Differential effects of quercetin, a natural polyphenolic flavonoid, on L-type calcium current in pituitary tumor (GH3) cells and neuronal NG108-15 cells

Journal of Cellular Physiology

Volumn 195, Issue 2, 2003, Pages 298-308

  Wu, Sheng Nan ^a,b   Chiang, Hung Ting ^a,b   Shen, Ai Yu ^c   Lo, Yuk Keung ^a,c,d  

^a KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^c FOOYIN UNIVERSITY   (Taiwan)

^d NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL L TYPE; CALCIUM ION; CYCLIC AMP; EPICATECHIN; FLAVONE; FLAVONOID; GENISTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; QUERCETIN; SODIUM ION; TERT BUTYL HYDROPEROXIDE; TETRODOTOXIN; TYROSINE; WORTMANNIN;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; DRUG EFFECT; HYPOPHYSIS TUMOR; ION CURRENT; NONHUMAN; PRIORITY JOURNAL; RAT; SODIUM CURRENT; VOLTAGE CLAMP;

ACTION POTENTIALS; ANIMALS; CALCIUM CHANNELS, L-TYPE; CATECHIN; CELLS, CULTURED; CYCLIC AMP; ENZYME INHIBITORS; FLAVONOIDS; MEMBRANE POTENTIALS; NEURONS; PITUITARY GLAND; PROLACTIN; QUERCETIN; RATS; TERT-BUTYLHYDROPEROXIDE; THIONUCLEOTIDES; TUMOR CELLS, CULTURED;

EID: 0037401519     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.10244     Document Type: Article

References (34)

1. Aviram M, Fuhrman B. 2002. Wine flavonoids protect against LDL oxidation and atherosclerosis. Ann N Y Acad Sci 957;146-161.
2. Bastianetto S, Zheng WH, Quirion R. 2000. Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide-related toxicity in cultured hippocampal neurons. Br J Pharmacol 131:711-720.
3. Candlish JK, Das NP. 1996. Antioxidants in food and chronic degenerative diseases. Biomed Environ Sci 9:117-123.
4. Chen CK, Pace-Asciak CR. 1996. Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta. Gen Pharmacol 27:363-366.
5. Cornish KM, Williamson G, Sanderson J. 2002. Quercetin metabolism in the lens: Role in inhibition of hydrogen peroxide induced cataract. Free Radic Biol Med 33:63-70.
6. Duarte J, Perez-Palencia R, Vargas F, Ocete MA, Perez-Vizcaino F, Zarzuelo A, Tamargo J. 2001. Antihypertensive effects of the flanonoid quercetin in spontaneously hypertensive rats. Br J Pharmacol 133:117-124.
7. Duthie SJ, Dobson VL. 1999. Dietary flavonoids protect human colonocyte DNA from oxidative attack in vitro. Eur J Nutr 38:28-34.
8. Formica JV, Regelson W. 1995. Review of the biology of quercetin and related bioflavonoids. Food Chem Toxicol 33:1061-1080.
9. Gao Z, Huang K, Xu H. 2001. Protective effects of flavonoids in the roots of Scutellaria baicaelensis Georgi against hydrogen peroxide-induced oxidative stress in HS-SY5Y cells. Pharmacol Res 43:173-178.
10. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ. 1981. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pfluegers Arch 391:85-100.
11. 2+ handling in rat islets of Langerhans. J Endocrinol 107:1-8.
12. Ibarra M, Perez-Vizcaino F, Cogolludo A, Duarte J, Zaragoza-Arnaez F, Lopez-Lopez JG, Tamargo J. 2002. Cardiovascular effects of isorhamnetin and quercetin in isolated rat and porcine vascular smooth muscle and isolated rat atria. Planta Med 68:307-310.
13. Ioku K, Tsushida T, Takei Y, Nakatani N, Terao J. 1995. Antioxidative activity of quercetin and quercetin monoglucosides in solution and phospholipid bilayers. Biochim Biophys Acta 1234:99-104.
14. Itoigawa M, Takeya K, Ito C, Furukawa H. 1999. Structure-activity relationship of cardiotonic flavonoids in guinea-pig papillary muscle. J Ethnopharmacol 65:267-272.
15. Kamp TJ, Mitas M, Fields KL, Asoh S, Chin H, Marban E, Nirenberg M. 1995. Transcriptional regulation of the neuronal L-type calcium channel alpha 1D subunit gene. Cell Mol Neurobiol 15:307-326.
16. Khanduja KL, Verma A, Bhardwaj A. 2001. Impairment of human sperm motility and viability by quercetin is independent of lipid peroxidation. Andrologia 33:277-281.
17. Kourie JI. 1998. Interaction of reactive oxygen species with ion transport mechanisms. Am J Physiol 275:C1-C24.
18. 2+ release channel behavior of skeletal muscle. Biophys J 82:1266-1277.
19. Li HF, Shen AY, Jan CR, Wu SN. 1998. Co-activation of nonselective cation channels by store depletion and oxidative stress in monocytic U937 cells. Chin J Physiol 41:113-119.
20. + channels by 1-[2-hydroxy-3-propyl-4-[(1H-tetrazol-5-yl)butoxyl]phenyl] ethanone (LY-171883) in neuroendocrine and neuroblastoma cell lines. J Cell Physiol 192:188-199.
21. Morales MA, Lozoya X. 1994. Calcium-antagonist effects of quercetin on aortic smooth muscle. Planta Med 60:313-317.
22. Morand C, Crespy V, Manach C, Besson C, Demigne C, Remesy C. 1998. Plasma metabolites of quercetin and their antioxidant properties. Am J Physiol 275:R212-R219.
23. Perez-Vizcaino F, Ibarra M, Cogolludo AL, Duarte J, Zaragoza-Arnaez F, Moreno L, Lopez-Lopez G, Tamargo J. 2002. Endothelium-independent vasodilator effects of the flavonoid quercetin and its methylated metabolites in rat conductance and resistance arteries. J Pharmacol Exp Ther 302:66-72.
24. Picq M, Cheav SL, Prigent AF. 1991. Effect of two flavonoid compounds on central nervous system: Analgesic activity. Life Sci 49:1979-1988.
25. Saija A, Scalese M, Lanza M, Marzullo D, Bonina F, Castelli F. 1995. Flavonoids as antioxidant agents: Importance of their interaction with biomembranes. Free Radic Biol Med 19:481-486.
26. 2+ channels in rat tail artery smooth muscle cells. Br J Pharmacol 135:1819-1827.
27. Soleas GJ, Diamandis EP, Goldberg DM. 1997. Wine as a biological fluid: History, production, and role in disease prevention. J Clin Lab Anal 11:287-313.
28. 1 cells. Eur J Pharmacol 414:125-133.
29. Walker EH, Pacold ME, Perisic O, Stephens L, Hawkins PT, Wymann MP, Williams RL. 2000. Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. Mol Cell 6:909-919.
30. Wu BY, Yu AC. 2000. Quercetin inhibits c-fos, heat shock protein, and glial fibrillary acidic protein expression in injured astrocytes. J Neurosci Res 62:730-736.
31. 2+ current. Brain Res 812:133-141.
32. Ca channel activity in the human osteoblast-like MG-63 cells. J Investig Med 49:522-533.
33. + current in pituitary GH3 cells. Chin J Physiol 44:161-167.
34. Wu SN, Lo YK, Chen CC, Li HF, Chiang HT. 2002. Inhibitory effect of the plant-extract osthole on L-type calcium current in NG108-15 neuronal cells. Biochem Pharmacol 63:199-206.