Assessment of p53 gene transfer and biological activities in a clinical study of adenovirus-p53 gene therapy for recurrent ovarian cancer

Cancer Gene Therapy

Volumn 10, Issue 3, 2003, Pages 224-238

  Wen, Shu Fen ^a   Mahavni, Vikas ^b   Quijano, Erlinda ^a   Shinoda, Jeremy ^a   Grace, Michael ^a   Musco Hobkinson, Mary Lynn ^a   Yang, Tong Yuan ^a   Chen, Yuetian ^a   Runnenbaum, Ingo ^c   Horowitz, JoAnn ^a   Maneval, Dan ^a   Hutchins, Beth ^a   Buller, Richard ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Gene therapy; Ovarian cancer; QPCR; rAd p53; SCH 58500

Indexed keywords

GEMCITABINE; PROTEIN BAX; PROTEIN MDM2; PROTEIN P21; PROTEIN P53; SURVIVIN;

ADENOVIRUS; ARTICLE; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE TRANSFER; GENETIC PROCEDURES; HUMAN; HUMAN CELL; NEUTROPHIL; OVARY CARCINOMA; PARTICULATE MATTER; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECURRENT DISEASE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR BIOPSY; UPREGULATION; VIRUS RECOMBINANT; WILD TYPE;

ADENOVIRIDAE; APOPTOSIS; ASCITIC FLUID; BIOPSY; COHORT STUDIES; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; FEMALE; GENE EXPRESSION; GENES, P53; GENETIC VECTORS; HUMANS; NEOPLASM RECURRENCE, LOCAL; OVARIAN NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P53; VIRION;

ADENOVIRIDAE;

EID: 0037347453     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700562     Document Type: Article

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