Chromosomal imbalances associated with acquired resistance to fluoropyrimidines in human colorectal cancer cells

European Journal of Cancer

Volumn 39, Issue 7, 2003, Pages 975-980

  Hidaka, S ^a   Yasutake, T ^a   Fukushima, M ^b   Yano, H ^a   Haseba, M ^a   Tsuji, T ^a   Sawai, T ^a   Yamaguchi, H ^a   Nakagoe, T ^a   Ayabe, H ^a   Tagawa, Y ^c  

^a NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^b TAIHO PHARMACEUTICAL CO LTD   (Japan)

^c NAGASAKI UNIVERSITY   (Japan)

Author keywords

5 Fluoro 2 deoxyuridine; 5 Fluorouracil; Colorectal cancer; Comparative genomic hybridisation; Drug resistance; Orotate phosphoribosyltransferase; Thymidine synthase

Indexed keywords

FLOXURIDINE; FLUOROPYRIMIDINE DERIVATIVE; FLUOROURACIL; OROTATE PHOSPHORIBOSYLTRANSFERASE; THYMIDYLATE SYNTHASE; URIDINE PHOSPHATE;

ARTICLE; CANCER CELL CULTURE; CANCER RESISTANCE; CHROMOSOME 3P; CHROMOSOME 3Q; CHROMOSOME ABERRATION; CHROMOSOME IDENTIFICATION; CHROMOSOME LOSS; COLORECTAL CARCINOMA; COMPARATIVE GENOMIC HYBRIDIZATION; CYTOTOXICITY; GENE AMPLIFICATION; GENE OVEREXPRESSION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

EID: 0037403254     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(03)00028-5     Document Type: Article

References (34)

1. Wasenius V.M., Jekunen A., Monni O.et al. Comparative genomic hybridization analysis of chromosomal changes occurring during development of acquired resistance to cisplatin in human ovarian carcinoma cells. Genes Chromosomes Cancer. 18:1997;286-291.
2. Struski S., Doco-Fenzy M., Trussardi A.et al. Identification of chromosomal loci associated with non-P-glycoprotein-mediated multidrug resistance to topoisomerase II inhibitor in lung adenocarcinoma cell line by comparative genomic hybridisation. Genes Chromosomes Cancer. 30:2001;136-142.
3. Obara K., Ghazizadeh M., Shimizu H.et al. Comparative genomic hybridization study of genetic changes associated with vindesine resistance in esophageal carcinoma. Int. J. Oncol. 20:2002;255-260.
4. Rooney P.H., Stevenson D.A., Marsh S.et al. Comparative genomic hybridization analysis of chromosomal alterations induced by the development of resistance to thymidylate synthase inhibitors. Cancer Res. 58:1998;5042-5045.
5. Johnston P.G., Lenz H.J., Leichman C.G.et al. Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Cancer Res. 55:1995;1407-1412.
6. Leichman L., Lenz H.J., Leichman C.G.et al. Quantitation of intratumoral thymidylate synthase expression predicts for resistance to protracted infusion of 5-fluorouracil and weekly leucovorin in disseminated colorectal cancers. preliminary report from an ongoing trial Eur. J. Cancer. 31:1995;1306-1310.
7. Aschele C., Sobrero A., Faderan M.A., Bertino J.R. Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules. Cancer Res. 52:1992;1855-1864.
8. Inaba M., Mitsuhashi J., Sawada H.et al. Reduced activity of anabolizing enzymes in 5-fluorouracil-resistant human stomach cancer cells. Jpn. J. Cancer Res. 87:1996;212-220.
9. Murakami Y., Kazuno H., Emura T., Tsujimoto H., Suzuki N., Fukushima M. Different mechanisms of acquired resistance to fluorinated pyrimidines in human colorectal cancer cells. Int. J. Oncol. 17:2000;277-283.
10. Kallioniemi O.P., Kallioniemi A., Piper J.et al. Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors. Genes Chromosomes Cancer. 10:1994;231-243.
11. Nishizaki T., DeVries S., Chew K.et al. Genetic alterations in primary breast cancers and their metastases. direct comparison using modified comparative genomic hybridisation Genes Chromosomes Cancer. 19:1997;267-272.
12. Qumsiyeh M.B., Valentine M.B., Suttle D.P. Localization of the gene for uridine monophosphate synthase to human chromosome region 3q13 by in situ hybridisation. Genomics. 5:1989;160-162.
13. Andou M., Sumi S., Togari H., Wada Y. Decreased fluorouracil cytotoxic effect on EB-virus transformed lymphocytes from hereditary orotic aciduria. Int. J. Mol. Med. 6:2000;69-72.
14. Papadopoulos N., Nicolaides N.C., Wei Y.F.et al. Mutation of a mutL homolog in hereditary colon cancer. Science. 263:1994;1625-1629.
15. Koi M., Umar A., Chauhan D.P.et al. Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N′-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation. Cancer Res. 54:1994;4308-4312.
16. Hawn M.T., Umar A., Carethers J.M.et al. Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint. Cancer Res. 55:1995;3721-3725.
17. Aebi S., Kurdi-Haidar B., Gordon R.et al. Loss of DNA mismatch repair in acquired resistance to cisplatin. Cancer Res. 56:1996;3087-3090.
18. Carethers J.M., Chauhan D.P., Fink D.et al. Mismatch repair proficiency and in vitro response to 5-fluorouracil. Gastroenterology. 117:1999;123-131.
19. Tokunaga E., Oda S., Fukushima M., Maehara Y., Sugimachi K. Differential growth inhibition by 5-fluorouracil in human colorectal carcinoma cell lines. Eur. J. Cancer. 36:2000;1998-2006.
20. Meyers M., Wagner M.W., Hwang H.S., Kinsella T.J., Boothman D.A. Role of the hMLH1 DNA mismatch repair protein in fluoropyrimidine-mediated cell death and cell cycle responses. Cancer Res. 51:2001;5193-5201.
21. Bhattacharyya N.P., Ganesh A., Phear G., Richards B., Skandalis A., Meuth M. Molecular analysis of mutations in mutator colorectal carcinoma cell lines. Hum. Mol. Genet. 4:1995;2057-2064.
22. Oki E., Oda S., Maehara Y., Sugimachi K. Mutated gene-specific phenotypes of dinucleotide repeat instability in human colorectal carcinoma cell lines deficient in DNA mismatch repair. Oncogene. 18:1999;2143-2147.
23. Hemminki A., Mecklin J.P., Jarvinen H., Aaltonen L.A., Joensuu H. Microsatellite instability is a favorable prognostic indicator in patients with colorectal cancer receiving chemotherapy. Gastroenterology. 119:2000;921-928.
24. Watanabe T., Wu T.T., Catalano P.J.et al. Molecular predictors of survival after adjuvant chemotherapy for colon cancer. N. Engl. J. Med. 344:2001;1196-1206.
25. Kim H., Jen J., Vogelstein B., Hamilton S.R. Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences. Am. J. Pathol. 145:1994;148-156.
26. Alexander J., Watanabe T., Wu T.T., Rashid A., Li S., Hamilton S.R. Histopathological identification of colon cancer with microsatellite instability. Am. J. Pathol. 158:2001;527-535.
27. Hori T., Takahashi E., Ayusawa D., Takeishi K., Kaneda S., Seno T. Regional assignment of the human thymidylate synthase (TS) gene to chromosome band 18p11.32 by nonisotopic in situ hybridisation. Hum. Genet. 85:1990;576-580.
28. Wang W., Marsh S., Cassidy J., McLeod H.L. Pharmacogenomic dissection of resistance to thymidylate synthase inhibitors. Cancer Res. 61:2001;5505-5510.
29. Copur S., Aiba K., Drake J.C., Allegra C.J., Chu E. Thymidylate synthase gene amplification in human colon cancer cell lines resistant to 5-fluorouracil. Biochem. Pharmacol. 49:1995;1419-1426.
30. Beck A., Etienne M.C., Cheradame S.et al. A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumour sensitivity to fluorouracil. Eur. J. Cancer. 10:1994;1517-1522.
31. Nita M.E., Tominaga O., Nagawa H., Tsuruo T., Muto T. Dihydropyrimidine dehydrogenase but not thymidylate synthase expression is associated with resistance to 5-fluorouracil in colorectal cancer. Hepatogastroenterology. 45:1998;2117-2122.
32. Scherf U., Ross D.T., Waltham M.et al. A gene expression database for the molecular pharmacology of cancer. Nat. Genet. 24:2000;236-244.
33. Takai S., Fernandez-Salguero P., Kimura S., Gonzalez F.J., Yamada K. Assignment of the human dihydropyrimidine dehydrogenase gene (DPYD) to chromosome region 1p22 by fluorescence in situ hybridisation. Genomics. 24:1994;613-614.
34. Kirihara Y., Yamamoto W., Toge T., Nishiyama M. Dihydropyrimidine dehydrogenase, multidrug resistance-associated protein, and thymidylate synthase gene expression levels can predict 5-fluorouracil resistance in human gastrointestinal cancer cells. Int. J. Oncol. 14:1999;551-556.