Androgen receptor activity at the prostate specific antigen locus: Steroidal and non-steroidal mechanisms

Molecular Cancer Research

Volumn 1, Issue 5, 2003, Pages 385-392

  Jia, Li ^a,b   Kim, Joshua ^a,b   Shen, Howard ^a,b   Clark, Peter E ^a,b   Tilley, Wayne D ^c   Coetzee, Gerhard A ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ANDROSTANOLONE; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; HISTONE; HISTONE H3; INTERLEUKIN 6; LIGAND; MESSENGER RNA; PROSTATE SPECIFIC ANTIGEN; PROTEIN P300; STEROID;

ACETYLATION; ANTIGEN EXPRESSION; ARTICLE; CANCER GROWTH; CELL PROLIFERATION; CHROMATIN; CONTROLLED STUDY; ENHANCER REGION; GENE ACTIVATION; GENE LOCUS; GENE TARGETING; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE CANCER; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RECEPTOR OCCUPANCY; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

ACETYLATION; ADENYLATE CYCLASE; CELL DIVISION; DIHYDROTESTOSTERONE; FORSKOLIN; GENES, REPORTER; HISTONES; HUMANS; INTERLEUKIN-6; LIGANDS; LUCIFERASES; MALE; PROMOTER REGIONS (GENETICS); PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; TUMOR CELLS, CULTURED;

EID: 0037360627     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Buchanan, G., Irvine, R. A., Coetzee, G. A., and Tilley, W. D. Contribution of the androgen receptor to prostate cancer predisposition and progression. Cancer Metastasis Rev., 20: 207-223, 2001.
2. Balk, S. Androgen receptor as a target in androgen-independent prostate cancer. Urology, 60: 132, 2002.
3. Feldman, B. J. and Feldman, D. The development of androgen-independent prostate cancer. Nat. Rev. Cancer, 1: 34-45, 2001.
4. Ueda, T., Bruchovsky, N., and Sadar, M. D. Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways. J. Biol. Chem., 277: 7076-7085, 2002.
5. Culig, Z., Bartsch, G., and Hobisch, A. Interleukin-6 regulates androgen receptor activity and prostate cancer cell growth. Mol. Cell. Endocrinol., 197: 231-238, 2002.
6. Ueda, T., Mawji, N. R., Bruchovsky, N., and Sadar, M. D. Ligand-independent activation of the androgen receptor by IL-6 and the role of the coactivator SRC-1 in prostate cancer cells. J. Biol. Chem., 277: 38087-38094, 2002.
7. Debes, J. D., Schmidt, L. J., Huang, H., and Tindall, D. J. p300 mediates androgen-independent transactivation of the androgen receptor by interleukin 6. Cancer Res., 62: 5632-5636, 2002.
8. Pratt, W. B. and Toft, D. O. Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocr. Rev., 18: 306-360, 1997.
9. Tyagi, R. K., Lavrovsky, Y., Ahn, S. C., Song, C. S., Chatterjee, B., and Roy, A. K. Dynamics of intracellular movement and nucleocytoplasmic recycling of the ligand-activated androgen receptor in living cells. Mol. Endocrinol., 14: 1162-1174, 2000.
10. Rosenfeld, M. G. and Glass, C. K. Coregulator codes of transcriptional regulation by nuclear receptors. J. Biol. Chem., 276: 36865-36868, 2001.
11. Cleutjens, K. B., van Eekelen, C. C., van der Korput, H. A., Brinkmann, A. O., and Trapman, J. Two androgen response regions cooperate in steroid hormone regulated activity of the prostate-specific antigen promoter. J. Biol. Chem., 271: 6379-6388, 1996.
12. Farmer, G., Connolly, E. S., Jr., Mocco, J., and Freedman, L. P. Molecular analysis of the prostate-specific antigen upstream gene enhancer. Prostate, 46: 76-85, 2001.
13. Huang, W., Shostak, Y., Tarr, P., Sawyers, C., and Carey, M. Cooperative assembly of androgen receptor into a nucleoprotein complex that regulates the prostate-specific antigen enhancer. J. Biol. Chem., 274: 25756-25768, 1999.
14. Shang, Y., Myers, M., and Brown, M. Formation of the androgen receptor transcription complex. Mol. Cell, 9: 601-610, 2002.
15. Ma, H., Hong, H., Huang, S. M., Irvine, R. A., Webb, P., Kushner, P. J., Coetzee, G. A., and Stallcup, M. R. Multiple signal input and output domains of the 160-kilodalton nuclear receptor coactivator proteins. Mol. Cell. Biol., 19: 6164-6173, 1999.
16. Irvine, R. A., Ma, H., Yu, M. C., Ross, R. K., Stallcup, M. R., and Coetzee, G. A. Inhibition of p160-mediated coactivation with increasing androgen receptor polyglutamine length. Hum. Mol. Genet., 9: 267-274, 2000.
17. Chen, D., Huang, S. M., and Stallcup, M. R. Synergistic, p160 coactivatordependent enhancement of estrogen receptor function by CARM1 and p300. J. Biol. Chem., 275: 40810-40816, 2000.
18. Dotzlaw, H., Moehren, U., Mink, S., Cato, A. C., Iniguez Lluhi, J. A., and Baniahmad, A. The amino terminus of the human AR is target for corepressor action and antihormone agonism. Mol. Endocrinol., 16: 661-673, 2002.
19. Cheng, S., Brzostek, S., Lee, S. R., Hollenberg, A. N., and Balk, S. P. Inhibition of the dihydrotestosterone-activated androgen receptor by nuclear receptor corepressor. Mol. Endocrinol., 16: 1492-1501, 2002.
20. Shang, Y., Hu, X., DiRenzo, J., Lazar, M. A., and Brown, M. Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell, 103: 843-852, 2000.
21. Kang, Z., Pirskanen, A., Janne, O. A., and Palvimo, J. J. Involvement of proteasome in the dynamic assembly of the androgen receptor transcription complex. J. Biol. Chem., 277: 48366-48371, 2002.
22. Sadar, M. D., Hussain, M., and Bruchovsky, N. Prostate cancer: molecular biology of early progression to androgen independence. Endocr. Relat. Cancer, 6: 487-502, 1999.
23. Chen, T., Cho, R. W., Stork, P. J., and Weber, M. J. Elevation of cyclic adenosine 3′,5′-monophosphate potentiates activation of mitogen-activated protein kinase by growth factors in LNCaP prostate cancer cells. Cancer Res., 59: 213-218, 1999.
24. Yeh, S., Lin, H. K., Kang, H. Y., Thin, T. H., Lin, M. F., and Chang, C. From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells. Proc. Natl. Acad. Sci. USA, 96: 5458-5463, 1999.
25. Craft, N., Shostak, Y., Carey, M., and Sawyers, C. L. A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase. Nat. Med., 5: 280-285, 1999.
26. Smith, P. C., Hobisch, A., Lin, D. L., Culig, Z., and Keller, E. T. Interleukin-6 and prostate cancer progression. Cytokine Growth Factor Rev., 12: 33-40, 2001,
27. Chung, T. D., Yu, J. J., Spiotto, M. T., Bartkowski, M., and Simons, J. W. Characterization of the role of IL-6 in the progression of prostate cancer. Prostate, 38: 199-207, 1999.
28. Hobisch, A., Ramoner, R., Fuchs, D., Godoy-Tundidor, S., Bartsch, G., Klocker, H., and Culig, Z. Prostate cancer cells (LNCaP) generated after longterm interleukin 6 (IL-6) treatment express IL-6 and acquire an IL-6 partially resistant phenotype. Clin. Cancer Res., 7: 2941-2948, 2001.
29. Blais, Y., Sugimoto, K., Carriere, M. C., Haagensen, D. E., Labrie, F., and Simard, J. Interleukin-6 inhibits the potent stimulatory action of androgens, glucocorticoids and interleukin-1 α on apolipoprotein D and GCDFP-15 expression in human breast cancer cells. Int. J. Cancer, 62: 732-737, 1995.
30. Kasper, S., Rennie, P. S., Bruchovsky, N., Lin, L., Cheng, H., Snoek, R., Dahlman-Wright, K., Gustafsson, J. A., Shiu, R. P., Sheppard, P. C., and Matusik, R. J. Selective activation of the probasin androgen-responsive region by steroid hormones. J. Mol. Endocrinol., 22: 313-325, 1999.
31. Snoek, R., Bruchovsky, N., Kasper, S., Matusik, R. J., Gleave, M., Sato, N., Mawji, N. R., and Rennie, P. S. Differential transactivation by the androgen receptor in prostate cancer cells. Prostate, 36: 256-263, 1998.