporation   (Japan)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^c SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Apomorphine; BDNF; Cultured mouse astrocytes; GDNF; NGF; Parkinson's disease; R ( ) 1 (Benzofuran 2 yl) 2 propylaminopentane ( ) BPAP ; Selegiline ( ) Deprenyl

Indexed keywords

1 (BENZOFURAN 2 YL) 2 PROPYLAMINOPENTANE; BENZOFURAN DERIVATIVE; BRAIN DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; NERVE GROWTH FACTOR; NEUROTROPHIC FACTOR; SELEGILINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; MOUSE; NONHUMAN; PROTEIN SYNTHESIS; STATISTICAL SIGNIFICANCE;

EID: 0037414392     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(03)00191-7     Document Type: Article

References (31)

1. Böttner M., Krieglstein K., Unsicker K. The transforming growth factor-βs: structure, signaling and roles in nervous system development and functions. Journal of Neurochemistry. 75(6):2000;2227-2240.
2. Connor B., Dragunow M. The role of neuronal growth factors in neurodegenerative disorders of the human brain. Brain Research Brain Research Review. 27(1):1998;1-39.
3. Feng L., Wang C.Y., Jiang H., Oho C., Mizuno K., Dugich-Djordjevic M., Lu B. Differential effects of GDNF and BDNF on cultured ventral mesencephalic neurons. Brain Research Molecular Brain Research. 66(1-2):1999;62-70.
4. Hamabe W., Fujita R., Yasusa T., Yoneda F., Yoshida A., Ueda H. (-)1-(Benzofuran-2-yl)-2-propylaminopentane shows survival effect on cortical neurons under serum-free condition through sigma receptors. Cellular and Molecular Neurobiology. 20(6):2000;695-702.
5. Hyman C., Hofer M., Barde Y.A., Juhasz M., Yancopoulos G.D., Squinto S.P., Lindsay R.M. BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature. 350(6315):1991;230-232.
6. Knoll J. Memories of my 45 years in research. Pharmacology & Toxicology. 75(2):1994;65-72.
7. Knoll J., Miklya I. Enhanced catecholaminergic and serotoninergic activity in rat brain from weaning to sexual maturity: rationale for prophylactic (-)deprenyl (selegiline) medication. Life Sciences. 56(8):1995;611-620.
8. Knoll J., Miklya I., Knoll B., Markó R., Kelemen K. (-)Deprenyl and (-)1-phenyl-2-propylaminopentane, [(-)PPAP], act primarily as potent stimulants of action potential-transmitter release coupling in the catecholaminergic neurons. Life Sciences. 58(10):1996;817-827.
9. Knoll J., Knoll B., Miklya I. High performing rats are more sensitive toward catecholaminergic activity enhancer (CAE) compounds than their low performing peers. Life Sciences. 58(11):1996;945-952.
10. Knoll J., Miklya I., Knoll B., Markó R., Rácz D. Phenylethylamine and tyramine are mixed-acting sympathomimetic amines in the brain. Life Sciences. 58(23):1996;2101-2114.
11. Knoll J. (-)Deprenyl (selegiline), a catecholaminergic activity enhancer (CAE) substance acting in the brain. Pharmacology & Toxicology. 82(2):1998;57-66.
12. Knoll J., Yoneda F., Knoll B., Ohde H., Miklya I. (-)1-(Benzofuran-2-yl)-2-propylaminopentane, [(-)BPAP), a selective enhancer of the impulse propagation mediated release of catecholamines and serotonin in the brain. British Journal of Pharmacology. 128(8):1999;1723-1732.
13. Knoll J. Antiaging compounds: (-)deprenyl (selegiline) and (-)1-(benzofuran-2-yl)-2-propylaminopentane, [(-)BPAP], a selective highly potent enhancer of the impulse propagation mediated release of catecholamines and serotonin in the brain. CNS Drug Reviews. 7(3):2001;317-345.
14. Knoll J., Miklya I., Knoll B., Yasusa T., Shimazu S., Yoneda F. 1-(Benzofuran-2-yl)-2-(3,3,3-trifluoropropyl)aminopentane HCl, 3-F-BPAP, antagonizes the enhancer effect of (-)-BPAP in the shuttle box and leaves the effect of (-)-deprenyl unchanged. Life Sciences. 71(17):2002;1975-1984.
15. Knoll J., Miklya I., Knoll B. Stimulation of the catecholaminergic and serotoninergic neurons in the rat brain by R-(-)-1-(benzofuran-2-yl)-2-propylaminopentane, (-)-BPAP. Life Sciences. 71(18):2002;2137-2144.
16. Lin L.-F., Doherty D.H., Lile J.D., Bektesh S., Collins F. GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science. 260(5111):1993;1130-1132.
17. Lindsay R.M., Wiegand S.J., Altar C.A., DiStefano P.S. Neurotrophic factors: from molecule to man. Trends in Neurosciences. 17(5):1994;182-190.
18. Mizuta I., Ohta M., Ohta K., Nishimura M., Mizuta E., Hayashi K., Kuno S. Selegiline and desmethylselegiline stimulate NGF, BDNF, and GDNF synthesis in cultured mouse astrocytes. Biochemical and Biophysical Research Communications. 279(3):2000;751-755.
19. Nagatsu T., Mogi M., Ichinose H., Togari A. Changes in cytokines and neurotrophins in Parkinson's disease. Journal of Neural Transmission Supplement. (60):2000;277-290.
20. Nishio T., Furukawa S., Akiguchi I., Sunohara N. Medial nigral dopamine neurons have rich neurotrophin support in humans. NeuroReport. 9(12):1998;2847-2851.
21. Ohta M., Mizuta I., Ohta K., Nishimura M., Mizuta E., Hayashi K., Kuno S. Apomorphine up-regulates NGF and GDNF synthesis in cultured mouse astrocytes. Biochemical and Biophysical Research Communications. 272(1):2000;18-22.
22. Ohta K., Ohta M., Mizuta I., Fujinami A., Shimazu S., Sato N., Yoneda F., Hayashi K., Kuno S. The novel catecholaminergic and serotoninergic activity enhancer R-(-)-1-(benzofuran-2-yl)-2- propylaminopentane up-regulates neurotrophic factor synthesis in mouse astrocytes. Neuroscience Letters. 328(3):2002;205-208.
23. Oka T., Yasusa T., Ando T., Watanabe M., Yoneda F., Ishida T., Knoll J. Enantioselective synthesis and absolute configuration of (-)-1-(benzofuran-2-yl)-2-propylaminopentane, ((-)-BPAP), a highly potent and selective catecholaminergic activity enhancer. Bioorganic and Medicinal Chemistry. 9(5):2001;1213-1219.
24. Parain K., Murer M.G., Yan Q., Faucheux B., Agid Y., Hirsch E., Raisman-Vozari R. Reduced expression of brain-derived neurotrophic factor protein in Parkinson's disease substantia nigra. NeuroReport. 10(3):1999;557-561.
25. Parkinson Study Group Effect of deprenyl on the progression of disability in early Parkinson's disease. New England Journal of Medicine. 321(20):1989;1364-1371.
26. Pencea V., Bingaman K.D., Wiegand S.J., Luskin M.B. Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus. Journal of Neuroscience. 21(17):2001;6706-6717.
27. Shimazu S., Takahata K., Katsuki H., Tsunekawa H., Tanigawa A., Yoneda F., Knoll J., Akaike A. (-)-1-(Benzofuran-2-yl)-2-propylaminopentane enhances locomotor activity in rats due to its ability to induce dopamine release. European Journal of Pharmacology. 421(3):2001;181-189.
28. Shimohama S., Tamura Y., Akaike A., Tsukahara T., Ohara O., Watanabe S., Kimura J. Brain-derived neurotrophic factor pretreatment exerts a partially protective effect against glutamate-induced neurotoxicity in cultured rat cortical neurons. Neuroscience Letters. 164(1-2):1993;55-58.
29. Tomac A.C., Grinberg A., Huang S.P., Nosrat C., Wang Y., Borlongan C., Lin S.Z., Chiang Y.H., Olson L., Westphal H., Hoffer B.J. Glial cell line-derived neurotrophic factor receptor alpha1 availability regulates glial cell line-derived neurotrophic factor signaling: evidence from mice carrying one or two mutated alleles. Neuroscience. 95(4):2000;1011-1023.
30. Walton K.M. GDNF: a novel factor with therapeutic potential for neurodegenerative disorders. Molecular Neurobiology. 19(1):1999;43-59.
31. Yoneda F., Moto T., Sakae M., Ohde H., Knoll B., Miklya I., Knoll J. Structure-activity studies leading to (-)1-(benzofuran-2-yl)-2-propylaminopentane, ((-)BPAP), a highly potent, selective enhancer of the impulse propagation mediated release of catecholamines and serotonin in the brain. Bioorganic & Medicinal Chemistry. 9(5):2001;1197-1212.