Role of phosphatase PTEN in the activation of extracellular signal-regulated kinases induced by estradiol in endometrial carcinoma cells

Chinese Medical Journal

Volumn 116, Issue 3, 2003, Pages 383-387

  Zhang, Yujun ^a   Wei, Lihui ^a   Wang, Jianliu ^a   Sun, Tiezheng ^a  

^a PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

Author keywords

Endometrial carcinoma; Estradiol extracellular signal regulated kinase; Phosphatase and tensin homologue

Indexed keywords

ESTRADIOL; ESTROGEN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; RECEPTOR SUBTYPE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOMETRIUM CARCINOMA; ENZYME ACTIVATION; FIBROBLAST CULTURE; GENE EXPRESSION; GENETIC TRANSFECTION; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

3T3 CELLS; ANIMALS; ENDOMETRIAL NEOPLASMS; ENZYME ACTIVATION; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORIC MONOESTER HYDROLASES; PTEN PHOSPHOHYDROLASE; RECEPTORS, ESTROGEN; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0037360318     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Weisz A, Bresciani F. Estrogen regulation of proto-oncogene coding for nuclear proteins. Crit Rev Oncogen 1993;4:361-388.
2. Castoria G, Barone MV, Domenico MD, et al. Non-transcriptional action of estradiol and progestin triggers DNA synthesis. EMBO J 1999;18:2500-2510.
3. Risinger JI, Hayes AK, Berchuck A, et al. PTEN/MMAC1 mutations in endometrial cancers. Cancer Res 1997;57:4736-4738.
4. Mutter GL, Lin MC, Fitzgerald JT, et al. Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers. J Nat Cancer Inst 2000;92:924-931.
5. Stambolic V, Tsao MS, Macpherson D, et al. High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten +/- mice. Oncogene 2000;234:567-589.
6. Yaginuma Y, Yamashita T, Ishiva T, et al. Abnormal structure and expression of PTEN/MMAC1 gene in human uterine cancers. Mol Carcinog 2000;2:110-116.
7. Li JJ. Estrogen carcinogenesis in hamster tissues: update. Endocr Rev 1993;1:94-95.
8. Migliaccio A, Domenico MD, Castoria G, et al. Tyrosine kinase/p21ras/MAP-Kinase pathway activation by estradiol-receptor complex in MCF-7 cells. EMBO J 1996;15:1292-1300.
9. Morrison DK. A MAPK scaffold of the Ras pathway. J Cell Sci 2001;114:1609-1612.
10. Simoncini T, Moghadam A, Brazil DP, et al. Interaction of estrogen receptor withtheregulationsubunitofphosphatidylinositol-3-OH kinase. Nature 2000;407:538-541.
11. Paech K, Webb P, Kuiper GG, et al. Differential ligand activation of estrogen receptors Erand ER at AP1 site. Science 1997;277:1508-1510.
12. Li J, Yen C, Liaw D, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate. Science 1997;5308:1943-1947.
13. Maehama T, Dixon JE. PTEN: a tumour suppressor that functions as a phospholipid phosphatase. Trends Cell Biol 1999; 4:125-128.
14. Myers MP, Pass I, Batty IH. The lipid phosphatase activity of PTEN is critical for its tumor suppressor function. Proc Natl Acad Sci U S A 1998;23:13513-13518.
15. Mutter GL, Lin MC, Fitzgerald JT, et al. Changes in endometrial PTEN expression throughout the human menstrual cycle. J Clin Endocrinol Metab 2000;85:1-5.