Clofazimine-induced crystal-storing histiocytosis producing chronic abdominal pain in a leprosy patient

American Journal of Surgical Pathology

Volumn 24, Issue 1, 2000, Pages 129-135

  Sukpanichnant, Sanya ^a   Hargrove, Narumol Srisuthapan ^a   Kachintorn, Udom ^a   Manatsathit, Sathaporn ^a   Chanchairujira, Thawee ^a   Siritanaratkul, Noppadol ^a   Akaraviputh, Thawatchai ^a   Thakerngpol, Kleophant ^a  

^a MAHIDOL UNIVERSITY   (Thailand)

Author keywords

Abdominal pain; Clofazimine; Crystal storing histiocytosis; Intestinal lymphoma; Leprosy; Lymphoplasmacytic lymphoma; Non Hodgkin's lymphoma

Indexed keywords

CLOFAZIMINE;

ABDOMINAL PAIN; ADULT; ARTICLE; CASE REPORT; HISTIOCYTOSIS; HISTOPATHOLOGY; HUMAN; INTESTINE LYMPHOMA; LEPROSY; MALE; MULTIPLE MYELOMA; SKIN DISCOLORATION;

ABDOMINAL PAIN; ADULT; BIOPSY; CHRONIC DISEASE; CLOFAZIMINE; CRYSTALLIZATION; CYTOPLASM; DIAGNOSIS, DIFFERENTIAL; FROZEN SECTIONS; HISTIOCYTES; HISTIOCYTOSIS; HUMANS; INTESTINAL MUCOSA; JEJUNUM; LEPROSTATIC AGENTS; LEPROSY; LYMPH NODES; MALE; MICROSCOPY, ELECTRON;

EID: 0033970962     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000478-200001000-00016     Document Type: Article

References (31)

1. Alfandari S, Chidiac C, Guery B, Senneville E, Mouton Y, Vinocour D. Pulmonary clofazimine crystals in two patients with the acquired immunodeficiency syndrome. Int J Tuberc Lung Dis 1997;1:88-9.
2. Aplin RT, McDougall AC. Identification of crystals of the riminophenazine compound B663 (lamprene: clofazimine) in mouse spleen macrophages by thin layer chromatography and mass spectrum analysis. Experientia 1975;15:468-9.
3. Atkinson AJ Jr, Sheagren JN, Rubio JB, Knight V. Evaluation of B.663 in human leprosy. Int J Lepr 1967;35:119-27.
4. Belaube P, Devaux J, Pizzi M, Boutboul R, Privat Y. Small bowel deposition of crystals associated with the use of clofazimine (lamprene) in the treatment of prurigo nodularis. Int J Lepr 1983;51: 328-30.
5. Browne SG, Hogerzeil LM. B663 in the treatment of leprosy. Preliminary report of a pilot trial. Lepr Rev 1962;33:6-10.
6. Bryceson A. Unnecessary laparotomy for abdominal pain and fever due to clofazimine. Lepr Rev 1979;50:258-9.
7. Cellona RV, Fajardo TT Jr, Kim D-I, et al. Joint chemotherapy trials in lepromatous leprosy conducted in Thailand, the Philippines, and Korea. Int J Lepr 1990;58:1-11.
8. Chong P-Y, Ti T-K. Severe abdominal pain in low dosage clofazimine. Pathology 1993;25:24-6.
9. Conalty ML, Barry VC, Jina A. The antileprosy agent B.663 (clofazimine) and the reticuloendothelial system. Int J Lepr 1971;39: 479-92.
10. de Bergeyck E, Janssens PG, de Muynck A. Radiological abnormalities of the ileum associated with the use of clofazimine (lamprene; B663) in the treatment of skin ulceration due to Mycobacterium ulcerans. Lepr Rev 1980;51:221-8.
11. Desikan KV, Ramanujam D, Ramu G, Balakrishnan S. Autopsy findings in a case of lepromatous leprosy treated with clofazimine. Lepr Rev 1975;46:181-9.
12. Harada M, Shimada M, Fukayama M, Kaneko T, Kitazume K, Weiss SW. Crystal-storing histiocytosis associated with lymphoplasmacytic lymphoma mimicking Weber - Christian disease: immunohistochemical, ultrastructural, and gene-rearrangement studies. Hum Pathol 1996;27:84-7.
13. Harvey RF, Harman RRM, Black C, et al. Abdominal pain and malabsorption due to tissue deposition of clofazimine (lamprene) crystals [Abstract]. Br J Dermatol 1977;97(Suppl. 15):19.
14. Hudson V, Cox F, Taylor L, Guill M, Wray B, Steele J. Pulmonary clofazimine crystals in a child with acquired immunodeficiency syndrome and disseminated Mycobacterium avium intracellulare infection. Pediatr Infect Dis J 1988;12:880-2.
15. Jagadeesan K, Visweswaran MK, Iyer KH. Acute abdomen in a patient treated with lamprene. Int Surg 1975;60:208-9.
16. Jopling WH. Complications of treatment with clofazimine (lamprene: B663). Lepr Rev 1976;47:1-3.
17. Kapadia SB, Enzinger FM, Heffner DK, Hyams VJ, Frizzera G. Crystal-storing histiocytosis associated with lymphoplasmacytic neoplasms. Report of three cases mimicking adult rhabdomyoma. Am J Surg Pathol 1993;17:461-7.
18. Karat ABA. Long-term follow-up of clofazimine (lamprene) in the management of reactive phrases of leprosy. Lepr Rev 1975; 46(Suppl.):105-9.
19. Kaufmann O, Hansen A, Deicke P, Burmester GR, Dietel M. Subcutaneous crystal-storing histiocytosis associated with lymphoplasmacytic lymphoma (immunocytoma). Pathol Res Pract 1996; 192:1148-51.
20. Llobet M, Castro P, Barcelo C, Trull JM, Campo E, Bernado L. Massive crystal-storing histiocytosis associated with low-grade malignant B-cell lymphoma of MALT-type of the parotid gland. Diagn Cytopathol 1997;17:148-52.
21. Mason GH, Ellis-Pegler RB, Arthur JF. Clofazimine and eosinophilic enteritis. Lepr Rev 1977;48:175-80.
22. Masur H. Recommendations on prophylaxis and therapy for disseminated Mycobacterium avium complex disease in patients infected with the human immunodeficiency virus. N Engl J Med 1993;329:898-904.
23. McDougall AC. Electron microscopic studies of the antileprosy drug B663 (clofazimine; lamprene). Int J Lepr 1974;42:1-12.
24. McDougall AC, Horsfall WR, Hede JE, Chaplin AJ. Splenic infarction and tissue accumulation of crystals associated with the use of clofazimine (lamprene; B663) in the treatment of pyoderma gangrenosum. Br J Dermatol 1980;102:227-30.
25. Prasad ML, Charney DA, Sarlin J, Keller SM. Pulmonary immunocytoma with massive crystal storing histiocytosis. A case report with review of the literature. Am J Surg Pathol 1998;22: 1148-53.
26. Sandler ED, Ng VL, Hadley WK. Clofazimine crystals in alveolar macrophages from a patient with the acquired immunodeficiency syndrome. Arch Pathol Lab Med 1992;116:541-3.
27. Schaefer HE. Gammopathy-related crystal-storing histiocytosis, pseudo- and pseudo-pseudo-Gaucher cells. Critical commentary and mini-review. Pathol Res Pract 1996;192:1152-62.
28. Silverman JF, Holter JR, Berns LA, Benning TL, Neill JS. Negative images due to clofazimine crystals simulating MAI infection in a bronchoalveolar lavage specimen. Diagn Cytopathol 1993;9: 534-9.
29. Takahashi K, Naito M, Takatsuki K, et al. Multiple myeloma, IgA kappa type, accompanying crystal-storing histiocytosis and amyloidosis. Acta Pathol Jpn 1987;37:141-54.
30. Venencie PY, Cortez A, Orieux G, Jost JL, Chomette G, Puissant A. Clofazimine enteropathy. J Am Acad Dermatol 1986;15:290-1.
31. Yamamoto T, Hishida A, Honda N, Ito I, Shirasawa H, Nagase M. Crystal-storing histiocytosis and crystalline tissue deposition in multiple myeloma. Arch Pathol Lab Med 1991;115:351-4.