Development and validation of sensitive assays to quantitate gene expression after p53 gene therapy and paclitaxel chemotherapy using in vivo dosing in tumor xenograft models

Cancer Gene Therapy

Volumn 7, Issue 11, 2000, Pages 1469-1480

  Wen, Shu Fen ^a   Xie, Lei ^a   Mcdonald, Matthew ^a   Digiacomo, Ruth ^a   Chang, Alice ^a   Gurnani, Maya ^a   Shi, Bin ^a   Liu, Suxing ^a   Indelicato, Stephen R ^a   Hutchins, Beth ^a   Nielsen, Loretta L ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Bax; Bcl 2; p21; p53 tumor suppressor gene therapy; Paclitaxel; Survivin

Indexed keywords

ACN 53; ANTINEOPLASTIC AGENT; PACLITAXEL; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; SCH 58500; SURVIVIN; UNCLASSIFIED DRUG;

ADENOVIRUS 5; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CANCER CHEMOTHERAPY; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; FEMALE; GENE EXPRESSION; HOUSEKEEPING GENE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MOUSE; MULTIMODALITY CANCER THERAPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TREATMENT OUTCOME; TUMOR BIOPSY; TUMOR SUPPRESSOR GENE; TUMOR XENOGRAFT; VALIDATION PROCESS;

ADENOVIRIDAE; ANIMALIA; HUMAN ADENOVIRUS TYPE 5;

EID: 0033664328     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700257     Document Type: Article

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