Light chain crystal deposition as a manifestation of plasma cell dyscrasias: The role of immunoelectron microscopy

Human Pathology

Volumn 34, Issue 3, 2003, Pages 270-277

  Gu, Xin ^b   Barrios, Roberto ^b   Cartwright, Joiner ^b   Font, Ramon L ^b   Truong, Luan ^b   Herrera, Guillermo A ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b NONE

Author keywords

Crystals; Immunoelectron microscopy; Kappa; Plasma cell dyscrasia

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CRYSTAL STRUCTURE; DIAGNOSTIC ERROR; DIAGNOSTIC PROCEDURE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOELECTRON MICROSCOPY; IMMUNOFLUORESCENCE; IMMUNOGOLD LABELING; IMMUNOHISTOCHEMISTRY; MALE; PLASMA CELL DYSCRASIA; ULTRASTRUCTURE;

EID: 0037343292     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1053/hupa.2003.27     Document Type: Article

References (35)

1. Thorner P, Bédard YC, Fernandes BJ: κlight chain nephropathy with Fanconi's syndrome. Arch Pathol Lab Med 107:654-657, 1983
2. Markowitz GS, Flis RS, Kambham N, et al: Fanconi syndrome with free kappa light chains in the urine. Am J Kidney Dis 35:777-781, 2000
3. Déret S, Denoroy L, Lamarine M, et al: Kappa light chain-associated Fanconi's syndrome molecular analysis of monoclonal immunoglobulin light chains from patients with and without intracellular crystals. Prot Eng 12:363-369, 1999
4. Truong LD, Mawad J, Cagle P, et al: Cytoplasmic crystals in multiple myeloma-associated Fanconi's syndrome: A morphological study including immunoelectron microscopy. Arch Pathol Lab Med 113:781-785, 1989
5. Herrera GA, Sanders PW, Reddy BV, et al: Ultrastructural immunolabeling: A unique diagnostic tool in monoclonal light chain-related renal diseases. Ultrastruct Pathol 18:401-416, 1994
6. Lajoie G, Leung R, Bargman JM: Clinical, biochemical, and pathological features in a patient with plasma cell dyscrasia and Fanconi syndrome. Ultrastruct Pathol 24:221-226, 2000
7. Thorson P, Hess JL: Transformation of monocytoid B-cell lymphoma to large cell lymphoma associated with crystal-storing histiocytes. Arch Pathol Lab Med 124:460-462, 2000
8. Garcia JF, Sanchez E, Lloret E, et al: Crystal-storing histiocytosis and immunocytoma associated with multifocal fibrosclerosis. Histopathology, 33:459-464, 1998
9. Llobet M, Castro P, Barcelo C, et al: Massive crystal-storing histiocytosis associated with low-grade malignant B-cell lymphoma of MALT-type of the parotid gland. Diag Cytopathol 17:148-152, 1997
10. Kaufmann O, Hansen A, Deicke P, et al: Subcutaneous crtstal-storing histiocytosis associated with lymphoplasmacytic lymphoma (immunocytoma). Pathol Res and Pract 192:1148-1151, 1996
11. Kapadia SB, Enzinger FM, Heffner DK, et al: Crystal-storing histiocytosis associated with lymphoplasmacytic neoplasms. Report of three cases mimicking adult rhabdomyoma. Am J Surg Pathol 17:461-467, 1993
12. Yamamoto T, Hishida A, Honda N, et al: Crystal-storing histiocytosis and crystalline tissue deposition in multiple myeloma. Arch Pathol Lab Med 115:351-354, 1991
13. Bosman C, Camassei FD, Boldrini R, et al: Solitary crystal-storing histiocytosis of the tongue in a patient with rheumatoid arthritis and polyclonal hypergammaglobulinemia. Arch Pathol Lab Med 122:920-924, 1998
14. Sukpanichnant S, Hargrove NS, Kachintorn U, et al: Clofazimine-induced crystal-storing histiocytosis producing chronic abdominal pain in a leprosy patient. Am J Surg Pathol 24:129-135, 2000
15. Cheetham GM, Hale G, Waldmann H, et al: Crystal structures of a rat anti-CD52 (CAMPATH-1) therapeutic antibody Fab fragment and its humanized counterpart. J Mol Biol 20:85-99, 1998
16. Font RL, Sobol W, Matoba A: Polychromatic corneal and conjunctival crystals secondary to clofazimine therapy in a leper. Ophthalmology 96:311-315, 1989
17. Glaus A: Über multiples myelozytom mit egnartigen, zum teil cristallahnlichen zelleingnlagerungen kombiniert mit elastolyse und ausgedehnter amyloidose und verkalkung. Virchows Arch Pathol Anat 223:301-339, 1917 (in German)
18. Abrikossof A, Wulff P: Über eiweisskristalbildung in einem fall von myelom. Virchows Arch Pathol Anat 22:270-277, 1927 (in German)
19. Apitz K: Die paraproteinosen: Über die störung des eiweisstoffwechsels bei plasmocytom. Virchows Arch Pathol Anat 306:631-398, 1940 (in German)
20. Bouiller M, Chantrel F, Paillard F, et al: Tubular dysfunction in plasma cell dyscrasia (abstract). J Am Soc Nephrol 10:97A, 1999
21. Klintworth GK, Bredehoeft SJ, Reed JW: Analysis of corneal crystalline deposits in multiple myeloma. Am J Ophthalmol 86:303-313, 1978
22. Stirling JW, Henderson DW, Rozenbilds MA, et al: Crystalloidal paraprotein deposits in the cornea: An ultrastructural study of two new cases with tubular crystalloids that contain IgG kappa light chains and IgG gamma heavy chains. Ultrastruct Pathol 21:337-344, 1997
23. Grossniklaus HE, Stulting RD, L'Hernault N: Corneal and conjunctival crystals in paraproteinemia. HUM PATHOL 21:1181-1183, 1990
24. Hirota S, Miyamoto M, Kasugai T, et al: Crystalline light chain deposition and amyloidosis in the thyroid gland and kidneys of a patient with myeloma. Arch Pathol Lab Med 114:429-431, 1990
25. Mullen B, Chalvardjian A: Crystalline tissue deposits in a case of multiple myeloma. Arch Pathol Lab Med 105:94-97, 1981
26. Schwartz H, Bonhomme P, Caulet S, et al: Bone marrow lambda-type light chain crystalline structures associated with multiple myeloma. Virchows Arch A 407:449-456, 1985
27. Maldonado JE, Velosa JA, Kyle RA, et al: Fanconi syndrome in adults: A manifestation of a latent form of myeloma. Am J Med 58:354-364, 1975
28. Messiaen T, Deret S, Mougenot B, et al: Adult Fanconi syndrome secondary to light chain gammopathy. Medicine 79:135-154, 2000
29. Aucouturier P, Bauwens M, Khamlichi AA, et al: Monoclonal IgL chain and L chain V domain fragment crystallization in myeloma-associated Fanconi's syndrome. J Immunol 150:3561-3568, 1993
30. Leboulleaux M, Lelongt B, Mougenot B, et al: Protease resistance and binding of Ig light chains in myeloma-associated tubulopathies. Kidney Int 48:72-79, 1995
31. Clyne DH, Brendstrup L, First MR, et al: Renal effects of intraperitoneal kappa chain injection. Lab Invest 31:131-142, 1794
32. Shipkey FH, Lieberman PH, Foote FW, et al: Ultrastructure of alveolar soft part sarcoma. Cancer 17:821-830, 1964
33. Mukai M, Torikata C: Alveolar soft part sarcoma: An electron microscopic study especially of uncrystallized granules using a tannic acid-containing fixative. Ultrastruct Pathol 14:41-50, 1990
34. Ekfors T, Autio-Harmainen H: Case for the panel: Crystallization in soft tissue neoplasm. Ultrastruct Pathol 10:93-105, 1986
35. Erlandson RA, Mackay B, Ro J, et al: Case to the panel: Crystallization in soft tissue neoplasm. Comments by the panel. Ultrastruct Pathol 10:93-105, 1986