Role of androgens in mild cognitive impairment and possible interventions during andropause

Medical Hypotheses

Volumn 60, Issue 3, 2003, Pages 448-452

  Tan, Robert S ^a   Pu, S J ^a   Culberson, J W ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; AROMATASE INHIBITOR; CLOMIFENE CITRATE; ESTRADIOL; FLAVONE DERIVATIVE; PLACEBO; PRASTERONE; PRASTERONE SULFATE; TESTOSTERONE CIPIONATE; TESTOSTERONE ENANTATE; TRESTOLONE;

ADULT; AGED; AGING; ALZHEIMER DISEASE; ANIMAL MODEL; BRAIN FUNCTION; CASTRATION; CLINICAL ARTICLE; CLINICAL TRIAL; COGNITION; COGNITIVE DEFECT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEMENTIA; DOUBLE BLIND PROCEDURE; HORMONE DEFICIENCY; HUMAN; HYPOGONADISM; INFERTILITY; MALE; MEMORY; NONHUMAN; ORCHIECTOMY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVIEW; TESTOSTERONE BLOOD LEVEL;

EID: 0037369341     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-9877(02)00447-4     Document Type: Review

References (46)

1. De Santi S., de Leon M. J., Rusinek H., Convit A., Tarshish C. Y., Roche A. et al. Hippocampal formation glucose metabolism and volume loss in MCI and AD. Neurobiol Aging 2001; 22: 529-539.
2. Lautenschlager N. T., Riemenschneider M., Drzezga A., Kurz A. F. Primary degenerative mild cognitive impairment: study population, clinical, brain imaging and biochemical findings. Dement Geriatri Cogn Disord 2001; 12: 379-386.
3. Arnaiz E., Jelic V., Almkvist O., Wahlund L. O., Winblad B., Valind S. et al. Impaired cerebral glucose metabolism and cognitive functioning predict deterioration in mild cognitive impairment. Neuroreport 2001; 12: 851-855.
4. Petersen R. C., Doody R., Kurz A., Mohs R. C., Morris J. C., Rabins P. V. et al. Current concepts in mild cognitive impairment. Arch Neurol 2001; 58: 1985-1992.
5. Jack C. R., Petersen R. C., Xu Y. C., O'Brien P. C., Smith G. E., Ivnik R. J. et al. Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment. Neurology 1999; 52: 1397-1403.
6. Mufsor E. J., Chen E. Y., Cochran E. J., Beckett L. A., Bennett D. A., Kordower J. H. Entorhmal cortex β-amyloid load in individuals with mild cognitive impairment. Exp Neurol 1999; 158: 469-490.
7. Price J. L., Morris J. C. Tangles and plagues in nondemented aging and preclinical Alzheimer's disease. Ann Neurol 1999; 45: 358-386.
8. Yaffe K., Sawaya G., Liebergurg I., Grady D. Estrogen therapy in postmenopausal women: effects on cognitive function and dementia. JAMA 1998; 279: 688-695.
9. Morley J. E., Perry III H. M. Androgen deficiency in aging men. Med Clin Nor Am 1999; 83: 1279-1289.
10. Janowsky J. S., Oviatt S. K., Orwoll E. S. Testosterone influences spatial cognition in older men. Behav Neurosci 1994; 108: 325-332.
11. Janowsky J. S., Chavez B. Sex steroids modify working memory. J Cogn Neurosci 2000; 12: 407-412.
12. Simerly R. B., Chang C., Muramatsu M., Swanson L. W. Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: an in situ hybridization study. J Compara Neurol 1990; 294: 76-95.
13. Lustig R. H. Sex hormone modulation of neural development in vitro. Hormo Behav 1994; 28: 383-395.
14. Hart B. L. Effect of gonadectomy on subsequent development of age-related cognitive impairment in dogs. J Am Vet Med Assoc 2001; 219: 51-56.
15. Flood J. F., Fair S., Kaiser F. E., La Regina M., Morley J. E. Age-related decrease of plasma testosterone in SAMP8 mice: replacement improve age-related impairment of learning and memory. Phsiol Behav 1995; 57: 669-673.
16. Papasonomenos S. C. The heat shock-induced hyperphosphorylation of tau is estrogen-independent and prevented by androgens: implication for Alzheimer disease. Proc Natl Acad Sci USA 1997; 94: 1997.
17. Gouras G. K., Xu H., Gross R. S., Greenfield J. P., Hai B., Wang R. et al. Testosterone reduces neuronal secretion of Alzheimer's β-amyloid peptides. Proc Natl Acad Sci USA 2000; 97: 1202-1205.
18. Pike C. J. Testosterone attenuates β-amyloid toxicity in cultured hippocampal neurons. Brain Res 2001; 919: 160-165.
19. Goodenough S., Engert S., Behl C. Testosterone stimulates rapid secretory amyloid precursor protein from rat hypothalamic cells via the activation of the mitogen-activated protein kinase pathway. Neurosci Left 2000; 296: 49-52.
20. Flood J F., Morley J. E. Learning and memory in the SAMP8 mouse. Neurosci Biobehav Rev 1998; 22: 1-20.
21. Rubinow D. R., Schmidt P. J. Androgen, brain, and behavior. Am J Psychiatry 1996; 153: 974-984.
22. Kemnitz J. W., Roecker E. B., Haffa A. L., Pinheiro J., Kurzman I., Ramsey J. J. et al. Serum dehydroepiandrosterone sulfate concentrations across the life span of laboratory-housed rhesus monkeys. Med Primatol 2000; 29: 330-337.
23. Herndon J. G., Lacreuse A., Ladinsky E., Killiany R. J., Rosene D. L., Moss M. B. Age-related decline in DHEAS is not related to cognitive impairment in aged monkeys. Neuroreport 1999; 10: 3507-3511.
24. Markowski M., Ungeheuer M., Bitran D., Locurto C. Memory-enhancing effects of DHEAS in aged mice on a win-shift water escape task. Physiol Behav 2001; 72: 521-525.
25. Reddy D. S., Kulkarni S. K. Possible role of nitric oxide in the nootropic and antiamnesic effects of neurosteroids on aging- and dizocilpine-induced learning impairment. Brain Res 1998; 799: 215-229.
26. Frye C. A., Lacey E. H. The neurosteroids DHEA and DHEAS may influence cognitive performance by altering affective state. Physiol Behav 1999; 66: 85-92.
27. Flood J. E., Roberts E. Dehydroepiandrosterone sulfate improve memory in aging mice. Brain Res 1988; 448: 178-181.
28. Kimonides; V. G., Khatibi N. H., Svendsen C. N., Sofroniew M. V., Herbert J. Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity. Proc Natl Acad Sci USA 1998; 17(95): 1852-1857.
29. Shen S., Cooley D. M., Glickman L. T., Glickman N., Waters D. J. Reduction in DNA damage in brain and peripheral blood lymphocytes of elderly dogs after treatment with dehydroepiandrosterone (DHEA). Mutat Res 2001; 480-481: 153.
30. Danenberg H. D., Haring R., Fisher A. Dehydroepiandrosterone (DHEA) increases production and release of Alzheimer's amyloid precursor protein. Life Sci 1996; 59: 1651-1657.
31. Milward E. A., Papadopoulos R., Fuller S. J., Morr R. D., Small D., Beyreuther K. et al. The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth. Neuron 1992; 9: 129-137.
32. Sisodia S. S., Koo E. H., Beyreuther K., Unterbeck A., Price D. L. Evidence that β-amyloid protein in Alzheimer's disease is not altered by normal processing. Science 1990; 248: 492-495.
33. Wolf O. T., Kirschbaum C. Actions of dehydroepiandrosterone and its sulfate in the central nervous system: effect on cognition and emotion in animals and humans. Brain Res Brain Rev 1999; 30: 265-288.
34. Tan R. S. Memory loss as a reported symptom of andropause. Arch Androl 2001; 47: 185-189.
35. Cherrier M. M., Asthana S., Plymate S., Baker L., Motsumoto A. M., Peskind E. et al. Testosterone supplementation improves spatial and verbal memory in healthy older men. Neurology 2001; 57: 80-88.
36. Sih R., Morley J., Kaiser F. E., Horrace M., Perry III H. M., Patric P. Testosterone replacement in older hypogondal Men: a 12-month randomized controlled trial. J Clin Endocrin Metab 1997; 82: 1661-1666.
37. Slabbekoorn D., van Goozen S. H. M., Megens J. Activating effects of cross-sex hormones on cognitive functioning: a study of short-term and long-term hormone effects on transsexuals. Psychoneuroendocrinology 1999; 24: 423-447.
38. O'Connor D. B., Archer J., Hair W. M., Wu F. C. Activational effects of testosterone on cognitive function in men. Neuropsychologia 2001; 39: 1385-1394.
39. Zitzmann M., Weckesser M., Schober O., Nieschlag E. Changes in cerebral glucose metabolism and visuospatial capacity in hypogonadal males under testosterone substitution therapy. Exp Clin Endocrinol Diabetes 2001; 109: 302-304.
40. Gandy S., Almeida O. P., Fonte J., Lim d., Waterrus A., Spry N. et al. Chemical andropause and amyloid-B peptide. JAMA 2001; 285: 2195-2196.
41. Carlson L. E., Sherwin B. B., Cherkow H. M. Relationships between Dehydroepiandrosterone sulfate (DHEAS) and cortisol (CRT) plasma levels and everyday memory in Alzheimer's disease patients compared to healthy controls. Harm Behav 1999; 35: 254-263.
42. Moffat S. D., Zonderman A. B., Harman S. M. The relationship between longitudinal declines in dehydroepiandrosterone sulfate concentrations and cognitive performance in older men. Arch Intern Med 2000; 160: 2193-2198.
43. Morrison M. F., Redei E., TenHave T., Parmelee P., Boyce A. A., Sinha P. S. et al. Dehydroepiandrosterone sulfate and psychiatric measures in a frail, elderly residential care population. Biol Psychiatry 2000; 47: 144-150.
44. Guay A. T., Bansal S., Headey G. J. Effect of raising endogenous testosterone levels in impotent men with secondary hypogonadism: double blind placebo-controlled trial; with clomiphene citrate. J Clin Endocrinol Metab 1995; 80: 3546-3552.
45. Burge M. R., Lanzi R. A., Skarda S. T., Eaton R. P. Idiopathic hypogonadotropic hypogonadism in a male runner is reserved by clomiphene citrate. Fertil Steril 1997; 67: 783-785.
46. Taxel P., Kennedy D. G., Fall P. M., Willard A. K., Clive J. M., Raisez L. G. The effect of aromatase inhibition on sex steroids, gonadotropins, and markers of bone turnover in older men. J Clin Endocrinol Meab 2001; 86: 2869-2874.