B-1 cells and the intestinal microflora

Current Topics in Microbiology and Immunology

Volumn 252, Issue , 2000, Pages 211-220

  Bos, N A ^a   Cebra, J J ^a   Kroese, F G M ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN M; IMMUNOGLOBULIN M ANTIBODY;

ANIMAL CELL; ANIMAL MODEL; B LYMPHOCYTE; CONFERENCE PAPER; HUMORAL IMMUNITY; INTESTINE FLORA; LAMINA PROPRIA; MESENTERY LYMPH NODE; MOUSE; NONHUMAN; PERITONEUM CELL; PEYER PATCH; PRIORITY JOURNAL; SCID MOUSE;

ANIMALIA;

EID: 0033762906     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-57284-5_22     Document Type: Conference Paper

References (20)

1. The influence of exogenous antigenic stimulation on the specificity repertoire of background immunoglobulin-secreting Cells of different isotypes
2. Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut
3. Segmented filamentous bacteria are potent stimuli of a physiologically normal state of the murine gut mucosal immune system
4. Natural polyreactive secretory immunoglobulin A autoantibodies as a possible barriere to infection in humans
5. Control of early viral and bacterial distribution and disease by natural antibodies
6. B-1 cells and their reactivity with the murine intestinal microflora
7. No apparent influence of immunoglobulins on indigenous oral and intestinal microbiota of mice
8. Pneumocystis carinii infection in transgenic B cell-deficient mice
9. Targeted deletion of the IgA constant region in mice leads to IgA deficiency with alterations in expression of other Ig isotypes
10. Absence of epithelial immunoglobulin A transport, with increased mucosal leakiness, in polymeric immunoglobulin receptor/ secretory componenet deficient mice
11. Many of the IgA producing plasma cells in murine gut are derived from self-replenishing precursors in the peritoneal cavity
12. Evidence that intestinal IgA plasma cells in mu, kappa transgenic mice are derived from B-1 (Ly-1 B) cells
13. Presence of germline and full-length IgA RNA transcripts among peritoneal B-1 cells
14. Peritoneal B-1 cells switch in vivo to IgA and these IgA antibodies can bind to bacteria of the normal intestinal microflora
15. Monoclonal Immunoglobulin A derived from peritoneal B cells is encoded by both germ line and somatically mutated VH genes and reactive with commensal bacteria
16. Intestinal IgA plasma cells of the B1 lineage are IL-5 dependent
17. The life span of IgA plasma cells from the mouse intestine
18. Survival of long-lived plasma cells is independent of antigen
19. Humoral immunity due to long-lived plasma cells
20. Interactions between gut-associated lymphoid tissues and indigenous, filamentous bacteria in the small intestine of mice