Sensitivity to methylmercury-induced autoimmune disease in mice correlates with resistance to apoptosis of activated CD4+ lymphocytes

Journal of Autoimmunity

Volumn 20, Issue 2, 2003, Pages 147-160

  Pheng, Say Ry ^a,b   Auger, Chantal ^a,b   Chakrabarti, Saroj ^a   Massicotte, Eric ^b   Lamontagne, Lucie ^b  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITÉ DU QUÉBEC À MONTRÉAL   (Canada)

Author keywords

Activation; Apoptosis; Autoimmunity; Immunodeficiency; Methylmercury; T lymphocytes

Indexed keywords

CD4 ANTIGEN; CONCANAVALIN A; FAS ANTIBODY; LIPOCORTIN 5; METHYLMERCURY; PROPIDIUM IODIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CELL STIMULATION; CELL SUBPOPULATION; CONTROLLED STUDY; DRUG INDUCED DISEASE; FEMALE; FLOW CYTOMETRY; LYMPHOCYTE ACTIVATION; LYMPHOID CELL; MOUSE; MOUSE STRAIN; NICK END LABELING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SPLEEN CELL;

EID: 0037347684     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-8411(02)00115-4     Document Type: Article

References (40)

1. Bagenstone L.M., Salgame P., Monestier M. Methylmercury-induced autoimmunity: a model of chemically related autoimmunity in humans. Immunol Res. 20:1999;67-78.
2. Blakely B.R., Sisodia C.S., Mukkur T.M. The effect of methylmercury, tetraethyl lead, and sodium arsenite on the humoral response in mice. Toxicol Appl Pharmacol. 52:1980;245-254.
3. Koller L.D., Exon J.H., Arbogast B. Methylmercury: effect of serum enzymes on humoral antibody. J Toxicol Environ Health. 2:1977;115-123.
4. Ohi G., Fukuda M., Deto H., Yagya H. Effect of methylmercury on humoral immune responses in mice under conditions simulated to practical situation. Bull Environ Contam Toxicol. 15:1976;175-180.
5. Ilback N.G. Effects of methylmercury exposure on spleen and blood natural killer (NK) cell activity in the mouse. Toxicology. 67:1991;117-124.
6. Hultmann P., Hansson-Georgiadis H. Methyl mercury-induced autoimmunity in mice. Toxicol Appl Pharmacol. 154:1999;203-211.
7. Hu H., Abedi-Valugerdi M., Moller G. Pretreatment of lymphocytes with mercury in vitro induces a response in T cells from genetically determined low responders and a shift of the interleukin profile. Immunology. 90:1997;198-204.
8. Pheng S., Chakrabarti S., Lamontagne L. Dose-dependent apoptosis induced by low concentrations of methylmercury in murine Fas+ T cell subsets. Toxicology. 149:2000;115-128.
9. Thompson S.A., Roellich K.L., Grossmana A., Gilbert S.G., Kavanagh T.J. Alterations in immune parameters associated with low level methylmercury exposure in mice. Immunopharmacol Immunotoxicol. 20:1988;299-314.
10. Hultman P., Bell L.J., Enestrom S., Pollard K.M. Murine susceptibility to mercury. I. Autoantibody profiles and systemic immune deposits in inbred, congenic, and intra-H-2-recombinant strains. Clin Immunol Immunopathol. 65:1992;98-109.
11. Hultman P., Turley S.J., Enestrom S., Lindh U., Pollard K.M. Murine genotype influences the specificity, magnitude and persistence of murine mercury-induced autoimmunity. J Autoimmun. 9:1996;139-149.
12. 2on murine lymphocytes. I. Preferable activation of CD4+ T cells in a responder strain. J Immunol. 154:1995;3138-3146.
13. Johansson U., Hansson-Georgiadis H., Hultman P. Murine silver-induced autoimmunity: silver shares induction of antinucleolar antibodies with mercury, but causes less activation of the immune system. Int Arch Allergy Immunol. 113:1997;432-443.
14. Zhou T., Bluethmann H., Zhang J., Edwards C.K., Mountz J.D. Defective maintenance of T cell tolerance to a superantigen in MRL lpr/lpr mice. J Exp Med. 176:1992;1063-1072.
15. Allena D.G., Johnson E.B., Wilson J., Beller D.I., Conlon P.J. SJL and NOD macrophages are uniquely characterized by genetically programmed, elevated expression of the IL-12 (p40) genes suggesting a conservative pathway for the induction of organ-specific autoimmunity. J Leukoc Biol. 69:2001;440-448.
16. Nakatsuru S., Oohashi J., Nozaki H., Nakada S., Imura N. Effect of mercurials on lymphocyte functions. Toxicology. 36:1985;297-305.
17. Thuvander A., Sundberg J., Oskarsson A. Immunomodulation effects after perinatal exposure to methylmercury in mice. Toxicology. 114:1996;163-175.
18. Brown D.L., Reuhlk K.R., Bormann S., Little J.E. Effects of methyl mercury on the microtubule system of mouse lymphocytes. Toxicol Appl Pharmacol. 94:1988;66-75.
19. Telford W.G., King L.E., Fraker P.J. Evaluation of glucocorticoid-induced DNA fragmentation in mouse thymocytes by flow cytometry. Cell Prolif. 24:1991;447-455.
20. Hotz M.A., Gong J., Traganos F., Darzynkiewicz Z. Flow cytometric detection of apoptosis: comparison of the assays of in situ DNA degradation and chromatin changes. Cytometry. 15:1994;237-244.
21. Mosmann T.J. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxic assays. J Immunol Methods. 65:1983;55-63.
22. Gerlier D., Thomasset N. Use of MTT colorimetric assay to measure cell activation. J Immunol Methods. 94:1986;57-63.
23. Kayagaki N., Yamaguchi N., Nagae F., Matsuo S., Maeda H., Okumura K., et al. Polymorphism of murine Fas ligand that affects the biological activity. Proc Natl Acad Sci USA. 94:1997;3914-3919.
24. Kroemer G., Petit P., Zamzami N., Vayssiere J.L., Mignotte B. The biochemistry of programmed cell death. FASEB J. 9:1995;1277-1282.
25. Shenker B.J., Datar S., Mansfield K., Shapiro I.M. Induction of apoptosis in human T-cells by organomercuric compounds: a flow cytometry analysis. Toxicol Appl Pharmacol. 143:1997;397-405.
26. Close A.H., Guo T.L., Shenker B.J. Activated human T lymphocytes exhibit reduced susceptibility to methylmercury chloride-induced apoptosis. Toxicol Sci. 49:1999;68-77.
27. Salmon M., Pilling D., Borthwick N.J., Viner N., Janossy G., Bacon P.A., et al. The progressive differentiation of primed T cells is associated with susceptibility to apoptosis. Eur J Immunol. 24:1994;892-899.
28. Sansom D.M., Hall N.D. B7-BB1, the ligand for CD28 is expressed on repeatedly activated human T cells in vitro. Eur J Immunol. 23:1993;295-301.
29. Lu L., Oian S., Hershberger P.A., Rudert W.A., Lynch D.H., Thomson A.W. Fas Ligand (CD95L) and B7 expression on dendritic cells provide counter-regulatory signals for T cell survival and proliferation. J Immunol. 158:1997;5676-5685.
30. Dhein J., Walczak H., Baulmer C., Debatin K.M., Krammer P.H. Autocrine T-cell suicide mediated by APO-1(Fas/CD95). Nature. 373:1995;438-440.
31. Ju S.T., Panka D.J., Cui H., Erringer R., El-Khatib M., Sherr D.H., et al. Fas (CD95)/FasL interactions required for programmed cell death after T cell activation. Nature. 373:1995;444-446.
32. Shenker B.J., Guo T.L., Shapiro I.M. Induction of apoptosis in human T cells by methylmercury: temporal relationship between mitochondrial dysfunction and loss of reductive reserve. Toxicol Appl Pharmacol. 157:1999;23-35.
33. Shenker B.J., Guo T.L., Shapiro I.M. Mercury-induced apoptosis in human lymphoid cells: evidence that the apoptotic pathway is mercurial species dependent. Environ Res. 84:2000;89-99.
34. Irani D.N. The susceptibility of mice to immune-mediated neurologic disease correlated with the degree to which their lymphocytes resist the effects of brain-derived gangliosides. J Immunol. 161:1998;2746-2752.
35. Choi Y., Simon-Stoos K., Puck J. Hypo-reactive variant of IL-2 and associated decreased T cell activation contributes to impaired apoptosis in autoimmune prone MRL mice. Eur J Immunol. 32:2002;677-685.
36. Behlke M.A., Chou H.S., Huppi K., Loh D.Y. Murine T-cell receptor mutants with deletions of β-chain variable region genes. Proc Natl Acad Sci USA. 83:1986;767-772.
37. Zhang J., Su X., Liu D., Liu W., Yang P., Wang Z., et al. Induction of specific T cell tolerance by Fas Ligand-expressing antigen-presenting cells. J Immunol. 162:1999;1423-1430.
38. Whitekus M.J., Santini R.P., Rosenspire A.J., McCabe M.J. Jr. Protection against CD95-mediated apoptosis by inorganic mercury in Jurkat T cells. J Immunol. 162:1999;7162-7170.
39. Pollard K., Lee D., Casiano C., Bluthner M., Johnston M., Tan E. The autoimmunity-inducing xenobiotic mercury interacts with the autoantigen fibrillarin and modifies its molecular and antigenic properties. J Immunol. 158:1997;3521-3528.
40. Kubicka-Muranyi M., Kremer J., Rottman N., Lubben B., Albers R., Bloksma N., et al. Murine systemic autoimmune disease induced by mercuric chloride: T helper cells reacting to self proteins. Int Arch Allergy Immunol. 109:1996;11-20.