Directed evolution of N-acetylneuraminic acid aldolase to catalyze enantiomeric aldol reactions

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 9, 2003, Pages 2091-2098

  Wada, Masaru ^a   Hsu, Che Chang ^a   Franke, Dirk ^a   Mitchell, Michael ^a   Heine, Andreas ^a   Wilson, Ian ^a   Wong, Chi Huey ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 DEOXY MANNO OCTULOSONIC ACID; AMINO ACID; ARABINOSE; BACTERIAL ENZYME; FRUCTOSE BISPHOSPHATE ALDOLASE; HISTIDINE; LEUCINE; LYSINE; MANNOSAMINE; MUTANT PROTEIN; N ACETYLNEURAMINIC ACID; PHENYLALANINE; SCHIFF BASE; SIALIC ACID; TYROSINE; VALINE;

ADDITION REACTION; ALDOL REACTION; ARTICLE; BACTERIAL MUTATION; CATALYSIS; CHEMICAL MUTAGENESIS; CONTROLLED STUDY; ENANTIOMER; ENANTIOSELECTIVITY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SUBUNIT; ESCHERICHIA COLI; MOLECULAR EVOLUTION; MUTAGENESIS; NONHUMAN; POLYMERASE CHAIN REACTION; POLYMERIZATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SPECIES DIFFERENCE; STRUCTURE ANALYSIS; SYNTHESIS; WILD TYPE; X RAY ANALYSIS;

ESCHERICHIA COLI;

EID: 0037401692     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(03)00052-X     Document Type: Article

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