Single cell analysis of adenoid CD5+ B cells and their protective contributions to nasopharyngeal immunity

Laryngoscope

Volumn 113, Issue 3, 2003, Pages 484-491

  Arita, Miori ^a   Kodama, Satoru ^a   Suzuki, Masashi ^a   Mogi, Goro ^a  

^a OITA UNIVERSITY   (Japan)

Author keywords

Adenoid, CD5+ B cells; Flow cytometry; Mucosal immunity

Indexed keywords

B7 ANTIGEN; CD27 ANTIGEN; CD5 ANTIGEN; CD86 ANTIGEN; FAS ANTIGEN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 10 RECEPTOR; INTERLEUKIN 4 RECEPTOR; INTERLEUKIN 5 RECEPTOR; INTERLEUKIN RECEPTOR; PROTEIN BCL 2;

ADENOID; ANTIBODY PRODUCING CELL; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; CELL FUNCTION; CELL ISOLATION; CELLULAR IMMUNITY; CHILD; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MONONUCLEAR CELL; NASOPHARYNX; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPPER RESPIRATORY TRACT;

ADENOIDECTOMY; ADENOIDS; ANTIBODIES, BACTERIAL; ANTIBODIES, MONOCLONAL; ANTIGENS, CD5; B-LYMPHOCYTES; CHILD; CHILD, PRESCHOOL; CULTURE TECHNIQUES; FEMALE; FLOW CYTOMETRY; HUMANS; HYPERTROPHY; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INFANT; MALE; NASOPHARYNX; RECEPTORS, INTERLEUKIN; RESPIRATORY TRACT INFECTIONS; T-LYMPHOCYTES;

EID: 0037334791     PISSN: 0023852X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005537-200303000-00017     Document Type: Article

References (50)

1. Mogi G. IgA immunocytes in tonsils. Acta Otolaryngol 1977;83:505-513.
2. Bernstein JM, Gorfien J, Brandtzaeg P. The immunobiology of the tonsils and adenoids. In: Ogra PL, Mestecky J, Lamm ME, Strober W, Bienenstock J, McGhee JR, eds. Mucosal Immunology, 2nd ed. San Diego: Academic, 1999:1339-1362.
3. Perry M, Whyte A. Immunology of the tonsils. Immunol Today 1998;19:414-421.
4. Brandtzaeg P. Regionalized immune function of tonsils and adenoids. Immunol Today 1999;20:383-384.
5. Brandtzaeg P. Immune functions and immunopathology of palatine and nasopharyngeal tonsils. In: Bernstein JM, Ogra PL, eds. Immunology of the Ear. New York: Raven, 1987:63-106.
6. Brandtzaeg P, Halstensen TS. Immunology and immunopathology of tonsils. Adv Otolaryngol 1992;47:64-75.
7. Kiyono H, Bienenstock J. Features of inductive and effector sites to consider in mucosal immunization and vaccine development. Reg Immunol 1992;4:54-62.
8. McGhee JR, Mestecky J, Dertzbaugh MT, Eldridge JH, Hirasawa M, Kiyono H. The mucosal immune system: from fundamental concepts to vaccine development. Vaccine 1992;10:75-88.
9. Kuper CF, Koornstra PJ, Hameleers DMH, et al. The role of nasopharyngeal lymphoid tissue. Immunol Today 1992;13:219-223.
10. Hiroi T, Iwatani K, Iijima H, Kodama S, Yanagita M, Kiyono H. Nasal immune system: distinctive Th0 and Th1/Th2 type environments in murine nasal-associated lymphoid tissues and nasal passage, respectively. Eur J Immunol 1998;28:3346-3353.
11. Herzenberg LA. B-1 cells: the lineage question revisited. Immunol Rev 2000;175:9-22.
12. Martin F, Kearney JF. B1 cells: similarities and differences with other B cell subsets. Curr Opin Immunol 2001;13:195-201.
13. Hayakawa K, Hardy RR. Development and function of B-1 cells. Curr Opin Immunol 2000;12:346-353.
14. Hayakawa K, Shinton SA, Asano M, Hardy RR. B-1 cell definition. Curr Topics Microbiol Immunol 2000;252:15-22.
15. Kipps TJ. The CD5 B cell. Adv Immunol 1989;47:117-185.
16. Herzenberg LA, Haughton G, Rajewsky K. CD5 B cells in development and disease. Ann N Y Acad Sci 1992;651:591-601.
17. Stall AM, Wells SM, Lam KP. B-1 cells: unique origins and functions. Semin Immunol 1996;8:45-59.
18. + B) cells. Int Immunol 1992;4:243-252.
19. Kroese FGM, Kantor AB, Herzenberg LA. The role of B-1 cells in mucosal immune responses. In: Ogra PL, Mestecky J, Lamm ME, Strober W, McGhee JR, Bienenstock J, eds. Handbook of Mucosal Immunology. San Diego: Academic, 1994:217-224.
20. Bos NA, Cebra JJ, Kroese FGM. B-1 cells and the intestional microflora. Curr Topics Microbiol Immunol 2000;252:211-220.
21. Hiroi T, Yanagita M, Iijima H, et al. Deficiency of IL-5 receptor α-chain selectively influences the development of the common mucosal immune system independent IgAproducing B-1 cell in mucosa-associated tissues. J Immunol 1999;162:821-828.
22. Kodama S, Suzuki M, Arita M, Mogi G. Increase in tonsillar germinal centre B-1 cell numbers in IgA nephropathy (IgAN) patients and reduced susceptibility to Fasmediated apoptosis. Clin Exp Immunol 2001;123:301-308.
23. Sakamoto N, Kurono Y, Suzuki M, Kerakawauchi H, Mogi G. Immune responses of adenoidal lymphocytes specific to Haemophilus influenzae in the nasopharynx. Laryngoscope 1998;108:1036-1041.
24. Kodama S, Suenaga S, Hirano T, Suzuki M, Mogi G. Induction of specific immunoglobulin A and Th2 immune responses to P6 outer membrane protein of nontypeable Haemophilus influenzae in middle ear mucosa by intranasal immunization. Infect Immunol 2000;68:2294-2300.
25. Murphy TF, Apicella MA. Nontypeable Haemophilus influenzae: a review of clinical aspects, surface antigens, and the human immune responses to infection. Rev Infect Dis 1987;9:1-15.
26. Gnehm HES, Pelton I, Gulati S, Rice PA. Characterization of antigens from nontypeable Haemophilus influenzae recognized by human bacterial antibobies. J Clin Invest 1985;75:1645-1658.
27. Jacquot S, Kobata T, Iwata S, Morimoto C, Schlossman SF. CD154/CD40 and CD70/CD27 interactions have different and sequential functions in T cell-dependent B cell responses: enhancement of plasma cell differentiation by CD27 signaling. J Immunol 1997;159:2652-2657.
28. Kindler V, Zubler RH. Memory, but not naive, peripheral blood B lymphocytes differentiate into Ig-secreting cells after CD40 ligation and costimulation with IL-4 and the differentiation factors IL-2, IL-10, and IL-3. J Immunol 1997;159:2085-2090.
29. Choe J, Kim HS, Zhang X, Armitage RJ, Choi YS. Cellular and molecular factors that regulate the differentiation and apoptosis of germinal center B cells: anti-Ig down-regulates Fas expression on CD40 ligand-stimulated germinal center B cells and inhibits Fas-mediated apoptosis. J Immunol 1996;157:1006-1016.
30. Allison AC, Nawata Y. Cytokines mediating the proliferation and differentiation of B-1 lymphocytes and their role in ontogeny and phylogeny. Ann N Y Acad Sci 1992;651:200-219.
31. June CH, Bluestone JA, Nadler LM, Thompson CB. The B7 and CD28 receptor families. Immunol Today 1994;15:321-325.
32. Schweitzer AN, Borriello F, Wong RCK, Abbas AK, Sharpe AH. Role of costimulators in T cell differentiation: studies using antigen-presenting cells lacking expression of CD80 or CD86. J Immunol 1997;158:2713-2722.
33. Nagata S. Apoptosis by death factor. Cell 1997;88:355-365.
34. Graves JD, Draves KE, Craxton A, Krebs EG, Clark A. A comparison of signaling requirements for apoptosis of human B lymphocytes induced by the B cell receptor and CD95/Fas. J Immunol 1998;161:168-174.
35. Kroemer G. The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nature Med 1997;3:614-620.
36. Fujiyoshi T, Watanabe T, Ichimiya I, Mogi G. Functional architecture of the nasopharyngeal tonsil. Am J Otolaryngol 1989;10:124-131.
37. Brandtzaeg P, Surjan L, Berdal P. Immunoglobulin systems of human tonsils, I: control subjects of various ages - quantification of Ig-producing cells, tonsillar morphometry, and serum Ig concentrations. Clin Exp Immunol 1978;31:367-381.
38. van Kempen MJ, Rijkers GT, van Cauwenberge PB. The immune response in adenoids and tonsils. Int Arch Allergy Immunol 2000;122:8-19.
39. Fagarasan S, Shinkura R, Kamata T, Nogaki F, Ikuta K, Honjo T. Mechanism of B1 cell differentiation and migration in GALT. Curr Topics Microbiol Immunol 2000;252:221-229.
40. Bergler W, Adam S, Gross HJ, Hormann K, Schwartz-Albiez R. Age-dependent altered proportions in subpopulations of tonsillar lymphocytes. Clin Exp Immunol 1998;116:9-18.
41. Rosenmann E, Rabinowitz R, Schlesinger M. Lymphocyte subsets in human tonsils: the effect of age and infection. Pediatr Allergy Immunol 1998;9:161-167.
42. Ochsenbein AF, Fehr T, Lutz C, Suter M, Brombacher F, Hengartner H, Zinkernagel RM. Control of early viral and bacterial distribution and disease by natural antibodies. Science 1999;286:2156-2159.
43. Baumgarth N, Herman OC, Jager GC, Brown LE, Herzenberg LA, Chen J. B1 and B2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infection. J Exp Med 2000;192:271-280.
44. Macpherson AJ, Gatto D, Sainsbury E, Harriman GR, Hengartner H, Zinkernagel RM. A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria. Science 2000;288:2222-2226.
45. + T cell deficiency on IgA synthesis. Reg Immunol 1992;4:70-78.
46. Xu-Amano J, Kiyono H, Jackson RJ, et al. Helper T cell subset for immunoglobulin A response: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues. J Exp Med 1993;178:1309-1320.
47. Beagley KW, Eldridge JH, Lee F, et al. Interleukins and IgA synthesis: human and murine interleukin 6 induce high rate IgA secretion in IgA-committed B cells. J Exp Med 1989;169:2133-2148.
48. Bagley CJ, Lopez AF, Vadas MA. New frontiers for IL-5. J Allergy Clin Immunol 1997;99:725-728.
49. + peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J Exp Med 1998;188:1679-1689.
50. Fischer M, Klein U, Kuppers R. Molecular single-cell analysis reveals that CD5-positive peripheral blood B cells in healthy humans are characterized by rearranged Vκ genes lacking somatic mutation. J Clin Invest 1997;100:1667-1676.