Integrated QSPR - Pharmacodynamic model of genomic effects of several corticosteroids

Journal of Pharmaceutical Sciences

Volumn 92, Issue 4, 2003, Pages 881-889

  Mager, Donald E ^a   Pyszczynski, Nancy A ^a   Jusko, William J ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Corticosteroids; Mathematica modeling; Pharmacodynamics; Pharmacogenomics; Pharmacokinetics; QSPR; Quantitative structure property relationships; Rat

Indexed keywords

CORTICOSTEROID DERIVATIVE; CORTICOSTEROID RECEPTOR; DEXAMETHASONE SODIUM PHOSPHATE; HYDROCORTISONE SODIUM SUCCINATE; METHYLPREDNISOLONE; PREDNISOLONE; TYROSINE AMINOTRANSFERASE;

ADRENALECTOMY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; IN VITRO STUDY; MALE; MATHEMATICAL MODEL; MODEL; NONHUMAN; PHARMACODYNAMICS; PHARMACOGENOMICS; PREDICTION; QUANTITATIVE STRUCTURE PROPERTY RELATION; RAT; RAT STRAIN; SIMULATION;

EID: 0037380380     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10343     Document Type: Article

References (24)

1. Jusko WJ, Ludwig EA. 1992. Corticosteroids. In: Evans WE, Schentag JJ, Jusko WJ, editors. Applied pharmacokinetics, 3rd ed. Vancouver: Applied Therapeutics, Inc.
2. Jusko WJ. 2001. Relationship of dose- and time-dependent corticosteroid responses to receptor turnover. In: Schleimer RP, O'Byrne PM, Szefler SJ, Brattsand R, editors. Inhaled steroids in asthma. New York: Marcel Dekker, Inc., pp 95-112.
3. Schimmer BP, Parker KL. 2001. Adrenocorticotropic hormone: Adrenocortical steroids and their synthetic analogs; Inhibitors of the synthesis and actions of adrenocortical hormones. In: Hardman JG, Limbird LE, Gilman AG, editors. Goodman & Gilman's the pharmacological basis of therapeutics, 10th ed. New York: McGraw-Hill, pp 1649-1677.
4. Ramakrishnan R, DuBois DC, Almon RR, Pyszczynski NA, Jusko WJ. 2002. Fifth-generation model for corticosteroid pharmacodynamics: Application to steady-state receptor down-regulation and enzyme induction patterns during seven-day continuous infusion of methylprednisolone in rats. J Pharmacokinet Pharmacodyn 29:1-24.
5. Boudinot FD, D'Ambrosio R, Jusko WJ. 1986. Receptor-mediated pharmacodynamics of prednisolone in the rat. J Pharmacokinet Biopharm 14:469-493.
6. Nichols AI, Boudinot FD, Jusko WJ. 1989. Second generation model for prednisolone pharmacodynamics in the rat. J Pharmacokinet Biopharm 17:209-227.
7. Xu ZX, Sun YN, DuBois DC, Almon RR, Jusko WJ. 1995. Third-generation model for corticosteroid pharmacodynamics: Roles of glucocorticoid receptor mRNA and tyrosine aminotransferase mRNA in rat liver. J Pharmacokinet Biopharm 23:163-181.
8. Sun YN, DuBois DC, Almon RR, Jusko WJ. 1998. Fourth-generation model for corticosteroid pharmacodynamics: A model for methylprednisolone effects on receptor/gene-mediated glucocorticoid receptor down-regulation and tyrosine aminotransferase induction in rat liver. J Pharmacokinet Biopharm 26:289-317.
9. Mager DE, Jusko WJ. 2002. Quantitative structure-pharmacokinetic/pharmacodynamic relationships of corticosteroids in man. J Pharm Sci 91:2441-2451.
10. Wolff ME, Baxter JD, Kollman PA, Lee DL, Kuntz ID, Bloom E, Matulich DT, Morris J. 1978. Nature of steroid-glucocorticoid receptor interactions: thermodynamic analysis of the binding reaction. Biochemistry 17:3201-3208.
11. Jusko WJ, Pyszczynski NA, Bushway MS, D'Ambrosio R, Mis SM. 1994. Fifteen years of operation of a high-performance liquid chromatographic assay for prednisolone, cortisol and prednisone in plasma. J Chromatogr B Biomed Appl 658:47-54.
12. Diamondstone TI. 1966. Assay of tyrosine aminotransferase activity by conversion of p-hydroxyphenylpyruvate to p-hydroxybenzaldehyde. Anal Biochem 16:395-401.
13. Lowry OM, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-272.
14. Nichols AI, Jusko WJ. 1990. Receptor-mediated prednisolone pharmacodynamics in rats: Model verification using a dose-sparing regimen. J Pharmacokinet Biopharm 18:189-208.
15. D'Argenio DZ, Schumitzky A. 1997. ADAPT II user's guide: Pharmacokinetic/pharmacodynamic systems analysis software. Los Angeles: Biomedical Simulations Resource.
16. Gabrielsson J, Weiner D. 1997. Pharmacokinetic and pharmacodynamic data analysis: Concepts and aplications. Stockholm: Swedish Pharmaceutical Press.
17. Izawa M, Yoshida A, Ichii S. 1982. Dynamics of glucocorticoid receptor and induction of tyrosine aminotransferase in rat liver. Endocrinol Jpn 29:209-218.
18. Chesnokov VN, Gadzhiev VG, Leontyeva GI, Zelenin SM, Mertvetsov NP. 1990. Hydrocortisone regulation and expression of tyrosine aminotransferase gene in various tissues of rat. Biomed Biochim Acta 49:1177-1186.
19. Mager DE, Jusko WJ. 2001. Pharmacodynamic modeling of time-dependent transduction systems. Clin Pharmacol Ther 70:210-216.
20. Dayneka NL, Garg V, Jusko WJ. 1993. Comparison of four basic models of indirect pharmacodynamic responses. J Pharmacokinet Biopharm 21:457-478.
21. Sun YN, Jusko WJ. 1998. Transit compartments versus gamma distribution function to model signal transduction processes in pharmacodynamics. J Pharm Sci 87:732-737.
22. Fouchecourt MO, Beliveau M, Krishnan K. 2001. Quantitative structure-pharmacokinetic relationship modelling. Sci Total Environ 274:125-135.
23. Hansch C, Leo A. 1995. Exploring QSAR. Hydrophobic, electronic, and steric constants. Washington: American Chemical Society.
24. Sun YN, DuBois DC, Almon RR, Pyszczynski NA, Jusko WJ. 1998. Dose-dependence and repeated-dose studies for receptor/gene-mediated pharmacodynamics of methylprednisolone on glucocorticoid receptor down-regulation and tyrosine aminotransferase induction in rat liver. J Pharmacokinet Biopharm 26:619-648.