Apoptosis in the brains of infants suffering intrauterine cerebral injury

Pediatric Research

Volumn 42, Issue 5, 1997, Pages 684-689

  Edwards, A D ^a   Yue, X ^a   Cox, P ^a   Hope, P L ^b   Azzopardi, D V ^a   Squier, M V ^c   Mehmet, H ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^c RADCLIFFE INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; ARTICLE; ASPHYXIA; BRAIN CELL; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN PROTECTION; CELL DEATH; CELL POPULATION; CINGULATE GYRUS; CLINICAL ARTICLE; FEMALE; HUMAN; HYPOXIA; INFANT; MALE; NECROSIS; NEWBORN; PRIORITY JOURNAL;

EID: 0030727371     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-199711000-00022     Document Type: Article

References (32)

1. Mehmet H, Yue X, Squier MV, Lorek A, Cady E, Penrice J, Sarraf C, Wylezinska M, Kirkbride V, Cooper C, Brown GC, Wyatt JS, Reynolds EOR, Edwards AD 1994 Increased apoptosis in the cingulate sulcus of newborn piglets following transient hypoxia-ischaemia is related to the degree of high energy phosphate depletion during the insult. Neurosci Lett 181:121-125
2. Yue X, Mehmet H, Penrice J, Cooper C, Cady E, Wyatt JS, Reynolds EOR, Edwards AD, Squier MV 1996 Apoptosis and necrosis in the newborn piglet brain following transient cerebral hypoxia-ischaemia. Neuropathol Appl Neurobiol 22:482-503
3. Linnik MD, Zobrist RH, Hatfield MD 1993 Evidence supporting a role for programmed cell death in focal cerebral ischaemia in rats. Stroke 24:2002-2008
4. Li Y, Chopp M, Jiang N, Yao F, Zaloga C 1995 Temporal profile of in situ DNA fragmentation after transient middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 15:389-397
5. Beilharz E, Williams CE, Dragunow M, Sirimanne E, Gluckman PD 1995 Mechanisms of cell death following hypoxic-ischaemic injury in the immature rat: evidence of apoptosis during selective neuronal loss. Mol Brain Res 29:1-14
6. MacManus JP, Buchan AM, Hill IE, Rasquinha I, Preston E 1993 Global ischaemia can cause DNA fragmentation indicative of apoptosis in rat brain. Neurosci Lett 164:89-92
7. Chariaut-Marlangue C, Margaill I, Plotkine M, Ben-Ari Y 1995 Early endonuclease activation following reversible focal ischemia in the rat brain. J Cereb Blood Flow Metab 15:385-388
8. Edwards AD, Yue X, Squier MV, Thoresen M, Cady EB, Penrice J, Cooper C, Wyatt JS Reynolds EOR, Mehmet H 1995 Specific inhibition of apoptosis after cerebral hypoxia-ischaemia by moderate post-insult hypothermia. Biochem Biophys Res Commun 217:1193-1199
9. Gluckman PD, Klempt N, Guan J, Mallard C, Sirimanne E, Dragunow M, Klempt M, Singh K, Williams CE, Nikolies K 1992 A role for IGF-1 in the rescue of CNS neurons following hypoxic-ischemic injury. Biochem Biophys Res Commun 182:593-599
10. Wyllie AH, Duvall E 1992 Cell injury and death. In: McGee JO, Isacsson PG, Wright NA (eds) Oxford Textbook of Pathology. Oxford University Press, Oxford, UK, pp 141-193
11. Ansari B, Coates PJ, Greenstein BD, Hall PA 1993 In situ end-labelling detects DNA strand breaks in apoptosis and other physiological and pathological states. J Pathol 179:1-8
12. Sarnat HB, Sarnat MS 1976 Neonatal encephalopathy following fetal distress - a clinical and electroencephalographic study. Ann Neurol 33:696-705
13. Raff MC 1992 Social controls on cell survival and cell death. Nature 356:397-400
14. Oppenheim RW 1991 Cell death during development of the nervous system. Ann Rev Neurosci 14:453-501.
15. Blaschke AJ, Staley K, Chun J 1996 Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex. Development 122:1165-1174
16. Ferner I, Bernet E, Soriano E, Del-Rio T, Fonseca M 1990 Naturally occurring cell death in the cerebral cortex of the rat and the removal of dead cells by transitory phagocytes. Neuroscience 39:451-458
17. MacManus JP, Hill IE, Preston E, Rasquinha I, Walker T, Buchan AM 1995 Differences in DNA fragmentation following transient cerebral or decapitation ischemia in rats. J Cereb Blood Flow Metab 15:728-737
18. Thompson CB 1995 Apoptosis in the pathogenesis and treatment of disease. Science 267:1456-1462
19. Wallen Ohman M, Lonnbro P, Schon A, Borrebaeck CA 1993 Antibody-induced apoptosis in a human leukemia cell line is energy dependent: thermochemical analysis of cellular metabolism. Cancer Lett 75:103-109
20. Richter C, Schweizer M, Cossarizza A, Franceschi C 1996 Control of apoptosis by the cellular ATP level. FEBS Lett 378:107-110
21. Du C, Hu R, Csernansky CA, Hsu CY, Choi DW 1996 Very delayed infarction after mild focal cerebral ischemia: a role for apoptosis? J Cereb Blood Flow Metab 16:195-201
22. Petito CK, Roberts B 1995 Effect of postmortem interval on in situ end-labeling of DNA uligonucleosomes. J Neuropathol Exp Neurol 54:761-765
23. Hope PL, Costello AM, Cady EB, Delpy DT, Tofts PS, Chu A, Hamilton PA. Reynolds EO, Wilkie DR 1984 Cerebral energy metabolism studied with phosphorus NMR spectroscopy in normal and birth-asphyxiated infants. Lancet 2:366-370
24. Azzopardi D, Wyatt JS, Cady EB, Delpy DT, Baudin J, Stewart AL, Hope PL, Hamilton PA, Reynolds EO 1989 Prognosis of newborn infants with hypoxicischemic brain injury assessed by phosphorus magnetic resonance spectroscopy. Pediatr Res 25:445-451
25. Roth SC, Edwards AD, Cady EB, Delpy DT, Wyatt JS, Azzopardi D, Baudin J, Townsend J, Stewart AL, Reynolds EOR 1992 Relation between cerebral oxidative metabolism following birth asphyxia and neurodevelopmental outcome and brain growth at one year. Dev Med Child Neurol 34:285-295
26. Traystman RJ, Kirsch JR, Koehler RC 1992 Oxygen radical mechanisms of brain injury following ischaemia and reperfusion. J Appl Physiol 71:1185-1195
27. Szatkowski M, Attwell D 1994 Triggering and execution of neuronal death in brain ischaemia: two phases of glutamate release by different mechanisms. Trends Neurosci 17:359-365
28. Majno G, Joris I 1995 Apoptosis, oncosis, and necrosis. An overview of cell death. Am J Pathol 146:3-15
29. Bonfoco E, Krainc D, Ankarcrona M, Nicotera P, Lipton SA 1995 Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc Natl Acad Sci USA 92:7162-7166
30. Ankarcrona M, Dypbukt JM, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton SA, Nicotera P 1995 Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15:961-973
31. Martinou JC, Dubois Dauphin M, Staple JK, Rodriguez I, Frankowski H, Missotten M, Albertini, P, Talabot D, Catsicas S, Pietra C, Huarte J 1994 Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron 13:1017-1030
32. Crumrine RC, Thomas AL, Morgan PF 1994 Attenuation of p53 expression protects against focal ischemic damage in transgenic mice. J Cereb Blood Flow Metab 14:887-891