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Volumn 81, Issue 3, 2003, Pages 135-140

Pharmacogenetics and pharmacogenomics: Recent developments, their clinical relevance and some ethical, social, and legal implications

Author keywords

Ethics; Medical genomics; Pharmacogenetics; Pharmacogenomics; Social accountability

Indexed keywords

BIOMEDICAL TECHNOLOGY ASSESSMENT; CLINICAL MEDICINE; CLINICAL RESEARCH; CLINICAL STUDY; DIAGNOSIS; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; DRUG USE; ECONOMICS; ETHICS; EVIDENCE BASED MEDICINE; GENETIC VARIABILITY; GENOTYPE; HEALTH CARE COST; HUMAN; LEGAL ASPECT; MEDICAL GENETICS; MEDICAL PRACTICE; METABOLISM; MODEL; MOLECULAR BIOLOGY; NONHUMAN; PERFORMANCE; PHARMACOGENETICS; PHARMACOGENOMICS; REVIEW; RISK BENEFIT ANALYSIS; SOCIAL ASPECT;

EID: 0037362097     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-002-0415-6     Document Type: Review
Times cited : (28)

References (43)
  • 1
    • 0035340020 scopus 로고    scopus 로고
    • Anticipating molecular medicine: Smooth transition from biomedical science to clinical practice?
    • Paul NW (2001) Anticipating molecular medicine: smooth transition from biomedical science to clinical practice? Am Fam Physician 63:1704-1706
    • (2001) Am Fam Physician , vol.63 , pp. 1704-1706
    • Paul, N.W.1
  • 2
    • 0033616127 scopus 로고    scopus 로고
    • From genotype to phenotype: Genetics and medical practice in the new millennium
    • Weatherall D (1999) From genotype to phenotype: genetics and medical practice in the new millennium. Philos Trans R Soc Lond B Biol Sci 3541995-2010
    • (1999) Philos Trans R Soc Lond B Biol Sci , pp. 3541995-3542010
    • Weatherall, D.1
  • 3
    • 0033928586 scopus 로고    scopus 로고
    • Impact of genomics on drug discovery and clinical medicine
    • Emilien G, et al (2000) Impact of genomics on drug discovery and clinical medicine. Q J Med 93:391-423
    • (2000) Q J Med , vol.93 , pp. 391-423
    • Emilien, G.1
  • 4
    • 0033159122 scopus 로고    scopus 로고
    • New collaborations make pharmacogenomics a SNP
    • Dawson E (1999) New collaborations make pharmacogenomics a SNP. Mol Med Today 5:280
    • (1999) Mol Med Today , vol.5 , pp. 280
    • Dawson, E.1
  • 5
    • 0033569516 scopus 로고    scopus 로고
    • Pharmacogenomics: Translating functional genomics into rational therapeutics
    • Evans WE, Relling MV (1999) Pharmacogenomics: translating functional genomics into rational therapeutics. Science 286:487-491
    • (1999) Science , vol.286 , pp. 487-491
    • Evans, W.E.1    Relling, M.V.2
  • 6
    • 12444313182 scopus 로고    scopus 로고
    • Die molekulargenetische interpretation des krebs: Ein paradigma, seine entwicklung und einige konsequenzen
    • Eckard W (ed). Thieme, Stuttgart
    • Paul NW (2000) Die molekulargenetische Interpretation des Krebs: ein Paradigma, seine Entwicklung und einige Konsequenzen/The molecular interpretation of cancer: a paradigm, a story, some consequences. In: Eckard W (ed) 100 years of organized cancer research. Thieme, Stuttgart, pp 95-100
    • (2000) 100 Years of Organized Cancer Research , pp. 95-100
    • Paul, N.W.1
  • 7
    • 0035865322 scopus 로고    scopus 로고
    • A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms
    • International SNP Map Working Group (2001) A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature 409:928-933
    • (2001) Nature , vol.409 , pp. 928-933
  • 8
    • 0034676273 scopus 로고    scopus 로고
    • Will genetics revolutionize medicine?
    • Sotos JG, et al (2000) Will genetics revolutionize medicine? N Engl J Med 343:1496-1498
    • (2000) N Engl J Med , vol.343 , pp. 1496-1498
    • Sotos, J.G.1
  • 9
    • 0034123469 scopus 로고    scopus 로고
    • How to count human genes
    • Aparicio SAJR (2000) How to count human genes. Nat Genet 25:129-130
    • (2000) Nat Genet , vol.25 , pp. 129-130
    • Aparicio, S.A.J.R.1
  • 10
    • 0034084035 scopus 로고    scopus 로고
    • Analysis of expressed sequence tags indicates 35:000 human genes
    • Ewing B, Green P (2000) Analysis of expressed sequence tags indicates 35:000 human genes. Nat Genet 25:232-234
    • (2000) Nat Genet , vol.25 , pp. 232-234
    • Ewing, B.1    Green, P.2
  • 11
    • 0034644254 scopus 로고    scopus 로고
    • Will genetics revolutionize medicine?
    • Holtzman NA, Marteau TM (2000) Will genetics revolutionize medicine? N Engl J Med 343:141-144
    • (2000) N Engl J Med , vol.343 , pp. 141-144
    • Holtzman, N.A.1    Marteau, T.M.2
  • 12
    • 0030776694 scopus 로고    scopus 로고
    • Genetic testing for Alzheimer disease. Practical and ethical issues
    • Roses AD (1997) Genetic testing for Alzheimer disease. Practical and ethical issues. Arch Neurol 54:1226-1229
    • (1997) Arch Neurol , vol.54 , pp. 1226-1229
    • Roses, A.D.1
  • 13
    • 0035951501 scopus 로고    scopus 로고
    • The use of common genetic polymorphisms to enhance the epidemiologic study of environmental carcinogens
    • Rothman N, et al (2001) The use of common genetic polymorphisms to enhance the epidemiologic study of environmental carcinogens. Biochim Biophys Acta 2:C1-C10
    • (2001) Biochim Biophys Acta , vol.2
    • Rothman, N.1
  • 14
    • 0034930262 scopus 로고    scopus 로고
    • The relative power of SNPs and haplotype as genetic markers for association tests
    • Bader JS (2001) The relative power of SNPs and haplotype as genetic markers for association tests. Pharmacogenomics 2:11-24
    • (2001) Pharmacogenomics , vol.2 , pp. 11-24
    • Bader, J.S.1
  • 15
    • 17144461485 scopus 로고    scopus 로고
    • A novel procedure for efficient genotyping of single nucleotide polymorphisms
    • Sauer S, et al (2000) A Novel procedure for efficient genotyping of single nucleotide polymorphisms. Nucleic Acids Res 28:E13
    • (2000) Nucleic Acids Res , vol.28
    • Sauer, S.1
  • 16
    • 0033403326 scopus 로고    scopus 로고
    • Technologies for detecting genetic polymorphisms in pharmacogenomics
    • Shi MM, Bleavins MR, de la Iglesia FA (1999) Technologies for detecting genetic polymorphisms in pharmacogenomics. Mol Diagn 4:343-351
    • (1999) Mol Diagn , vol.4 , pp. 343-351
    • Shi, M.M.1    Bleavins, M.R.2    De La Iglesia, F.A.3
  • 17
    • 0034139860 scopus 로고    scopus 로고
    • High-throughput genotyping assay approaches
    • Kwok PY (2000) High-throughput genotyping assay approaches. Pharmacogenomics 1:95-100
    • (2000) Pharmacogenomics , vol.1 , pp. 95-100
    • Kwok, P.Y.1
  • 18
    • 0034655976 scopus 로고    scopus 로고
    • Pharmacogenetics and future drug development and delivery
    • Roses AD (2000) Pharmacogenetics and future drug development and delivery. Lancet 355:1358-1361
    • (2000) Lancet , vol.355 , pp. 1358-1361
    • Roses, A.D.1
  • 19
    • 0034660560 scopus 로고    scopus 로고
    • Pharmacogenetics and the practice of medicine
    • Roses AD (2000) Pharmacogenetics and the practice of medicine. Nature 405:857-865
    • (2000) Nature , vol.405 , pp. 857-865
    • Roses, A.D.1
  • 20
    • 0035958868 scopus 로고    scopus 로고
    • Genetics. SNP-ing drugs to size
    • Gura T (2001) Genetics. SNP-ing drugs to size. Science 293:595
    • (2001) Science , vol.293 , pp. 595
    • Gura, T.1
  • 21
    • 0034139799 scopus 로고    scopus 로고
    • The predictive power of haplotypes in clinical response
    • Judson R, Stephens JC, Windemuth A (2000) The predictive power of haplotypes in clinical response. Pharmacogenomics 1:15-26
    • (2000) Pharmacogenomics , vol.1 , pp. 15-26
    • Judson, R.1    Stephens, J.C.2    Windemuth, A.3
  • 22
    • 0034929664 scopus 로고    scopus 로고
    • Notes from the SNP vs. haplotype front
    • Judson R, Stephens JC (2001) Notes from the SNP vs. haplotype front. Pharmacogenomics 2:7-10
    • (2001) Pharmacogenomics , vol.2 , pp. 7-10
    • Judson, R.1    Stephens, J.C.2
  • 23
    • 0034022213 scopus 로고    scopus 로고
    • The use of single-nucleotide polymorphism maps in pharmacogenomics
    • McCarthy JJ, Hilfiker R (2000) The use of single-nucleotide polymorphism maps in pharmacogenomics. Nat Biotechnol 18:505-508
    • (2000) Nat Biotechnol , vol.18 , pp. 505-508
    • McCarthy, J.J.1    Hilfiker, R.2
  • 24
    • 0032748555 scopus 로고    scopus 로고
    • Pharmacogenetics and pharmacogenomics: Why is this relevant to the clinical geneticist?
    • Nebert DW (1999) Pharmacogenetics and pharmacogenomics: why is this relevant to the clinical geneticist? Clin Genet 56:247-258
    • (1999) Clin Genet , vol.56 , pp. 247-258
    • Nebert, D.W.1
  • 25
    • 0034139510 scopus 로고    scopus 로고
    • The use of single nucleotide polymorphisms in the isolation of common disease genes
    • Riley JH, et al (2000) The use of single nucleotide polymorphisms in the isolation of common disease genes. Pharmacogenomics 1:39-47
    • (2000) Pharmacogenomics , vol.1 , pp. 39-47
    • Riley, J.H.1
  • 27
    • 0036397680 scopus 로고    scopus 로고
    • Technologies for individual genotyping: Detection of genetic polymorphisms in drug targets and disease genes
    • Shi MM (2002) Technologies for individual genotyping: detection of genetic polymorphisms in drug targets and disease genes. Am J Pharmcogenomics 2:197-205
    • (2002) Am J Pharmcogenomics , vol.2 , pp. 197-205
    • Shi, M.M.1
  • 28
    • 0035286694 scopus 로고    scopus 로고
    • Ethical and legal implications of pharmacogenomics
    • Rothstein MA, Epps PG (2001) Ethical and legal implications of pharmacogenomics. Nat Rev Genet 2:228-231
    • (2001) Nat Rev Genet , vol.2 , pp. 228-231
    • Rothstein, M.A.1    Epps, P.G.2
  • 29
    • 0034192322 scopus 로고    scopus 로고
    • Clinical trials in pharmacogenetics and pharmacogenomics: Methods and applications
    • Rioux PP (2000) Clinical trials in pharmacogenetics and pharmacogenomics: methods and applications. Am J Health-Syst Pharm 57:887-898
    • (2000) Am J Health-Syst Pharm , vol.57 , pp. 887-898
    • Rioux, P.P.1
  • 30
    • 0028809482 scopus 로고
    • Informed consent for genetic research on stored tissue samples
    • Clayton EW, et al (1995) Informed consent for genetic research on stored tissue samples. JAMA 274:1786-1792
    • (1995) JAMA , vol.274 , pp. 1786-1792
    • Clayton, E.W.1
  • 31
    • 0034189084 scopus 로고    scopus 로고
    • Current pharmacogenomic approaches to clinical drug development
    • Murphy MP (2000) Current pharmacogenomic approaches to clinical drug development. Pharmacogenomics 1:115-123
    • (2000) Pharmacogenomics , vol.1 , pp. 115-123
    • Murphy, M.P.1
  • 32
    • 85038454022 scopus 로고    scopus 로고
    • Press Office of the President of the United States, Washington
    • Clinton B (2000) On human subjects in clinical trials. Press Office of the President of the United States, Washington
    • (2000) On Human Subjects in Clinical Trials
    • Clinton, B.1
  • 33
    • 12444292395 scopus 로고
    • The discursive construction of economic space: Logics of organization and disorganization
    • Daly G (1991) The discursive construction of economic space: logics of organization and disorganization. Econ Soc 23:173-200
    • (1991) Econ Soc , vol.23 , pp. 173-200
    • Daly, G.1
  • 34
    • 0033086312 scopus 로고    scopus 로고
    • Human genome epidemiology (HuGE): Translating advances in human genetics into population-based data for medicine and public health
    • Khoury MJ (1999) Human genome epidemiology (HuGE): translating advances in human genetics into population-based data for medicine and public health. Genet Med 1:71-73
    • (1999) Genet Med , vol.1 , pp. 71-73
    • Khoury, M.J.1
  • 35
    • 0033941114 scopus 로고    scopus 로고
    • Human genome epidemiologic reviews: The beginning of something HuGE
    • Khoury MJ, Little J (2000) Human genome epidemiologic reviews: the beginning of something HuGE. Am J Epidemiol 151:2-3
    • (2000) Am J Epidemiol , vol.151 , pp. 2-3
    • Khoury, M.J.1    Little, J.2
  • 36
    • 0029366376 scopus 로고
    • Medical technology assessment and ethics - Ambivalent relations
    • Have H ten (1995) Medical technology assessment and ethics - ambivalent relations. Hastings Cent Rep 25:13-19
    • (1995) Hastings Cent Rep , vol.25 , pp. 13-19
    • Ten Have, H.1
  • 39
    • 0029433964 scopus 로고
    • The social construction of medical knowledge
    • Jordanova L (1995) The social construction of medical knowledge. Soc History Med 8:361-381
    • (1995) Soc History Med , vol.8 , pp. 361-381
    • Jordanova, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.