BRCA1 splice variants exhibit overlapping and distinct transcriptional transactivation activities

Journal of Cellular Biochemistry

Volumn 89, Issue 1, 2003, Pages 120-132

  McEachern, Kristen A ^a   Archey, William B ^a   Douville, Karen ^a   Arrick, Bradley A ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

Alternative splicing; BRCA1; Breast cancer; Gene expression

Indexed keywords

COMPLEMENTARY DNA; ESTROGEN RECEPTOR ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYMPHOTOXIN; PHOSPHOTRANSFERASE; PROTEIN BCL 2; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BREAST EPITHELIUM; CELL LINE; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; DNA BINDING; DNA MICROARRAY; DOWN REGULATION; EPITHELIUM CELL; EVALUATION; EXON; GENE CONSTRUCT; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; MUTANT; MUTATION; ONCOGENE; PRIORITY JOURNAL; PROMOTER REGION; SERUM RESPONSIVE ELEMENT; TRANSACTIVATION; WILD TYPE;

ALTERNATIVE SPLICING; BASE SEQUENCE; BREAST; CELL LINE; DNA, COMPLEMENTARY; FEMALE; GENE EXPRESSION; GENES, BRCA1; HUMANS; NF-KAPPA B; PROMOTER REGIONS (GENETICS); PROTEIN-SERINE-THREONINE KINASES; TRANS-ACTIVATION (GENETICS); TRANSFECTION;

EID: 0037405013     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.10487     Document Type: Article

References (58)

1. Aprelikova O, Pace AJ, Fang B, Koller BH, Liu ET. 2001. BRCA1 is a selective co-activator of 14-3-3σ gene transcription in mouse embryonic stem cells. J Biol Chem 276: 25647-25650.
2. Archey WB, McEachern KA, Robson M, Offit K, Vaziri SAJ, Casey G, Borg Å, Arrick BA. 2002. Increased CpG methylation of the estrogen receptor gene in BRCA1-linked estrogen receptor-negative breast cancers. Oncogene 21: 7034-7041.
3. Barchowsky A, Dudek EJ, Treadwell MD, Wetterhahn KE. 1996. Arsenic induced oxidant stress and NF-κB activation in cultured aortic endothelial cells. Free Radic Biol Med 21:783-790.
4. Berns EMJJ, Van Staveren IL, Verhoog L, Van de Ouweland AMW, Meijer-van Gelder M, Meijers-Heijboer H, Portengen H, Foekens JA, Dorssers LCJ, Klijn JGM. 2001. Molecular profiles of BRCA1-mutated and matched sporadic breast tumours: Relation with clinico-pathological features. Br J Cancer 85:538-545.
5. Bochar DA, Wang L, Beniya H, Kinev A, Xue YT, Lane WS, Wang WD, Kashanchi F, Shiekhattar R. 2000. BRCA1 is associated with a human SWI/SNF-related complex: Linking chromatin remodeling to breast cancer. Cell 102: 257-265.
6. Catteau A, Harris WH, Xu CF, Solomon E. 1999. Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: Correlation with disease characteristics. Oncogene 18:1957-1965.
7. WAF1/CIP1 promoter. Oncogene 18:263-268.
8. Chai YL, Chipitsyna G, Cui JQ, Liao BS, Liu S, Aysola K, Yezdani M, Reddy ESP, Rao VN. 2001. c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells. Oncogene 20:1357-1367.
9. Chapman MS, Verma IM. 1996. Transcriptional activation by BRCA1. Nature 382:678-679.
10. Chrivia JC, Kwok RP, Lamb N, Hagiwara M, Montminy MR, Goodmar RH. 1993. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365:855-859.
11. Cui JQ, Shao N, Chai Y, Wang H, Redd ESP, Rao VN. 1998. BRCA1 variants BRCA1a and BRCA1b associate with CBP co-activator. Oncology Reports 5:591-595.
12. DeConinck EC, McPherson LA, Weigel RJ. 1995. Transcriptional regulation of estrogen receptor in breast carcinomas. Mol Cell Biol 15:2191-2196.
13. Freneaux P, Stoppa-Lyonnet D, Mouret E, Kambouchner M, Nicolas A, Zafrani B, Vincent-Salomon A, Fourquet A, Magdelenat H, Sastre-Garau X. 2000. Low expression of bcl-2 in Brca1-associated breast cancers. Br J Cancer 83:1318-1322.
14. Fujita T, Nolan GP, Liou H-C, Scott ML, Baltimore D. 1993. The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-κB p50 homodimers. Genes Dev 7:1354-1363.
15. Gowen LC, Johnson BL, Latour AM, Sulik KK, Koller BH. 1996. Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nature Genet 12:191-194.
16. Habib A, Chatterjee S, Park S, Ratan R, Lefebvre S, Vartanian T. 2001. The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-κB (NF-κB)-inducing kinase to activate NF-κB. J Biol Chem 276:8865-8874.
17. Hakem R, de la Pompa JL, Sirard C, Mo R, Woo M, Hakem A, Wakeham A, Potter J, Reitmair A, Billia F, Firpo E, Hui CC, Roberts J, Rossant J, Mak TW. 1996. The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell 85:1009-1023.
18. Harkin DP, Bean JM, Miklos D, Song YH, Truong VB, Englert C, Christians FC, Ellisen LW, Maheswaran S, Oliner JD, Haber DA. 1999. Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1. Cell 97:575-586.
19. Hedenfalk I, Duggan D, Chen YD, Radmacher M, Bittner M, Simon R, Meltzer P, Gusterson B, Esteller M, Kallioniemi OP, Wilfond B, Borg A, Trent J. 2001. Gene-expression profiles in hereditary breast cancer. N Engl J Med 344:539-548.
20. Houvras Y, Benezra M, Zhang HB, Manfredi JJ, Weber BL, Licht JD. 2000. BRCA1 physically and functionally interacts with ATF1. J Biol Chem 275:36230-36237.
21. Jazaeri AA, Yee CJ, Sotiriou C, Brantley KR, Boyd J, Liu ET. 2002. Gene expression profiles, of BRCA1-linked, BRCA2-linked, and sporadic ovarian cancers. J Natl Cancer Inst 94:990-1000.
22. Jóhannsson OT, Idvall I, Anderson C, Borg A, Barkardóttir RB, Egilsson V, Olsson H. 1997. Tumour biological features of BRCA1-induced breast and ovarian cancer. Eur J Cancer [B] 33:362-371.
23. Karp SE, Tonin PN, Bégin LR, Martinez JJ, Zhang JC, Pollak MN, Foulkes WD. 1997. Influence of BRCA1 mutations on nuclear grade and estrogen receptor status of breast carcinoma in Ashkenazi Jewish women. Cancer 80:435-441.
24. Klampfer L, Zhang J, Zelenetz AO, Uchida H, Nimer SD. 1995. The AML1/ETO fusion protein activates transcription of BCL-2. Proc Natl Acad Sci USA 93:14059-14064.
25. Kwok RP, Lundblad JR, Chrivia JC, Richards JP, Bachinger HP, Brennan RG, Green MR, Goodman RH. 1994. Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature 370:177.
26. Lee WY, Jin YT, Chang TW, Lin PW, Su IJ. 1999. Immunolocalization of BRCA1 protein in normal breast tissue and sporadic invasive ductal carcinomas: A correlation with other biological parameters. Histopathology 34:106-112.
27. Lin L, DeMartino G, Greene W. 1998a. Cotranslational biogenesis of NF-kB p50 by the 26S proteasome. Cell 92: 819-828.
28. Lin X, Mu Y, Cunningham E, Marcu K, Geleziunas R, Greene W. 1998b. Molecular determinants of NF-κB-Inducing kinase action. Mol Cell Biol 18:5899-5907.
29. Loman N, Johannsson O, Bendahl PO, Borg Å, Fernö M, Olsson H. 1998. Steroid receptors in hereditary breast carcinomas associated with BRCA1 or BRCA2 mutations or unknown susceptibility genes. Cancer 83:310-319.
30. Lu ML, Arrick BA. 2000. Transactivation of the p21 promoter by BRCA1 splice variants in mammary epithelial cells: Evidence for both common and distinct activities of wildtype and mutant forms. Oncogene 19:6351-6360.
31. Lu ML, Conzen SD, Cole CN, Arrick BA. 1996. Characterization of functional messenger RNA splice variants of BRCA1 expressed in nonmalignant and tumor-derived breast cells. Cancer Res 56:4578-4581.
32. MacLachlan TK, Somasundaram K, Sgagias M, Shifman Y, Muschel RJ, Cowan KH, El-Deiry WS. 2000. BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression. J Biol Chem 275: 2777-2785.
33. Malinin NL, Boldin MP, Kovalenko AV, Wallach D. 1997. MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95, and IL-1. Nature 385:540-544.
34. Matsushima A, Kaisho T, Rennert PD, Nakano H, Kurosawa K, Uchida D, Takeda K, Akira S, Matsumoto M. 2001. Essential role of nuclear factor (NF)-κB-inducing kinase and inhibitor of κB (IκB) kinase α in NF-κB activation through lymphotoxin β receptor, but not through tumor necrosis factor receptor I. J Exp Med 193:631-636.
35. Mengshol JA, Vincenti MP, Brinckerhoff CE. 2001. IL-1 induced collagenase-3 (MMP-13) promoter activity in stably transfected chondrocytic cells: requirement for Runx-2 and activation by p38 MAPK and JNK pathways. Nucleic Acids Res 29:4361-4372.
36. Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S, Liu Q, Cochran C, Bennett LM, Ding W, Bell R, Rosenthal J, Hussey C, Tran T, McClure M, Frye C, Hattier T, Phelps R, Haugen-Strano A, Katcher H, Yakumo K, Gholami Z, Shaffer D, Stone S. 1994. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266:66-71.
37. Monteiro ANA, August A, Hanafusa H. 1996. Evidence for a transcriptional activation function of BRCA1 C-terminal region. Proc Natl Acad Sci USA 93:13595-13599.
38. Mullan PB, McWilliams S, Quinn J, Andrews H, Gilmore P, McCabe N, McKenna S, Harkin DP. 2001. Uncovering BRCA1-regulated signaling pathways by microarray-based expression profiling. Biochem Soc Trans 29:678-683.
39. Nissen LJ, Gelly J, Hipskind RA. 2001. Induction-independent recruitment of CREB-binding protein to the c-fos serum response element through interactions between the bromodomain and Elk-1. J Biol Chem 276:5213-5221.
40. Ouchi T, Monteiro ANA, August A, Aaronson SA, Hanafusa H. 1998. BRCA1 regulates p53-dependent gene expression. Proc Natl Acad Sci USA 95:2302-2306.
41. Pao GM, Janknecht R, Ruffner H, Hunter T, Verma IM. 2000. CBP/p300 interact with and function as transcriptional coactivators of BRCA1. Proc Natl Acad Sci USA 97:1020-1025.
42. Ramirez S, Ali SA, Philippe R, Trouche D, Harel-Bellan A. 1997. The CREB-binding protein (CBP) cooperates with the serum response factor for transactivation of the c-fos serum response element. J Biol Chem 272:31016-31021.
43. Schlegel BP, Green VJ, Ladias JAA, Parvin JD. 2000. BRCA1 interaction with RNA polymerase II reveals a role for hRPB2 and hRPB10α in activated transcription. Proc Natl Acad Sci USA 97:3148-3153.
44. Scully R, Anderson SF, Chao DM, Wei WJ, Ye LY, Young RA, Livingston DM, Parvin JD. 1997. BRCA1 is a component of the RNA polymerase II holoenzyme. Proc Natl Acad Sci USA 94:5605-5610.
45. Shaulian E, Karin M. 2001. AP-1 in cell proliferation and survival. Oncogene 20:2390-2400.
46. Somasundaram K, MacLachlan TK, Burns TF, Sgagias M, Cowan KH, Weber BL, El-Deiry WS. 1999. BRCA1 signals ARF-dependent stabilization and coactivation of p53. Oncogene 18:6605-6614.
47. Thakur S, Zhang HB, Peng Y, Le H, Carroll B, Ward T, Yao J, Farid LM, Couch FJ, Wilson RB, Weber BL. 1997. Localization of BRCA1 and a splice variant identifies the nuclear localization signal. Mol Cell Biol 17:444-452.
48. Tobin SW, Brown MK, Douville K, Payne DC, Eastman A, Arrick BA. 2001. Inhibition of transforming growth factor β signaling in MCF-7 cells results in resistance to tumor necrosis factor α: A role for Bcl-2. Cell Growth Differ 12:109-117.
49. Van't Veer LJ, Dai HY, Van de Vijver MJ, He YDD, Hart AAM, Mao M, Peterse HL, Van der Kooy K, Marton MJ, Witteveen AT, Schreiber GJ, Kerkhoven RM, Roberts C, Linsley PS, Bernards R, Friend SH. 2002. Gene expression profiling predicts clinical outcome of breast cancer. Nature 415:530-536.
50. Wang Q, Zhang HT, Kajino K, Greene MI. 1998. BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells. Oncogene 17:1939-1948.
51. Welcsh PL, Lee MK, Gonzalez-Hernandez RM, Black DJ, Mahadevappa M, Swisher EM, Warrington JA, King MC. 2002. BRCA1 transcriptionally regulates genes involved in breast tumorigenesis. Proc Natl Acad Sci USA 99: 7560-7565.
52. Wilson CA, Payton MN, Elliott GS, Buaas FW, Cajulis EE, Grosshans D, Ramos L, Reese DM, Slamon DJ, Calzone FJ. 1997. Differential subcellular localization, expression, and biological toxicity of BRCA1 and the splice variant BRCA1-Δ11b. Oncogene 14:1-16.
53. Xiao G, Harhaj EW, Sun S-C. 2001. NF-κB inducing kinase regulates the processing of NF-κB2 p100. Mol Cell 7:401-409.
54. Xu X, Weaver Z, Linke SP, Li C, Gotay J, Wang XW, Harris CC, Ried T, Deng CX. 1999. Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol Cell 3:389-395.
55. Yarden RI, Brody LC. 1999. BRCA1 interacts with components of the histone deacetylase complex. Proc Natl Acad Sci USA 96:4983-4988.
56. Yin K, Wu L, Wesche H, Authur CD, White JM, Goeddel DV, Schreiber RD. 2001. Defective lymphotoxin-β receptor-induced NFκ-B transcriptional activity in NIK-deficient mice. Science 291:2162-2165.
57. Zhang HB, Somasundaram K, Peng Y, Tian H, Zhang HX, Bi DK, Weber BL, El-Deiry WS. 1998. BRCA1 physically associates with p53 and stimulates its transcriptional activity. Oncogene 16:1713-1721.
58. Zheng L, Pan HY, Li S, Flesken-Nikitin A, Chen PL, Boyer TG, Lee WH. 2000. Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1. Mol Cell 6:757-768.