Cardioplegia in pediatric cardiac surgery: Do we believe in magic?

Annals of Thoracic Surgery

Volumn 75, Issue 5, 2003, Pages 1668-1677

  Doenst, Torsten ^a   Schlensak, Christian ^a   Beyersdorf, Friedhelm ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AGE; AORTA CLAMPING; ASCENDING AORTA; CARDIOPLEGIA; CHEMICAL COMPOSITION; CHILD; HEART MUSCLE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART SURGERY; HUMAN; HYPOTHERMIA; INFANT; LOW TEMPERATURE PROCEDURES; PEDIATRIC SURGERY; PRIORITY JOURNAL; REVIEW; STANDARD; SURGICAL RISK; SURGICAL TECHNIQUE; CRYOANESTHESIA; HEART ARREST; METABOLISM; METHODOLOGY;

CARDIAC SURGICAL PROCEDURES; CHILD; HEART ARREST, INDUCED; HUMANS; HYPOTHERMIA, INDUCED; MYOCARDIUM;

EID: 0037407224     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-4975(02)04829-4     Document Type: Review

References (92)

1. Preusse CJ, Gebhard MM, Bretschneider HJ. Myocardial "equilibration processes" and myocardial energy turnover during initiation of artificial cardiac arrest with cardioplegic solution - reasons for a sufficiently long cardioplegic perfusion. Thorac Cardiovasc Surg 1981;29:71-6.
2. Bretschneider HJ. Myocardial protection. Thorac Cardiovasc Surg 1980;28:295-302.
3. Hearse D, Braimbridge M, Jynge P. Protection of the ischemic myocardium: cardioplegia. New York: Raven Press, 1981.
4. Spieckermann PG, Braun U, Hellberg K, et al. Survival and resuscitation time of the heart during ketamine, barbiturates and halothane anesthesia. Z Prakt Anasth 1970;5:365-72.
5. Reimer KA, Jennings RB, Tatum AH. Pathobiology of acute myocardial ischemia: metabolic, functional and ultrastructural studies. Am J Cardiol 1983;52:72A-81A.
6. Hosenpud JD, Bennett LE, Keck BM, et al. The Registry of the International Society for Heart and Lung Transplantation: eighteenth official report-2001. J Heart Lung Transplant 2001;20:805-15.
7. Buckberg G. Update on current techniques of myocardial protection. Ann Thorac Surg 1995;60:805-14.
8. Beyersdorf F, Kirsh M, Buckberg GD, et al. Warm glutamate/aspartate-enriched blood cardioplegic solution for perioperative sudden death. J Thorac Cardiovasc Surg 1992;104:1141-7.
9. Svedjeholm R, Hakanson E, Vanhanen I. Rationale for metabolic support with amino acids and glucose-insulin-potassium (GIK) in cardiac surgery. Ann Thor Surg 1995; 59(Suppl 2):S15-22.
10. Englander R, Cardarelli MG. Efficacy of leukocyte filters in the bypass circuit for infants undergoing cardiac operations. Ann Thorac Surg 1995;60:S533-5.
11. Bull C, Cooper J, Stark J. Cardioplegic protection of the child's heart. J Thorac Cardiovasc Surg 1984;88:287-93.
12. Allen BS, Barth MJ, Ilbawi MN. Pediatric myocardial protection: an overview. Sem Thorac Cardiovasc Surg 2001;13:56-72.
13. Young JN, Choy IO, Silva NK, et al. Antegrade cold blood cardioplegia is not demonstrably advantageous over cold crystalloid cardioplegia in surgery for congenital heart disease. J Thorac Cardiovasc Surg 1997;114:1002-8.
14. Yano Y, Braimbridge MV, Hearse DJ. Protection of the pediatric myocardium. Differential susceptibility to ischemic injury of the neonatal rat heart. J Thorac Cardiovasc Surg 1987;94:887-96.
15. Niazi SA, Lewis FJ. Effect of carbon dioxide on ventricular fibrillation and heart block during hypothermia in rats and dogs. S Forum 1955;5:106-9.
16. Van Arsdell GS, Maharaj GS, Tom J, et al. What is the optimal age for repair of tetralogy of Fallot? Circulation 2000;102:III123-9.
17. Drinkwater DC, Laks H. Pediatric cardioplegic techniques. Sem Thorac Cardiovasc Surg 1993;5:168-75.
18. Jonas RA. Myocardial protection for neonates and infants. Thorac Cardiovasc Surg 1998;46:288-91.
19. Parry AJ, McElhinney DB, Kung GC, et al. Elective primary repair of acyanotic tetralogy of Fallot in early infancy: overall outcome and impact on the pulmonary valve. J Am Coll Cardiol 2000;36:2279-83.
20. Demmy TL, Biddle JS, Bennet LE, et al. Organ preservation solutions in heart transplantation - patterns of usage and related survival. Ann Thorac Surg 1997;63:262-96.
21. Bigelow WG, Callaghan JC, Hopps JA. General hypothermia for experimental intracardiac surgery: the use of electrophrenic respirations, an artificial pacemaker for cardiac standstill and radiofrequency rewarming in general hypothermia. Ann Surg 1950;132:531-9.
22. Bigelow WG, Mustard WT, Evans JW. Some physiologic concepts of hypothermia and their applications to cardiac surgery. J Thorac Surg 1954;28:463-80.
23. Litasova EE, Lomivorotov VN. Hypothermic protection (26-25 degrees C) without perfusion cooling for surgery of congenital cardial defects using prolonged occlusion. Thorax 1988;43:201-11.
24. Bilfinger TV, Moeller JT, Kurusz M, et al. Pediatric myocardial protection in the United States: a survey of current clinical practice. Thorac Cardiovasc Surg 1992;40:214-8.
25. McGowan FXJ, Cao-Dahn H, Takeuchi K, et al. Prolonged neonatal myocardial preservation with a highly buffered low-calcium solution. J Thorac Cardiovasc Surg 1994;108:772-9.
26. Pearl JM, Hiramoto J, Laks H, et al. Fumarate-enriched blood cardioplegia results in complete functional recovery of immature myocardium. Ann Thorac Surg 1994;57:1636-41.
27. Julia P, Young HH, Buckberg GD, et al. Studies of myocardial protection in the immature heart. IV. Improved tolerance of immature myocardium to hypoxia and ischemia by intravenous metabolic support. J Thorac Cardiovasc Surg 1991;101:23-32.
28. Bove EL, Stammers AH. Recovery of left ventricular function after hypothermic global ischemia. Age-related differences in the isolated working rabbit heart. J Thorac Cardiovasc Surg 1986;91:115-22.
29. Karck M, Ziemer G, Haverich A. Myocardial protection in chronic volume-overload hypertrophy of immature rat hearts. Eur J Cardiothorac Surg 1996;10:690-8.
30. Boiling K, Kronon M, Allen BS, et al. Myocardial protection in normal and hypoxically stressed neonatal hearts: the superiority of blood versus crystalloid cardioplegia. J Thorac Cardiovasc Surg 1997;113:994-1003.
31. Pearl JM, Laks H, Drinkwater DC, et al. Normocalcemic blood or crystalloid cardioplegia provides better neonatal myocardial protection than does low-calcium cardioplegia. J Thorac Cardiovasc Surg 1993;105:761-4.
32. Baker EJ, Boerboom LE, Olinger GN, et al. Tolerance of the developing heart to ischemia: impact of hypoxemia from birth. Am J Physiol 1995;268:H1165-73.
33. Ganzel BL, Katzmark SL, Mavroudis C. Myocardial preservation in the neonate. Beneficial effects of cardioplegia and systemic hypothermia on piglets undergoing cardiopulmonary bypass and myocardial ischemia. J Thorac Cardiovasc Surg 1988;96:414-22.
34. Bartels C, Gerdes A, Babin-Ebell J, et al. Cardiopulmonary bypass: evidence or experience based? J Thorac Cardiovasc Surg 2002;124:20-7.
35. Taegtmeyer H, Goodwin GW, Doenst T, et al. Substrate metabolism as a determinant for postischemic functional recovery of the heart. Am J Cardiol 1997;80:3A-10A.
36. Goodwin GW, Ahmad F, Doenst T, et al. Energy provision from glycogen, glucose and fatty acids upon adrenergic stimulation of isolated working rat heart. Am J Physiol 1998;274:H1239-47.
37. Lopaschuk GD, Spafford MA, Marsh DR. Glycolysis is predominant source of ATP production immediately after birth. Am J Physiol 1991;261:H1698-705.
38. Makinde A-O, Gamble J, Lopaschuk GD. Upregulation of 5′-AMP-activated protein kinase is responsible for the increase in myocardial fatty acid oxidation rates following birth in the newborn rabbit. Circ Res 1997;80:482-9.
39. Clark CMJ. Characterization of glucose metabolism in the isolated rat heart during fetal and early neonatal development. Diabetes 1973;22:41-9.
40. Depre C, Shipley G, Chen W, et al. Unloaded heart in vivo replicates fetal gene expression of cardiac hypertrophy. Nat Med 1998;4:1269-75.
41. Johnson M, Everitt B. The high concentration of glycogen in fetal cardiac muscle probably explains why the heart can maintain its contractile activity in the face of severe hypoxia. In: Essential Reproduction, 3rd edit., Ed. Oxford: Blackwell Scientific Publ. 1988:275.
42. Liu B, Clanachan AS, Schulz R, et al. Cardiac efficiency is improved after ischemia by altering both the source and fate of protons. Circ Res 1996;79:940-8.
43. Depre C, Vanoverschelde JL, Melin JA, et al. Structural and metabolic correlates of the reversibility of chronic left ventricular ischemic dysfunction in humans. Am J Physiol 1995;268:H1265-75.
44. Lopaschuk GD, Warmbolt RB, Barr RL. An imbalance between glycolysis and glucose oxidation is a possible explanation for the detrimental effects of high levels of fatty acids during aerobic reperfusion of ischemic hearts. J Pharmacol Experim Therap 1993;264:135-44.
45. Mallet RT. Pyruvate: metabolic protector of cardiac performance. Proc Soc Exp Biol Med 2000;223:136-48.
46. + channels in isolated guinea pig cardiac myocytes. Science 1987;238:67-9.
47. 2+ transport. Circ Res 1995;77:88-97.
48. Sodi-Pallares D, Testelli MR, Fishleder BL, et al. Effects of intravenous infusion of a potassium-glucose-insulin solution on the electrocardiographic signs of myocardial infarction. Am J Cardiol 1962;9:166-81.
49. Fath-Ordoubadi F, Beatt KJ. Glucose-insulin-potassium therapy for treatment of acute myocardial infarction. An overview of randomized placebo-controlled trials. Circulation 1997;96:1152-6.
50. Lazar HL, Zhang X, Rivers S, et al. Limiting ischemic myocardial damage using glucose-insulin-potassium solutions. Ann Thorac Surg 1995;60:411-6.
51. Gradinac S, Coleman GM, Taegtmeyer H, et al. Improved cardiac function with glucose-insulin-potassium after coronary bypass surgery. Ann Thorac Surg 1989;48:484-9.
52. Johansson S, Personal communication, 2002.
53. Doenst T, Richwine TR, Bray MS, et al. Insulin improves functional and metabolic recovery of reperfused working rat heart. Ann Thorac Surg 1999;67:1682-8.
54. Doenst T, Beyersdorf F. Cardiac dysfunction and inefficiency after substrate-enriched warm blood cardioplegia editorial comment. Eur J Cardiothorac Surg 2001;20:562-4.
55. Boland R, Martonosi M, Tillack TW. Developmental changes in the composition and function of sarcoplasmic reticulum. J Biol Chem 1974;249:612-23.
56. Gombosova I, Boknik P, Kirchhefer U, et al. Postnatal changes in contractile time parameters, calcium regulatory proteins, and phosphatases. Am J Physiol 1998;274:H2123-32.
57. Klitzner TS. Maturational changes in excitation-contraction coupling in mammalian myocardium. J Am Coll Cardiol 1991;17:218-25.
58. Pieske B, Schlotthauer K, Schattmann J, et al. Ca(2+)-dependent and Ca(2+)-independent regulation of contractility in isolated human myocardium. Basic Res Cardiol 1997;92:75-86.
59. Bolling K, Kronen M, Allen BS, et al. Myocardial protection in normal and hypoxically stressed neonatal hearts: the superiority of hypocalcemic versus normocalcemic blood cardiopleiga. J Thorac Cardiovasc Surg 1996;112:1193-200.
60. Kronon MT, Allen BS, Hernan J, et al. Superiority of magnesium cardioplegia in neonatal myocardial protection. Ann Thorac Surg 1999;68:2285-91.
61. Kofsky ER, Julia P, Buckberg GD, et al. Studies of myocardial protection in the immature heart. V. Safety of prolonged aortic clamping with hypocalcemic glutamate/aspartate blood cardioplegia. J Thorac Cardiovasc Surg 1991;101:33-43.
62. Baker EJ, Olinger GN, Baker JE. Calcium content of St. Thomas' II cardioplegic solution damages ischemic immature myocardium. Ann Thorac Surg 1991;52:993-9.
63. Teoh KH, Mickle DAG, Weisel RD, et al. Effect of oxygen tension and cardiovascular operations on the myocardial antioxidant enzyme activities in patients with tetralogy of Fallot and aorta-coronary bypass. J Thorac Cardiovasc Surg 1992;104:159-64.
64. del Nido PJ, Mickle DA, Wilson GJ, et al. Inadequate myocardial protection with cold cardioplegic arrest during repair of tetralogy of Fallot. J Thorac Cardiovasc Surg 1988;95:223-9.
65. del Nido PJ, Mickle DA, Wilson GJ, et al. Evidence of myocardial free radical injury during elective repair of tetralogy of Fallot. Circulation 1987;76:V174-9.
66. Hayashi Y, Sawa Y, Nishimura M, et al. Clinical evaluation of leukocyte-depleted blood cardioplegia for pediatric open heart operation. Ann Thorac Surg 2000;69:1914-9.
67. Kawata H, Sawatari K, Mayer JE. Evidence for the role of neutrophils in reperfusion injury after cold cardioplegic ischemia in neonatal lambs. J Thorac Cardiovasc Surg 1992;103:908-18.
68. Rosenkranz ER, Okamoto F, Buckberg GD, et al. Biochemical studies: failure of tissue adenosine triphosphate levels to predict recovery of contractile function after controlled reperfusion. J Thorac Cardiovasc Surg 1986;92:488-501.
69. Taegtmeyer H, Roberts AFC, Rayne AEG. Energy metabolism in reperfused rat heart: return of function before normalization of ATP content. J Am Coll Cardio11985;6:864-70.
70. Path G, Robitaille PM, Merkle H, et al. Correlation between transmural high energy phosphate levels and myocardial blood flow in the presence of graded coronary stenosis. Circ Res 1990;67:660-73.
71. Hammon JWJ, Graham TPJ, Boucek RJJ, et al. Myocardial adenosine triphosphate content as a measure of metabolic and functional myocardial protection in children undergoing cardiac operation. Ann Thorac Surg 1987;44:467-70.
72. Kitakaze M, Weisfeldt M, Marban E. Acidosis during early reperfusion prevents myocardial stunning in perfused ferret hearts. J Clin Invest 1988;82:920-7.
73. Bolling SF, Olszanski DA, Bove EL, et al. Enhanced myocardial protection during global ischemia with 5′-nucleotidase inhibitors. J Thorac Cardiovasc Surg 1992;103:73-7.
74. Pridjian AK, Bove EL, Bolling SF, et al. Developmental differences in myocardial protection in response to 5′-nucleotidase inhibition. J Thorac Cardiovasc Surg 1994;107:520-6.
75. Artman M, Kithas PA, Wike JS, et al. Inotropic responses change during postnatal maturation in rabbits. Am J Physiol 1988;255:H335-42.
76. Awad WI, Shattock MJ, Chambers DJ. Ischemic preconditioning in immature myocardium. Circulation 1998;98:II206-13.
77. Doenst T, Taegtmeyer H. Ischemic preconditioning: from bench to bedside. In: Ischemia-Reperfusion in Cardiac Surgery. Beyersdorf F, Austin: Landes Pub, 2001:108-24.
78. Imura H, Caputo MAP, Parry A, et al. Age-dependent and hypoxia-related differences in myocardial protection during open heart surgery. Circulation 2001;103:1551-6.
79. Drinkwater DCJ, Cushen CK, Laks H, et al. The use of combined antegrade-retrograde infusion of blood cardioplegic solution in pediatric patients undergoing heart operations. J Thorac Cardiovasc Surg 1992;104:1349-55.
80. Oriaku G, Xiang B, Dai G, et al. Effects of retrograde cardioplegia on myocardial perfusion and energy metabolism in immature porcine myocardium. J Thorac Cardiovasc Surg 2000;119:1102-9.
81. Schlensak C, Doenst T, Beyersdorf F. Clinical experience with blood cardioplegia. Thorac Cardiovasc Surg 1998;46:282-5.
82. Corno AF, Bethencourt DM, Laks H, et al. Myocardial protection in the neonatal heart. A comparison of topical hypothermia and crystalloid and blood cardioplegic solutions. J Thorac Cardiovasc Surg 1987;93:163-72.
83. Bove EL, Stammers AH, Gallagher KP. Protection of the neonatal myocardium during hypothermic ischemia. Effect of cardioplegia on left ventricular function in the rabbit. J Thorac Cardiovasc Surg 1987;94:115-23.
84. Magovern JA, Pae WEJ, Waldhausen JA. Protection of the immature myocardium. An experimental evaluation of topical cooling, single-dose, and multi-dose administration of St. Thomas' Hospital cardioplegic solution. J Thorac Cardiovasc Surg 1988;96:408-13.
85. Lynch MJ, Bove EL, Zweng TN, et al. Protection of the neonatal heart following normothermic ischemia: a comparison of oxygenated saline and oxygenated versus nonoxygenated cardioplegia. Ann Thorac Surg 1988;45:650-5.
86. Avkiran M, Hearse DJ. Protection of the myocardium during global ischemia. Is crystalloid cardioplegia effective in the immature myocardium. J Thorac Cardiovasc Surg 1989;97:220-8.
87. Konishi T, Apstein CS. Comparison of three cardioplegic solutions during hypothermic ischemic arrest in neonatal blood-perfused rabbit hearts. J Thorac Cardiovasc Surg 1989;98:1132-7.
88. Baker JE, Boerboom LE, Olinger GN. Cardioplegia-induced damage to ischemic immature myocardium is independent of oxygen availability. Ann Thorac Surg 1990;50:934-9.
89. Diaco M, DiSesa VJ, Sun SC, et al. Cardioplegia for the immature myocardium. A comparative study in the neonatal rabbit. J Thorac Cardiovasc Surg 1990;100:910-3.
90. Fujiwara T, Heinle J, Britton L, et al. Myocardial preservation in neonatal lambs. Comparison of hypothermia with crystalloid and blood cardioplegia. J Thorac Cardiovasc Surg 1991;101:703-12.
91. Hosseinzadeh T, Tchervenkov CI, Quantz M, et al. Adverse effect of prearrest hypothermia in immature hearts: rate versus duration of cooling. Ann Thorac Surg 1992;53:464-71.
92. Baker JE, Boerboom LE, Olinger GN. Age and protection of the ischemic myocardium: is alkaline cardioplegia appropriate? Ann Thorac Surg 1993;55:747-55.