Acidosis has opposite effects on neuronal survival during hypoxia and reoxygenation

Journal of Neurochemistry

Volumn 84, Issue 5, 2003, Pages 1018-1027

  Almaas, Runar ^a   Pytte, Morten ^a   Lindstad, Julie K ^a   Wright, Marianne ^a   Saugstad, Ola Didrik ^a   Pleasure, David ^b   Rootwelt, Terje ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Acidosis; Apoptosis; Human; Ischemia; Neurone; Reoxygenation

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CALPASTATIN; CASPASE INHIBITOR; DIZOCILPINE; DNA FRAGMENT; ETHIDIUM; GLUCOSE; HOE 33342; HYPOXANTHINE; ISOPROSTANE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OXYGEN; STAUROSPORINE;

ACIDOSIS; APOPTOSIS; ARTICLE; CELL HYPOXIA; CELL NUCLEUS; CELL SURVIVAL; CONTROLLED STUDY; HUMAN; HUMAN CELL; ISCHEMIA; NERVE CELL NECROSIS; NEUROTOXICITY; PH; PRIORITY JOURNAL; REOXYGENATION;

ACIDOSIS; APOPTOSIS; CASPASES; CELL DEATH; CELL HYPOXIA; CELL LINE; CELL NUCLEUS; CELL SURVIVAL; CULTURE MEDIA; DNA FRAGMENTATION; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; FREE RADICALS; GLUCOSE; HUMANS; HYDROGEN-ION CONCENTRATION; N-METHYLASPARTATE; NECROSIS; NEURONS; OXYGEN; POLY(ADP-RIBOSE) POLYMERASES; STAUROSPORINE;

EID: 0037341973     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01593.x     Document Type: Article

References (43)

1. Almaas R., Rootwelt T., Øyasæter S. and Saugstad O. D. (1997) Ascorbic acid enhances hydroxyl radical formation in iron-fortified infant cereals and infant formulas. Eur. J. Pediatr. 156, 488-492.
2. Almaas R., Saugstad O. D., Pleasure D. and Rootwelt T. (2000) Effect of barbiturates on hydroxyl radicals, lipid peroxidation, and hypoxic cell death in human NT2-N neurons. Anesthesiology 92, 764-774.
3. Almaas R., Saugstad O. D., Pleasure D. and Rootwelt T. (2002) Neuronal formation of free radicals plays a minor role in hypoxic cell death in human NT2-N neurons. Pediatr. Res. 51, 136-143.
4. Beilharz E. J., Williams C. E., Dragunow M., Sirimanne E. S. and Gluckman P. D. (1995) Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat: evidence for apoptosis during selective neuronal loss. Mol. Brain Res. 29, 1-14.
5. Bonfoco E., Krainc D., Ankarcrona M., Nicotera P. and Lipton S. A. (1995) Apoptosis and necrosis: Two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc. Natl Acad. Sci. USA 92, 7162-7166.
6. Borlongan C. V., Tajima Y., Trojanowski J. Q., Lee V. M. and Sanberg P. R. (1998) Transplantation of cryopreserved human embryonal carcinoma-derived neurons (NT2N cells) promotes functional recovery in ischemic rats. Exp. Neurol. 149, 310-321.
7. Bralet J., Schreiber L. and Bouvier C. (1992) Effect of acidosis and anoxia on iron delocalization from brain homogenates. Biochem. Pharmacol. 43, 979-983.
8. Colbourne F., Sutherland G. R. and Auer R. N. (1999) Electron microscopic evidence against apoptosis as the mechanism of neuronal death in global ischemia. J. Neurosci. 19, 4200-4210.
9. Edwards A. D., Yue X., Cox P., Hope P. L., Azzopardi D. V., Squier M. V. and Mehmet H. (1997) Apoptosis in the brains of infants suffering intrauterine cerebral injury. Pediatr Res. 42, 684-689.
10. Giffard R. G., Monyer H., Christine C. W. and Choi D. W. (1990) Acidosis reduces NMDA receptor activation, glutamate neurotoxicity, and oxygen-glucose deprivation neuronal injury in cortical cultures. Brain Res. 506, 339-342.
11. Hagberg H., Andersson P., Kjellmer I., Thiringer K. and Thordstein M. (1987) Extracellular overflow of glutamate, aspartate, GABA and taurine in the cortex and basal ganglia of fetal lambs during hypoxia-ischmia. Neurosci. Lett. 78, 311-317.
12. Hardy M., Younkin D., Tang C. M., Pleasure S. J., Shi Q. Y., Williams M. and Pleasure D. (1994) Expression of non-NMDA glutamate receptor channel genes by clonal human neurons. J. Neurochem. 63, 482-489.
13. Hartley R. S., Margulis M., Fishman P. S., Lee V. M. and Tang C. M. (1999) Functional synapses are formed between human NTera2 (NT2N, hNT) neurons grown on astrocytes. J. Comp. Neurol. 407, 1-10.
14. Holowach-Thurston J., Hauhart R. E. and Jones E. M. (1974) Anoxia in mice: reduced glucose in brain with normal of elevated glucose in plasma and increased survival after glucose treatment. Pediatr. 8, 238-243.
15. Joashi U. C., Greenwood K., Taylor D. L., Kozma M., Mazarakis N. D., Edwards A. D. and Mehmet H. (1999) Poly (ADP ribose) polymerase cleavage precedes neuronal death in hippocampus and cerebellum following injury to the developing rat forebrain. Eur J. Neurosci. 11, 91-100.
16. Kaal E. C. A., Veldman H., Sodaar P., Joosten E. A. J. and Dop Bar P. R. (1998) Oxidant treatment causes a dose-dependent phenotype of apoptosis in cultured motoneurons. J. Neurosci. Res. 54, 778-786.
17. Lankiewiez S., Luetjens C. M., Bui N. T., Krohn A. J., Poppe M., Cole G. M., Saido T. C. and Prehn J. H. M. (2000) Activation of calpain I converts excitotoxic neuron death into a caspase-independent cell death. J. Biol. Chem. 275, 17064-17071.
18. LeBlanc M. H., Huang M., Vig V., Patel A. and Smith E. E. (1993) Glucose affects the severity of hypoxic-ischemic brain injury in the newborn pig. Stroke 24, 1055-1062.
19. Li H., Colbourne F., Sun P., Zhao Z. and Buchan A. M. (2000) Caspase inhibitors reduce neuronal injury after focal but not global cerebral ischemia in rats. Stroke 31, 176-182.
20. Lorek A., Takei Y., Cady E. B., Wyatt J. S., Penrice J., Edwards A. D. Peebles D., Wylezinska M., Owen-Reece H., Kirkbride V. et al. (1994) Delayed ('secondary') cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: continuous 48-hour studies by phosphorus magnetic resonance spectroscopy. Pediatr. Res. 36, 699-706.
21. Lundgren J., Zhang H., Agardh C.-D., Smith M. L., Evans P. J. Halliwell B. and Siesjö B. K. (1991) Acidosis-induced isehemic brain damage: are free radicals involved? J. Cereb. Blood Flow Metab. 11, 587-596.
22. McDonald J. W., Bhattacharyya T., Sensi S. L., Lobner D., Ying H. S. Canzoniero L. M. T. and Choi D. (1998) Extracellular acidity potentiates AMPA receptor-mediated cortical neuronal death J. Neurosci. 18, 6290-6299.
23. McGowan J. E., Marro P. J., Mishra O. P. and Delivoria-Papadopoulos M. (1995) Brain cell membrane function during hypoxia in hyperglycemia newborn piglets. Pediatr. Res. 37, 133-139.
24. Neelands T. R., King A. P. J. and Macdonald R. L. (2000) Functional expression of L-, N-, P/Q-, and R.-type calcium channels in the human NT2-N cell line. J. Neurophysiol. 84, 2933-2944.
25. Nicholson D. W., Ali A., Thornberry N. A., Vaillancourt J. P., Ding C. K., Gallant M., Gareau Y., Griffin P. R., Labelle M., Lazebnik Y. A. et al. (1995) Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376, 37-43.
26. Nitsch R., Bechman I., Deisz R. A., Haas D., Lehman T. N., Wendling U. and Zipp F. (2000) Human brain-cell death induced by tumor-necrosis-factor-related apoptosis-inducing ligand (TRAIL). Lancet 356, 827-828.
27. Park H. J., Lyons J. C., Ohtsubo T. and Song C. W. (1999) Acid environment causes apoptosis by increasing caspase activity. Br. J. Canc. 80, 1892-1897.
28. Pleasure S. J. and Lee V. M.-Y. (1993) NTera 2 cells. A human cell line which displays characteristics expected of a human committed neurorial progenitor cell. J. Neurosci. Res. 35, 585-602.
29. Pleasure S. J., Page C. and Lee V. M.-Y. (1992) Pure, postmitotic, polarized human neurons derived from NTera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons. J. Neurosci. 12, 1802-1815.
30. Prado R., Ginsberg M. D., Dietrich W. D., Watson B. D. and Busto R. (1988) Hyperglycemia increases infarct size in collaterally perfused but not in end-arterial vascular territories. J. Cereb. Blood Flow Metab. 8, 186-192.
31. Rootwelt T., Dunn M., Yudkoff M., Itoh T., Almaas R. and Pleasure D. (1998) Hypoxic cell death in human NT2-N neurons: involvement of NMDA and non-NMDA glutamate receptors. J. Neurochem. 17, 1544-1553.
32. Saugstad O. D. (1988) Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr. Res. 23, 143-150.
33. Sheldon R. A., Partridge C. J. and Ferriero D. M. (1992) Postischemic hyperglycemia is not protective to the neonatal rat brain. Pediatr. Res. 32, 489-493.
34. Shimizu H., Graham S. H., Chang L. H., Mintorovitch J., James T. L., Faden A. I. and Weinstein P. R. (1993) Relationship between extracellular neurotransmitter amino acids and energy metabolism during cerebral ischemia in rats monitored by microdialysis and in vivo magnetic resonance spectroscopy. Brain Res. 605, 33-42.
35. Siesjö B. K., Bendek G., Koide T., Westerberg E. and Wieloch T. (1985) Influence of acidosis on lipid peroxidation in brain tissues in vitro. J. Cereb. Blood Flow Metab. 5, 253-258.
36. Tang C.-M., Dichter M. and Morad M. (1990) Modulation of the N-methyl-D-aspartate channel by extracellular H+. Proc. Natl Acad. Sci. USA 87, 6445-6449.
37. Tombaugh G. C. and Sapolsky R. M. (1990) Mild acidosis protects hippocampal neurons from injury induced by oxygen and glucose deprivation. Brain Res. 506, 343-345.
38. Vannucci R. C., Rossini A. and Towfigh J. (1996) Effect of hyperglycemia on ischemic brain damage during hypothermic circulatory arrest in newborn dogs. Pediatr. Res. 40, 177-184.
39. Voorhies T. M., Rawlinson D. and Vannucci R. C. (1986) Glucose and perinatal hypoxic-ischemic brain damage in the rat. Neurology 36, 1115-1118.
40. Wass C. T. and Lanier W. L. (1996) Glucose modulation of ischemic brain injury: review and clinical recommendations. Mayo Clin. Proc. 71, 801-812.
41. Xu L., Glassford A. I. M., Giaccia A. J. and Giffard R. G. (1998) Acidosis reduces neuronal apoptosis. Neuroreport 9, 875-879.
42. Ying W., Han S.-K., Miller J. W. and Swanson R. A. (1999) Acidosis potentiates oxidative neuronal death by multiple mechanisms. J. Neurochem. 73, 1549-1556.
43. Younkin D. P., Tang C. M., Hardy M., Reddy U. R., Shi Q. Y., Pleasure S. J., Lee V. M.-Y. and Pleasure D. (1993) Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line. Proc. Natl Acad. Sci. USA 90, 2174-2178.