(-)1-(Benzofuran-2-yl)-2-propylaminopentane shows survival effect on cortical neurons under serum-free condition through sigma receptors

Cellular and Molecular Neurobiology

Volumn 20, Issue 6, 2000, Pages 695-702

  Hamabe, Wakako ^a   Fujita, Ryousuke ^a   Yasusa, Takuya ^b   Yoneda, Fumio ^b   Yoshida, Akira ^a   Ueda, Hiroshi ^a  

^a NAGASAKI UNIVERSITY   (Japan)

^b Fujimoto Pharmaceutical Corporation   (Japan)

Author keywords

(+) pentazocine; Apoptosis; Impulse enhancer; Neuroprotection; Sigma receptor

Indexed keywords

1 (BENZOFURAN 2 YL) 2 PROPYLAMINOPENTANE; BASIC FIBROBLAST GROWTH FACTOR; BENZOFURAN DERIVATIVE; BRAIN DERIVED NEUROTROPHIC FACTOR; PENTAZOCINE; SIGMA OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING COMPETITION; BRAIN CORTEX; BRAIN NERVE CELL; CELL SURVIVAL; CONTROLLED STUDY; CULTURE MEDIUM; DRUG RECEPTOR BINDING; FETUS; MEMBRANE BINDING; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SYNAPTIC MEMBRANE;

ANIMALS; BENZOFURANS; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; CULTURE MEDIA, SERUM-FREE; FETUS; KINETICS; NEURONS; PENTAZOCINE; RATS; RATS, WISTAR; RECEPTORS, SIGMA;

ANIMALIA;

EID: 0033711865     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007050808754     Document Type: Article

References (20)

1. σ Receptor-mediated neuroprotection against glutamate toxicity in primary rat neuronal cultures
2. Serum-free induced neuronal apoptosis-like cell death is independent of caspase activity
3. 1-binding site
4. Phrmacokinetic aspects of L-deprenyl (selegiline) and its metabolites
5. Assessing the effects of deprenyl on longevity and antioxidant defences in different animal models
6. (-)Deprenyl (selegiline), a catecholaminergic activity enhancer (CAE) substance acting in the brain
7. (-)Deprenyl and (-)1-phenyl-2-propylaminopentane [PPAP], act primarily as potent stimulants of action potential-transmitter release coupling in the catecholaminergic neurons
8. (-)1-(Benzofuran-2-yl)-2-propylaminopentane, [(-)BPAP], a selective enhancer of the impulse propagation mediated release of catecholamines and serotonin in the brain
9. Distinct neuroprotective profiles for σ ligands against N-methyl-D-aspartate (NMDA), and hypoxia-mediated neurotoxicity neuronal culture toxicity studies
10. Neuroprotective effects of SKF 10,047 in cultured rat cerebellar neurons and in gerbil grobal brain ischemia
11. 35S]GTPγS stimulated by (+)-pentazocine, sigma receptor agonist, is abundant in the guinea pig spleen
12. Characterization of two novel σ receptor ligands: Antidystonic effects in rats suggest σ receptor antagonism
13. Possible celebroprotective and in vivo NMDA antagonist activities of σ agents
14. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study
15. Low-density induced apoptosis of cortical neurons is inhibited by serum factors
16. Effect of SA4503, a novel σ1 receptor agonist, against glutamate neurotoxicity in cultured rat retinal neurons
17. σ Receptor ligands attenuate N-methyl-D-aspartate cytotoxicity in dopaminergic neurons of mesencephalic slice cultures
18. PPBP [4-phenyl-1-(4-phenylbutyl)piperidine] decreases brain injury after transient focal ischemia in rats
19. Selective coupling of mouse brain metabotropic sigma (σ) receptor with recombinant G(il)
20. Neuronal death inhibitor and its signal transduction