Racl mediates dendrite formation in response to melanocyte stimulating hormone and ultraviolet light in a murine melanoma model

Journal of Investigative Dermatology

Volumn 111, Issue 2, 1998, Pages 243-250

  Scott, Glynis A ^a,b   Cassidy, Linda ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Actin; GTPbinding protein; Melanosome

Indexed keywords

ACTIN BINDING PROTEIN; ALPHA INTERMEDIN; CELL CYCLE PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; INTERMEDIN; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; RAC1 PROTEIN; UNCLASSIFIED DRUG; ACTIN; CALCIUM; RAC PROTEIN;

ANIMAL CELL; ARTICLE; CELL TRANSPORT; CONTROLLED STUDY; DENDRITIC CELL; HUMAN; HUMAN CELL; KERATINOCYTE; MALIGNANT TRANSFORMATION; MELANOCYTE; MELANOMA; MELANOSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; ULTRAVIOLET RADIATION; ANIMAL; CELL CULTURE; DENDRITE; DRUG EFFECT; EXPERIMENTAL MELANOMA; METABOLISM; PATHOLOGY; PHYSIOLOGY; RABBIT; RADIATION EXPOSURE;

ACTINS; ANIMALS; CALCIUM; DENDRITES; GTP-BINDING PROTEINS; HUMANS; MELANOCYTE-STIMULATING HORMONES; MELANOMA, EXPERIMENTAL; MICE; RABBITS; RAC GTP-BINDING PROTEINS; TUMOR CELLS, CULTURED; ULTRAVIOLET RAYS;

EID: 0031596340     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.1998.00276.x     Document Type: Article

References (72)

1. Abdel-Malek Z, Swope V, Smalara D, Babcock G, Dawes S, Nordlund J: Analysis of the UV induced melanogenesis and growth arrest of human melanocytes. Pig Cell Res 7:326-332, 1994
2. Abdel-Malek Z, Swope VB, Suzuki I, et al: Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides. Proc Natl Sci USA 92:1789-1793, 1995
3. Abo A, Pick E, Hall A, Trotty N, Teahan CG, Segal AW: Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1. Nature 353:668-670, 1991
4. Adams AEM, Johnson DI, Longnecker RM, Sloat BR, Pringle JR: Cdc42 and cdc43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae. J Cell Biol 111:131-142, 1990
5. Adunyah SE, Wheeler BJ, Cooper RS: Evidence for the involvement of LCK and MAP kinase (ERK-1) in the signal transduction mechanism of interleukin-15. Biochem Biophys Res Comm 232:754-758, 1997
6. Albelda SM, Mette SA, Elder DE, Stewart R, Damjanovich L, Herlyn M, Buck CA: Integrin distribution in malignant melanoma: Association ot the β3 subunit with tumor progression. Cancer Res 50:6757-6764, 1990
7. Altun-Gultekin ZF, Wagner JA: Src, Ras, and Rac mediate the migratory response elicited by NGF and PMA in PC12 cells. J Neuroscience Res 44:308-327, 1996
8. Archambault M, Yaar M, Gilchrest B: A: Keratinocytes and fibroblasts in a human skin equivalent model enhance melanocyte survival and melanin synthesis after ultraviolet irradiation. J Invest Dermatol 104:859-867, 1995
9. Berg N, Ostergaard HL: T cell receptor engagement induces tyrosine phosphorylation of FAK and Pyk2 and their association with Lck. J Immuno 159:1753-1757, 1997
10. Bokoch GM, Bohl BP, Chuang T-H: Guanine nucleotide exchange regulates membrane translation of Rac/Rho GTP-binding proteins. J Biol Chem 269:31674-31679, 1994
11. Bologna I, Murray M, Pawelek J: UVB-induced melanogenesis may be mediated through the MSH-receptor system. J Invest Dermatol 92:651-656, 1989
12. Bourne HA, Sanders DA, McCormick F: The GTPase superfamily: conserved structure and molecular mechanism. Nature 349:117-127, 1991
13. Buffey J, Thody AJ, Bleehen SS, Mac Neil S: Alpha-melanocyte-stimulating hormone stimulates protein kinase C activity in murine B16 melanoma. J Endocr 133:333-340, 1992
14. Chakraborty AK, Orlow SJ, Bologna JL, Pawelek JM: Structural/functional relationships between internal and external MSH receptors: Modulation of expression in Coudman melanoma cells by UVB radiation. J Cell Physiol 147:1-6, 1991
15. Chakraborty AK, Funasaka Y, Slominski A, Ermak C, Hwang J, Pawelek JM, Ichihashi M: Production and release of proopiomelanocortin (POMC) derived peptides by human melanocytes and keratinocytes in culture: regulation by ultraviolet B. Biochem Biophys Acta 1313:130-138, 1996
16. Chuang T-H, Bohl BP, Bokoch GM: Biologically active lipids are regulators of Rac.GDI complexation. J Biol Chem 268:26206-26211, 1993
17. Cone RD, Mountjoy KG, Robbins LS, Nadeau JH, Johnson KR, Roselli-Rehfuss L, Mortrud MT: Cloning and functional characterization of a family of receptors for the melanotropic peptides. Ann NY Acad Sci 680:342-363, 1993
18. Easty DJ, Herlyn M, Bennett DC: Abnormal protein tyrosine kinase gene expression during melanoma progression and metastasis. Int J Cancer 60:129-136, 1995
19. Fitzpatrick TB, Miyamoto M, Ishikawa K: The evolution of concepts of melanin biology. Arch Dermatol 96:305-323, 1967
20. Flinn HM, Ridley AJ: Rho stimulates tyrosine phosphorylation of focal adhesion kinase, p130 and paxillin. J Cell Sci 109:1133-1141, 1996
21. Freshney NW, Goonesekera SD, Feig LA: Activation of the exchange factor Ras-GRF by calcium requires an intact Dbl homology domain. FEBS Lett 407:111-115, 1997
22. Friedmann PS, Gilchrest BA: Ultraviolet radiation directly induces pigment production by cultured human melanocytes. J Cell Physiol 133:88-94, 1987
23. Gordon PR, Mansur CP, Gilchrest BA: Regulation of human melanocyte growth, dendricity, and melanization by keratinocyte derived factors. J Invest Dermatol 92:565-572, 1989
24. Han J, Das B, Wei W, et al: Lck regulates Vav activation of members of the Rho family of GTPases. Mol Cell Biol 17:1346-1353, 1997
25. Hara M, Yaar M, Gilchrest BA: Endothelin-1 of keratinocyte origin is a mediator of melanocyte dendricity. J Invest Dermatol 105:744-748, 1995
26. Herlyn M, Mancianti ML, Jambrosic J, Bolen JB, Koprowski H: Regulatory factors that determine growth and phenotype of normal human melanocytes. Exp Cell Res 179:322-331, 1988
27. Hill SE, Buffey J, Thody AJ, Oliver I, Bleehen SS, Mac Neil S: Investigation of the regulation in α-melanocyte stimulating hormone responsive and unresponsive cultured B16 melanoma cells. Pig Cell Res 2:161-166, 1989
28. Hirobe T: Stimulation of dedritogenesis in the epidermal melanocytes of newborn mice by melanocyte-stimulating hormone. J Cell Sci 33:371-383, 1978
29. Hirobe T: Melanocyte stimulating hormone induces the differentiation of mouse epidermal melanocytes in serum-free culture. J Cell Physiol 152:337-345, 1992
30. Hunt G: Melanocyte stimulating hormone: A regulator of human melanocyte physiology. Pathobiol 63:12-21, 1995
31. Hunt G, Donatien PD, Lunec J, Todd C, Kyne S, Thody A: Cultured human melanocytes respond to MSH peptides and ACTH. Pig Cell Res 7:217-221, 1994
32. Im S, Moro S, Peng F, et al: Activation of the cAMP pathway by α-melanotropin mediates the response of human melanocytes to UVB radiation. Cancer Res 58:47-54, 1998
33. Imokawa G, Miyagishi M, Yada Y: Endothelin-1 as a new melanogen: coordinated expression of its gene and the tyrosinase gene in UVB-exposed human epidermis. J Invest Derm 105:32-37, 1995
34. Ivengar B: UV guided dendritic growth patterns and the networking of melanocytes. Experientia 50:669-672, 1994
35. Jimbow K, Pathak MA, Fitzpatrick TB: Effect of ultraviolet light on the distribution pattern of microfilaments and microtubules and on the nucleus in human melanocytes. Yale J Biol Med 46:411-426, 1973
36. Jimenez M, Kameyama K, Maloy WL, Tomita Y, Hearing VJ: Mammalian tyrosinase biosynthesis, processing and modulation by melanocyte stimulating hormone. Proc Natl Acad Sci USA 85:3830-3834, 1988
37. Johnson DI, Pringle JR: Molecular characterization of cdc42, a Saccharomyces cerevisiae gene involved in the development of cell polarity. J Cell Biol 111:143-152, 1990
38. Knaus UG, Heyworth PG, Evans T, Curnette JT, Bokoch GM: Regulation of phagocyte oxygen radical production by the GTP binding protien Rac2. Science 254:1512-1515, 1991
39. Kozma R, Ahmed S, Best A, Lim A: The Ras-related protein cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts. Mol Cell Biol 15:1942-1952, 1995
40. Kozma R, Sohail A, Best A, Lim L: The GTPase-activating protien n-chimaerin cooperates with rac1 and cdc42hs to induce the formation of lamellipodia and filopodia. Mol Cell Biol 16:5069-5080, 1996
41. Kozma R, Sarner S, Ahmed S, Lim L: Rho family GTPases and neuronal growth cone remodeling: relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid. Mol Cell Biol 17:1201-1211, 1997
42. Kwong CH, Malech HL, Rotrosen D, Leto T: L: Regulation of the human neutrophil NADPH oxidase by rho-related G-proteins. Biochemistry 32:5711-5717, 1993
43. Lacour JP, Gordon PR, Eller M, Bhawan J, Gilchrest BA: Cytoskeletal events underlying dendrite formation by cultured pigment cells. J Cell Physiol 151:287-299, 1992
44. Luo L, Hensch TK, Ackerman L, Barbel S, Jan LY, Jan YN: Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines. Nature 379:837-840, 1996
45. Mac Neil S, Johnson SK, Bleehen SS, Brown BL, Tomlinson S: Stimulation of the adenylate cyclase of a B16 melanoma cell line by proopiocortin-related peptides-a structure-activity study. Regulatory Peptides 2:193-200, 1981
46. Mac Neil S, Dobson J, Bleehen SS, Buffey JA: MSH increases intracellular calcium in melanoma cells. Br J Dermatol 123:828, 1990
47. Marshall JF, Nesbitt SA, Helfrich MH, Horton MA, Polakova K, Hart RI: Integrin expression in human melanoma cell lines: Heterogeneity of vitronectin receptor composition and function. Int J Cancer 49:924-931, 1991
48. Matsui MS, DeLeo VA: Induction of protein kinase C activity by ultraviolet radiation. Carcinogen 11:229-234, 1990
49. Matsui MS, Wang N, MacFarlane D, DeLeo VA: Long-wave ultraviolet radiation induces protein kinase C in normal human keratinocytes. Photochem Photobiol 59:53-57, 1994
50. Matsui MS, Wang N, DeLeo V: A: Ultraviolet radiation B induces differentiation and protein kinase C in normal human epidermal keratinocytes. Photoimmunol Photomed 12:103-108, 1996
51. Mattingly RR, Macara IG: Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein beta gamma subunits. Nature 382:268-272, 1996
52. McGuire J, Moellmann G, McKeon F: Cytochalasin B and pigment translocation. J Cell Biol 52:765-758, 1972
53. Mercer JA, Seperack PK, Strobel MC, Copeland NG, Jenkins NA: Novel myosin heavy chain encoded by murine dilute coat colour locus. Nature 349:709-713, 1991
54. Moellmann G, McGuire J, Lerner AB: Intracellular dynamics and the fine structure of melanocytes. Yale J Biol Med 46:337-360, 1973
55. Mountjoy KG, Robbins LS, Mortrud MT, Cone RD: The cloning of a family of genes that encode the melanocortin receptors. Science 257:1248-1251, 1992
56. Nobes CD, Hall A: Rho, rac and cdc42 GTPases: regulators of actin structures, cell adhesion and motility. Biochem Soc Trans 23:456-459, 1995a
57. Nobes CD, Hall A: Rho, Rac, Cdc42 GTPases regulate the assembly of multimoleculer focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81:53-62, 1995b
58. Oka M, Ichibashi M, Chakraborty AK: Enhanced expression of protein kinase C subspecies in melanogenic compartments in B16 melanoma cells by UVB or MSH. J Invest Dermatol 106:377-378, 1996
59. Pawelek JM, Chakraborty AK, Osber MP, Orlow SJ, Mm KK, Rosenzweig KE, Bologna JL: Molecular cascades in UV-induced melanogenesis: A central role for melanotropins? Pig Cell Res 5:348-356, 1992
60. Peak, JG, Woloschak GE, Peak MJ: Enhanced expression of protien kinase C gene caused by solar radiation. Photochem Photobiol 53:395-397, 1991
61. Provance DW Jr, Wei M, Ipe V, Mercer JA: Cultured melanocytes from dilute mutant mice exhibit dendritic morphology and altered melanosome distribution. Proc Natl Acad Sci USA 93:14554-14558, 1996
62. Quinn MT, Evans T, Toetterle LR, Jesaitis AJ, Bokoch GM: Translocation of Rac correlates with NADPH oxidase activation. J Biol Chem 268:20983-20987, 1993
63. Ridley AJ, Hall A: The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70:389-399, 1992
64. Ridley AJ, Hall A: Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tryosine kinase. EMBO J 13:2600-2610, 1994
65. Ridley AJ, Paterson, HF, Johnston CL, Diekmann D, Hall A: The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70:401-410, 1992
66. Romero-Graillet C, Aberdam E, Biagoli N, Massabni W, Ortonne JP, Ballotti R: Ultraviolet B radiation acts through the nitric oxide and cGMP signal transduction pathway to stimulate melanogenesis in human melanoyctes. J Biol Chem 271:28052-28056, 1996
67. Sawyer TK, Hruby VJ, Darman PS, Hadley ME: (half-Cys4,half-Cys 10) alpha melanocyte stimulating hormone: a cyclic alpha melanotropic exhibiting superagonist biological activity. Proc Natl Acad Sci USA 79:1751-1755, 1982
68. Suzuki I, Cone RD, Im S, Nordlund J, Abdel-Malek ZA: Binding of melanotropic hormones to the melanocortin recpetor MCIR on human melanocytes stimulates proliferation and melanogenesis. Endocrin 137:1627-1633, 1996
69. Swope VB, Medrano EE, Smalara D, Abdel-Malek Z: Long-term proliferation of human melanocytes is supported by the physiologic mitogens alpha-melanotropin, endothelin-1, and basic fibroblast growth factor. Exp Cell Res 217:453-459, 1995
70. Teramoto H, Salem P, Robbins KC, Bustelo XR, Gutkind JS: Tyrosine phosphorylation of the vav proto-oncogene product links FcepsilonRI to the Rac1-JNK pathway. J Biol Chem 272:10751-10755, 1997
71. Wu X, Bowers B, Wei Q, Kocher B, Hammer IIIJA: Myosin V associates with melanosomes in mouse melanocytes: evidence that myosin V is an organelle motor. J Cell Sci 110:847-859, 1997
72. Yaar M, Grossman K, Eller M, Gilchrest BA: Evidence for nerve growth factor-mediated paracrine effects in human epidermis. J Cell Biol 115:821-828, 1991