Tryptase, a novel link between allergic inflammation and fibrosis

Trends in Immunology

Volumn 24, Issue 4, 2003, Pages 158-161

  Levi Schaffer, Francesca ^a   Piliponsky, Adrian M ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 2 ANTAGONIST; PROTEINASE INHIBITOR; SERINE PROTEINASE INHIBITOR; TRYPTASE; TRYPTASE INHIBITOR; UNCLASSIFIED DRUG;

ALLERGY; EOSINOPHIL; FIBROBLAST; FIBROSIS; FILTRATION; HUMAN; HYPOTHESIS; INFLAMMATION; MAST CELL; MAST CELL DEGRANULATION; PROTEIN INTERACTION; PROTEIN SYNTHESIS; REVIEW;

EID: 0037385229     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4906(03)00058-9     Document Type: Review

References (24)

1. Galli S.J., Williams C.M. The diverse potential effector and immunoregulatory roles of mast cells in allergic disease. J. Allergy Clin. Immunol. 105:2000;847-859.
2. Gleich G.J. Mechanism of eosinophil-associated inflammation. J. Allergy Clin. Immunol. 105:2000;651-663.
3. Levi-Schaffer F., et al. Mast cells enhance eosinophil survival in vitro: role of TNF-α and granulocyte-macrophage-colony stimulating factor. J. Immunol. 160:1998;5554-5561.
4. Temkin V., Levi-Schaffer F. Mechanism of tumor necrosis factor-α-mediated eosinophil survival. Cytokine. 15:2001;20-26.
5. Temkin V., et al. Tryptase activates the mitogen-activated protein kinase/activator protein-1 pathway in human peripheral-blood eosinophils, causing cytokine production and release. J. Immunol. 169:2002;2662-2669.
6. Piliponsky, A.M., et al. Non-IgE dependent activation of human lung and cord blood-derived mast cells is induced by eosinophil major basic protein and modulated by the membrane form of stem cell factor. Blood 10.1182/blood-2002-05-1488 ( http://www.blood.journal.org ).
7. Piliponsky A.M., et al. Human eosinophils induce histamine release from antigen-activated rat peritoneal mast cells: a possible role for mast cells in late-phase allergic reactions. J. Allergy Clin. Immunol. 107:2001;993-1000.
8. Redington A.E. Fibrosis and airway remodeling. Clin. Exp. Allergy. 30:(Suppl. 1):2000;42-45.
9. Garbuzenko E., et al. Human mast cells stimulate fibroblast proliferation, collagen synthesis and lattice contraction: a direct role for mast cells in skin fibrosis. Clin. Exp. Allergy. 32:2002;237-246.
10. Levi-Schaffer F., et al. Human eosinophils regulate human lung- and skin-derived fibroblast properties in vitro: a role for transforming growth factor-β (TGF-β). Proc. Natl. Acad. Sci. U. S. A. 96:1999;9660-9665.
11. Fireman E., et al. Secretion of stem-cell factor by alveolar fibroblasts in interstitial lung diseases. Immunol. Lett. 67:1999;229-236.
12. Yamamoto T., et al. Role of stem-cell factor and monocyte chemoattractant protein-1 in the interaction between fibroblasts and mast cells in fibrosis. J. Dermatol. Sci. 26:2001;106-111.
13. Solomon A., et al. Conjunctival fibroblasts enhance the survival and functional activity of peripheral-blood eosinophils in vitro. Invest. Ophthalmol. Vis. Sci. 41:2000;1038-1044.
14. Abraham W.M. Tryptase: a potential role in airway inflammation and remodeling. Am. J. Physiol. Lung Cell. Mol. Physiol. 282:2002;L193-L196.
15. Schwartz L.B., et al. The α form of human tryptase is the predominant type present in blood at baseline in normal subjects and is elevated in those with systemic mastocytosis. J. Clin. Invest. 96:1995;2702-2710.
16. Lan R.S., et al. Role of protease-activated receptors in airway function: a target for therapeutic intervention? Pharmacol. Ther. 95:2002;239-257.
17. He S., et al. Potent induction of a neutrophil and eosinophil-rich infiltrate in vivo by human mast-cell tryptase: selective enhancement of eosinophil recruitment by histamine. J. Immunol. 159:1997;6216-6225.
18. Schmidlin F., et al. Protease-activated receptor 2 mediates eosinophil infiltration and hyper-reactivity in allergic inflammation of the airway. J. Immunol. 169:2002;5315-5321.
19. Frungieri M.B., et al. Proliferative action of mast-cell tryptase is mediated by PAR2, COX2, prostaglandins and PPARγ: possible relevance to human fibrotic disorders. Proc. Natl. Acad. Sci. U. S. A. 99:2002;15072-15077.
20. Brown J.K., et al. Tryptase's potent mitogenic effects in human airway smooth muscle cells are via non-proteolytic actions. Am. J. Physiol. Lung Cell. Mol. Physiol. 282:2002;L197-L206.
21. Damiano B.P., et al. Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1. J. Pharmacol. Exp. Ther. 288:1999;671-678.
22. Oh S.-W., et al. Tryptase inhibition blocks airway inflammation in a mouse asthma model. J. Immunol. 168:2002;1992-2000.
23. Huang C., et al. Evaluation of the substrate specificity of human mast-cell tryptase βI demonstration of its importance in bacterial infections of the lung. J. Biol. Chem. 276:2001;26276-26284.
24. Wong G.W., et al. Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase γ J. Biol. Chem. 277:2002;41906-41915.