Crystalloidal paraprotein deposits in the cornea: An ultrastructural study of two new cases with tubular crystalloids that contain IgGκ light chains and IgGγ heavy chains

Ultrastructural Pathology

Volumn 21, Issue 4, 1997, Pages 337-344

  Stirling, John W ^a,c   Henderson, Douglas W ^a   Rozenbilds, Michael A M ^a   Skinner, John M ^a   Filipic, Marijan ^b  

^a FLINDERS UNIVERSITY   (Australia)

^b SYDNEY EYE HOSPITAL   (Australia)

^c FLINDERS MEDICAL CENTRE   (Australia)

Author keywords

Cornea; Crystalloids; Electron microscopy; Immunoglobulin; Immunolabeling; Keratopathy

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN;

ADULT; AGED; ARTICLE; CASE REPORT; CRYSTALLOID; HUMAN; HUMAN TISSUE; IMMUNOELECTRON MICROSCOPY; KERATOPATHY; LYMPHOPROLIFERATIVE DISEASE; MALE; NONHODGKIN LYMPHOMA; PARAPROTEINEMIA; PRIORITY JOURNAL;

EID: 0030991868     PISSN: 01913123     EISSN: None     Source Type: Journal    
DOI: 10.3109/01913129709021931     Document Type: Article

References (22)

1. Henderson DW, Stirling JW, Lipsett J, Rozenbilds MAM, Roberts-Thomson PJ, Coster DJ. Paraproteinemic crystalloidal keratopathy: an ultrastructural study of two cases, including immunoelectron microscopy. Ultrastruct Pathol. 1993;17:643-668.
2. Stirling JW, Graft P. Antigen unmasking for immunoelectron microscopy: labeling is improved by treating with sodium ethoxide or sodium metaperiodate, then heating on retrieval medium. J Histochem Cytochem. 1995;43:115-123.
3. Stirling JW. Use of tannic acid and silver enhancer to improve staining for electron microscopy and immunogold labeling. J Histochem Cytochem. 1993;41:643-648.
4. Komai Y, Ushiki T. The three-dimensional organisation of collagen fibrils in the human cornea and sclera. Invest Ophthalmol Vis Sci. 1991;32:2244-2258.
5. Pusateri TJ, Margo CE, Groden LR. Corneal manifestations of scleromyxedema. Ophthalmology. 1987;94:510-513.
6. McDonnell PJ, Schanzlin DJ, Rao NA. Immunoglobulin deposition in the cornea after application of autologous serum. Arch Ophthalmol. 1988;106:1423-1425.
7. Kömüves LG, Nichols BL, Hutchens W, Heath JP. Formation of crystalloid inclusions in the small intestine of neonatal pigs: an immunocytochemical study using colloidal gold. Histochem J. 1993;25:19-29.
8. Henderson DW, Papadimitriou JM, Coleman M. Stromal ultrastructure. In: Ultrastructural Appearances of Tumours: Diagnosis and Classification of Human Neoplasia by Electron Microscopy, 2d ed. Edinburgh: Churchill Livingstone; 1986:57-72.
9. Rodrigues MM, Krachmer JH, Miller SD, Newsome DA. Posterior corneal crystalline deposits in benign monoclonal gammopathy: a clinicopathologic case report. Arch Ophthalmol. 1979;97:124-128.
10. Spencer WH. Inherited systemic metabolic diseases with corneal involvement. In: Spencer WH, ed. Ophthalmic Pathology: An Atlas and Textbook, 4th ed. Philadelphia: WB Saunders; 1996:306-310.
11. Callihan TR, Jaffe ES. Identification of crystalline deposits. Arch Ophthalmol. 1980;98:386.
12. Burns CA. Indomethacin, reduced retinal sensitivity, and corneal deposits. Am J Ophthalmol. 1968;66:825-835.
13. Garner A, Kirkness CM. Corneal gammopathy. Cornea. 1988;7:44-49.
14. Høisen H, Ringvold A, Kildahl-Anderson O. Corneal crystalline deposits in multiple myeloma. Acta Ophthalmol. 1983;61:493-500.
15. Miller KH, Green WR, Stark WJ, Wells HA, Mendelson G, Kanhofer H. Immunoprotein deposition in the cornea. Ophthalmology. 1980;87:944-950.
16. Langlands DR, Dawkins RL, Matz LR, et al. Arthritis associated with a crystallizing cryoprecipitable IgG paraprotein. Am J Med. 1980;68:461-465.
17. Tillmann W, Keitel L. Indomethacin induced corneal deposits. Klin Monatsbl Augenheilkd. 1977;170:756-759.
18. Frucht-Pery J, Zauberman H. The effect of indomethacin on prostaglandin E2 in human cornea and conjunctiva. Arch Ophthalmol. 1992;110:343-345.
19. Tsuchisaka H, Takase M. Permeability of uveal vessels after experimental filtering surgery in rabbits. Jpn J Ophthalmol. 1985;29:263-271.
20. Nishida T, Ueda A, Otori T, Fujita H. Long-term storage of endocytosed latex beads in keratocytes in vivo. Cornea. 1991;10:532-535.
21. Suttorp-Schulten MS, Nunes-Cardozo B, Breebaart AC, Kijlstra A. The fate of antigen-antibody complexes in the rabbit cornea. Curr Eye Res. 1991;10:773-778.
22. Verhagen C, den Heijer R, Klooster J, Breebart AC, Kijlstra A. Elimination of immune precipitates from the rat corneal stroma: a histological study. Exp Eye Res. 1991;53:471-478.