Tyr→Trp-substituted peptide 115-129 of a Lys49 phospholipase A2 expresses enhanced membrane-damaging activities and reproduces its in vivo myotoxic effect

Biochimica et Biophysica Acta - Biomembranes

Volumn 1461, Issue 1, 1999, Pages 19-26

  Lomonte, Bruno ^a   Pizarro Cerdá, Javier ^b   Angulo, Yamileth ^a   Gorvel, Jean Pierre ^b   Moreno, Edgardo ^c  

^a UNIVERSIDAD DE COSTA RICA   (Costa Rica)

^b CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

^c UNIVERSIDAD NACIONAL   (Costa Rica)

Author keywords

Bactericidal; Myotoxin; Phospholipase A2; Snake venom; Synthetic peptide

Indexed keywords

HEPARIN; PHOSPHOLIPASE A2; SNAKE VENOM; SYNTHETIC PEPTIDE; CREATINE KINASE; LYSINE; MYOTOXIN II, BOTHROPS ASPER; NEUROTOXIN; PEPTIDE FRAGMENT; PHOSPHOLIPASE A; TRYPTOPHAN; TYROSINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL MODEL; ANTIGEN BINDING; ARTICLE; BACTERICIDAL ACTIVITY; BINDING SITE; CONTROLLED STUDY; CYTOTOXICITY; EDEMA; ENDOTHELIUM CELL; ERYTHROCYTE; ESCHERICHIA COLI; IN VITRO STUDY; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS ADMINISTRATION; MEMBRANE DAMAGE; MOUSE; MUSCLE NECROSIS; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN BINDING; SUBCUTANEOUS DRUG ADMINISTRATION; AMINO ACID SEQUENCE; ANIMAL; BLOOD; CELL CULTURE; CHEMISTRY; DRUG EFFECT; ENDOTHELIUM; ENZYME IMMUNOASSAY; IMMUNOLOGY; ISOLATION AND PURIFICATION; MEMBRANE; PATHOLOGY; SKELETAL MUSCLE;

AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; CREATINE KINASE; CROTALID VENOMS; ENDOTHELIUM; ERYTHROCYTES; ESCHERICHIA COLI; IMMUNOENZYME TECHNIQUES; INJECTIONS, INTRAMUSCULAR; LYSINE; MEMBRANES; MICE; MUSCLE, SKELETAL; NEUROTOXINS; PEPTIDE FRAGMENTS; PHOSPHOLIPASES A; TRYPTOPHAN; TYROSINE;

EID: 0033370390     PISSN: 00052736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0005-2736(99)00143-1     Document Type: Article

References (41)

1. P. Rosenberg, in: W.T. Shier, D. Mebs (Eds.), Handbook of Toxicology, Marcel Dekker, New York, 1990, pp. 67-277.
2. Harris J.B., Cullen M.J. Electron Microsc. Rev. 3:1990;183-211.
3. Dennis E.A. J. Biol. Chem. 269:1994;13057-13060.
4. Alape-Girón A., Persson B., Cederlund E., Flores-Díaz M., Gutiérrez J.M., Thelestam M., Bergman T., Jörnvall H. Eur. J. Biochem. 259:1999;225-234.
5. 2 Enzymes: Structure, Function, and Mechanism, John Wiley and Sons, England, 1997, pp. 455-497.
6. 2 Enzymes: Structure, Function, and Mechanism, John Wiley and Sons, England, 1997, pp. 321-352.
7. Lomonte B., Tarkowski A., Hanson L.Å. Toxicon. 32:1994;1359-1369.
8. Lomonte B., Angulo Y., Rufini S., Cho W., Giglio J.R., Ohno M., Daniele J.J., Geoghegan P., Gutiérrez J.M. Toxicon. 37:1999;145-158.
9. Van den Bergh C.J., Slotboom A.J., Verheij H.M., De Haas G.H. J. Cell. Biochem. 39:1989;379-390.
10. Li Y., Yu B., Zhu H., Jain M., Tsai M. Biochemistry. 33:1994;14714-14722.
11. Homsi-Brandeburgo M.I., Queiroz L.S., Santo-Neto H., Rodrigues-Simioni L., Giglio J.R. Toxicon. 26:1988;615-627.
12. Lomonte B., Gutiérrez J.M. Toxicon. 27:1989;725-733.
13. Kihara H., Uchikawa R., Hattori S., Ohno M. Biochem. Int. 28:1992;895-903.
14. Pedersen J.Z., De Arcuri B.F., Morero R., Rufini S. Biochim. Biophys. Acta. 1190:1994;177-180.
15. Francis B., Gutiérrez J.M., Lomonte B., Kaiser I.I. Arch. Biochem. Biophys. 284:1991;352-359.
16. Arni R.K., Ward R.J., Gutiérrez J.M., Tulinsky A. Acta Cryst. D51:1995;311-317.
17. Calderón L., Lomonte B. Arch. Biochem. Biophys. 358:1998;343-350.
18. Renetseder R., Brunie S., Dijkstra B.W., Drenth J., Sigler P.B. J. Biol. Chem. 260:1985;11627-11634.
19. Lomonte B., Moreno E., Tarkowski A., Hanson L.Å., Maccarana M. J. Biol. Chem. 269:1994;29867-29873.
20. Páramo L., Lomonte B., Pizarro-Cerdá J., Bengoechea J.A., Gorvel J.P., Moreno E. Eur. J. Biochem. 253:1998;452-461.
21. Calderón L., Lomonte B. Toxicon. 37:1999;683-687.
22. Díaz C., Alape A., Lomonte B., Olamendi T., Gutiérrez J.M. Arch. Biochem. Biophys. 312:1994;336-339.
23. Kyte J., Doolittle R.F. J. Mol. Biol. 157:1982;105-132.
24. Valerio R.M., Bray A.M., Campbell R.A., DiPasquale A., Margellis C., Rodda S.J., Geysen H.M., Maeji N.J. Int. J. Pept. Protein Res. 42:1993;1-9.
25. Lomonte B., Tarkowski A., Bagge U., Hanson L.Å. Biochem. Pharmacol. 47:1994;1509-1518.
26. Moreira L., Borkow G., Ovadia M., Gutiérrez J.M. Toxicon. 32:1994;977-987.
27. Lomonte B., Tarkowski A., Hanson L.Å. Inflammation. 17:1993;93-105.
28. Selistre de Araujo H.S., White S.P., Ownby C.L. Arch. Biochem. Biophys. 326:1996;21-30.
29. Fujii S., Ikeda K., Hayashi K. J. Toxicol. Toxin Rev. 17:1998;279-313.
30. Rufini S., Cesaroni P., Desideri A., Farias R., Gubensek F., Gutiérrez J.M., Luly P., Massoud R., Morero R., Pedersen J.Z. Biochemistry. 31:1992;12424-12430.
31. Yau W.M., Wimley W.C., Gawrisch K., White S.H. Biochemistry. 37:1998;14713-14718.
32. Baker S.F., Othman R., Wilton D.C. Biochemistry. 37:1998;13203-13211.
33. Mollier P., Chwetzoff S., Bouet F., Harvey A.L., Menez A. Eur. J. Biochem. 185:1989;263-270.
34. Maraganore J.M., Heinrikson R.L. J. Biol. Chem. 261:1986;4797-4804.
35. Blondelle S.E., Houghten R.A. Pept. Res. 4:1991;12-18.
36. Blondelle S.E., Simpkins L.R., Perez-Paya E., Houghten R.A. Biochim. Biophys. Acta. 1202:1993;331-336.
37. Cirino G., Peers S.H., Wallace J.L., Flower R.J. Eur. J. Pharmacol. 166:1989;505-510.
38. Lloret S., Moreno J.J. Toxicon. 31:1993;949-956.
39. Liu C.S., Chen J.M., Chang C.H., Chen S.W., Teng C.M., Tsai I.H. Biochim. Biophys. Acta. 1077:1991;362-370.
40. Landucci E.C., Castro R.C., Pereira M.F., Cintra A.C., Giglio J.R., Marangoni S., Oliveira B., Cirino G., Antunes E., De Nucci G. Eur. J. Pharmacol. 343:1998;257-263.
41. Wang J.P., Teng C.M. Eur. J. Pharmacol. 190:1990;347-354.